ATE360205T1 - Verfahren und vorrichtung zum in-vitro-nachweis und kennzeichnung psychoaktiver substanzen, unter verwendung einer analyse der repetitiven elektrischen aktivität in einer neuronalen probe - Google Patents

Verfahren und vorrichtung zum in-vitro-nachweis und kennzeichnung psychoaktiver substanzen, unter verwendung einer analyse der repetitiven elektrischen aktivität in einer neuronalen probe

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Publication number
ATE360205T1
ATE360205T1 AT00944867T AT00944867T ATE360205T1 AT E360205 T1 ATE360205 T1 AT E360205T1 AT 00944867 T AT00944867 T AT 00944867T AT 00944867 T AT00944867 T AT 00944867T AT E360205 T1 ATE360205 T1 AT E360205T1
Authority
AT
Austria
Prior art keywords
sample
vitro
neuronal
analysis
labeling
Prior art date
Application number
AT00944867T
Other languages
English (en)
Inventor
Gary Lynch
Makoto Taketani
Ken Shimono
Hirokazu Sugihara
Original Assignee
Matsushita Electric Industrial Co Ltd
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matsushita Electric Industrial Co Ltd, Univ California filed Critical Matsushita Electric Industrial Co Ltd
Application granted granted Critical
Publication of ATE360205T1 publication Critical patent/ATE360205T1/de

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48714—Physical analysis of biological material of liquid biological material by electrical means for determining substances foreign to the organism, e.g. drugs or heavy metals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT00944867T 1999-06-21 2000-06-21 Verfahren und vorrichtung zum in-vitro-nachweis und kennzeichnung psychoaktiver substanzen, unter verwendung einer analyse der repetitiven elektrischen aktivität in einer neuronalen probe ATE360205T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14033999P 1999-06-21 1999-06-21

Publications (1)

Publication Number Publication Date
ATE360205T1 true ATE360205T1 (de) 2007-05-15

Family

ID=22490788

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00944867T ATE360205T1 (de) 1999-06-21 2000-06-21 Verfahren und vorrichtung zum in-vitro-nachweis und kennzeichnung psychoaktiver substanzen, unter verwendung einer analyse der repetitiven elektrischen aktivität in einer neuronalen probe

Country Status (11)

Country Link
US (1) US6511817B1 (de)
EP (1) EP1192461B1 (de)
JP (1) JP3617972B2 (de)
KR (1) KR20020042535A (de)
CN (1) CN1457430A (de)
AT (1) ATE360205T1 (de)
AU (1) AU772584B2 (de)
CA (1) CA2375550A1 (de)
DE (1) DE60034452T2 (de)
HK (1) HK1043696A1 (de)
WO (1) WO2000079273A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040137515A1 (en) * 1999-06-21 2004-07-15 Gary Lynch Methods and device for in vitro detection and characterization of psychoactives using analysis of repetitive electrical activity in a neuronal sample
KR20020042535A (ko) * 1999-06-21 2002-06-05 유니버시티 오브 캘리포니아, 어빈 뉴런 샘플에서 반복 전기 활성 분석을 사용한 정신활성의시험관내 검출 및 특성화를 위한 방법 및 장치
EP1444506A2 (de) * 2001-10-12 2004-08-11 Matsushita Electric Industrial Co., Ltd. Nachweis und charakterisierung von psychopharmaka mit hilfe von parallelen assays an mehreren orten im nervengewebe
US20030091980A1 (en) * 2001-10-12 2003-05-15 Gary Lynch Detection and characterization of psychoactives using analysis of network level physiological responses in a neuronal sample
US20040219184A1 (en) * 2003-03-25 2004-11-04 The Regents Of The University Of California Growth of large patterned arrays of neurons on CCD chips using plasma deposition methods
CN101128734A (zh) * 2003-10-15 2008-02-20 松下电器产业株式会社 用于评估神经元变性的系统和方法
WO2005071057A1 (ja) * 2004-01-22 2005-08-04 Japan Science And Technology Agency 磁場又は電場刺激装置及びその磁場又は電場刺激装置を用いた生体細胞若しくは生体組織の成長及び機能の促進、抑制又は障害方法
EP1740261A2 (de) * 2004-03-23 2007-01-10 Matsushita Electric Industrial Co., Ltd. Elektrophysiologiesystem mit hohem durchsatz
JP5541863B2 (ja) 2005-08-12 2014-07-09 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ 神経雪崩アッセイ
WO2010135731A1 (en) * 2009-05-22 2010-11-25 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
JP5713251B2 (ja) * 2010-01-22 2015-05-07 国立大学法人浜松医科大学 細胞判別方法、細胞判別用の参照データ生成方法、および細胞判別装置
JP5969640B2 (ja) * 2015-02-26 2016-08-17 浜松ホトニクス株式会社 細胞判別方法および細胞判別装置
GB2544030A (en) * 2015-05-28 2017-05-10 Neurexpert Ltd Quantification of postsynaptic neuronal activity
CN106226509B (zh) * 2016-08-12 2019-09-06 中国人民解放军第四军医大学 一种在小鼠前扣带回皮层诱发dse现象的方法
CN109621152A (zh) * 2019-01-28 2019-04-16 邹珍友 一种用强场脉冲激光无介入性地干预动物认知意识活动与行为的方法

