ATE356809T1 - Monomer- und dimer-arylisochinolinalkaloide und derivate - Google Patents
Monomer- und dimer-arylisochinolinalkaloide und derivateInfo
- Publication number
- ATE356809T1 ATE356809T1 AT98966748T AT98966748T ATE356809T1 AT E356809 T1 ATE356809 T1 AT E356809T1 AT 98966748 T AT98966748 T AT 98966748T AT 98966748 T AT98966748 T AT 98966748T AT E356809 T1 ATE356809 T1 AT E356809T1
- Authority
- AT
- Austria
- Prior art keywords
- monomeric
- present
- arylisoquinoline
- compounds
- derivatives
- Prior art date
Links
- 229930013930 alkaloid Natural products 0.000 title abstract 3
- 239000000178 monomer Substances 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 5
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- YGRSXJJORLXYPT-UHFFFAOYSA-N 1-naphthalen-1-ylisoquinoline Chemical class C1=CC=C2C(C=3C4=CC=CC=C4C=CC=3)=NC=CC2=C1 YGRSXJJORLXYPT-UHFFFAOYSA-N 0.000 abstract 1
- 241000893024 Ancistrocladaceae Species 0.000 abstract 1
- 241000893022 Dioncophyllaceae Species 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- 150000003797 alkaloid derivatives Chemical class 0.000 abstract 1
- 230000000078 anti-malarial effect Effects 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 239000003430 antimalarial agent Substances 0.000 abstract 1
- 238000001212 derivatisation Methods 0.000 abstract 1
- ZTVGDICRDKHNSL-UHFFFAOYSA-N dioncophylline D Natural products C1C(C)NC(C)C2=C(O)C(C3=C4C=C(C)C=C(C4=C(O)C=C3)OC)=CC=C21 ZTVGDICRDKHNSL-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 229930014623 naphthyl-isoquinoline alkaloid Natural products 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000006257 total synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/001,801 US6140339A (en) | 1994-02-14 | 1997-12-31 | Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE356809T1 true ATE356809T1 (de) | 2007-04-15 |
Family
ID=21697901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98966748T ATE356809T1 (de) | 1997-12-31 | 1998-12-23 | Monomer- und dimer-arylisochinolinalkaloide und derivate |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6140339A (de) |
| EP (1) | EP1045837B1 (de) |
| AT (1) | ATE356809T1 (de) |
| AU (1) | AU751591B2 (de) |
| BR (1) | BR9814575A (de) |
| CA (1) | CA2313487A1 (de) |
| DE (1) | DE69837349D1 (de) |
| WO (1) | WO1999033811A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6140339A (en) | 1994-02-14 | 2000-10-31 | The United States Of America As Represented By The Department Of Health And Human Services | Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof |
| US8449858B2 (en) * | 2009-06-10 | 2013-05-28 | Carbon Solutions, Inc. | Continuous extraction technique for the purification of carbon nanomaterials |
| US8394159B2 (en) * | 2011-01-31 | 2013-03-12 | Honda Motor Co., Ltd. | Vehicle air cleaner housing |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH541609A (de) * | 1970-02-03 | 1973-09-15 | Ciba Geigy Ag | Verfahren zur Herstellung von Bi-isochinolinonen und deren Verwendung als Fluoreszenzfarbstoffe in Kunststoffen |
| US4096190A (en) * | 1976-11-26 | 1978-06-20 | Ici Americas Inc. | Oxidative coupling of alkylphenols catalyzed by metal ammonia complexes |
| US5001115A (en) * | 1989-05-17 | 1991-03-19 | University Of Florida | Prodrugs of biologically active hydroxyaromatic compounds |
| US5025020A (en) * | 1989-09-28 | 1991-06-18 | Cancer Biologics Of America, Inc. | Use of tetrandrine and its derivatives to treat malaria |
| EP0594795B1 (de) * | 1991-04-12 | 2002-02-13 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Michellamine zur verwendung als antivirale wirkstoffe, zusammensetzung und behandlungsverfahren |
| DE4117080A1 (de) * | 1991-05-25 | 1992-11-26 | Basf Ag | Anwendung von dioncophyllinen als fungizide |
| WO1994024108A1 (en) * | 1993-04-19 | 1994-10-27 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Michellamines useful as antiviral agents |
| US5571919A (en) * | 1994-07-22 | 1996-11-05 | The United States Of America As Represented By The Department Of Health And Human Services | Dimeric naphthylisoquinoline alkaloids and synthesis methods thereof |
| US5578729A (en) * | 1994-07-22 | 1996-11-26 | The United States Of America As Represented By The Department Of Health And Human Services | Dimeric arylisoquinoline alkaloid compounds |
| US5552550A (en) * | 1994-07-22 | 1996-09-03 | The United States Of America, As Represented By The Department Of Health And Human Services | Monomeric Naphthylisoquinoline alkaloids and synthesis methods thereof |
| US5639761A (en) * | 1994-02-14 | 1997-06-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof |
| US6140339A (en) | 1994-02-14 | 2000-10-31 | The United States Of America As Represented By The Department Of Health And Human Services | Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof |
| US5409938A (en) * | 1994-02-14 | 1995-04-25 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Antimalarial korupensamines and pharmaceutical compositions and medical uses thereof |
| DK0772595T3 (da) * | 1994-07-22 | 2003-07-21 | Us Health | Monomerisk og dimerisk naphthylisoquinolinalkaloider og syntesemetoder deraf |
| US5543523A (en) * | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
-
1997
- 1997-12-31 US US09/001,801 patent/US6140339A/en not_active Expired - Fee Related
-
1998
- 1998-12-23 AU AU24496/99A patent/AU751591B2/en not_active Ceased
- 1998-12-23 WO PCT/US1998/027407 patent/WO1999033811A1/en not_active Ceased
- 1998-12-23 EP EP98966748A patent/EP1045837B1/de not_active Expired - Lifetime
- 1998-12-23 DE DE69837349T patent/DE69837349D1/de not_active Expired - Lifetime
- 1998-12-23 BR BR9814575-4A patent/BR9814575A/pt not_active Application Discontinuation
- 1998-12-23 AT AT98966748T patent/ATE356809T1/de not_active IP Right Cessation
- 1998-12-23 CA CA002313487A patent/CA2313487A1/en not_active Abandoned
-
2000
- 2000-03-16 US US09/527,002 patent/US6331630B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1045837A1 (de) | 2000-10-25 |
| WO1999033811A1 (en) | 1999-07-08 |
| DE69837349D1 (de) | 2007-04-26 |
| BR9814575A (pt) | 2000-10-10 |
| EP1045837B1 (de) | 2007-03-14 |
| AU751591B2 (en) | 2002-08-22 |
| CA2313487A1 (en) | 1999-07-08 |
| AU2449699A (en) | 1999-07-19 |
| US6140339A (en) | 2000-10-31 |
| US6331630B1 (en) | 2001-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |