ATE361761T1 - Poly(ethylen glykol)-konjugate von insulinähnlichem wachstumfaktor bindenden protein-4 - Google Patents
Poly(ethylen glykol)-konjugate von insulinähnlichem wachstumfaktor bindenden protein-4Info
- Publication number
- ATE361761T1 ATE361761T1 AT03778269T AT03778269T ATE361761T1 AT E361761 T1 ATE361761 T1 AT E361761T1 AT 03778269 T AT03778269 T AT 03778269T AT 03778269 T AT03778269 T AT 03778269T AT E361761 T1 ATE361761 T1 AT E361761T1
- Authority
- AT
- Austria
- Prior art keywords
- insulin
- growth factor
- binding protein
- factor binding
- conjugates
- Prior art date
Links
- 102000004369 Insulin-like growth factor-binding protein 4 Human genes 0.000 title abstract 3
- 108090000969 Insulin-like growth factor-binding protein 4 Proteins 0.000 title abstract 3
- 229920001223 polyethylene glycol Polymers 0.000 title abstract 3
- -1 POLY(ETHYLENE GLYCOL) Polymers 0.000 title 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02021844 | 2002-09-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE361761T1 true ATE361761T1 (de) | 2007-06-15 |
Family
ID=32039114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03778269T ATE361761T1 (de) | 2002-09-27 | 2003-09-25 | Poly(ethylen glykol)-konjugate von insulinähnlichem wachstumfaktor bindenden protein-4 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060100144A1 (de) |
| EP (1) | EP1545623B1 (de) |
| JP (1) | JP4237703B2 (de) |
| AT (1) | ATE361761T1 (de) |
| AU (1) | AU2003285286A1 (de) |
| CA (1) | CA2498062C (de) |
| DE (1) | DE60313786T2 (de) |
| ES (1) | ES2285215T3 (de) |
| WO (1) | WO2004028568A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100028302A1 (en) * | 2004-09-27 | 2010-02-04 | Ludwig-Maximilians- Universität München | Use of IGFBP-2 in Senescence Diseases and for the Maintenance of Organ Functions |
| WO2006094530A1 (en) * | 2005-03-11 | 2006-09-14 | Siegfried Ltd. | Di-polymer protein conjugates and processes for their preparation |
| JP2011507801A (ja) | 2007-09-11 | 2011-03-10 | ユニバーシティ オブ マサチューセッツ | 癌の処置のためのインスリン様成長因子結合タンパク質７ |
| WO2011003780A1 (en) | 2009-07-06 | 2011-01-13 | F. Hoffmann-La Roche Ag | Bi-specific digoxigenin binding antibodies |
| US20130041134A1 (en) * | 2009-11-05 | 2013-02-14 | Sangart ,Inc. | Methods for preparing polyethylene glycol maleimide using n-(2-hydroxyethyl) maleimide as a starting material |
| CA2822481A1 (en) | 2011-01-03 | 2012-07-12 | F. Hoffmann-La Roche Ag | A pharmaceutical composition of a complex of an anti-dig antibody and digoxigenin that is conjugated to a peptide |
| WO2013040504A2 (en) | 2011-09-14 | 2013-03-21 | University Of Massachusetts | Srpx for treatment of cancer |
| MX387205B (es) * | 2014-08-19 | 2025-03-18 | Biogen Ma Inc | Método de pegilación. |
| US20160151511A1 (en) | 2014-12-02 | 2016-06-02 | Antriabio, Inc. | Proteins and protein conjugates with increased hydrophobicity |
| WO2016196017A1 (en) | 2015-06-04 | 2016-12-08 | Antriabio, Inc. | Amine pegylation methods for the preparation of site-specific protein conjugates |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6004775A (en) * | 1990-08-03 | 1999-12-21 | The Salk Institute For Biological Studies | DNA encoding IGFBP-4 |
| US5212074A (en) * | 1990-08-28 | 1993-05-18 | Chiron Corporation | Genetic material encoding new insulin-like growth factor binding protein igfbp-6 |
| US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| US6207640B1 (en) * | 1994-04-07 | 2001-03-27 | Genentech, Inc. | Treatment of partial growth hormone insensitivity syndrome |
| US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| US6841386B2 (en) * | 2001-04-10 | 2005-01-11 | Viacell, Inc. | Modulation of primary stem cell differentiation using an insulin-like growth factor binding protein |
| CA2449290A1 (en) * | 2001-06-07 | 2002-12-12 | F. Hoffmann-La Roche Ag | Mutants of igf binding proteins and methods of production of antagonists thereof |
-
2003
- 2003-09-25 CA CA2498062A patent/CA2498062C/en not_active Expired - Fee Related
- 2003-09-25 EP EP03778269A patent/EP1545623B1/de not_active Expired - Lifetime
- 2003-09-25 AU AU2003285286A patent/AU2003285286A1/en not_active Abandoned
- 2003-09-25 WO PCT/EP2003/010658 patent/WO2004028568A1/en not_active Ceased
- 2003-09-25 AT AT03778269T patent/ATE361761T1/de not_active IP Right Cessation
- 2003-09-25 ES ES03778269T patent/ES2285215T3/es not_active Expired - Lifetime
- 2003-09-25 JP JP2004539015A patent/JP4237703B2/ja not_active Expired - Fee Related
- 2003-09-25 DE DE60313786T patent/DE60313786T2/de not_active Expired - Lifetime
- 2003-09-26 US US10/529,090 patent/US20060100144A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60313786T2 (de) | 2008-01-24 |
| JP4237703B2 (ja) | 2009-03-11 |
| AU2003285286A1 (en) | 2004-04-19 |
| WO2004028568A1 (en) | 2004-04-08 |
| JP2006503843A (ja) | 2006-02-02 |
| EP1545623A1 (de) | 2005-06-29 |
| CA2498062A1 (en) | 2004-04-08 |
| ES2285215T3 (es) | 2007-11-16 |
| CA2498062C (en) | 2010-05-25 |
| US20060100144A1 (en) | 2006-05-11 |
| DE60313786D1 (de) | 2007-06-21 |
| EP1545623B1 (de) | 2007-05-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |