ATE363473T1 - Substituierte pyrazoloverbindungen zur behandlung von entzündungen - Google Patents

Substituierte pyrazoloverbindungen zur behandlung von entzündungen

Info

Publication number
ATE363473T1
ATE363473T1 AT02763656T AT02763656T ATE363473T1 AT E363473 T1 ATE363473 T1 AT E363473T1 AT 02763656 T AT02763656 T AT 02763656T AT 02763656 T AT02763656 T AT 02763656T AT E363473 T1 ATE363473 T1 AT E363473T1
Authority
AT
Austria
Prior art keywords
sub
sup
inflammation
compounds
group
Prior art date
Application number
AT02763656T
Other languages
English (en)
Inventor
Suzanne Metz
Michael Clare
Joyce Crich
Timothy Hagen
Gunnar Hanson
He Huang
Stephen Houdek
Michael Stealey
Michael Vazquez
Richard Weier
Xiangdong Xu
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Application granted granted Critical
Publication of ATE363473T1 publication Critical patent/ATE363473T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT02763656T 2001-09-19 2002-09-19 Substituierte pyrazoloverbindungen zur behandlung von entzündungen ATE363473T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32329701P 2001-09-19 2001-09-19
US38322602P 2002-05-24 2002-05-24

Publications (1)

Publication Number Publication Date
ATE363473T1 true ATE363473T1 (de) 2007-06-15

Family

ID=26983875

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02763656T ATE363473T1 (de) 2001-09-19 2002-09-19 Substituierte pyrazoloverbindungen zur behandlung von entzündungen

Country Status (10)

Country Link
US (1) US7211597B2 (de)
EP (1) EP1427706B1 (de)
JP (1) JP2005510466A (de)
AT (1) ATE363473T1 (de)
BR (1) BR0212617A (de)
CA (1) CA2460939C (de)
DE (1) DE60220422T2 (de)
ES (1) ES2286275T3 (de)
MX (1) MXPA04002682A (de)
WO (1) WO2003024936A1 (de)

