ATE366121T1 - Systemische verabreichung von serum-stabilen plasmid-lipid partikeln zur krebstherapie - Google Patents
Systemische verabreichung von serum-stabilen plasmid-lipid partikeln zur krebstherapieInfo
- Publication number
- ATE366121T1 ATE366121T1 AT99903557T AT99903557T ATE366121T1 AT E366121 T1 ATE366121 T1 AT E366121T1 AT 99903557 T AT99903557 T AT 99903557T AT 99903557 T AT99903557 T AT 99903557T AT E366121 T1 ATE366121 T1 AT E366121T1
- Authority
- AT
- Austria
- Prior art keywords
- serum
- cancer therapy
- systemic administration
- lipid particles
- stable plasmid
- Prior art date
Links
- 238000011275 oncology therapy Methods 0.000 title 1
- 239000002245 particle Substances 0.000 title 1
- 238000007910 systemic administration Methods 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000009826 neoplastic cell growth Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7359898P | 1998-02-03 | 1998-02-03 | |
| US8691798P | 1998-05-27 | 1998-05-27 | |
| US10142998P | 1998-09-22 | 1998-09-22 | |
| US11238498P | 1998-12-14 | 1998-12-14 | |
| US24310299A | 1999-02-02 | 1999-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE366121T1 true ATE366121T1 (de) | 2007-07-15 |
Family
ID=27535971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99903557T ATE366121T1 (de) | 1998-02-03 | 1999-02-03 | Systemische verabreichung von serum-stabilen plasmid-lipid partikeln zur krebstherapie |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1053023B2 (de) |
| JP (1) | JP2002502831A (de) |
| AT (1) | ATE366121T1 (de) |
| AU (1) | AU749881B2 (de) |
| CA (2) | CA2319468A1 (de) |
| DE (1) | DE69936444T3 (de) |
| WO (2) | WO1999039741A2 (de) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2138191A1 (de) | 1998-01-05 | 2009-12-30 | University Of Washington | Erhöhter Transport unter Benutzung membranzerstörender Stoffe |
| EP1459761A4 (de) * | 2001-06-08 | 2005-04-13 | Fourth Military Medical Univ | Pharmazeutisches set mit anti-human sperma-plasmaprotein einzelketten-antikörper/human-carboxypeptidase fusionsprotein und prodrug |
| CA2469623C (en) | 2001-12-12 | 2012-05-29 | F H Faulding & Co Limited | Composition for the preservation of viruses |
| AU2003239368A1 (en) | 2002-05-06 | 2003-11-17 | Board Of Regents, The University Of Texas System | Targeting proteins to deliver therapeutic or diagnostic reagents |
| EP4241767B1 (de) | 2008-11-10 | 2024-10-23 | Arbutus Biopharma Corporation | Neuartige lipide und zusammensetzungen zur verabreichung von therapeutika |
| EP4714454A2 (de) | 2016-10-26 | 2026-03-25 | Acuitas Therapeutics Inc. | Lipidnanopartikelformulierungen |
| MA47800A (fr) | 2017-03-17 | 2020-01-22 | Univ Newcastle | Délivrance par vecteur viral adéno-associé d'un fragment de micro-dystrophine pour traiter la dystrophie musculaire |
| WO2018191719A1 (en) | 2017-04-13 | 2018-10-18 | Acuitas Therapeutics, Inc. | Lipid delivery of therapeutic agents to adipose tissue |
| WO2019089828A1 (en) | 2017-10-31 | 2019-05-09 | Acuitas Therapeutics, Inc. | Lamellar lipid nanoparticles |
| BR112020025995A2 (pt) | 2018-06-18 | 2021-03-23 | Research Institute At Nationwide Children's Hospital | administração de microdistrofina músculo-específica por vetor de vírus adeno-associado para tratar a distrofia muscular |
| IL281615B2 (en) | 2018-09-21 | 2026-01-01 | Acuitas Therapeutics Inc | Systems and methods for producing lipid nanoparticles and liposomes |
| ES2918001B2 (es) | 2019-08-14 | 2026-05-13 | Acuitas Therapeutics Inc | Nanoparticulas lipidicas mejoradas para el suministro de acidos nucleicos |
| IL296781A (en) | 2020-03-30 | 2022-11-01 | BioNTech SE | Rna compositions targeting claudin-18.2 |
| BR112022025586A2 (pt) | 2020-06-15 | 2023-03-07 | Res Inst Nationwide Childrens Hospital | Liberação de vetor de vírus adenoassociado para distrofias musculares |
| WO2025056938A1 (en) | 2023-09-11 | 2025-03-20 | BioNTech SE | Rna compositions for delivery of incretin agents |
| WO2022215036A1 (en) | 2021-04-08 | 2022-10-13 | Vaxthera Sas | Coronavirus vaccine comprising a mosaic protein |
| WO2023023055A1 (en) | 2021-08-16 | 2023-02-23 | Renagade Therapeutics Management Inc. | Compositions and methods for optimizing tropism of delivery systems for rna |
| TW202328067A (zh) | 2021-09-14 | 2023-07-16 | 美商雷納嘉德醫療管理公司 | 環狀脂質及其使用方法 |
| EP4402121A1 (de) | 2021-09-14 | 2024-07-24 | Renagade Therapeutics Management Inc. | Acyclische lipide und verfahren zur verwendung davon |
| EP4426832A1 (de) | 2021-11-03 | 2024-09-11 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Genaue genomeditierung mit retrons |
| JP2024542188A (ja) | 2021-11-16 | 2024-11-13 | セイル バイオメディシンズ インコーポレイテッド | 新規イオン化可能な脂質および脂質ナノ粒子ならびにそれらを使用する方法 |
| KR20240128683A (ko) | 2021-11-22 | 2024-08-26 | 세일 바이오메디슨스, 인크. | 신규한 이온화 가능 지질 및 지질 나노입자, 및 이를 사용하는 방법 |
| CA3243054A1 (en) | 2021-12-23 | 2025-04-08 | Renagade Therapeutics Management Inc. | Constrained Lipids and Associated Utilization Processes |
| WO2023141602A2 (en) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| EP4469063A1 (de) | 2022-01-27 | 2024-12-04 | BioNTech SE | Pharmazeutische zusammensetzungen zur abgabe von herpes-simplex-virus-antigenen und zugehörige verfahren |
| EP4499607A1 (de) | 2022-03-25 | 2025-02-05 | Sail Biomedicines, Inc. | Neue ionisierbare lipide und lipidnanopartikel und verfahren zur verwendung davon |
| WO2023196931A1 (en) | 2022-04-07 | 2023-10-12 | Renagade Therapeutics Management Inc. | Cyclic lipids and lipid nanoparticles (lnp) for the delivery of nucleic acids or peptides for use in vaccinating against infectious agents |
| WO2023218431A1 (en) | 2022-05-13 | 2023-11-16 | BioNTech SE | Rna compositions targeting hiv |
| WO2023230295A1 (en) | 2022-05-25 | 2023-11-30 | BioNTech SE | Rna compositions for delivery of monkeypox antigens and related methods |
| CN119562807A (zh) | 2022-05-30 | 2025-03-04 | 生物技术公司 | 用于递送核酸的复合物 |
| EP4581012A2 (de) | 2022-08-31 | 2025-07-09 | Sail Biomedicines, Inc. | Neue ionisierbare lipide und lipidnanopartikel und verfahren zur verwendung davon |
| AU2023347390A1 (en) | 2022-09-23 | 2025-04-10 | BioNTech SE | Compositions for delivery of plasmodium csp antigens and related methods |
| WO2024063789A1 (en) | 2022-09-23 | 2024-03-28 | BioNTech SE | Compositions for delivery of malaria antigens and related methods |
