ATE360033T1 - Ortsspezifische proteinmodifizierung durch mutagenese - Google Patents
Ortsspezifische proteinmodifizierung durch mutageneseInfo
- Publication number
- ATE360033T1 ATE360033T1 AT99930486T AT99930486T ATE360033T1 AT E360033 T1 ATE360033 T1 AT E360033T1 AT 99930486 T AT99930486 T AT 99930486T AT 99930486 T AT99930486 T AT 99930486T AT E360033 T1 ATE360033 T1 AT E360033T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- polyethylene glycol
- amino acid
- acid residue
- mutagenesis
- Prior art date
Links
- 238000002703 mutagenesis Methods 0.000 title 1
- 231100000350 mutagenesis Toxicity 0.000 title 1
- 230000009145 protein modification Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 239000002202 Polyethylene glycol Substances 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- 229920001223 polyethylene glycol Polymers 0.000 abstract 4
- 125000000539 amino acid group Chemical group 0.000 abstract 3
- 230000021615 conjugation Effects 0.000 abstract 2
- 230000001268 conjugating effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 abstract 1
- 102000035118 modified proteins Human genes 0.000 abstract 1
- 108091005573 modified proteins Proteins 0.000 abstract 1
- 230000004952 protein activity Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/102,530 US6451986B1 (en) | 1998-06-22 | 1998-06-22 | Site specific protein modification |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE360033T1 true ATE360033T1 (de) | 2007-05-15 |
Family
ID=22290346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99930486T ATE360033T1 (de) | 1998-06-22 | 1999-06-18 | Ortsspezifische proteinmodifizierung durch mutagenese |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US6451986B1 (de) |
| EP (2) | EP1090036B1 (de) |
| JP (1) | JP3578991B2 (de) |
| AT (1) | ATE360033T1 (de) |
| AU (1) | AU767630B2 (de) |
| CA (1) | CA2331337C (de) |
| DE (1) | DE69935855T2 (de) |
| ES (1) | ES2285843T3 (de) |
| NZ (1) | NZ509424A (de) |
| WO (1) | WO1999067291A2 (de) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6451986B1 (en) * | 1998-06-22 | 2002-09-17 | Immunex Corporation | Site specific protein modification |
| US7431921B2 (en) | 1999-08-27 | 2008-10-07 | Maxygen Aps | Interferon beta-like molecules |
| US6531122B1 (en) | 1999-08-27 | 2003-03-11 | Maxygen Aps | Interferon-β variants and conjugates |
| US7144574B2 (en) | 1999-08-27 | 2006-12-05 | Maxygen Aps | Interferon β variants and conjugates |
| US7230081B1 (en) | 1999-11-12 | 2007-06-12 | Maxygen Holdings, Ltd. | Interferon gamma conjugates |
| SK8292002A3 (en) * | 1999-11-12 | 2002-12-03 | Maxygen Holdings Ltd | A conjugate exhibiting interferon gamma activity, nucleotide sequence encoding for a polypeptide fraction of conjugate, an expression vector and a host cell containing nucleotide sequence, pharmaceutical composition comprising the same and use thereof |
| US6646110B2 (en) | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
| US6555660B2 (en) | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
| US6831158B2 (en) | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
| AU4541101A (en) * | 2000-03-02 | 2001-09-12 | Xencor Inc | Design and discovery of protein based tnf-alpha variants for the treatment of tnf-alpha related disorders |
| CA2414076A1 (en) | 2000-06-08 | 2001-12-13 | La Jolla Pharmaceutical Company | Multivalent platform molecules comprising high molecular weight polyethylene oxide |
| WO2002036626A1 (en) * | 2000-11-02 | 2002-05-10 | Maxygen Aps | Single-chain multimeric polypeptides |
| PL367154A1 (en) | 2001-02-27 | 2005-02-21 | Maxygen Aps | New interferon beta-like molecules |
| US7038015B2 (en) | 2001-04-06 | 2006-05-02 | Maxygen Holdings, Ltd. | Interferon gamma polypeptide variants |
| US6958388B2 (en) | 2001-04-06 | 2005-10-25 | Maxygen, Aps | Interferon gamma polypeptide variants |
| ATE468862T1 (de) | 2001-07-11 | 2010-06-15 | Maxygen Inc | G-csf konjugate |
| US6908963B2 (en) | 2001-10-09 | 2005-06-21 | Nektar Therapeutics Al, Corporation | Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith |
| US7138134B2 (en) * | 2001-12-18 | 2006-11-21 | Arizona Health Consulting Group, Llc | Preparation and administration of jojoba product for reducing weight, fat and blood lipid levels |
| WO2004005341A2 (en) | 2002-07-03 | 2004-01-15 | Maxygen Holdings Ltd. | Full-length interferon gamma polypeptide variants |
| EP1491554A1 (de) * | 2003-06-23 | 2004-12-29 | CONARIS research institute AG | PEGlierte lösliche gp130-Dimeren geignet als Medikament |
| WO2005047337A1 (en) * | 2003-11-13 | 2005-05-26 | Hanmi Pharmaceutical Co., Ltd. | A pharmaceutical composition comprising an immunoglobulin fc region as a carrier |
