ATE353957T1 - Verwendung von lezithin-cholesterin- azetyltransferase für die behandlung von atherosklerose - Google Patents

Verwendung von lezithin-cholesterin- azetyltransferase für die behandlung von atherosklerose

Info

Publication number: ATE353957T1
Authority: AT; Austria
Prior art keywords: atherosclerosis; treatment; acetyl transferase; lecithin cholesterol; cholesterol acetyl
Prior art date: 1995-11-09

Application number

AT96940403T

Other languages

English (en)

Inventor

Silvia Santamarina-Fojo

Jeffrey M Hoeg

H Bryan Brewer Jr

Original Assignee

Us Gov Health & Human Serv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-09

Filing date

1996-11-08

Publication date

2007-03-15

1996-11-08 Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv

2007-03-15 Application granted granted Critical

2007-03-15 Publication of ATE353957T1 publication Critical patent/ATE353957T1/de

Links

HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 4
201000001320 Atherosclerosis Diseases 0.000 title abstract 2
235000012000 cholesterol Nutrition 0.000 title abstract 2
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 title 1
102000005421 acetyltransferase Human genes 0.000 title 1
108020002494 acetyltransferase Proteins 0.000 title 1
229940067606 lecithin Drugs 0.000 title 1
235000010445 lecithin Nutrition 0.000 title 1
239000000787 lecithin Substances 0.000 title 1
101001130226 Homo sapiens Phosphatidylcholine-sterol acyltransferase Proteins 0.000 abstract 2
102100031538 Phosphatidylcholine-sterol acyltransferase Human genes 0.000 abstract 2
238000009825 accumulation Methods 0.000 abstract 1
239000002552 dosage form Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
210000002966 serum Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/107—Rabbit
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0375—Animal model for cardiovascular diseases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Zoology (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Environmental Sciences (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Biodiversity & Conservation Biology (AREA)
Plant Pathology (AREA)
Animal Behavior & Ethology (AREA)
Animal Husbandry (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Confectionery (AREA)

AT96940403T 1995-11-09 1996-11-08 Verwendung von lezithin-cholesterin- azetyltransferase für die behandlung von atherosklerose ATE353957T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US640095P	1995-11-09	1995-11-09

Publications (1)

Publication Number	Publication Date
ATE353957T1 true ATE353957T1 (de)	2007-03-15

Family

ID=21720680

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96940403T ATE353957T1 (de)	1995-11-09	1996-11-08	Verwendung von lezithin-cholesterin- azetyltransferase für die behandlung von atherosklerose

Country Status (8)

Country	Link
US (1)	US6635614B1 (de)
EP (1)	EP0871713B1 (de)
AT (1)	ATE353957T1 (de)
AU (1)	AU728257B2 (de)
CA (1)	CA2236982C (de)
DE (1)	DE69636907T2 (de)
ES (1)	ES2283007T3 (de)
WO (1)	WO1997017434A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6498019B1 (en) *	1997-04-11	2002-12-24	Takeda Chemical Industries, Ltd.	Lecithin-cholesterol acyltransferase protein
AU5931600A (en) *	1999-07-14	2001-02-05	Betagene, Inc.	Lcat recombinant cell line compositions and methods
WO2003040369A2 (fr) *	2001-09-17	2003-05-15	Molecular Engines Laboratories	Sequences impliquees dans les phenomenes de suppression tumorale, reversion tumorale, apoptose et/ou resistance aux virus et leur utilisation comme medicaments
WO2003062416A1 (fr) *	2002-01-21	2003-07-31	Takeda Chemical Industries, Ltd.	Procede de criblage d'agents preventifs et de remedes pour l'arteriosclerose
SE0201581D0 (sv)	2002-05-29	2002-05-29	Scandinavian Biotechnology Res	New improved acyltransferase
US20080096900A1 (en) *	2006-06-26	2008-04-24	Amgen Inc.	Methods for treating atherosclerosis
HRP20140315T1 (hr) *	2007-07-26	2014-05-09	Amgen Inc.	Modificirani enzimi lecitin-kolesterol aciltransferaze
SG175390A1 (en)	2009-04-29	2011-12-29	Amarin Corp Plc	Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
JP5759988B2 (ja) *	2009-06-12	2015-08-05	アルファコアファーマリミテッドライアビリティカンパニーＡｌｐｈａｃｏｒｅＰｈａｒｍａＬｌｃ	貧血および赤血球機能不全を治療するためのｌｃａｔの使用
JP6635655B2 (ja)	2011-12-08	2020-01-29	アムジエン・インコーポレーテツド	ヒトｌｃａｔ抗原結合タンパク質および治療法におけるそれらの使用
US10495652B1 (en) *	2012-04-13	2019-12-03	Roar Holding Llc	Determination of LCAT
JP2021501793A (ja) *	2017-11-07	2021-01-21	アルファコアファーマリミテッドライアビリティカンパニーＡｌｐｈａｃｏｒｅＰｈａｒｍａＬｌｃ	心疾患、心血管疾患及び関連する病状と症状を治療し保護する方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0239631A4 (de)	1985-10-04	1989-01-12	Biotech Res Partners Ltd	Rekombinante apolipoproteine und verfahren.
US4943527A (en) *	1985-10-04	1990-07-24	California Biotechnology Inc.	Mature apoai protein production under serum free culturing conditions
US5049488A (en)	1985-11-08	1991-09-17	Genentech, Inc.	Method and nucleic acid for the preparation of lecithin:cholesterol acyltransferase
DE4128288A1 (de)	1991-08-27	1993-03-04	Boehringer Ingelheim Kg	Verwendung von paf-antagonisten zur behandlung und diagnose von cholestase und anderen krankheiten, die durch einen erhoehten lipoprotein-x spiegel gekennzeichnet sind
JPH07507554A (ja) *	1992-06-12	1995-08-24	エヌ・ブイ・イノゲネテイクス・エス・エイ	新規ペプチドおよびタンパク質，それらの調製方法，ならびにコレステロール受容体としてのそれらの使用
SE9203753D0 (sv) *	1992-12-11	1992-12-11	Kabi Pharmacia Ab	Expression system for producing apolipoprotein ai-m
FR2718329B1 (fr)	1994-03-21	2002-09-20	Rhone Poulenc Rorer Sa	Lapin transgénique sensibilisé aux dyslipoprotéinémies.
FR2731710B1 (fr)	1995-03-14	1997-04-30	Rhone Poulenc Rorer Sa	Virus recombinants exprimant la lecithine cholesterol acyltransferase et utilisations en therapie genique