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DE10229762A1 (de) 2002-07-03 2004-01-22 Aventis Pharma Deutschland Gmbh Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase
EP1556053A4 (de) 2002-10-31 2006-04-19 Amgen Inc Entzündungshemmende mittel
KR20060006031A (ko) * 2003-04-09 2006-01-18 밀레니엄 파머슈티컬스 인코퍼레이티드 염증 질환 치료에 유용한 베타-카르볼린
US7132428B2 (en) 2003-07-03 2006-11-07 Aventis Pharmaceuticals Inc. Pyrazoloisoquinoline derivative as kinase inhibitors for the treatment of various disorders
EP1644371B1 (de) * 2003-07-03 2008-02-13 Aventis Pharmaceuticals Inc. Pyrazoloisoquinolinenderivaten als kinase inhibitoren
US7572914B2 (en) * 2003-12-19 2009-08-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP2206713A1 (de) 2004-04-09 2010-07-14 Millennium Pharmaceuticals, Inc. Für die Behandlung von Entzündlichen Krankenheiten Nützliche beta-Carbolinen
WO2005105788A1 (en) * 2004-04-23 2005-11-10 Takeda San Diego, Inc. Indole derivatives and use thereof as kinase inhibitors
TW200616967A (en) 2004-06-24 2006-06-01 Smithkline Beecham Corp Novel indazole carboxamides and their use
WO2006023931A2 (en) * 2004-08-18 2006-03-02 Takeda San Diego, Inc. Kinase inhibitors
DE602005024572D1 (de) * 2004-08-18 2010-12-16 4Sc Ag Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin
TW200626142A (en) 2004-09-21 2006-08-01 Glaxo Group Ltd Chemical compounds
EP1812439B2 (de) 2004-10-15 2017-12-06 Takeda Pharmaceutical Company Limited Kinaseinhibitoren
AU2006208709A1 (en) * 2005-01-27 2006-08-03 4Sc Ag Novel indolopyridines , benzofuranopyridines and benzothienopyridines
WO2006079644A1 (en) * 2005-01-28 2006-08-03 Nycomed Gmbh Indolopyridines, benzofuranopyridines and benzothienopyridines
RU2408584C2 (ru) 2005-06-23 2011-01-10 Мерк Шарп Энд Домэ Корп. Ингибиторы тирозинкиназы
CN101203495B (zh) * 2005-06-23 2013-07-17 默沙东公司 作为受体酪氨酸激酶met抑制剂的苯并环庚三烯并吡啶化合物
TW200738638A (en) * 2005-06-23 2007-10-16 Merck & Co Inc Tyrosine kinase inhibitors
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
NZ563687A (en) 2005-06-30 2011-07-29 Smithkline Beecham Corp 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[2-(1-methylethyl)-2,3-dihydro-1H-isoindol-5-yl]-1H-indole-7-carboxamide for inhibiting IKK2 (aka IKKbeta)
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
AU2006306499A1 (en) * 2005-10-21 2007-05-03 Merck Sharp & Dohme Corp. Tyrosine kinase inhibitors
AU2006306496A1 (en) * 2005-10-21 2007-05-03 Merck Sharp & Dohme Corp. Tyrosine kinase inhibitors
US8530493B2 (en) * 2006-02-22 2013-09-10 4Sc Ag Indolopyridines as Eg5 kinesin modulators
AU2007217562A1 (en) * 2006-02-22 2007-08-30 4Sc Ag Indolopyridines as EG5 kinesin modulators
TW200813054A (en) 2006-06-02 2008-03-16 Elan Pharm Inc Fused, tricyclic sulfonamide inhibitors of gamma secretase
TW200813021A (en) * 2006-07-10 2008-03-16 Merck & Co Inc Tyrosine kinase inhibitors
WO2008006883A2 (en) * 2006-07-13 2008-01-17 4Sc Ag Benzopyranopyrazoles
EP2223925A1 (de) * 2006-10-09 2010-09-01 Takeda Pharmaceutical Company Limited Kinase-Inhibitoren
JP2010505962A (ja) 2006-10-09 2010-02-25 武田薬品工業株式会社 キナーゼ阻害剤
AR065804A1 (es) 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
WO2009132050A2 (en) 2008-04-21 2009-10-29 Otonomy, Inc. Auris formulations for treating otic diseases and conditions
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
EP2303890A4 (de) * 2008-06-19 2012-04-11 Progenics Pharm Inc Inhibitoren von phosphatidylinosit-3-kinase
US20110263588A1 (en) * 2008-10-27 2011-10-27 Glaxo Group Limited Tricyclic compounds as glutamate receptor modulators
US8354539B2 (en) 2009-03-10 2013-01-15 Glaxo Group Limited Indole derivatives as IKK2 inhibitors
EP3795694A3 (de) 2012-10-02 2021-06-23 The General Hospital Corporation d/b/a Massachusetts General Hospital Verfahren für mit dem dna-erfassungspfad assoziierten leiden
RU2663898C2 (ru) * 2013-06-24 2018-08-13 Мерк Патент Гмбх Пиразольные соединения в качестве модуляторов fshr и их применение
WO2015196335A1 (en) * 2014-06-23 2015-12-30 Tocopherx, Inc. Pyrazole compounds as modulators of fshr and uses thereof
EP3478269A4 (de) 2016-06-29 2020-04-08 Otonomy, Inc. Triclyceridformulierungen für das ohr und verwendungen davon
WO2019011228A1 (zh) * 2017-07-10 2019-01-17 上海瑛派药业有限公司 咪唑并[1,2-b]嘧啶并[4,5-d]哒嗪-5(6H)-酮类化合物及其应用
EP4577206A2 (de) * 2022-08-26 2025-07-02 Celmatix Inc. Neue modulatoren von fshr und deren verwendungen

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US5260328A (en) 1989-04-06 1993-11-09 Farmitalia Carlo Erba Srl Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the treatment of rheumatoid arthritis
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US5466823A (en) * 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
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Also Published As

Publication number Publication date
WO2003024936A1 (en) 2003-03-27
DE60220422D1 (de) 2007-07-12
ES2286275T3 (es) 2007-12-01
US7211597B2 (en) 2007-05-01
CA2460939A1 (en) 2003-03-27
JP2005510466A (ja) 2005-04-21
US20030114432A1 (en) 2003-06-19
BR0212617A (pt) 2005-02-09
MXPA04002682A (es) 2004-06-18
EP1427706A1 (de) 2004-06-16
DE60220422T2 (de) 2008-02-07
CA2460939C (en) 2008-07-29
EP1427706B1 (de) 2007-05-30

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Legal Events

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