ATE362487T1 - N-substituierte l-aminosäuren enthaltende peptide,zur prävention der beta-strang assoziation - Google Patents

N-substituierte l-aminosäuren enthaltende peptide,zur prävention der beta-strang assoziation

Info

Publication number
ATE362487T1
ATE362487T1 AT00948175T AT00948175T ATE362487T1 AT E362487 T1 ATE362487 T1 AT E362487T1 AT 00948175 T AT00948175 T AT 00948175T AT 00948175 T AT00948175 T AT 00948175T AT E362487 T1 ATE362487 T1 AT E362487T1
Authority
AT
Austria
Prior art keywords
peptide
beta
substituted
nalpha
strand
Prior art date
Application number
AT00948175T
Other languages
English (en)
Inventor
Kelvin Stott
Original Assignee
Senexis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senexis Ltd filed Critical Senexis Ltd
Application granted granted Critical
Publication of ATE362487T1 publication Critical patent/ATE362487T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT00948175T 1999-07-28 2000-07-28 N-substituierte l-aminosäuren enthaltende peptide,zur prävention der beta-strang assoziation ATE362487T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9917724.8A GB9917724D0 (en) 1999-07-28 1999-07-28 Peptides

Publications (1)

Publication Number Publication Date
ATE362487T1 true ATE362487T1 (de) 2007-06-15

Family

ID=10858096

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00948175T ATE362487T1 (de) 1999-07-28 2000-07-28 N-substituierte l-aminosäuren enthaltende peptide,zur prävention der beta-strang assoziation

Country Status (10)

Country Link
US (1) US7125838B1 (de)
EP (1) EP1203019B1 (de)
JP (1) JP2003505469A (de)
AT (1) ATE362487T1 (de)
AU (1) AU766992B2 (de)
CA (1) CA2378779A1 (de)
DE (1) DE60034888D1 (de)
GB (1) GB9917724D0 (de)
NZ (1) NZ516441A (de)
WO (1) WO2001007473A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
AU2002320045B2 (en) 2001-05-31 2008-05-08 Adlyfe, Inc. Misfolded protein sensor method
DE10230141B4 (de) * 2002-07-04 2004-07-15 Priontype Gmbh Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc)
WO2004005336A2 (en) * 2002-07-08 2004-01-15 Applied Research Systems Ars Holding N.V. β-SHEET BREAKING PEPTIDES
US20070293422A1 (en) * 2003-04-30 2007-12-20 Applied Research Systems Ars Holding N.V. Beta-Amyloid Inhibitors and Use Thereof
ATE528649T1 (de) * 2005-02-15 2011-10-15 Adlyfe Inc Verfahren zum nachweis falsch gefalteter proteine und prionen
TWI515007B (zh) 2006-01-05 2016-01-01 美國猶他大學研究基金會 改善以神經系統為標的之藥劑之性質之方法及組合物
US8673579B2 (en) * 2006-07-28 2014-03-18 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
WO2011156003A2 (en) 2010-06-09 2011-12-15 New York University Peptoid and synthetic oligomers, pharmaceutical compositions and methods of using same
CN103517712A (zh) 2010-12-15 2014-01-15 神经佐剂股份有限公司 神经肽类似物、组合物和治疗疼痛的方法
WO2013054110A2 (en) * 2011-10-10 2013-04-18 University Of Lancaster Compositions for binding to amyloid proteins
CN114630584A (zh) * 2019-11-07 2022-06-14 纽崔西亚公司 具有致耐受性肽的深度乳清蛋白水解产物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11514333A (ja) * 1995-03-14 1999-12-07 プレーシス ファーマスーティカルズ インコーポレイテッド アミロイドの凝集の調節剤
EP0866805A1 (de) * 1995-12-12 1998-09-30 Karolinska Innovations AB Peptide, das die KLVFF Sequenz von beta-Amyloid bindet
US6034211A (en) * 1996-06-03 2000-03-07 Kelly; Jeffery W. β-sheet nucleating peptidomimetics
DE19725619A1 (de) 1997-06-17 1998-12-24 Fraunhofer Ges Forschung Peptide als Agonisten und/oder Inhibitoren der Amyloidbildung und Zytotoxizität sowie der Verwendung bei Alzheimer'schen Krankheit, beim Typ II Diabetes mellitus und bei spongiformen Encephalopathien

Also Published As

Publication number Publication date
JP2003505469A (ja) 2003-02-12
US7125838B1 (en) 2006-10-24
GB9917724D0 (en) 1999-09-29
EP1203019B1 (de) 2007-05-16
AU766992B2 (en) 2003-10-30
NZ516441A (en) 2003-11-28
CA2378779A1 (en) 2001-02-01
AU6173700A (en) 2001-02-13
WO2001007473A1 (en) 2001-02-01
EP1203019A1 (de) 2002-05-08
DE60034888D1 (de) 2007-06-28

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Legal Events

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