ATE362988T1 - Chimaeres protein enthaltend die cystein protease aus dem grossen leberegel fusioniert an das hepatitis b core protein oder ubiquitin; pflanzen,welches dieses protein exprimieren, sowie deren verwendung als vakzine - Google Patents

Chimaeres protein enthaltend die cystein protease aus dem grossen leberegel fusioniert an das hepatitis b core protein oder ubiquitin; pflanzen,welches dieses protein exprimieren, sowie deren verwendung als vakzine

Info

Publication number
ATE362988T1
ATE362988T1 AT03786456T AT03786456T ATE362988T1 AT E362988 T1 ATE362988 T1 AT E362988T1 AT 03786456 T AT03786456 T AT 03786456T AT 03786456 T AT03786456 T AT 03786456T AT E362988 T1 ATE362988 T1 AT E362988T1
Authority
AT
Austria
Prior art keywords
protein
vaccines
liver fluke
plants
chimate
Prior art date
Application number
AT03786456T
Other languages
English (en)
Inventor
Andrzej Legocki
Katarzyna Miedzinska
Magdalena Czaplinska
Anna Modelska
Tomasz Pniewski
Andrzej Plucienniczak
Malgorzata Kezik
Anna Porebska
Halina Wedrychowicz
Juliusz Mieszczanek
Luiza Jedlina-Panasiuk
Jacek Wojciechowicz
Original Assignee
Inst Of Bioorg Chemistry
Inst Of Biotechnology Antibiot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Of Bioorg Chemistry, Inst Of Biotechnology Antibiot filed Critical Inst Of Bioorg Chemistry
Application granted granted Critical
Publication of ATE362988T1 publication Critical patent/ATE362988T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/641—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
AT03786456T 2002-12-04 2003-12-04 Chimaeres protein enthaltend die cystein protease aus dem grossen leberegel fusioniert an das hepatitis b core protein oder ubiquitin; pflanzen,welches dieses protein exprimieren, sowie deren verwendung als vakzine ATE362988T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL357517A PL201419B1 (pl) 2002-12-04 2002-12-04 Białko chimeryczne, sekwencja, konstrukt, komórka roślinna, sposób otrzymywania białka chimerycznego, transgenicznej rośliny, transgeniczna roślina

Publications (1)

Publication Number Publication Date
ATE362988T1 true ATE362988T1 (de) 2007-06-15

Family

ID=32464755

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03786456T ATE362988T1 (de) 2002-12-04 2003-12-04 Chimaeres protein enthaltend die cystein protease aus dem grossen leberegel fusioniert an das hepatitis b core protein oder ubiquitin; pflanzen,welches dieses protein exprimieren, sowie deren verwendung als vakzine

Country Status (9)

Country Link
EP (1) EP1613752B1 (de)
AT (1) ATE362988T1 (de)
AU (1) AU2003295293B2 (de)
DE (1) DE60314017T2 (de)
DK (1) DK1613752T3 (de)
ES (1) ES2288223T3 (de)
NZ (1) NZ540582A (de)
PL (1) PL201419B1 (de)
WO (1) WO2004050883A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL196114B1 (pl) * 2002-12-31 2007-12-31 Inst Biotechnologii I Antybiot Ciałka inkluzyjne jako antygeny do doustnej immunizacji zwierząt
CN101014711A (zh) * 2004-06-25 2007-08-08 阿尔特生物科学公司 植物中组织因数的制造
JP5832445B2 (ja) * 2009-12-10 2015-12-16 エスコラ スペリオール アグラリア デ コインブラＥｓｃｏｌａ Ｓｕｐｅｒｉｏｒ Ａｇｒａｒｉａ Ｄｅ Ｃｏｉｍｂｒａ 免疫原と、その調製方法及びポリクローナル抗体産生のシステムでの使用
WO2014124047A1 (en) * 2013-02-06 2014-08-14 Academia Sinica Antimicrobial peptides derived from hepatitis b virus core protein arginine-rich domain
WO2017205631A1 (en) 2016-05-27 2017-11-30 Academia Sinica Modified antimicrobial peptide derived from an arginine-rich domain

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3048689A (en) * 1988-01-13 1989-08-11 University Of North Carolina At Chapel Hill, The Immunogenic peptides
EP0666919B1 (de) * 1992-10-21 2003-05-14 John Pius Dalton Thiolprotease enthaltender impfstoff
JPH07505787A (ja) * 1993-02-05 1995-06-29 ダラテク・プロプライエタリー・リミテッド ファスキオラ種から取得可能なポリペプチド類，およびワクチン，処置法およびそのｄｎａ配列
GB9312324D0 (en) * 1993-06-15 1993-07-28 Pitman Moore Inc Vaccine
US6319503B1 (en) * 1998-02-19 2001-11-20 Proteinix Company Heat shock fusion-based vaccine system

Also Published As

Publication number Publication date
NZ540582A (en) 2008-05-30
EP1613752B1 (de) 2007-05-23
WO2004050883A2 (en) 2004-06-17
EP1613752A2 (de) 2006-01-11
PL357517A1 (en) 2004-06-14
DE60314017T2 (de) 2008-01-17
AU2003295293A1 (en) 2004-06-23
ES2288223T3 (es) 2008-01-01
AU2003295293B2 (en) 2009-12-03
WO2004050883A3 (en) 2004-11-04
DK1613752T3 (da) 2007-09-10
PL201419B1 (pl) 2009-04-30
DE60314017D1 (de) 2007-07-05

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