ATE362368T1 - Substituierte piperidin- und piperazin-derivative als melanocortin-4 receptor modulatoren - Google Patents

Substituierte piperidin- und piperazin-derivative als melanocortin-4 receptor modulatoren

Info

Publication number
ATE362368T1
ATE362368T1 AT03006253T AT03006253T ATE362368T1 AT E362368 T1 ATE362368 T1 AT E362368T1 AT 03006253 T AT03006253 T AT 03006253T AT 03006253 T AT03006253 T AT 03006253T AT E362368 T1 ATE362368 T1 AT E362368T1
Authority
AT
Austria
Prior art keywords
melanocortin
substituted piperidine
piperazine derivatives
receptor modulators
disorders
Prior art date
Application number
AT03006253T
Other languages
English (en)
Inventor
Michael Soeberdt
Philipp Weyermann
Von Andreas Sprecher
Original Assignee
Santhera Pharmaceuticals Ch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santhera Pharmaceuticals Ch filed Critical Santhera Pharmaceuticals Ch
Application granted granted Critical
Publication of ATE362368T1 publication Critical patent/ATE362368T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Child & Adolescent Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT03006253T 2003-03-20 2003-03-20 Substituierte piperidin- und piperazin-derivative als melanocortin-4 receptor modulatoren ATE362368T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03006253A EP1460070B1 (de) 2003-03-20 2003-03-20 Substituierte Piperidin- und Piperazin-Derivative als Melanocortin-4 Receptor Modulatoren

Publications (1)

Publication Number Publication Date
ATE362368T1 true ATE362368T1 (de) 2007-06-15

Family

ID=32798839

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03006253T ATE362368T1 (de) 2003-03-20 2003-03-20 Substituierte piperidin- und piperazin-derivative als melanocortin-4 receptor modulatoren

Country Status (9)

Country Link
US (1) US20060276485A1 (de)
EP (2) EP1460070B1 (de)
JP (1) JP2006520363A (de)
AT (1) ATE362368T1 (de)
AU (1) AU2004222096B2 (de)
CA (1) CA2519444A1 (de)
DE (1) DE60313844T2 (de)
ES (1) ES2286345T3 (de)
WO (1) WO2004083199A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050119252A1 (en) * 2003-10-22 2005-06-02 Neurocrine Biosciences, Inc. Ligands of melanocortin receptors and compositions and methods related thereto
US20080255149A1 (en) * 2005-09-27 2008-10-16 Novartis Ag Carboxyamine Compounds and Methods of Use Thereof
US8084477B2 (en) * 2007-10-31 2011-12-27 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production
BRPI0819188B1 (pt) 2007-11-05 2021-06-22 Ipsen Pharma S.A.S. Uso de melanocortinas para a preparação de um medicamento para tratar resistência à insulina

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676053B1 (fr) * 1991-05-03 1993-08-27 Sanofi Elf Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
EP0714299B1 (de) * 1993-07-16 2002-04-24 Merck & Co. Inc. Benzoxazinon- und Benzopyrimidinon- piperidinyl-Verbindungen als tokolytische Oxytocin-Rezeptor-Antagonisten
US5968929A (en) * 1996-10-30 1999-10-19 Schering Corporation Piperazino derivatives as neurokinin antagonists
CA2438272A1 (en) * 2001-03-02 2002-10-10 John Macor Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same
US7115607B2 (en) * 2001-07-25 2006-10-03 Amgen Inc. Substituted piperazinyl amides and methods of use
US6977264B2 (en) * 2001-07-25 2005-12-20 Amgen Inc. Substituted piperidines and methods of use

Also Published As

Publication number Publication date
EP1460070B1 (de) 2007-05-16
CA2519444A1 (en) 2004-09-30
AU2004222096B2 (en) 2007-07-12
EP1606281A1 (de) 2005-12-21
AU2004222096A1 (en) 2004-09-30
ES2286345T3 (es) 2007-12-01
EP1460070A1 (de) 2004-09-22
JP2006520363A (ja) 2006-09-07
US20060276485A1 (en) 2006-12-07
DE60313844T2 (de) 2008-01-31
DE60313844D1 (de) 2007-06-28
WO2004083199A1 (en) 2004-09-30

Similar Documents

Publication Publication Date Title
ATE490239T1 (de) Substituierte phenylpiperidinderivate als melanocortin-4-rezeptormodulatoren
ATE530541T1 (de) Substituierte heteroarylpiperidinderivate als modulatoren des melanocortin-4-rezeptors
WO2004083208A8 (en) Substituted piperidine and piperazine derivatives as melanocortin-4 receptor modulators
ATE511511T1 (de) Neue piperidinylaminothienoä2,3-dü pyrimidinverbindungen
CL2009000943A1 (es) Metodos de preparacion de compuestos intermediarios del tipo pirazoles condensados para la preparacion de moduladores de los receptores de serotonina. (divisional solicitud n° 2384-04)
MXPA05008212A (es) Nuevos compuestos de arilpiperazinilo.
ATE449090T1 (de) Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren
EA200700047A1 (ru) Новые алкильные производные в качестве метаботропных рецепторов глутамата
PT1716152E (pt) Compostos heterocíclicos fundidos e sua utilização como antagonistas do receptor metabotrópico para o tratamento de distúrbios gastrointestinais
CY1111858T1 (el) Ετεροκυκλικα παραγωγα ως διαμορφωτες υποδοχεα οπιοειδων
NO20076344L (no) Piperazin-piperidin-antagonister og agonister av 5-HT1A-reseptoren
CY1113559T1 (el) Παραγωγα υποκατεστημενης αζεπινης ως ρυθμιστες υποδοχεων σεροτονινης
DE602006006850D1 (de) Als modulatoren von dopamin-d3-rezeptoren geeignete azabicyclo-(3,1,0)-hexan-derivate
NO20065814L (no) Thiendopyridinon forbindelser og fremgangsmater for behandling
DK1765816T3 (da) Substituerede 1-propinylpiperaziner med affinitet for MGluR5-receptoren til behandling af smertetilstande
ATE367391T1 (de) Substituierte piperidin- und piperazin-derivate als melanocortin-4 rezeptor modulatoren
ATE429421T1 (de) Arylindenopyridin- und arylindenopyrimidinverbindungen und ihre verwendung als adenosin-a2a-rezeptor antagonisten
EA200501594A1 (ru) Замещенные производные азабициклогексана в качестве антагонистов мускаринового рецептора
ATE362368T1 (de) Substituierte piperidin- und piperazin-derivative als melanocortin-4 receptor modulatoren
ATE415390T1 (de) Neue aminopyridinderivate als mglur5-antagonisten
DE602004011914D1 (de) Benzimidazole derivate und ihre anwendung als gaba a rezeptor komplex modulatoren
ATE359269T1 (de) 4-arylsulphonylpiperidin-derivate als 5-ht2a - rezeptor antagonisten
WO2004080407A3 (en) New serotonin modulating compounds and uses therefor
UA84570C2 (ru) Производные циклопропила как антагонисты рецептора nk3
DE602006018149D1 (de) Substituierte triazolderivate und ihre verwendung als antagonisten des neurokinin-3-rezeptors

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1460070

Country of ref document: EP

REN Ceased due to non-payment of the annual fee