ATE360032T1 - Cystein-reiche rezeptoren-train - Google Patents

Cystein-reiche rezeptoren-train

Info

Publication number
ATE360032T1
ATE360032T1 AT98944859T AT98944859T ATE360032T1 AT E360032 T1 ATE360032 T1 AT E360032T1 AT 98944859 T AT98944859 T AT 98944859T AT 98944859 T AT98944859 T AT 98944859T AT E360032 T1 ATE360032 T1 AT E360032T1
Authority
AT
Austria
Prior art keywords
train
cystein
receptor
rich receptor
rich
Prior art date
Application number
AT98944859T
Other languages
English (en)
Inventor
Jurg Tschopp
Catherine Hession
Original Assignee
Biogen Idec Inc
Apotech R & D Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc, Apotech R & D Sa filed Critical Biogen Idec Inc
Application granted granted Critical
Publication of ATE360032T1 publication Critical patent/ATE360032T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153 or CD154

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98944859T 1997-09-12 1998-09-11 Cystein-reiche rezeptoren-train ATE360032T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5863197P 1997-09-12 1997-09-12
US8442298P 1998-05-06 1998-05-06

Publications (1)

Publication Number Publication Date
ATE360032T1 true ATE360032T1 (de) 2007-05-15

Family

ID=26737837

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98944859T ATE360032T1 (de) 1997-09-12 1998-09-11 Cystein-reiche rezeptoren-train

Country Status (9)

Country Link
US (4) US7223852B2 (de)
EP (2) EP1012282B1 (de)
JP (1) JP4357738B2 (de)
AT (1) ATE360032T1 (de)
AU (2) AU9386398A (de)
CA (1) CA2301173C (de)
DE (1) DE69837606T2 (de)
ES (1) ES2286856T3 (de)
WO (2) WO1999013078A1 (de)

Families Citing this family (36)

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US7528239B1 (en) 1997-02-13 2009-05-05 Immunex Corporation Receptor that binds trail
US6072047A (en) 1997-02-13 2000-06-06 Immunex Corporation Receptor that binds trail
ATE397662T1 (de) * 1997-02-27 2008-06-15 Ono Pharmaceutical Co Neues polypeptid, dafür kodierende dna und deren verwendungen
US6342369B1 (en) 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
ES2286856T3 (es) 1997-09-12 2007-12-01 Biogen Idec Ma Inc. Receptores train ricos en cisteina.
IL136988A0 (en) * 1997-12-29 2001-06-14 Regeneron Pharma Novel nucleic acid and polypeptide
EP1053351A4 (de) * 1998-01-27 2002-09-25 Millennium Pharm Inc Neue moleküle der tnf-rezeptorsuperfamilie und verwendungen dafür
AU2486300A (en) * 1998-12-30 2000-07-31 Millennium Pharmaceuticals, Inc. Secreted proteins and nucleic acids encoding them
WO2000049149A1 (fr) * 1999-02-19 2000-08-24 Toshio Kitamura Nouvelles proteines du type recepteurs des tnf
KR20090016772A (ko) 1999-08-17 2009-02-17 바이오겐 아이덱 엠에이 인코포레이티드 Ｂａｆｆ 수용체(ｂｃｍａ), 면역조절제
EP1212413A1 (de) * 1999-08-25 2002-06-12 Genome Therapeutics Corporation Eine transmembranfalle zur isolierung von membrangebundenen proteinen
WO2001030850A1 (en) * 1999-10-22 2001-05-03 Zymogenetics, Inc. Umlr polypeptides
GB9927681D0 (en) * 1999-11-23 2000-01-19 Glaxo Group Ltd Protein
EP1254176B1 (de) * 2000-02-11 2008-01-09 Genetics Institute, LLC Verwendung der extrazellulären Domäne von TRADE Molekülen in Medikamenten zur Behandlung von Neoplasie
US6900185B1 (en) 2000-04-12 2005-05-31 University Of Iowa Research Foundation Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer
TWI318983B (en) 2000-05-02 2010-01-01 Uab Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
US7279160B2 (en) 2000-05-02 2007-10-09 The Uab Research Foundation Combinations of DR5 antibodies and other therapeutic agents
US7476383B2 (en) 2000-05-02 2009-01-13 The Uab Research Foundation Antibody selective for DR4 and uses thereof
WO2002079377A2 (en) * 2000-11-08 2002-10-10 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
JP4309758B2 (ja) 2001-05-25 2009-08-05 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド Ｔｒａｉｌレセプターに免疫特異的に結合する抗体
US7361341B2 (en) 2001-05-25 2008-04-22 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
US7348003B2 (en) 2001-05-25 2008-03-25 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
SG151294A1 (en) 2004-03-23 2009-04-30 Biogen Idec Inc Receptor coupling agents and therapeutic uses thereof
EP1789070B1 (de) 2004-08-03 2012-10-24 Biogen Idec MA Inc. Taj in der neuronalen funktion
US8129124B2 (en) 2005-02-02 2012-03-06 The Uab Research Foundation Agents and methods related to reducing resistance to apoptosis-inducing death receptor agonists
JP4898126B2 (ja) * 2005-02-28 2012-03-14 中外製薬株式会社 Ｔｒｏｙシグナルが阻害されたトランスジェニック非ヒト動物
PE20071101A1 (es) 2005-08-31 2007-12-21 Amgen Inc Polipeptidos y anticuerpos
EP2010917B1 (de) * 2006-04-10 2012-06-27 Trustees of Boston University Melanom-biomarker und verwendungsverfahren dafür
BR112012010698A2 (pt) 2009-11-05 2016-11-29 Uab Research Foundation método para tratamento de um sujeito com câncer, método de triagem de uma célula de câncer de mama, e , anticorpo
US8703712B2 (en) 2010-03-18 2014-04-22 The Uab Research Foundation Targeting cancer stem cells with DR5 agonists
WO2012057288A1 (ja) 2010-10-29 2012-05-03 第一三共株式会社 新規抗ｄｒ５抗体
ES2847578T3 (es) 2011-04-15 2021-08-03 Dexcom Inc Calibración avanzada de sensor de analito y detección de errores
EP2825096B1 (de) 2012-03-16 2023-04-26 Dexcom, Inc. Systeme und verfahren zur verarbeitung von analytsensordaten
WO2019083939A1 (en) 2017-10-24 2019-05-02 Dexcom, Inc. PRECONNECTED ANALYTE SENSORS
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors

