ATE363473T1 - Substituierte pyrazoloverbindungen zur behandlung von entzündungen - Google Patents
Substituierte pyrazoloverbindungen zur behandlung von entzündungenInfo
- Publication number
- ATE363473T1 ATE363473T1 AT02763656T AT02763656T ATE363473T1 AT E363473 T1 ATE363473 T1 AT E363473T1 AT 02763656 T AT02763656 T AT 02763656T AT 02763656 T AT02763656 T AT 02763656T AT E363473 T1 ATE363473 T1 AT E363473T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- sup
- inflammation
- compounds
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32329701P | 2001-09-19 | 2001-09-19 | |
| US38322602P | 2002-05-24 | 2002-05-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE363473T1 true ATE363473T1 (de) | 2007-06-15 |
Family
ID=26983875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02763656T ATE363473T1 (de) | 2001-09-19 | 2002-09-19 | Substituierte pyrazoloverbindungen zur behandlung von entzündungen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7211597B2 (de) |
| EP (1) | EP1427706B1 (de) |
| JP (1) | JP2005510466A (de) |
| AT (1) | ATE363473T1 (de) |
| BR (1) | BR0212617A (de) |
| CA (1) | CA2460939C (de) |
| DE (1) | DE60220422T2 (de) |
| ES (1) | ES2286275T3 (de) |
| MX (1) | MXPA04002682A (de) |
| WO (1) | WO2003024936A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10229762A1 (de) | 2002-07-03 | 2004-01-22 | Aventis Pharma Deutschland Gmbh | Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase |
| JP2006512313A (ja) | 2002-10-31 | 2006-04-13 | アムジェン インコーポレイテッド | 抗炎症剤 |
| RS20050832A (sr) * | 2003-04-09 | 2007-12-31 | Millennium Pharmaceuticals Inc., | Beta-karbolini koji su korisni u tretiranju inflamatornih bolesti |
| DE60319158T2 (de) * | 2003-07-03 | 2009-02-05 | Aventis Pharmaceuticals Inc. | Pyrazoloisochinolinenderivaten als kinase inhibitoren |
| US7132428B2 (en) | 2003-07-03 | 2006-11-07 | Aventis Pharmaceuticals Inc. | Pyrazoloisoquinoline derivative as kinase inhibitors for the treatment of various disorders |
| US7572914B2 (en) * | 2003-12-19 | 2009-08-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| DE602005020263D1 (de) | 2004-04-09 | 2010-05-12 | Millennium Pharm Inc | Für die behandlung von entzündlichen krankheiten nützliche beta-carboline |
| EP1763524A1 (de) * | 2004-04-23 | 2007-03-21 | Takeda San Diego, Inc. | Indolderivate und deren verwendung als kinaseinhibitoren |
| TW200616967A (en) | 2004-06-24 | 2006-06-01 | Smithkline Beecham Corp | Novel indazole carboxamides and their use |
| WO2006023931A2 (en) * | 2004-08-18 | 2006-03-02 | Takeda San Diego, Inc. | Kinase inhibitors |
| US7718665B2 (en) * | 2004-08-18 | 2010-05-18 | 4Sc Ag | Benzothienopyridines for use as inhibitors of Eg5 kinesin |
| TW200626142A (en) | 2004-09-21 | 2006-08-01 | Glaxo Group Ltd | Chemical compounds |
| US7713973B2 (en) * | 2004-10-15 | 2010-05-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| AU2006208709A1 (en) * | 2005-01-27 | 2006-08-03 | 4Sc Ag | Novel indolopyridines , benzofuranopyridines and benzothienopyridines |
| JP2008528551A (ja) * | 2005-01-28 | 2008-07-31 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | インドロピリジン、ベンゾフラノピリジン及びベンゾチエノピリジン |
| TW200738638A (en) * | 2005-06-23 | 2007-10-16 | Merck & Co Inc | Tyrosine kinase inhibitors |
| ATE524445T1 (de) * | 2005-06-23 | 2011-09-15 | Merck Sharp & Dohme | Benzocycloheptapyridine als inhibitoren der tyrosinkinase met |
| CN101203495B (zh) * | 2005-06-23 | 2013-07-17 | 默沙东公司 | 作为受体酪氨酸激酶met抑制剂的苯并环庚三烯并吡啶化合物 |
| US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| UA99699C2 (ru) | 2005-06-30 | 2012-09-25 | Смитклайн Бичам Корпорейшн | Производные индолкарбоксамида и фармацевтическая композиция, которая их содержит |
| US8119655B2 (en) * | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| JP2009513580A (ja) * | 2005-10-21 | 2009-04-02 | メルク エンド カムパニー インコーポレーテッド | チロシンキナーゼ阻害剤 |
| EP1951047A2 (de) * | 2005-10-21 | 2008-08-06 | Merck & Co., Inc. | Tyrosin-kinase-hemmer |
| JP5349056B2 (ja) * | 2006-02-22 | 2013-11-20 | ４エスツェー アクチェンゲゼルシャフト | Ｅｇ５キネシンモジュレーターとしてのインドロピリジン類 |
| EA015151B1 (ru) * | 2006-02-22 | 2011-06-30 | 4ЭсЦэ АГ | Индолопиридины в качестве модуляторов кинезина eg5 |
| TW200813054A (en) | 2006-06-02 | 2008-03-16 | Elan Pharm Inc | Fused, tricyclic sulfonamide inhibitors of gamma secretase |
| TW200813021A (en) * | 2006-07-10 | 2008-03-16 | Merck & Co Inc | Tyrosine kinase inhibitors |
| JP2009542777A (ja) * | 2006-07-13 | 2009-12-03 | ４エスツェー アクチェンゲゼルシャフト | ベンゾピラノピラゾール |
| EP2223925A1 (de) * | 2006-10-09 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Kinase-Inhibitoren |
| GEP20135728B (en) | 2006-10-09 | 2013-01-25 | Takeda Pharmaceuticals Co | Kinase inhibitors |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| KR101449785B1 (ko) | 2008-04-21 | 2014-10-14 | 오토노미, 인코포레이티드 | 귀 질환 및 병태를 치료하기 위한 귀 조제물 |
| WO2009155527A2 (en) * | 2008-06-19 | 2009-12-23 | Progenics Pharmaceuticals, Inc. | Phosphatidylinositol 3 kinase inhibitors |
| WO2010049366A1 (en) * | 2008-10-27 | 2010-05-06 | Glaxo Group Limited | Tricyclic compounds as glutamate receptor modulators |
| JP2012520257A (ja) | 2009-03-10 | 2012-09-06 | グラクソ グループ リミテッド | Ｉｋｋ２阻害剤としてのインドール誘導体 |
| EP2904119B1 (de) | 2012-10-02 | 2020-06-17 | The General Hospital Corporation d/b/a Massachusetts General Hospital | Verfahren für mit dem dna-erfassungspfad assoziierten leiden |
| CA2912921C (en) * | 2013-06-24 | 2021-05-18 | Merck Patent Gmbh | Pyrazole compounds as modulators of fshr and uses thereof |
| WO2015196335A1 (en) * | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
| JP7033789B2 (ja) | 2016-06-29 | 2022-03-11 | オトノミー，インク． | トリグリセリド耳用製剤とその使用 |
| US11345710B2 (en) * | 2017-07-10 | 2022-05-31 | Impact Therapeutics (Shanghai), Inc | Imidazo[1,2-b]pyrimido[4,5-d]pyridazin-5(6H)-ones and the use thereof |
| EP4577206A2 (de) * | 2022-08-26 | 2025-07-02 | Celmatix Inc. | Neue modulatoren von fshr und deren verwendungen |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3940418A (en) * | 1972-04-07 | 1976-02-24 | G. D. Searle & Co. | Esters and amides of 4,5-dihydrobenz[g]indazole-3-carboxylic acids and related compounds |
| US4678499A (en) * | 1985-03-11 | 1987-07-07 | E. I. Du Pont De Nemours And Company | Herbicidal sulfonamides |
| JPS63166588A (ja) * | 1986-12-27 | 1988-07-09 | Kanzaki Paper Mfg Co Ltd | クロメノ化合物およびクロメノ化合物を用いた感熱記録体 |
| US4816467A (en) * | 1987-01-09 | 1989-03-28 | Farmitalia Carlo Erba S.R.L | Heteroaryl 3-oxo-propanenitrile derivatives, pharmaceutical compositions and use |
| GB8814587D0 (en) | 1988-06-20 | 1988-07-27 | Erba Carlo Spa | Condensed pyrazole 3-oxo-propanenitrile derivatives & process for their preparation |
| GB2227741B (en) | 1989-02-06 | 1992-08-05 | Erba Carlo Spa | Condensed 3-oxo-propanenitrile derivatives and process for their preparation |
| GB8907799D0 (en) * | 1989-04-06 | 1989-05-17 | Erba Carlo Spa | Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of rheumatoid arthritis and other autoimmune diseases |
| US5260328A (en) * | 1989-04-06 | 1993-11-09 | Farmitalia Carlo Erba Srl | Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the treatment of rheumatoid arthritis |
| GB8916290D0 (en) * | 1989-07-17 | 1989-08-31 | Erba Carlo Spa | Heteroaryl-3-oxo-propanenitrile derivatives useful in stimulating myelopoiesis |
| US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| US5696143A (en) * | 1994-09-20 | 1997-12-09 | Talley; John J. | Benz G! indazolyl derivatives for the treatment of inflammation |
| US5547975A (en) | 1994-09-20 | 1996-08-20 | Talley; John J. | Benzopyranopyrazolyl derivatives for the treatment of inflammation |
| US5886016A (en) * | 1995-09-15 | 1999-03-23 | G.D. Searle & Co. | Benzopyranopyrazolyl derivatives for the treatment of inflammation |
| US5756529A (en) | 1995-09-29 | 1998-05-26 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies |
| BR9708574A (pt) * | 1996-04-12 | 1999-08-03 | Searle & Co | Derivados benzeno sulfonamida substituídos como pródrogas de inibidores cox-2 |
