ATE362770T1 - Verwendung von relaxin zur behandlung von durch gefässverengung bedingten erkrankungen - Google Patents

Verwendung von relaxin zur behandlung von durch gefässverengung bedingten erkrankungen

Info

Publication number
ATE362770T1
ATE362770T1 AT01909098T AT01909098T ATE362770T1 AT E362770 T1 ATE362770 T1 AT E362770T1 AT 01909098 T AT01909098 T AT 01909098T AT 01909098 T AT01909098 T AT 01909098T AT E362770 T1 ATE362770 T1 AT E362770T1
Authority
AT
Austria
Prior art keywords
relaxin
diseases
vaso
construction
treatment
Prior art date
Application number
AT01909098T
Other languages
English (en)
Inventor
Kirk Conrad
Martyn Lewis
Elaine Unemori
Xinfan Huang
Carol Tozzi
Original Assignee
Bas Medical Inc
Univ Pittsburgh
Univ New Jersey Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bas Medical Inc, Univ Pittsburgh, Univ New Jersey Med filed Critical Bas Medical Inc
Application granted granted Critical
Publication of ATE362770T1 publication Critical patent/ATE362770T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01909098T 2000-02-09 2001-02-09 Verwendung von relaxin zur behandlung von durch gefässverengung bedingten erkrankungen ATE362770T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18140800P 2000-02-09 2000-02-09
US20028400P 2000-04-28 2000-04-28
US24221600P 2000-10-20 2000-10-20

Publications (1)

Publication Number Publication Date
ATE362770T1 true ATE362770T1 (de) 2007-06-15

Family

ID=27391410

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01909098T ATE362770T1 (de) 2000-02-09 2001-02-09 Verwendung von relaxin zur behandlung von durch gefässverengung bedingten erkrankungen

Country Status (7)

Country Link
US (2) US6723702B2 (de)
EP (1) EP1253929B1 (de)
AT (1) ATE362770T1 (de)
AU (1) AU2001236886A1 (de)
CA (1) CA2397200C (de)
DE (1) DE60128540T2 (de)
WO (1) WO2001058468A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2408399A1 (en) * 2000-05-09 2001-11-15 Nitromed, Inc. Infrared thermography and methods of use
CN1274365C (zh) * 2000-06-27 2006-09-13 安增子摩祺株式会社 用于血管形成治疗的药物组合物
US20040265238A1 (en) * 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
ITFI20030328A1 (it) * 2003-12-24 2005-06-25 Mario Bigazzi Uso della relaxina come adiuvante nella differenziazione
US7878978B2 (en) 2004-03-18 2011-02-01 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Use of relaxin to increase arterial compliance
AU2005223694B2 (en) * 2004-03-19 2011-04-28 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Use of relaxin to increase arterial compliance
EP1729817B1 (de) * 2004-03-30 2014-03-05 Industry-Academic Cooperation Foundation Relaxin-gen enthaltendes genverabreichungssystem und pharmazeutische zusammensetzung, die relaxin verwendet
AU2005247332A1 (en) * 2004-04-30 2005-12-08 Corthera, Inc. Methods and compositions for control of fetal growth via modulation of relaxin
US20090088374A1 (en) * 2005-01-07 2009-04-02 Judithann Lee Novel use
AU2006235489A1 (en) * 2005-04-12 2006-10-19 Intradigm Corporation Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases
US7893244B2 (en) * 2005-04-12 2011-02-22 Intradigm Corporation Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases
US20060281669A1 (en) * 2005-06-13 2006-12-14 Yue Samuel K Method and compositions for the treatment of diabetes and related complications
US8496446B2 (en) * 2005-08-29 2013-07-30 Carrier Corporation Compressor muffler
JP2009544734A (ja) * 2006-07-25 2009-12-17 アルコン リサーチ， リミテッド 目の障害の予防および処置のための内皮分化遺伝子ファミリー３（ｅｄｇ−３、ｓ１ｐ３）レセプターのアンタゴニスト
JP5291704B2 (ja) * 2007-05-11 2013-09-18 コーニング インコーポレイテッド 改良された端部支持条件を用いたアイソパイプのサグ・コントロール
JP5651586B2 (ja) 2008-05-16 2015-01-14 コーセラ，インコーポレーテッド 急性心不全に伴う呼吸困難のリラキシンによる治療
US20100041603A1 (en) * 2008-05-16 2010-02-18 Corthera, Inc. Method of Promoting Wound Healing
MX2011005454A (es) 2008-11-24 2011-06-20 Corthera Inc Prediccion y prevencion de preeclampsia.
EP2405933A1 (de) * 2009-03-13 2012-01-18 Medtronic, Inc Verfahren zur behandlung von herzinsuffizienz
CN102883742B (zh) 2010-03-10 2014-09-24 佛罗里达大学研究基金会有限公司 用松弛素调节水孔蛋白
EP3572091B1 (de) 2010-08-17 2023-12-13 Ambrx, Inc. Modifizierte relaxinpolypeptide und deren verwendungen
RU2014103288A (ru) 2011-07-01 2015-08-10 Байер Интеллектчуал Проперти Гмбх Слитые полипептиды релаксина и их применение
EP2739647B1 (de) * 2011-08-04 2016-07-20 Relaxera GmbH & Co. KG i.G. c/o Immundiagnostik AG Verfahren zur herstellung von humanem relaxin-2
US10493131B2 (en) * 2011-08-31 2019-12-03 University Of Florida Research Foundation, Incorporated Materials and methods for modulating activity of bone marrow derived cells
US9393288B2 (en) 2012-05-29 2016-07-19 The University Of Vermont And State Agricultural College Methods of treating diseases associated with PPARγ
AU2013296720B2 (en) * 2012-07-31 2016-06-16 Novartis Ag Treating inflammation using serelaxin
US9381231B2 (en) 2012-10-09 2016-07-05 University Of Florida Research Foundation, Inc. Use of relaxin to restore maternal physiology in pregnancies conceived by assisted reproductive technologies
PT3387019T (pt) 2015-12-09 2022-01-14 Scripps Research Inst Proteínas de fusão de imunoglobulina de relaxina e métodos de uso
KR102533456B1 (ko) 2016-05-18 2023-05-17 모더나티엑스, 인크. 릴랙신을 인코딩하는 폴리뉴클레오타이드
CN116802289A (zh) * 2020-10-15 2023-09-22 东北大学 用于增加胶原蛋白产量的工程化细胞
WO2025056188A1 (en) 2023-09-15 2025-03-20 Relaxera Pharmazeutische Gmbh & Co. Kg Relaxin medication

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3003917A (en) * 1959-01-14 1961-10-10 Nat Drug Co Wound healing composition
DE3236264A1 (de) * 1982-09-30 1984-04-05 Serono Pharmazeutische Präparate GmbH, 7800 Freiburg Verfahren zur gewinnung von relaxin
CH661662A5 (en) * 1984-04-16 1987-08-14 Georg L Prof Dr Floersheim Product for the treatment of the skin and of the connective tissue
US4910317A (en) * 1987-07-14 1990-03-20 Warner-Lambert Company Benzofurans and benzothiophenes having antiallergic activity and method of use thereof
AU626840B2 (en) * 1988-02-26 1992-08-13 Genentech Inc. Human relaxin formulation
US5166191A (en) 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy
WO1995003822A2 (en) * 1993-07-27 1995-02-09 Mario Bigazzi Use of relaxin as therapeutic or preventing agent
AU7687194A (en) 1993-09-14 1995-04-03 Mallinckrodt Medical, Inc. Therapeutic treatment for inhibiting blood vessel blockage using a polypeptide
CA2229479C (en) * 1995-08-15 2010-03-30 Connective Therapeutics, Inc. Method of promoting angiogenesis
US6251863B1 (en) * 1998-09-08 2001-06-26 Samuel K. Yue Method of preventing and treating symptoms of aging and neurodegenerative dysfunctions with relaxin

Also Published As

Publication number Publication date
CA2397200C (en) 2010-11-23
EP1253929A4 (de) 2003-03-05
US20040266685A1 (en) 2004-12-30
EP1253929B1 (de) 2007-05-23
US20020019349A1 (en) 2002-02-14
EP1253929A1 (de) 2002-11-06
AU2001236886A1 (en) 2001-08-20
HK1051001A1 (en) 2003-07-18
DE60128540D1 (de) 2007-07-05
WO2001058468A1 (en) 2001-08-16
DE60128540T2 (de) 2008-01-31
CA2397200A1 (en) 2001-08-16
US6723702B2 (en) 2004-04-20

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