ATE357436T1 - Verfahren zur herstellung von halbfertigen produkten verwendbar für die synthese des paclitaxels - Google Patents
Verfahren zur herstellung von halbfertigen produkten verwendbar für die synthese des paclitaxelsInfo
- Publication number
- ATE357436T1 ATE357436T1 AT03789656T AT03789656T ATE357436T1 AT E357436 T1 ATE357436 T1 AT E357436T1 AT 03789656 T AT03789656 T AT 03789656T AT 03789656 T AT03789656 T AT 03789656T AT E357436 T1 ATE357436 T1 AT E357436T1
- Authority
- AT
- Austria
- Prior art keywords
- paclitaxel
- synthesis
- finished products
- producing semi
- treated
- Prior art date
Links
- 229930012538 Paclitaxel Natural products 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229960001592 paclitaxel Drugs 0.000 title abstract 2
- 239000011265 semifinished product Substances 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 2
- OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 abstract 1
- HOJZAHQWDXAPDJ-UHFFFAOYSA-N 3-anilino-2-hydroxypropanoic acid Chemical class OC(=O)C(O)CNC1=CC=CC=C1 HOJZAHQWDXAPDJ-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229930014667 baccatin III Natural products 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
- 150000003918 triazines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL357881A PL194032B1 (pl) | 2002-12-19 | 2002-12-19 | Sposób wytwarzania półproduktów użytecznych w syntezie paklitakselu |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE357436T1 true ATE357436T1 (de) | 2007-04-15 |
Family
ID=32678124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03789656T ATE357436T1 (de) | 2002-12-19 | 2003-12-11 | Verfahren zur herstellung von halbfertigen produkten verwendbar für die synthese des paclitaxels |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1575929B1 (de) |
| AT (1) | ATE357436T1 (de) |
| AU (1) | AU2003294189A1 (de) |
| DE (1) | DE60312734D1 (de) |
| PL (1) | PL194032B1 (de) |
| WO (1) | WO2004056790A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101020672B (zh) * | 2006-12-28 | 2010-08-25 | 上海百灵医药科技有限公司 | 多烯紫杉醇的合成方法 |
| KR101096282B1 (ko) * | 2009-04-24 | 2011-12-20 | 주식회사 삼양제넥스 | 탁산 유도체를 제조하는 방법 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0884314B1 (de) * | 1991-09-23 | 2004-01-21 | Florida State University | Metallalkoxide |
| GB9512471D0 (en) * | 1995-06-20 | 1995-08-23 | Pharmacia Spa | Method for the preparation of taxol and its derivatives |
| US6150537A (en) * | 1997-12-12 | 2000-11-21 | Emory University | Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents |
-
2002
- 2002-12-19 PL PL357881A patent/PL194032B1/pl not_active IP Right Cessation
-
2003
- 2003-12-11 AU AU2003294189A patent/AU2003294189A1/en not_active Abandoned
- 2003-12-11 EP EP03789656A patent/EP1575929B1/de not_active Expired - Lifetime
- 2003-12-11 AT AT03789656T patent/ATE357436T1/de not_active IP Right Cessation
- 2003-12-11 DE DE60312734T patent/DE60312734D1/de not_active Expired - Lifetime
- 2003-12-11 WO PCT/PL2003/000139 patent/WO2004056790A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003294189A1 (en) | 2004-07-14 |
| WO2004056790A1 (en) | 2004-07-08 |
| EP1575929B1 (de) | 2007-03-21 |
| PL194032B1 (pl) | 2007-04-30 |
| PL357881A1 (en) | 2004-06-28 |
| DE60312734D1 (de) | 2007-05-03 |
| EP1575929A1 (de) | 2005-09-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |