ATE360988T1 - Methode zur induzierung neurofibrillärer tangles in transgenen tieren - Google Patents

Methode zur induzierung neurofibrillärer tangles in transgenen tieren

Info

Publication number: ATE360988T1
Authority: AT; Austria
Prior art keywords: neurofibrillary tangles; disease; neurodegenerative diseases; abeta42; inducing
Prior art date: 2001-08-24

Application number

AT02796273T

Other languages

English (en)

Inventor

Juergen Goetz

St Mallett

Roger Nitsch

Feng Chen

Original Assignee

Univ Zuerich

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-24

Filing date

2002-08-24

Publication date

2007-05-15

2002-08-24 Application filed by Univ Zuerich filed Critical Univ Zuerich

2007-05-15 Application granted granted Critical

2007-05-15 Publication of ATE360988T1 publication Critical patent/ATE360988T1/de

Links

238000000034 method Methods 0.000 title abstract 2
241001465754 Metazoa Species 0.000 title 1
230000001939 inductive effect Effects 0.000 title 1
230000009261 transgenic effect Effects 0.000 title 1
210000002682 neurofibrillary tangle Anatomy 0.000 abstract 4
208000024827 Alzheimer disease Diseases 0.000 abstract 2
108010064539 amyloid beta-protein (1-42) Proteins 0.000 abstract 2
238000002347 injection Methods 0.000 abstract 2
239000007924 injection Substances 0.000 abstract 2
230000004770 neurodegeneration Effects 0.000 abstract 2
208000015122 neurodegenerative disease Diseases 0.000 abstract 2
102400000574 Amyloid-beta protein 42 Human genes 0.000 abstract 1
102100040243 Microtubule-associated protein tau Human genes 0.000 abstract 1
241000699660 Mus musculus Species 0.000 abstract 1
210000004727 amygdala Anatomy 0.000 abstract 1
DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
210000004556 brain Anatomy 0.000 abstract 1
210000005056 cell body Anatomy 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
238000005462 in vivo assay Methods 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
238000011830 transgenic mouse model Methods 0.000 abstract 1
238000010200 validation analysis Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Environmental Sciences (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Husbandry (AREA)
Biodiversity & Conservation Biology (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Neurology (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Catching Or Destruction (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)

AT02796273T 2001-08-24 2002-08-24 Methode zur induzierung neurofibrillärer tangles in transgenen tieren ATE360988T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US31430301P	2001-08-24	2001-08-24
EP01120348		2001-08-24

Publications (1)

Publication Number	Publication Date
ATE360988T1 true ATE360988T1 (de)	2007-05-15

Family

ID=34042746

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02796273T ATE360988T1 (de)	2001-08-24	2002-08-24	Methode zur induzierung neurofibrillärer tangles in transgenen tieren

Country Status (7)

Country	Link
US (2)	US20050015819A1 (de)
EP (1)	EP1418807B8 (de)
JP (1)	JP2005500076A (de)
AT (1)	ATE360988T1 (de)
AU (1)	AU2002333704A1 (de)
DE (1)	DE60219925T2 (de)
WO (1)	WO2003017918A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5511144B2 (ja) *	2008-02-12	2014-06-04	学校法人福岡大学	てんかんモデル非ヒト哺乳動物
CA2813493C (en)	2010-10-11	2019-07-09	University Of Zurich	Human anti-tau antibodies
CA2896066C (en)	2012-12-21	2022-07-12	Biogen Ma Inc.	Human anti-tau antibodies
BR112016029579A2 (pt)	2014-06-26	2017-08-22	Janssen Vaccines & Prevention Bv	anticorpos e fragmentos de ligação ao antígeno que se ligam especificamente à proteína tau associada a microtúbulos
ZA201608812B (en)	2014-06-26	2019-08-28	Janssen Vaccines & Prevention Bv	Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6172277B1 (en) *	1997-10-28	2001-01-09	The Miriam Hospital	Non-transgenic rodent model of alzheimer's disease
WO1999057129A1 (en) *	1998-05-01	1999-11-11	Mayo Foundation For Medical Education And Research	Pathogeniv tau mutations
US6664443B1 (en) *	1998-05-01	2003-12-16	Mayo Foundation For Medical Education And Research	Pathogenic Tau mutations in transgenic mice

2002
- 2002-08-24 DE DE60219925T patent/DE60219925T2/de not_active Expired - Lifetime
- 2002-08-24 JP JP2003522441A patent/JP2005500076A/ja active Pending
- 2002-08-24 AU AU2002333704A patent/AU2002333704A1/en not_active Abandoned
- 2002-08-24 EP EP02796273A patent/EP1418807B8/de not_active Expired - Lifetime
- 2002-08-24 WO PCT/EP2002/009491 patent/WO2003017918A2/en not_active Ceased
- 2002-08-24 US US10/487,546 patent/US20050015819A1/en not_active Abandoned
- 2002-08-24 AT AT02796273T patent/ATE360988T1/de not_active IP Right Cessation
2007
- 2007-10-23 US US11/976,318 patent/US7550648B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1418807B1 (de)	2007-05-02
DE60219925T2 (de)	2008-01-17
EP1418807B8 (de)	2008-04-23
DE60219925D1 (de)	2007-06-14
US20080261878A1 (en)	2008-10-23
JP2005500076A (ja)	2005-01-06
WO2003017918A2 (en)	2003-03-06
EP1418807A2 (de)	2004-05-19
WO2003017918A3 (en)	2003-12-04
US20050015819A1 (en)	2005-01-20
US7550648B2 (en)	2009-06-23
AU2002333704A1 (en)	2003-03-10

Legal Events

Date	Code	Title	Description
2007-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
JP7837033B2 (ja)	2026-03-30	認知症の予防、軽減、及び／または治療のためのシステムならびに方法
Gouras et al.	2005	Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease
Onos et al.	2016	Toward more predictive genetic mouse models of Alzheimer's disease
Gomes et al.	2014	Inhibition of the polyamine system counteracts β-amyloid peptide-induced memory impairment in mice: involvement of extrasynaptic NMDA receptors
ATE475432T1 (de)	2010-08-15	Arzneimittel für herzversagen
Saman et al.	2014	Proteins recruited to exosomes by tau overexpression implicate novel cellular mechanisms linking tau secretion with Alzheimer's disease
CY1108740T1 (el)	2014-04-09	ΕΞΑΝΘΡΩΠΙΣΜΕΝΑ ΑΝΤΙΣΩΜΑΤΑ ΤΑ ΟΠΟΙΑ ΑΝΑΓΝΩΡΙΖΟΥΝ ΤΟ ΠΕΠΤΙΔΙΟ β-ΑΜΥΛΟΕΙΔΟΥΣ
ATE360988T1 (de)	2007-05-15	Methode zur induzierung neurofibrillärer tangles in transgenen tieren
WO2006050041A2 (en)	2006-05-11	Methods for reducing or inhibiting brain inflammation or for promoting neurogenesis
Jhee et al.	2001	β-Amyloid therapies in Alzheimer’s disease
Salari et al.	2016	A review of animal models of Alzheimer's disease: a brief insight into pharmacologic and genetic models
Röskam et al.	2010	APP transgenic mice: the effect of active and passive immunotherapy in cognitive tasks
WO2003093442A3 (en)	2004-04-01	Cell cultures from animal models of alzheimer's disease for screening and testing drug efficacy
Mileusnic et al.	2007	Protection against Aβ-induced memory loss by tripeptide D-Arg-L-Glu-L-Arg
HK40086450A (zh)	2023-08-25	用於预防、减轻和/或治疗痴呆的系统和方法
ATE387460T1 (de)	2008-03-15	Verfahren und kit zur beurteilung des ausbruchs von rheumatoider arthritis
Ingram	2003	Alzheimer's Disease: The molecualr origins of the disease are coming to light, suggesting several novel therapies
Galán-Acosta	2021	Recombinant Brichos Domains Delivered over the Blood-Brain Barrier: A Possible Way to Treat Alzheimer´ s Disease
Chouly	2024	Towards the long-term, conditional and tractable disruption of Notch3 signaling in zebrafish neural stem and progenitor cells
Morrissette	2009	Effects of mouse genetic background strain on Alzheimer-like pathology and behavior in the triple transgenic mouse model of Alzheimer Disease
de Figueiredo	2020	The Effect of Excessive Glutamate Release on Neuronal Fitness, Hyperactivity, and Locomotor Performance in a Drosophila Model of Alzheimer’s Disease
Hardy	2015	Do repeated bouts of inflammation lead to sustained elevation of amyloid beta in the brain?
ES2335848B1 (es)	2011-02-02	Composicion celular in vitro con sobreexpresion simultanea de genes humanos mutados ps1 m146v, app swe y tau p301l.
Gregg	2018	Modeling Alzheimer's Disease in Induced Pluripotent Stem Cells
Duyckaerts et al.	0	Alzheimer’s brain inoculation in Aß-plaque bearing mice: synaptic loss is linked to tau seeding and low microglial activity