ATE365713T1 - N-acyl-n-benzyl-alkylendiaminoderivate - Google Patents

N-acyl-n-benzyl-alkylendiaminoderivate

Info

Publication number: ATE365713T1
Authority: AT; Austria
Prior art keywords: alkyl; branched; straight; hydrogen; acyl
Prior art date: 2003-11-24

Application number

AT04803133T

Other languages

English (en)

Inventor

Florian Thaler

David Cibele Sabido

Laura Faravelli

Stefania Gagliardi

Elena Colombo

Patricia Salvati

Original Assignee

Newron Pharm Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-24

Filing date

2004-11-12

Publication date

2007-07-15

2004-11-12 Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa

2007-07-15 Application granted granted Critical

2007-07-15 Publication of ATE365713T1 publication Critical patent/ATE365713T1/de

Links

229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
108090000312 Calcium Channels Proteins 0.000 abstract 1
102000003922 Calcium Channels Human genes 0.000 abstract 1
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical group O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
108010052164 Sodium Channels Proteins 0.000 abstract 1
102000018674 Sodium Channels Human genes 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
208000012931 Urologic disease Diseases 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000004419 alkynylene group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
150000003951 lactams Chemical class 0.000 abstract 1
230000007246 mechanism Effects 0.000 abstract 1
208000030159 metabolic disease Diseases 0.000 abstract 1
230000002503 metabolic effect Effects 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
230000000926 neurological effect Effects 0.000 abstract 1
230000001575 pathological effect Effects 0.000 abstract 1
230000007170 pathology Effects 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
208000014001 urinary system disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Pulmonology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Immunology (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrrole Compounds (AREA)

AT04803133T 2003-11-24 2004-11-12 N-acyl-n-benzyl-alkylendiaminoderivate ATE365713T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03027044A EP1535908A1 (de)	2003-11-24	2003-11-24	N-Acyl-N'-Beznylalyklendiamin Derivate

Publications (1)

Publication Number	Publication Date
ATE365713T1 true ATE365713T1 (de)	2007-07-15

Family

ID=34442866

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04803133T ATE365713T1 (de)	2003-11-24	2004-11-12	N-acyl-n-benzyl-alkylendiaminoderivate

Country Status (20)

Country	Link
US (1)	US7411091B2 (de)
EP (2)	EP1535908A1 (de)
JP (1)	JP2007514658A (de)
KR (1)	KR20060111523A (de)
CN (1)	CN1886370A (de)
AT (1)	ATE365713T1 (de)
AU (1)	AU2004295042B2 (de)
BR (1)	BRPI0416914A (de)
CA (1)	CA2546961A1 (de)
CY (1)	CY1106847T1 (de)
DE (1)	DE602004007291T2 (de)
DK (1)	DK1689708T3 (de)
ES (1)	ES2289578T3 (de)
IL (1)	IL175848A0 (de)
NO (1)	NO20062350L (de)
PL (1)	PL1689708T3 (de)
PT (1)	PT1689708E (de)
RU (1)	RU2387636C2 (de)
SI (1)	SI1689708T1 (de)
WO (1)	WO2005054189A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RS51411B (sr) *	2004-09-10	2011-02-28	Newron Pharmaceuticals S.P.A.	Upotreba (r)-(halobenziloksi) benzilamino-propanamida kao selektivnih modulatora natrijumovih i/ili kalcijumovih kanala
IN266803B (de) *	2005-12-22	2015-06-03	Newron Pharm Spa
US8168296B2 (en) *	2007-02-07	2012-05-01	Air Products And Chemicals, Inc.	Benzylated polyalkylene polyamines and uses thereof
CN107709314A (zh)	2015-06-11	2018-02-16	巴斯利尔药物国际股份公司	外排泵抑制剂及其治疗性用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9727521D0 (en) *	1997-12-31	1998-02-25	Pharmacia & Upjohn Spa	Substituted 2-benzylamino-2-phenyl-acetamide compounds
GB9727523D0 (en) *	1997-12-31	1998-02-25	Pharmacia & Upjohn Spa	Alpha-aminoamide derivatives useful as analgesic agents

2003
- 2003-11-24 EP EP03027044A patent/EP1535908A1/de not_active Withdrawn
2004
- 2004-11-12 SI SI200430357T patent/SI1689708T1/sl unknown
- 2004-11-12 PT PT04803133T patent/PT1689708E/pt unknown
- 2004-11-12 RU RU2006117786/04A patent/RU2387636C2/ru not_active IP Right Cessation
- 2004-11-12 ES ES04803133T patent/ES2289578T3/es not_active Expired - Lifetime
- 2004-11-12 WO PCT/EP2004/012834 patent/WO2005054189A1/en not_active Ceased
- 2004-11-12 US US10/580,367 patent/US7411091B2/en not_active Expired - Fee Related
- 2004-11-12 KR KR1020067010037A patent/KR20060111523A/ko not_active Ceased
- 2004-11-12 BR BRPI0416914-0A patent/BRPI0416914A/pt not_active IP Right Cessation
- 2004-11-12 AT AT04803133T patent/ATE365713T1/de not_active IP Right Cessation
- 2004-11-12 PL PL04803133T patent/PL1689708T3/pl unknown
- 2004-11-12 JP JP2006540264A patent/JP2007514658A/ja not_active Withdrawn
- 2004-11-12 AU AU2004295042A patent/AU2004295042B2/en not_active Ceased
- 2004-11-12 DE DE602004007291T patent/DE602004007291T2/de not_active Expired - Lifetime
- 2004-11-12 EP EP04803133A patent/EP1689708B1/de not_active Expired - Lifetime
- 2004-11-12 CA CA002546961A patent/CA2546961A1/en not_active Abandoned
- 2004-11-12 DK DK04803133T patent/DK1689708T3/da active
- 2004-11-12 CN CNA2004800346019A patent/CN1886370A/zh active Pending
2006
- 2006-05-23 IL IL175848A patent/IL175848A0/en unknown
- 2006-05-23 NO NO20062350A patent/NO20062350L/no not_active Application Discontinuation
2007
- 2007-09-06 CY CY20071101153T patent/CY1106847T1/el unknown

Also Published As

Publication number	Publication date
IL175848A0 (en)	2006-10-05
PL1689708T3 (pl)	2007-11-30
EP1689708A1 (de)	2006-08-16
NO20062350L (no)	2006-05-23
US20070142455A1 (en)	2007-06-21
EP1689708B1 (de)	2007-06-27
DK1689708T3 (da)	2007-10-29
WO2005054189A1 (en)	2005-06-16
ES2289578T3 (es)	2008-02-01
KR20060111523A (ko)	2006-10-27
EP1535908A1 (de)	2005-06-01
CY1106847T1 (el)	2012-05-23
CN1886370A (zh)	2006-12-27
JP2007514658A (ja)	2007-06-07
US7411091B2 (en)	2008-08-12
AU2004295042A1 (en)	2005-06-16
DE602004007291T2 (de)	2008-03-20
RU2006117786A (ru)	2007-11-27
PT1689708E (pt)	2007-09-26
CA2546961A1 (en)	2005-06-16
AU2004295042B2 (en)	2010-03-11
SI1689708T1 (sl)	2007-10-31
RU2387636C2 (ru)	2010-04-27
BRPI0416914A (pt)	2007-01-16
DE602004007291D1 (de)	2007-08-09

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