ATE365224T1 - Verfahren zum screening nach verbindungen, die die enzymatische aktivität des gwt1 genproduktes hemmen - Google Patents
Verfahren zum screening nach verbindungen, die die enzymatische aktivität des gwt1 genproduktes hemmenInfo
- Publication number
- ATE365224T1 ATE365224T1 AT03774148T AT03774148T ATE365224T1 AT E365224 T1 ATE365224 T1 AT E365224T1 AT 03774148 T AT03774148 T AT 03774148T AT 03774148 T AT03774148 T AT 03774148T AT E365224 T1 ATE365224 T1 AT E365224T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibit
- compounds
- screening
- gene product
- enzymatic activity
- Prior art date
Links
- 101001074628 Homo sapiens Phosphatidylinositol-glycan biosynthesis class W protein Proteins 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000012216 screening Methods 0.000 title abstract 2
- 230000002255 enzymatic effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 210000002421 cell wall Anatomy 0.000 abstract 3
- 230000002538 fungal effect Effects 0.000 abstract 3
- 102000002702 GPI-Linked Proteins Human genes 0.000 abstract 2
- 108010043685 GPI-Linked Proteins Proteins 0.000 abstract 2
- 102100036253 Phosphatidylinositol-glycan biosynthesis class W protein Human genes 0.000 abstract 1
- 230000025845 adhesion to host Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000005924 transacylation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002339418 | 2002-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE365224T1 true ATE365224T1 (de) | 2007-07-15 |
Family
ID=32375774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03774148T ATE365224T1 (de) | 2002-11-22 | 2003-11-21 | Verfahren zum screening nach verbindungen, die die enzymatische aktivität des gwt1 genproduktes hemmen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8323917B2 (de) |
| EP (1) | EP1564299B1 (de) |
| JP (1) | JP4061309B2 (de) |
| CN (1) | CN100371456C (de) |
| AT (1) | ATE365224T1 (de) |
| AU (1) | AU2003284635A1 (de) |
| DE (1) | DE60314538T2 (de) |
| WO (1) | WO2004048604A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2286387C2 (ru) * | 2000-07-07 | 2006-10-27 | Эйсай Ко., Лтд. | Ген синтеза клеточной стенки грибков |
| JP4315907B2 (ja) | 2002-11-22 | 2009-08-19 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | マラリア原虫のｇｐｉの生合成を阻害する化合物をスクリーニングする方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9400600A (pt) * | 1994-02-17 | 1995-10-24 | Finep Financiadora De Estudos | Processos para produção de uma protéina recombinante e/ou de glicosilfosfatidilinositol (GPI) em células de microorganismos eucariontes e para a obtenção de leveduras de S. cerevisae; célula de levedura sequência de nucleotídios; meio de cultura; medicamento ou vacina; e produto dos ditos processos |
| US6747137B1 (en) * | 1998-02-13 | 2004-06-08 | Genome Therapeutics Corporation | Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics |
| RU2286387C2 (ru) | 2000-07-07 | 2006-10-27 | Эйсай Ко., Лтд. | Ген синтеза клеточной стенки грибков |
| US20040038239A1 (en) | 2000-07-07 | 2004-02-26 | Kappei Tsukahara | Fungal cell wall synthesis gene |
| EP1341817A2 (de) * | 2000-12-08 | 2003-09-10 | Novo Nordisk A/S | Tff-peptide |
| JP2005168301A (ja) | 2001-12-28 | 2005-06-30 | Eisai Co Ltd | 真菌細胞壁合成阻害活性を有する化合物をスクリーニングする方法 |
| JP4315907B2 (ja) | 2002-11-22 | 2009-08-19 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | マラリア原虫のｇｐｉの生合成を阻害する化合物をスクリーニングする方法 |
-
2003
- 2003-11-21 WO PCT/JP2003/014909 patent/WO2004048604A1/ja not_active Ceased
- 2003-11-21 CN CNB2003801091169A patent/CN100371456C/zh not_active Expired - Fee Related
- 2003-11-21 DE DE60314538T patent/DE60314538T2/de not_active Expired - Lifetime
- 2003-11-21 JP JP2004555006A patent/JP4061309B2/ja not_active Expired - Lifetime
- 2003-11-21 US US10/536,935 patent/US8323917B2/en not_active Expired - Fee Related
- 2003-11-21 EP EP03774148A patent/EP1564299B1/de not_active Expired - Lifetime
- 2003-11-21 AT AT03774148T patent/ATE365224T1/de not_active IP Right Cessation
- 2003-11-21 AU AU2003284635A patent/AU2003284635A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1742095A (zh) | 2006-03-01 |
| EP1564299A1 (de) | 2005-08-17 |
| AU2003284635A8 (en) | 2004-06-18 |
| US20060240429A1 (en) | 2006-10-26 |
| CN100371456C (zh) | 2008-02-27 |
| EP1564299B1 (de) | 2007-06-20 |
| AU2003284635A1 (en) | 2004-06-18 |
| EP1564299A4 (de) | 2006-07-05 |
| DE60314538T2 (de) | 2008-02-28 |
| WO2004048604A1 (ja) | 2004-06-10 |
| JP4061309B2 (ja) | 2008-03-19 |
| US8323917B2 (en) | 2012-12-04 |
| JPWO2004048604A1 (ja) | 2006-03-23 |
| DE60314538D1 (de) | 2007-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |