ATE360018T1 - Thienylalaninderivate als inhibitoren der zelladhäsion - Google Patents
Thienylalaninderivate als inhibitoren der zelladhäsionInfo
- Publication number
- ATE360018T1 ATE360018T1 AT00989987T AT00989987T ATE360018T1 AT E360018 T1 ATE360018 T1 AT E360018T1 AT 00989987 T AT00989987 T AT 00989987T AT 00989987 T AT00989987 T AT 00989987T AT E360018 T1 ATE360018 T1 AT E360018T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- cell
- formula
- inhibitors
- cell adhesion
- Prior art date
Links
- 230000021164 cell adhesion Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- WTOFYLAWDLQMBZ-UHFFFAOYSA-N 2-azaniumyl-3-thiophen-2-ylpropanoate Chemical class OC(=O)C(N)CC1=CC=CS1 WTOFYLAWDLQMBZ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 102100022337 Integrin alpha-V Human genes 0.000 abstract 2
- 108010048673 Vitronectin Receptors Proteins 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 230000003993 interaction Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000006386 Bone Resorption Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000024279 bone resorption Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000008619 cell matrix interaction Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000008611 intercellular interaction Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 210000002997 osteoclast Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Printed Wiring (AREA)
- Fixed Capacitors And Capacitor Manufacturing Machines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99124971A EP1108721A1 (de) | 1999-12-15 | 1999-12-15 | Thienylalaninderivate als Inhibitoren der Zelladhäsion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE360018T1 true ATE360018T1 (de) | 2007-05-15 |
Family
ID=8239611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00989987T ATE360018T1 (de) | 1999-12-15 | 2000-12-12 | Thienylalaninderivate als inhibitoren der zelladhäsion |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6762190B2 (de) |
| EP (2) | EP1108721A1 (de) |
| AT (1) | ATE360018T1 (de) |
| AU (1) | AU2674201A (de) |
| CA (1) | CA2394767A1 (de) |
| DE (1) | DE60034482T2 (de) |
| WO (1) | WO2001044237A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101360736A (zh) * | 2005-11-23 | 2009-02-04 | 阿斯利康(瑞典)有限公司 | L-丙氨酸衍生物 |
| JP2009539815A (ja) * | 2006-06-09 | 2009-11-19 | アストラゼネカ アクチボラグ | 固形腫瘍の治療用のａ５ｂ１アンタゴニストとしてのＮ−（ベンゾイル）−Ｏ−［２−（ピリジン−２−イルアミノ）エチル］−Ｌ−チロシン誘導体と関連化合物 |
| US20090062267A1 (en) * | 2007-01-29 | 2009-03-05 | Astrazeneca Ab | L-ALANINE DERIVATIVES AS a5beta1 ANTAGONISTS |
| WO2008125811A1 (en) * | 2007-04-11 | 2008-10-23 | Astrazeneca Ab | N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5204350A (en) * | 1991-08-09 | 1993-04-20 | Merck & Co., Inc. | Method of inhibiting osteoclast-mediated bone resorption by administration of n-heterocyclicalkyl-substituted phenyl derivatives |
| JP3322878B2 (ja) * | 1992-10-14 | 2002-09-09 | メルク エンド カンパニー インコーポレーテッド | フィブリノーゲンレセプターアンタゴニスト |
| ES2186720T3 (es) * | 1994-05-27 | 2003-05-16 | Merck & Co Inc | Composiciones para inhibir la reabsorcion osea mediada por osteoclastos. |
| JP3895792B2 (ja) * | 1995-12-08 | 2007-03-22 | プロスケリア・エス・ア・エス | 骨形成促進剤 |
| DE19629816A1 (de) * | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
| BR9907735A (pt) * | 1998-01-23 | 2000-10-17 | Aventis Pharma Gmbh | Derivados de sulfonamida como inibidores da reabsorção óssea e como inibidores da aderência celular |
| EP0960882A1 (de) * | 1998-05-19 | 1999-12-01 | Hoechst Marion Roussel Deutschland GmbH | Thienyl substituiertre Acylguanidine und ihre Verwendung als Knochenresorptionhemmer und als Vitronectinrezeptor-Antagoniste |
-
1999
- 1999-12-15 EP EP99124971A patent/EP1108721A1/de not_active Withdrawn
-
2000
- 2000-12-12 EP EP00989987A patent/EP1240161B1/de not_active Expired - Lifetime
- 2000-12-12 US US10/169,612 patent/US6762190B2/en not_active Expired - Lifetime
- 2000-12-12 AT AT00989987T patent/ATE360018T1/de not_active IP Right Cessation
- 2000-12-12 AU AU26742/01A patent/AU2674201A/en not_active Abandoned
- 2000-12-12 DE DE60034482T patent/DE60034482T2/de not_active Expired - Lifetime
- 2000-12-12 WO PCT/EP2000/012877 patent/WO2001044237A1/en not_active Ceased
- 2000-12-12 CA CA002394767A patent/CA2394767A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2394767A1 (en) | 2001-06-21 |
| US6762190B2 (en) | 2004-07-13 |
| DE60034482T2 (de) | 2008-01-10 |
| EP1240161A1 (de) | 2002-09-18 |
| DE60034482D1 (de) | 2007-05-31 |
| EP1108721A1 (de) | 2001-06-20 |
| WO2001044237A1 (en) | 2001-06-21 |
| EP1240161B1 (de) | 2007-04-18 |
| US20030105080A1 (en) | 2003-06-05 |
| AU2674201A (en) | 2001-06-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |