ATE364717T1 - Diagnose durch bestimmung von polymorphismen in der promoterregion des tgf-beta 1 gens - Google Patents

Diagnose durch bestimmung von polymorphismen in der promoterregion des tgf-beta 1 gens

Info

Publication number: ATE364717T1
Authority: AT; Austria
Prior art keywords: tgf; beta; diagnosis; gene; promoter region
Prior art date: 1996-01-17

Application number

AT97915646T

Other languages

English (en)

Inventor

David John Grainger

Timothy David Spector

Kirsten Heathcote

Original Assignee

Sequenom Gemini Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-17

Filing date

1997-01-17

Publication date

2007-07-15

1996-01-17 Priority claimed from GBGB9600957.6A external-priority patent/GB9600957D0/en

1996-08-23 Priority claimed from GBGB9617674.8A external-priority patent/GB9617674D0/en

1997-01-17 Application filed by Sequenom Gemini Ltd filed Critical Sequenom Gemini Ltd

2007-07-15 Application granted granted Critical

2007-07-15 Publication of ATE364717T1 publication Critical patent/ATE364717T1/de

Links

238000003745 diagnosis Methods 0.000 title abstract 2
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title abstract 2
101150084750 1 gene Proteins 0.000 title 1
108700039691 Genetic Promoter Regions Proteins 0.000 title 1
102000054765 polymorphisms of proteins Human genes 0.000 title 1
201000001320 Atherosclerosis Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Analytical Chemistry (AREA)
Physical Education & Sports Medicine (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Immunology (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Pathology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
General Engineering & Computer Science (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Application Of Or Painting With Fluid Materials (AREA)
External Artificial Organs (AREA)

AT97915646T 1996-01-17 1997-01-17 Diagnose durch bestimmung von polymorphismen in der promoterregion des tgf-beta 1 gens ATE364717T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9600957.6A GB9600957D0 (en)	1996-01-17	1996-01-17	Diagnostic method and apparatus
GBGB9617674.8A GB9617674D0 (en)	1996-08-23	1996-08-23	Diagnostic method and apparatus

Publications (1)

Publication Number	Publication Date
ATE364717T1 true ATE364717T1 (de)	2007-07-15

Family

ID=26308478

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97915646T ATE364717T1 (de)	1996-01-17	1997-01-17	Diagnose durch bestimmung von polymorphismen in der promoterregion des tgf-beta 1 gens

Country Status (9)

Country	Link
US (1)	US5998137A (de)
EP (1)	EP0889972B1 (de)
JP (1)	JP2000504226A (de)
AT (1)	ATE364717T1 (de)
AU (1)	AU723751B2 (de)
CA (1)	CA2243191A1 (de)
DE (1)	DE69737812T2 (de)
NZ (1)	NZ331041A (de)
WO (1)	WO1997028280A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6407082B1 (en)	1996-09-13	2002-06-18	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a vitamin D compound
US6511970B1 (en)	1996-09-13	2003-01-28	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6034074A (en)	1996-09-13	2000-03-07	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a Vitamin D compound
US6765002B2 (en)	2000-03-21	2004-07-20	Gustavo Rodriguez	Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6028064A (en)	1996-09-13	2000-02-22	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of progestin products
GB9822682D0 (en) *	1998-10-16	1998-12-09	Gemini Research Limited	Diagnostic method and apparatus based on polymorphism in a TGF-B-Gene
US6586177B1 (en) *	1999-09-08	2003-07-01	Exact Sciences Corporation	Methods for disease detection
US20010044431A1 (en) *	2000-03-21	2001-11-22	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
EP1307590A4 (de) *	2000-07-25	2005-01-12	Dz Genes Llc	POLYMORPHISMEN FüR DIE DIAGNOSTIK DES TGF-BETA1 PROMOTERS
GB0111277D0 (en) *	2001-05-09	2001-06-27	Univ Sheffield	Gentle marker
GB2381526A (en) *	2001-11-03	2003-05-07	Sequenom Inc	Detection of predisposition to osteoporosis
KR20040008815A (ko) *	2002-07-19	2004-01-31	한미약품 주식회사	혈장 내 전환성장인자-베타 1의 정량 방법
WO2008049953A1 (es)	2006-10-23	2008-05-02	Neocodex, S.L.	Método de pronóstico y/o diagnóstico in vitro de hipersensibilidad a estrógenos o a sustancias con actividad estrogénica
HU227658B1 (en) *	2007-04-27	2011-10-28	Univ Szegedi	Process for diagnosting of susceptibility to posttraumatic respiratory scaring
CA2930693A1 (en)	2013-11-15	2015-05-21	The Board Of Trustees Of The Leland Stanford Junior Unversity	Methods of treating heart failure with agonists of hypocretin receptor 2

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4801531A (en) *	1985-04-17	1989-01-31	Biotechnology Research Partners, Ltd.	Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
AU2254792A (en) *	1991-07-01	1993-02-11	Blood Center Of Southeastern Wisconsin, The	Pen polymorphism of human platelet membrane glycoprotein iiia and diagnostic and therapeutic application thereof
DK0652975T3 (da) *	1992-07-31	2005-02-14	Garvan Inst Med Res	Vurdering af allelvariation med hensyn til trans-virkende faktorer
US5445941A (en) *	1993-06-21	1995-08-29	Eli Lilly And Company	Method for screening anti-osteoporosis agents
WO1995015334A1 (en) *	1993-11-30	1995-06-08	California Pacific Medical Center Research Institute	cDNA PROBE FOR BREAST CANCER DIAGNOSIS AND TREATMENT
US5698399A (en) *	1996-04-05	1997-12-16	Duff; Gordon W.	Detecting genetic predisposition for osteoporosis

1997
- 1997-01-17 US US08/784,386 patent/US5998137A/en not_active Expired - Lifetime
- 1997-01-17 JP JP9527452A patent/JP2000504226A/ja not_active Ceased
- 1997-01-17 AU AU23046/97A patent/AU723751B2/en not_active Ceased
- 1997-01-17 CA CA002243191A patent/CA2243191A1/en not_active Abandoned
- 1997-01-17 WO PCT/IB1997/000425 patent/WO1997028280A1/en not_active Ceased
- 1997-01-17 NZ NZ331041A patent/NZ331041A/en not_active IP Right Cessation
- 1997-01-17 EP EP97915646A patent/EP0889972B1/de not_active Expired - Lifetime
- 1997-01-17 DE DE69737812T patent/DE69737812T2/de not_active Expired - Lifetime
- 1997-01-17 AT AT97915646T patent/ATE364717T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU723751B2 (en)	2000-09-07
DE69737812T2 (de)	2008-02-21
EP0889972A1 (de)	1999-01-13
AU2304697A (en)	1997-08-22
JP2000504226A (ja)	2000-04-11
US5998137A (en)	1999-12-07
CA2243191A1 (en)	1997-08-07
WO1997028280A1 (en)	1997-08-07
DE69737812D1 (de)	2007-07-26
NZ331041A (en)	2001-06-29
EP0889972B1 (de)	2007-06-13

Legal Events

Date

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Description

2007-11-15

UEP

Publication of translation of european patent specification

Ref document number: 0889972

Country of ref document: EP

2010-10-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE364717T1 (de)	2007-07-15	Diagnose durch bestimmung von polymorphismen in der promoterregion des tgf-beta 1 gens
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EP1006870A4 (de)	2000-06-14	Vorhersage von herzrythmusstörungen durch erkennen von mikropotentialen
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IT1139353B (it)	1986-09-24	Procedimento e dispositivo per la lavorazione,preferibilmente per la fresatura o la levigatura di bordi e raggi su pezzi in un'unica operazione
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DE69734890D1 (de)	2006-01-19	Rdgb-proteine
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