ATE362939T1 - Dimere von thrombinpeptidderivaten - Google Patents

Dimere von thrombinpeptidderivaten

Info

Publication number: ATE362939T1
Authority: AT; Austria
Prior art keywords: gly; polypeptide; thrombin peptide; dimers; asp
Prior art date: 2002-07-02

Application number

AT03763062T

Other languages

English (en)

Inventor

Darrell Carney

Original Assignee

Orthologic Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-02

Filing date

2003-07-01

Publication date

2007-06-15

2003-07-01 Application filed by Orthologic Corp filed Critical Orthologic Corp

2007-06-15 Application granted granted Critical

2007-06-15 Publication of ATE362939T1 publication Critical patent/ATE362939T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
108090000190 Thrombin Proteins 0.000 title abstract 3
229960004072 thrombin Drugs 0.000 title abstract 3
239000000539 dimer Substances 0.000 title abstract 2
229920001184 polypeptide Polymers 0.000 abstract 4
102000004196 processed proteins & peptides Human genes 0.000 abstract 4
150000001413 amino acids Chemical group 0.000 abstract 3
239000012634 fragment Substances 0.000 abstract 2
229940117028 Thrombin receptor agonist Drugs 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
OXHYRVSBKWIFES-WWSDOYNLSA-N trap-14 peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=CC=C1 OXHYRVSBKWIFES-WWSDOYNLSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT03763062T 2002-07-02 2003-07-01 Dimere von thrombinpeptidderivaten ATE362939T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US39357902P	2002-07-02	2002-07-02

Publications (1)

Publication Number	Publication Date
ATE362939T1 true ATE362939T1 (de)	2007-06-15

Family

ID=30115603

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03763062T ATE362939T1 (de)	2002-07-02	2003-07-01	Dimere von thrombinpeptidderivaten

Country Status (8)

Country	Link
US (2)	US7456250B2 (de)
EP (1)	EP1539800B1 (de)
JP (1)	JP4668612B2 (de)
AT (1)	ATE362939T1 (de)
AU (1)	AU2003247848B2 (de)
CA (1)	CA2491135A1 (de)
DE (1)	DE60313982T2 (de)
WO (1)	WO2004005317A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL1559431T3 (pl) *	2003-12-31	2007-10-31	Orthologic Corp	Kompozycja farmaceutyczna dla pochodnych peptydu trombiny
US8334259B2 (en) *	2006-09-22	2012-12-18	The Board Of Regents, The University Of Texas System	Method of treating endothelial dysfunction comprising administration of a thrombin peptide derivative
WO2008100567A2 (en) *	2007-02-15	2008-08-21	Orthologic Corp.	Thrombin peptide derivatives for treating fractures in osteopenic patients
EP2155234A1 (de) *	2007-04-10	2010-02-24	The Board of Regents,The University of Texas System	Kombinationstherapie gegen chronische hautgeschwüre
US20100303793A1 (en) *	2007-04-10	2010-12-02	The Board Of Regents, The University Of Texas Syst	Combination therapy for cardiac revascularization and cardiac repair
WO2009120307A2 (en) *	2008-03-26	2009-10-01	Orthologic Corp.	Method of treating peripheral arterial disease
AU2009229395A1 (en) *	2008-03-26	2009-10-01	The Board Of Regents, The University Of Texas System	Method of treating degenerative diseases
CA2719940A1 (en) *	2008-03-26	2009-11-26	Orthologic Corp.	Methods for treating acute myocardial infarction
US20110117075A1 (en) *	2008-03-26	2011-05-19	Orthologic Corp.	Thrombin derived peptides for smooth muscle relaxation
CU23716A1 (es) *	2008-09-30	2011-10-05	Ct Ingenieria Genetica Biotech	Péptido antagonista de la actividad de la interleucina-15
AU2011265228A1 (en)	2010-06-11	2013-05-23	The Board Of Regents, The University Of Texas System	Methods of mitigating effects of radiation and reducing the risk of systemic infection
US10220078B2 (en)	2014-06-11	2019-03-05	The Board Of Regents Of The University Of Texas System	Methods of using thrombin derivatives to treat medulloblastoma
WO2020210087A1 (en) *	2019-04-12	2020-10-15	Affirmed Pharma, Llc	Rusalatide acetate compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5352664A (en) *	1986-10-31	1994-10-04	Board Of Regents, The University Of Texas System	Thrombin derived polypeptides; compositions and methods for use
US6500934B1 (en) *	1996-07-24	2002-12-31	Michael Rush Lerner	Bivalent agonists for G-protein coupled receptors
TWI257307B (en) *	2000-07-12	2006-07-01	Orthologic Corp	Pharmaceutical composition for cardiac tissue repair
TR200400260T4 (tr) *	2000-07-19	2004-03-22	The Board Of Regents, The University Of Texas System	Trombin peptid türevleri ile kemik büyümesinin uyarılması
DE60105772T2 (de) *	2000-07-20	2006-02-16	Board of Regents, The University of Texas System, Austin	Stimulation des knorpelwachstums mit agonisten des nicht-proteolytisch aktivierten thrombin rezeptors
DE60212143T2 (de) *	2001-07-27	2007-04-12	Orthologic Corp., Tempe	Verwendung von thrombin-peptidderivaten zur behandlung von chronischen hautulcera
TW200407905A (en) *	2002-11-06	2004-05-16	Leadtek Research Inc	Data write-in and read-out method of flash memory and circuit thereof
PL1559431T3 (pl) *	2003-12-31	2007-10-31	Orthologic Corp	Kompozycja farmaceutyczna dla pochodnych peptydu trombiny

2003
- 2003-07-01 AT AT03763062T patent/ATE362939T1/de not_active IP Right Cessation
- 2003-07-01 AU AU2003247848A patent/AU2003247848B2/en not_active Ceased
- 2003-07-01 JP JP2004519705A patent/JP4668612B2/ja not_active Expired - Fee Related
- 2003-07-01 DE DE60313982T patent/DE60313982T2/de not_active Expired - Lifetime
- 2003-07-01 WO PCT/US2003/020626 patent/WO2004005317A2/en not_active Ceased
- 2003-07-01 CA CA002491135A patent/CA2491135A1/en not_active Abandoned
- 2003-07-01 EP EP03763062A patent/EP1539800B1/de not_active Expired - Lifetime
2004
- 2004-12-30 US US11/027,795 patent/US7456250B2/en not_active Expired - Lifetime
2008
- 2008-10-10 US US12/287,703 patent/US7919457B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60313982D1 (de)	2007-07-05
CA2491135A1 (en)	2004-01-15
AU2003247848A1 (en)	2004-01-23
US20090124550A1 (en)	2009-05-14
AU2003247848B2 (en)	2006-12-21
EP1539800A2 (de)	2005-06-15
JP2006507229A (ja)	2006-03-02
JP4668612B2 (ja)	2011-04-13
AU2003247848C1 (en)	2004-01-23
EP1539800B1 (de)	2007-05-23
US7456250B2 (en)	2008-11-25
WO2004005317A3 (en)	2004-09-30
US7919457B2 (en)	2011-04-05
DE60313982T2 (de)	2008-01-17
US20050153893A1 (en)	2005-07-14
WO2004005317A2 (en)	2004-01-15
EP1539800A4 (de)	2005-11-16

Legal Events

Date	Code	Title	Description
2007-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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