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Publication number Priority date Publication date Assignee Title
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
US5965388A (en) 1996-07-09 1999-10-12 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO2002008284A2 (en) 2000-07-20 2002-01-31 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
DE69834027D1 (de) * 1997-01-14 2006-05-18 Human Genome Sciences Inc Tumor-nekrose-faktor rezeptor 5
US6072047A (en) * 1997-02-13 2000-06-06 Immunex Corporation Receptor that binds trail
ATE397662T1 (de) * 1997-02-27 2008-06-15 Ono Pharmaceutical Co Neues polypeptid, dafür kodierende dna und deren verwendungen
ES2281126T3 (es) * 1997-03-17 2007-09-16 Human Genome Sciences, Inc. Receptor 5 que contiene un dominio de muerte.
AU9376498A (en) 1997-09-05 1999-03-22 University Of Washington Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
ES2286856T3 (es) 1997-09-12 2007-12-01 Biogen Idec Ma Inc. Receptores train ricos en cisteina.
US20030027272A1 (en) * 1997-09-18 2003-02-06 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
JP2001520033A (ja) 1997-10-18 2001-10-30 ジェネティックス・インスチチュート・インコーポレーテッド 分泌蛋白およびそれらをコードするポリヌクレオチド
IL136988A0 (en) 1997-12-29 2001-06-14 Regeneron Pharma Novel nucleic acid and polypeptide
AU2093499A (en) 1997-12-30 1999-07-19 Chiron Corporation Members of tnf and tnfr families
EP1053351A4 (de) 1998-01-27 2002-09-25 Millennium Pharm Inc Neue moleküle der tnf-rezeptorsuperfamilie und verwendungen dafür
EP1093516A2 (de) 1998-07-06 2001-04-25 Schering Corporation Säugergenen; dendritische zellen prostaglandin- förmigen transporterprotein (dc-pgt), hdtea84, hsljd37r und rankl, hcc5 chemokine, deubiquitine 11 und 12 (dub11, dub12), md-1, md2 und cyclin e2, zugehörige reagenzien und verfahren
JP2000098232A (ja) * 1998-09-25 2000-04-07 Canon Inc 光学素子及びそれを用いた光学系
WO2000049149A1 (fr) 1999-02-19 2000-08-24 Toshio Kitamura Nouvelles proteines du type recepteurs des tnf
CA2362427A1 (en) 1999-03-08 2000-09-14 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
GB9927681D0 (en) 1999-11-23 2000-01-19 Glaxo Group Ltd Protein
EP1254176B1 (de) 2000-02-11 2008-01-09 Genetics Institute, LLC Verwendung der extrazellulären Domäne von TRADE Molekülen in Medikamenten zur Behandlung von Neoplasie
AU6802801A (en) 2000-03-01 2001-09-24 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU6531101A (en) 2000-06-02 2001-12-17 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1309620A2 (de) 2000-06-23 2003-05-14 Genentech, Inc. Zusammensetzungen und verfahren zur diagnose und der behandlung von krankheiten, bei denen die angiogenese eine rolle spielt
JP2004514420A (ja) 2000-07-20 2004-05-20 ジェネンテック・インコーポレーテッド 分泌及び膜貫通ポリペプチドとそれをコードする核酸
AU2002328173A1 (en) 2001-08-07 2003-02-24 Genset S.A. Omoxin agonists and antagonists for use in the treatment of metabolic disorders
EP1694116A2 (de) 2003-12-16 2006-08-30 Genentech, Inc. Neue gendisruptionen, zusammensetzungen und verfahren hierfür
EP1789070B1 (de) 2004-08-03 2012-10-24 Biogen Idec MA Inc. Taj in der neuronalen funktion
US20070186296A1 (en) * 2006-02-02 2007-08-09 Wyeth Cloning, characterization, and application of tnfrsf19 in neurological disorders

Also Published As

Publication number Publication date
EP1012282B1 (de) 2007-04-18
US20090004188A1 (en) 2009-01-01
AU9230398A (en) 1999-03-29
US20110158993A1 (en) 2011-06-30
US7838639B2 (en) 2010-11-23
ES2286856T3 (es) 2007-12-01
JP2002505843A (ja) 2002-02-26
WO1999012963A2 (en) 1999-03-18
CA2301173A1 (en) 1999-03-18
WO1999013078A1 (en) 1999-03-18
DE69837606T2 (de) 2008-02-14
AU9386398A (en) 1999-03-29
HK1028417A1 (en) 2001-02-16
JP4357738B2 (ja) 2009-11-04
WO1999012963A3 (en) 1999-05-06
EP1012282A1 (de) 2000-06-28
AU738688B2 (en) 2001-09-27
US7223852B2 (en) 2007-05-29
US7402658B2 (en) 2008-07-22
EP1012179A2 (de) 2000-06-28
DE69837606D1 (de) 2007-05-31
US20030219860A1 (en) 2003-11-27
CA2301173C (en) 2015-04-14
US20060233792A1 (en) 2006-10-19

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