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US4385053A (en) * 1981-03-11 1983-05-24 Barry Reisberg Treatment for human memory impairment associated with aging
JPH01222767A (ja) * 1988-02-29 1989-09-06 Shimadzu Corp 薬剤試験用装置
JP2566625B2 (ja) * 1988-08-02 1996-12-25 沖電気工業株式会社 バイオ素子
JPH03246457A (ja) * 1990-02-26 1991-11-01 Sumitomo Electric Ind Ltd 細胞計測用セル
WO1993015184A1 (en) 1992-01-24 1993-08-05 Yale University Assay for neuro-excitatory agents
JPH0759554A (ja) * 1993-08-19 1995-03-07 Fujitsu Ltd 生体組織表示方法及び装置
JP3204875B2 (ja) * 1994-06-13 2001-09-04 松下電器産業株式会社 細胞電位測定装置
US5563067A (en) 1994-06-13 1996-10-08 Matsushita Electric Industrial Co., Ltd. Cell potential measurement apparatus having a plurality of microelectrodes
FR2733055B1 (fr) * 1995-04-12 1997-12-19 Chemodyne Sa Nouveau dispositif d'etude de cultures organotypiques et ses applications en electrophysiologie
US5902732A (en) * 1995-10-04 1999-05-11 Cytoscan Sciences Llc Drug screening process measuring changes in cell volume
US5772983A (en) * 1995-10-16 1998-06-30 Worcester Foundation For Biomedical Research Methods of screening for compounds which modulate insect behavior
KR100291052B1 (ko) * 1996-01-24 2004-11-26 마쯔시다덴기산교 가부시키가이샤 조직또는세포의물리화학적특성측정방법,약품검사방법및그장치
WO1999020315A1 (en) 1997-10-23 1999-04-29 The Research Foundation Of State University Of New York Methods of screening potential atypical antipsychotic drugs
KR20020042535A (ko) * 1999-06-21 2002-06-05 유니버시티 오브 캘리포니아, 어빈 뉴런 샘플에서 반복 전기 활성 분석을 사용한 정신활성의시험관내 검출 및 특성화를 위한 방법 및 장치
JP2001206135A (ja) * 2000-01-28 2001-07-31 Nippon Sharyo Seizo Kaisha Ltd バルクローリの安全装置
CA2398961A1 (en) * 2000-02-03 2001-08-09 The Regents Of The University Of California Assays for the detection of agents that affect cognition

Also Published As

Publication number Publication date
AU5889900A (en) 2001-01-09
HK1043696A1 (zh) 2002-09-20
WO2000079273A2 (en) 2000-12-28
CA2375550A1 (en) 2000-12-28
AU772584B2 (en) 2004-04-29
EP1192461B1 (de) 2007-04-18
JP2003506695A (ja) 2003-02-18
KR20020042535A (ko) 2002-06-05
JP3617972B2 (ja) 2005-02-09
DE60034452T2 (de) 2007-12-13
WO2000079273A3 (en) 2001-05-25
DE60034452D1 (de) 2007-05-31
US6511817B1 (en) 2003-01-28
EP1192461A2 (de) 2002-04-03
CN1457430A (zh) 2003-11-19

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