1996
- 1996-11-08 AT AT96940403T patent/ATE353957T1/de not_active IP Right Cessation
- 1996-11-08 AU AU77293/96A patent/AU728257B2/en not_active Expired
- 1996-11-08 ES ES96940403T patent/ES2283007T3/es not_active Expired - Lifetime
- 1996-11-08 CA CA2236982A patent/CA2236982C/en not_active Expired - Lifetime
- 1996-11-08 DE DE69636907T patent/DE69636907T2/de not_active Expired - Lifetime
- 1996-11-08 WO PCT/US1996/018159 patent/WO1997017434A2/en not_active Ceased
- 1996-11-08 US US09/068,386 patent/US6635614B1/en not_active Expired - Lifetime
- 1996-11-08 EP EP96940403A patent/EP0871713B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2236982C (en)	2010-07-27
US6635614B1 (en)	2003-10-21
AU728257B2 (en)	2001-01-04
WO1997017434A3 (en)	1997-06-19
AU7729396A (en)	1997-05-29
WO1997017434A2 (en)	1997-05-15
EP0871713B1 (de)	2007-02-14
DE69636907T2 (de)	2007-11-22
DE69636907D1 (de)	2007-03-29
ES2283007T3 (es)	2007-10-16
EP0871713A2 (de)	1998-10-21
CA2236982A1 (en)	1997-05-15

Legal Events

Date	Code	Title	Description
2007-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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UA70958C2 (uk)	2004-11-15	Спосіб лікування захворювання, пов'язаного з порушенням метаболізму естрогену (варіанти)
DE69815090D1 (de)	2003-07-03	Verwendung von cholinesterasehemmer zur behandlung von konzentrationsstörungen
ATE353957T1 (de)	2007-03-15	Verwendung von lezithin-cholesterin- azetyltransferase für die behandlung von atherosklerose
BG101717A (bg)	1998-02-27	Инхибитори на микрозомалния триглицерид пренасящ белтък и метод
ATE207349T1 (de)	2001-11-15	Thip zur behandlung von schlafstörungen
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DE3869490D1 (de)	1992-04-30	Verfahren zur elektrochemischen behandlung von stoffen.
DE69805973D1 (de)	2002-07-18	Behandlung von herzrythmusstörungen durch hemmung einer multifunktionalen calcium/calmodulin-abhängigen protein kinase
ATA76995A (de)	2002-04-15	Stabiles präparat zur behandlung von blutgerinnungsstörungen
EP1098642A4 (de)	2004-08-18	Verfahren zur behandlung von zustanden moduliert durch lactosylceramiden
DE69634951D1 (de)	2005-08-25	Topische verwendung von betulinsäure zur behandlung bösartiger melanome
ATE338563T1 (de)	2006-09-15	Verfahren zur behandlung von patienten die unter multipler sklerose leiden mit konsensus- interferon
DE69535264D1 (de)	2006-11-23	Verfahren zur behandlung von diabetes mittels kgf
HUP9800731A2 (hu)	1998-07-28	Eljárás ivarsejt osztódás stimulálására
ATE321548T1 (de)	2006-04-15	Verwendung von statin zur behandlung von hauterkrankungen
DE69825286D1 (de)	2004-09-02	Verwendung von cholinesterasehemmern zur behandlung von aufmerksamkeitsmangel-störungen
EP0876149A4 (de)	2001-09-26	Verfahren zur behandlung von störungen, die von einer cytidin- deaminase oder desoxycytidin- deaminase überexpression charakteriziert werden
ATE484294T1 (de)	2010-10-15	Anti-interleukin-9 antikörper oder anti- interleukin-9 rezeptor antikörper zur behandlung von bronchialem hyperreaktionsvermögen
DE69129953D1 (de)	1998-09-17	Verwendung von Bisphosphonsäure zur Behandlung von Störungen des Kalziummetabolismus