| WO1999055335A1 (en) | 1998-04-30 | 1999-11-04 | Basf Aktiengesellschaft | Substituted tricyclic pyrazole derivatives with protein kinase activity |
| EP1142889A1 (de) | 2000-04-03 | 2001-10-10 | Pfizer Products Inc. | Pyrazolderivate als entzündungs-/schmerzhemmende Mittel |
-
2002
- 2002-09-19 ES ES02763656T patent/ES2286275T3/es not_active Expired - Lifetime
- 2002-09-19 BR BR0212617-6A patent/BR0212617A/pt not_active IP Right Cessation
- 2002-09-19 AT AT02763656T patent/ATE363473T1/de not_active IP Right Cessation
- 2002-09-19 JP JP2003528784A patent/JP2005510466A/ja active Pending
- 2002-09-19 MX MXPA04002682A patent/MXPA04002682A/es active IP Right Grant
- 2002-09-19 CA CA002460939A patent/CA2460939C/en not_active Expired - Fee Related
- 2002-09-19 EP EP02763656A patent/EP1427706B1/de not_active Expired - Lifetime
- 2002-09-19 US US10/247,028 patent/US7211597B2/en not_active Expired - Fee Related
- 2002-09-19 WO PCT/US2002/029625 patent/WO2003024936A1/en not_active Ceased
- 2002-09-19 DE DE60220422T patent/DE60220422T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BR0212617A (pt) | 2005-02-09 |
| MXPA04002682A (es) | 2004-06-18 |
| CA2460939C (en) | 2008-07-29 |
| CA2460939A1 (en) | 2003-03-27 |
| ES2286275T3 (es) | 2007-12-01 |
| US7211597B2 (en) | 2007-05-01 |
| DE60220422D1 (de) | 2007-07-12 |
| US20030114432A1 (en) | 2003-06-19 |
| EP1427706A1 (de) | 2004-06-16 |
| DE60220422T2 (de) | 2008-02-07 |
| WO2003024936A1 (en) | 2003-03-27 |
| EP1427706B1 (de) | 2007-05-30 |
| JP2005510466A (ja) | 2005-04-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE363473T1 (de) | Substituierte pyrazoloverbindungen zur behandlung von entzündungen | |
| EA200600294A1 (ru) | [1,8] нафтиридин-2-оны и родственные соединения для лечения шизофрении | |
| CY1107747T1 (el) | Υποκατεστημενα τετρακυκλικα παραγωγα πυρρολοκινολονης χρησιμα ως αναστολεις της φωσφοδιεστερασης | |
| DE60219793D1 (de) | Methode zur behandlung von zytokinvermittelten erkrankungen | |
| ATE311386T1 (de) | Verfahren zur herstellung von 1,5,6,7- tetrahydropyrrolo(3,2-c)derivaten zur behandlung der fettleibigkeit | |
| MXPA04000622A (es) | Pirazolilcarboxanilidas como funguicidas. | |
| ATE343388T1 (de) | Pde-v hemmer zur behandlung von morbus parkinson | |
| DK1353672T3 (da) | Syntese af 4-amino-thalidomidenantiomerer | |
| MXPA04002070A (es) | Compuestos de indazol sustituidos para el tratamiento de la inflamacion. | |
| ATE389395T1 (de) | Substituierte 2-aminotetraline zur vorbeugenden behandlung von morbus parkinson | |
| CY1109808T1 (el) | Αρυλινδενο-πυριδινες και αρυλινδενο-πυριμιδινες και η χρηση τους ως ανταγωνιστων των υποδοχεων αδενοσινης α2α | |
| PL376324A1 (en) | Piperazinyl and diazapanyl benzamides and benzthioamides | |
| MY141011A (en) | Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones | |
| ATE363474T1 (de) | Benzimidazole zur behandlung sexueller fehlfunktionen | |
| ATE432278T1 (de) | Verbindungen zur behandlung von krankheiten | |
| ATE367380T1 (de) | Zur behandlung von zns-erkrankungen geeignete piperazinylchinolinderivate | |
| ATE432930T1 (de) | Benzosulfonamide derivate, deren verfahren zum herstellung, und deren verwendung zur behandlung von schmerzen | |
| GEP20053590B (en) | Phenyl Heterocyclyl Ether Derivatives as Serotonin Re-Uptake Inhibitors | |
| ATE179168T1 (de) | Substituierte spiroverbindungen zur behandlung von entzündungen | |
| DE602004021363D1 (de) | Imidazotriazin verbindungen zur behandlung von krebserkrankungen | |
| MXPA05004845A (es) | N-oxidos y derivados de melfalan para el tratamiento de estados de enfermedad asociados a un factor inducible por hipoxia. | |
| ATE346040T1 (de) | Aryl-sulfonamide als serotonin-antagonisten für de behandlung von fettleibigkeit | |
| DE60226971D1 (de) | Corticotropinfreisetzungsfaktor antagonisten | |
| ATE315387T1 (de) | Verwendung von substituierten 6- dimethylaminomethyl-1-phenyl- cyclohexanverbindungen zur therapie der harninkontinenz | |
| NO20040203L (no) | Kjemiske forbindelser |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |