ATE361375T1 - Methoden zur modelierung die funktion von polypeptid galnac transferasen und zurscreening substanzen dafür - Google Patents

Methoden zur modelierung die funktion von polypeptid galnac transferasen und zurscreening substanzen dafür

Info

Publication number
ATE361375T1
ATE361375T1 AT01931464T AT01931464T ATE361375T1 AT E361375 T1 ATE361375 T1 AT E361375T1 AT 01931464 T AT01931464 T AT 01931464T AT 01931464 T AT01931464 T AT 01931464T AT E361375 T1 ATE361375 T1 AT E361375T1
Authority
AT
Austria
Prior art keywords
galnac
lectin domains
transferases
functions
inhibitors
Prior art date
Application number
AT01931464T
Other languages
English (en)
Inventor
Henrik Clausen
Helle Hassan
Celso Albuquerque Reis
Eric Paul Bennett
Original Assignee
Glycozym Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycozym Aps filed Critical Glycozym Aps
Application granted granted Critical
Publication of ATE361375T1 publication Critical patent/ATE361375T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91091—Glycosyltransferases (2.4)
    • G01N2333/91097—Hexosyltransferases (general) (2.4.1)
    • G01N2333/91102—Hexosyltransferases (general) (2.4.1) with definite EC number (2.4.1.-)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT01931464T 2000-05-11 2001-05-10 Methoden zur modelierung die funktion von polypeptid galnac transferasen und zurscreening substanzen dafür ATE361375T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20333100P 2000-05-11 2000-05-11

Publications (1)

Publication Number Publication Date
ATE361375T1 true ATE361375T1 (de) 2007-05-15

Family

ID=22753535

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01931464T ATE361375T1 (de) 2000-05-11 2001-05-10 Methoden zur modelierung die funktion von polypeptid galnac transferasen und zurscreening substanzen dafür

Country Status (5)

Country Link
EP (1) EP1282725B1 (de)
AT (1) ATE361375T1 (de)
AU (1) AU2001258234A1 (de)
DE (1) DE60128218D1 (de)
WO (1) WO2001085215A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7338932B2 (en) 2000-05-11 2008-03-04 Glycozym Aps Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments
ATE365794T1 (de) * 2002-11-08 2007-07-15 Glycozym Aps Verfahren zur identifizierung von die funktionen von polypeptid-galnac-transferasen modulierenden agentien, solche agentien umfassende pharmazeutische zusammensetzungen und verwendung solcher agentien zur herstellung von arzneimitteln
AU2005265214A1 (en) * 2004-06-21 2006-01-26 Exelixis, Inc. P4HAS as modifiers of the IGFR pathway and methods of use
AU2007304590A1 (en) 2006-10-04 2008-04-10 Cancer Research Technology Limited Generation of a cancer-specific immune response toward MUC1 and cancer specific MUC1 antibodies
JP2013503321A (ja) * 2009-08-25 2013-01-31 オンコセラピー・サイエンス株式会社 乳癌に関連する遺伝子およびポリペプチド
WO2014024820A1 (ja) * 2012-08-06 2014-02-13 塩野義製薬株式会社 新規慢性腎臓病治療用医薬組成物及び新規慢性腎臓病治療薬のスクリーニング方法
GB201406767D0 (en) 2014-04-15 2014-05-28 Cancer Rec Tech Ltd Humanized anti-Tn-MUC1 antibodies anf their conjugates
US11058675B2 (en) 2018-03-29 2021-07-13 Carnegie Mellon University Cell-based screening and compounds that modulate GaINAc-transferases
ES3018477T3 (es) * 2021-01-21 2025-05-16 Agency Science Tech & Res Anticuerpo anti-calnexina para su uso para reducir la degradación del cartílago

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268364A (en) * 1991-12-12 1993-12-07 The Biomembrane Institute Method for inhibiting selectin-dependent adhesion of leukocytes and platelets by O-glycosylation modification
PL339773A1 (en) * 1997-09-05 2001-01-02 Glycim Oy Synthetic bivalent polylactose amines containing slex and method of using them
JP2002517474A (ja) * 1998-06-10 2002-06-18 グリコデザイン インコーポレイテッド 定方向のコンビナトリアル化合物ライブラリおよびそれをスクリーニングするための高スループットアッセイ

Also Published As

Publication number Publication date
WO2001085215A2 (en) 2001-11-15
WO2001085215A3 (en) 2002-06-27
EP1282725A2 (de) 2003-02-12
DE60128218D1 (de) 2007-06-14
AU2001258234A1 (en) 2001-11-20
WO2001085215A9 (en) 2002-01-24
EP1282725B1 (de) 2007-05-02

Similar Documents

Publication Publication Date Title
Vićovac et al. Galectin-1 and-3 in cells of the first trimester placental bed.
Turk et al. Lysosomal cathepsins: structure, role in antigen processing and presentation, and cancer
Säfholm et al. A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells
ATE361375T1 (de) Methoden zur modelierung die funktion von polypeptid galnac transferasen und zurscreening substanzen dafür
ATE517922T1 (de) Stabilisierte einzel-domänen-antikörper in einer pharmazeutischen zusammensetzung ausgestaltet für inhalation
EA200601738A1 (ru) Модифицированные белки буганины, цитотоксины и способы их применения
Sato et al. Molecular basis of the recognition of nephronectin by integrin α8β1
WO1999002552A3 (en) Chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof
DK1461073T3 (da) Peptidagonister til prostataspecifikt antigen og anvendelser heraf
EP2343318A3 (de) Antikörper die an ein C-terminales Fragment des Apolipoproteins E binden
DE60030450D1 (de) Von MUC-1 abgeleitete Peptide
WO2003066830A3 (en) Human monoclonal antibodies against membrane proteins
ATE469981T1 (de) Tests auf proteinkinasen mit fluoreszierenden proteinsubstraten
PL378566A1 (pl) Ligandy dla białek wiążących TGF-beta i ich zastosowania
GEP20094629B (en) Nogo receptor binding protein
EE05558B1 (et) Antikeha v?i selle antigeeni siduva fragmendi v?i lahustuva polpeptiidi kasutamine farmatseutilise kompositsiooni valmistamiseks
BR112022005426A2 (pt) Polipeptídeos de fusão dap10/dap12
WO2007073509A3 (en) Modified annexin proteins and methods for their use in organ transplantation
ATE462727T1 (de) An menschliches roundabout bindende antikörper, polypeptide und ihre verwendung zur hemmung der angiogenese
EP0772773A4 (de) Src SH3 BINDENDE PEPTIDE UND VERFAHREN ZU IHRER ISOLIERUNG UND VERWENDUNG
DE60114363D1 (de) Oligomere von konformationsbeschränkten, nicht-peptidischen di- oder tripeptid-mimetika, und ihre verwendung zur synthese von künstlichen polypeptiden und proteinen
DK1242450T3 (da) Organtransplantatafstödning og tilknyttede tilstande
AU2021278998A8 (en) Anti-human LAG-3 antibodies and their use in immunohistochemistry (IHC)
DK0996636T3 (da) HA-1-antigenet
ATE283369T1 (de) Ein zweihybrid-screeningsystem in bakterien für proteinwechselwirkung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties