ATE357452T1 - Sialyl-lewisa und sialyl lewisx epitop-analoge - Google Patents

Sialyl-lewisa und sialyl lewisx epitop-analoge

Info

Publication number
ATE357452T1
ATE357452T1 AT97901546T AT97901546T ATE357452T1 AT E357452 T1 ATE357452 T1 AT E357452T1 AT 97901546 T AT97901546 T AT 97901546T AT 97901546 T AT97901546 T AT 97901546T AT E357452 T1 ATE357452 T1 AT E357452T1
Authority
AT
Austria
Prior art keywords
sialyl
lewisa
lewisx
epitop
analogue
Prior art date
Application number
AT97901546T
Other languages
English (en)
Inventor
Reinhold Oehrlein
Original Assignee
Glycomimetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycomimetics Inc filed Critical Glycomimetics Inc
Application granted granted Critical
Publication of ATE357452T1 publication Critical patent/ATE357452T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT97901546T 1996-01-30 1997-01-17 Sialyl-lewisa und sialyl lewisx epitop-analoge ATE357452T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH23096 1996-01-30

Publications (1)

Publication Number Publication Date
ATE357452T1 true ATE357452T1 (de) 2007-04-15

Family

ID=4182259

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97901546T ATE357452T1 (de) 1996-01-30 1997-01-17 Sialyl-lewisa und sialyl lewisx epitop-analoge

Country Status (6)

Country Link
US (1) US6169077B1 (de)
EP (1) EP0886640B1 (de)
AT (1) ATE357452T1 (de)
AU (1) AU1542397A (de)
DE (1) DE69737496D1 (de)
WO (1) WO1997028173A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756489B1 (en) * 1997-08-08 2004-06-29 Aventis Pharma Deutschland Gmbh Substituted tetrahydropyrane derivatives, method for producing same, their use as medicine or diagnostic agent, as well as medicine containing same
SE9904581D0 (sv) * 1999-12-15 1999-12-15 A & Science Invest Ab A novel helicobacter pylori-binding substance and use thereof
US7481790B2 (en) * 2000-12-27 2009-01-27 Advanced Cardiovascular Systems, Inc. Vessel enlargement by arteriogenic factor delivery
WO2003097658A2 (en) * 2002-05-16 2003-11-27 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
JP2006502986A (ja) * 2002-07-03 2006-01-26 グリコミメティクス， インコーポレイテッド 新脈管形成に関与する医学的状態の診断および治療のための組成物および方法
AU2003301209A1 (en) * 2002-12-20 2004-07-22 Glycomimetics, Inc. Oligosaccharides and conjugates thereof for the treatement of pseudomonas bacteria infection
US20040219158A1 (en) * 2003-05-02 2004-11-04 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
WO2005054264A2 (en) * 2003-11-19 2005-06-16 Glycomimetics, Inc. Glycomimetic antagonists for both e- and p-selectins
EP1763533B1 (de) * 2003-11-19 2008-01-09 GlycoMimetics, Inc. Spezifischer antagonist sowohl für e- als auch p-selektine
US8201377B2 (en) * 2004-11-05 2012-06-19 Faus Group, Inc. Flooring system having multiple alignment points
US20090036386A1 (en) * 2005-05-25 2009-02-05 Glycomimetics, Inc Heterobifunctional compounds for selectin inhibition
CN101291946B (zh) * 2005-08-09 2011-06-29 糖模拟物有限公司 对来自假单胞菌的pa-il凝集素、pa-iil凝集素或其两者的糖模拟物抑制剂
PL2264043T3 (pl) 2005-09-02 2018-04-30 Glycomimetics, Inc. Heterobifunkcyjne inhibitory pan-selektyny
US20090176717A1 (en) * 2006-06-01 2009-07-09 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
EP2074132B1 (de) 2006-10-12 2013-05-15 GlycoMimetics, Inc. Glycomimetischer ersatz für hexosen und n-acetyl-hexosamine
AU2008216794A1 (en) * 2007-02-09 2008-08-21 Glycomimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and N-acetyl hexosamines
US8039442B2 (en) 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
WO2009126556A1 (en) 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
CN102088983B (zh) * 2008-06-13 2013-01-30 糖模拟物有限公司 利用选择的糖模拟化合物的血液癌症的治疗
CA2760292A1 (en) * 2009-05-01 2010-11-04 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
KR102055958B1 (ko) 2011-12-22 2019-12-13 글리코미메틱스, 인크. E-셀렉틴 길항제 화합물, 조성물, 및 이용 방법
GB201214736D0 (en) * 2012-08-17 2012-10-03 Isis Innovation Inflammation imaging and therapy
US9867841B2 (en) 2012-12-07 2018-01-16 Glycomimetics, Inc. Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells
JP6689854B2 (ja) 2014-12-03 2020-04-28 グリコミメティクス， インコーポレイテッド Ｅ−セレクチンおよびｃｘｃｒ４ケモカイン受容体のヘテロ二官能性阻害剤
JP2019502727A (ja) 2016-01-22 2019-01-31 グリコミメティクス， インコーポレイテッド Ｐａ−ｉｌおよび／またはｐａ−ｉｉｌレクチンの糖模倣体阻害剤
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
AU2017341065B2 (en) 2016-10-07 2023-04-06 Crescent Biopharma, Inc. Highly potent multimeric E-selectin antagonists
EP3596096A1 (de) 2017-03-15 2020-01-22 GlycoMimetics, Inc. Galactopyranosyl-cyclohexyl-derivate als e-selectin-antagonisten
JP7275131B2 (ja) 2017-11-30 2023-05-17 グリコミメティクス， インコーポレイテッド 骨髄浸潤リンパ球を動員する方法、およびその使用
KR20200104889A (ko) 2017-12-29 2020-09-04 글리코미메틱스, 인크. E-셀렉틴 및 갈렉틴-3의 이종이기능성 억제제
KR20200128025A (ko) 2018-03-05 2020-11-11 글리코미메틱스, 인크. 급성 골수성 백혈병 및 관련 병태의 치료 방법
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925796A (en) * 1986-03-07 1990-05-15 Massachusetts Institute Of Technology Method for enhancing glycoprotein stability
CZ298895A3 (en) 1993-05-14 1996-04-17 Cytel Corp Compound analogous to sialyl lex, pharmaceutical composition containing thereof and process for preparing lactosammonium salt
SE9301677L (sv) 1993-05-14 1994-11-18 Kurt G I Nilsson Syntesmetod

Also Published As

Publication number Publication date
AU1542397A (en) 1997-08-22
WO1997028173A1 (en) 1997-08-07
EP0886640B1 (de) 2007-03-21
DE69737496D1 (de) 2007-05-03
US6169077B1 (en) 2001-01-02
EP0886640A1 (de) 1998-12-30

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