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| ES2632504T3 (es) | 2007-11-20 | 2017-09-13 | Ambrx, Inc. | Polipéptidos de insulina modificados y sus usos |
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| EP2516455A4 (de) | 2009-12-21 | 2013-05-22 | Ambrx Inc | Modifizierte schweine-somatotropin-polypeptide und deren verwendungen |
| EP3025728B1 (de) | 2010-02-04 | 2018-08-08 | BioMarin Pharmaceutical Inc. | Reinigungsverfahren von prokaryotischen phenylalanin-ammoniak-lyase-varianten |
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| DK2694095T3 (en) | 2011-04-05 | 2018-05-28 | Longevity Biotech Inc | COMPOSITIONS COMPREHENSIVE GLUCAGON ANALOGS AND METHODS FOR PREPARING AND USING THE SAME |
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| EP3155002B1 (de) | 2014-06-10 | 2019-11-27 | Amgen Inc. | Apelin polypeptides |
| BR112017008157A2 (pt) | 2014-10-24 | 2017-12-19 | Bristol Myers Squibb Co | polipeptídeos de fgf-21 modificados e usos dos mesmos |
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| US10266578B2 (en) | 2017-02-08 | 2019-04-23 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
| EP3678686A1 (de) | 2017-09-08 | 2020-07-15 | Bristol-Myers Squibb Company | Modifizierter fibroblasten-wachstumsfaktor 21 (fgf-21) für die verwendung in verfahren zur behandlung von nichtalkoholischer steatohepatitis (nash) |
| WO2019191728A1 (en) | 2018-03-29 | 2019-10-03 | Ambrx, Inc. | Humanized anti-prostate-specific membrane antigen (psma) antibody drug conjugates |
| AU2019297327A1 (en) | 2018-07-03 | 2021-02-18 | Bristol-Myers Squibb Company | FGF21 formulations |
| KR20210063351A (ko) | 2018-08-28 | 2021-06-01 | 암브룩스, 인코포레이티드 | 항-cd3 항체 폴레이트 생체접합체 및 이들의 용도 |
| EP3876996A1 (de) | 2018-11-05 | 2021-09-15 | Bristol-Myers Squibb Company | Verfahren zur aufreinigung von pegyliertem protein |
| WO2021173889A1 (en) | 2020-02-26 | 2021-09-02 | Ambrx, Inc. | Uses of anti-cd3 antibody folate bioconjugates |
| JP7842232B2 (ja) * | 2022-02-18 | 2026-04-07 | 江蘇衆紅生物工程創薬研究院有限公司 | 生物活性分子の活性放出制御及び活性徐放を達成する方法及びその薬物への応用 |
| CN120344270A (zh) | 2022-10-07 | 2025-07-18 | Ambrx 公司 | 药物接头及其抗体缀合物 |
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|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| US5235028A (en) | 1990-08-31 | 1993-08-10 | University Of Minnesota | Polyethylene glycol derivatives for solid-phase applications |
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| US6451986B1 (en) * | 1998-06-22 | 2002-09-17 | Immunex Corporation | Site specific protein modification |
-
1998
- 1998-06-22 US US09/102,530 patent/US6451986B1/en not_active Expired - Lifetime
-
1999
- 1999-06-18 EP EP99930486A patent/EP1090036B1/de not_active Expired - Lifetime
- 1999-06-18 ES ES99930486T patent/ES2285843T3/es not_active Expired - Lifetime
- 1999-06-18 EP EP07003818A patent/EP1829554A3/de not_active Withdrawn
- 1999-06-18 WO PCT/US1999/013953 patent/WO1999067291A2/en not_active Ceased
- 1999-06-18 DE DE69935855T patent/DE69935855T2/de not_active Expired - Lifetime
- 1999-06-18 JP JP2000555941A patent/JP3578991B2/ja not_active Expired - Fee Related
- 1999-06-18 AU AU47020/99A patent/AU767630B2/en not_active Ceased
- 1999-06-18 CA CA002331337A patent/CA2331337C/en not_active Expired - Fee Related
- 1999-06-18 AT AT99930486T patent/ATE360033T1/de active
- 1999-06-18 NZ NZ509424A patent/NZ509424A/en unknown
-
2000
- 2000-05-26 US US09/580,181 patent/US6441136B1/en not_active Expired - Lifetime
- 2000-05-26 US US09/580,235 patent/US6433158B1/en not_active Expired - Lifetime
-
2002
- 2002-09-12 US US10/243,230 patent/US7129203B2/en not_active Expired - Lifetime
-
2006
- 2006-10-26 US US11/588,655 patent/US20070048837A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP3578991B2 (ja) | 2004-10-20 |
| NZ509424A (en) | 2002-05-31 |
| DE69935855D1 (de) | 2007-05-31 |
| US7129203B2 (en) | 2006-10-31 |
| DE69935855T2 (de) | 2008-01-10 |
| US6433158B1 (en) | 2002-08-13 |
| US20070048837A1 (en) | 2007-03-01 |
| EP1090036B1 (de) | 2007-04-18 |
| CA2331337A1 (en) | 1999-12-29 |
| EP1090036A2 (de) | 2001-04-11 |
| AU4702099A (en) | 2000-01-10 |
| WO1999067291A3 (en) | 2000-03-09 |
| US6441136B1 (en) | 2002-08-27 |
| ES2285843T3 (es) | 2007-11-16 |
| AU767630B2 (en) | 2003-11-20 |
| CA2331337C (en) | 2008-07-29 |
| US20020081309A1 (en) | 2002-06-27 |
| JP2002518522A (ja) | 2002-06-25 |
| EP1829554A3 (de) | 2007-09-26 |
| US6451986B1 (en) | 2002-09-17 |
| US20030023049A1 (en) | 2003-01-30 |
| EP1829554A2 (de) | 2007-09-05 |
| WO1999067291A2 (en) | 1999-12-29 |
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