| WO2024063788A1 (en) | 2022-09-23 | 2024-03-28 | BioNTech SE | Compositions for delivery of malaria antigens and related methods |
| CN120225219A (zh) | 2022-09-23 | 2025-06-27 | 生物技术欧洲股份公司 | 用于递送肝期抗原的组合物及相关方法 |
| AU2023357320A1 (en) | 2022-10-06 | 2025-04-17 | BioNTech SE | Rna compositions targeting claudin-18.2 |
| WO2024074211A1 (en) | 2022-10-06 | 2024-04-11 | BioNTech SE | Rna compositions targeting claudin-18.2 |
| EP4642797A1 (de) | 2022-12-28 | 2025-11-05 | BioNTech SE | Gegen hiv gerichtete rna-zusammensetzungen |
| AU2024266138A1 (en) | 2023-05-03 | 2025-11-13 | Manifold Biotechnologies, Inc. | Methods and compositions for high-throughput protein delivery, screening, and detection |
| WO2024228044A1 (en) | 2023-05-03 | 2024-11-07 | BioNTech SE | Optimized csp variants and related methods |
| AU2024265158A1 (en) | 2023-05-03 | 2025-11-06 | BioNTech SE | Optimized csp variants and related methods |
| IL325865A (en) | 2023-07-21 | 2026-03-01 | BioNTech SE | Compositions for administering Plasmodium antigens and related methods |
| WO2025024324A1 (en) | 2023-07-21 | 2025-01-30 | BioNTech SE | Compositions for delivery of plasmodium antigens and related methods |
| WO2025024337A1 (en) | 2023-07-24 | 2025-01-30 | BioNTech SE | Compositions for delivery of plasmodium antigens and related methods |
| WO2025027089A1 (en) | 2023-08-01 | 2025-02-06 | BioNTech SE | Ionizable thiolipids and uses thereof |
| WO2025026545A1 (en) | 2023-08-01 | 2025-02-06 | BioNTech SE | Ionizable thioplipids and uses thereof |
| WO2025030154A1 (en) | 2023-08-03 | 2025-02-06 | The Trustees Of The University Of Pennsylvania | Pharmaceutical compositions for delivery of herpes simplex virus glycoprotein b antigens and related methods |
| CN121866336A (zh) | 2023-08-03 | 2026-04-14 | 百欧恩泰欧洲股份公司 | 靶向hiv的rna组合物 |
| WO2025027579A2 (en) | 2023-08-03 | 2025-02-06 | BioNTech SE | Rna compositions targeting hiv |
| CN121772938A (zh) | 2023-08-03 | 2026-03-31 | 百欧恩泰欧洲股份公司 | 用于递送单纯疱疹病毒抗原的药物组合物及相关方法 |
| WO2025054556A1 (en) | 2023-09-07 | 2025-03-13 | BioNTech SE | Rna compositions for delivery of mpox antigens and related methods |
| AU2024343011A1 (en) | 2023-09-11 | 2026-03-26 | BioNTech SE | Rna compositions for delivery of incretin agents |
| WO2025064850A1 (en) | 2023-09-22 | 2025-03-27 | BioNTech SE | Rna constructs with n-terminal degrons to enhance an immune response |
| AU2024357861A1 (en) | 2023-10-12 | 2026-04-23 | Renagade Therapeutics Management Inc. | Nickase-retron template-based precision editing system and methods of use |
| WO2025106738A1 (en) | 2023-11-15 | 2025-05-22 | BioNTech SE | Sars-cov-2 immunogenic compositions |
| TW202539697A (zh) | 2023-11-15 | 2025-10-16 | 德商拜恩技術股份公司 | 冠狀病毒疫苗 |
| WO2025124711A1 (en) | 2023-12-13 | 2025-06-19 | BioNTech SE | Glycolipid compositions |
| WO2025134066A1 (en) | 2023-12-21 | 2025-06-26 | Biontech Delivery Technologies Gmbh | Ionizable lipids |
| WO2025133105A1 (en) | 2023-12-21 | 2025-06-26 | Biontech Delivery Technologies Gmbh | Compositions and methods |
| TW202525287A (zh) | 2023-12-21 | 2025-07-01 | 德商拜恩技術運輸科技有限責任公司 | 可離子化脂質 |
| WO2025149492A1 (en) | 2024-01-08 | 2025-07-17 | BioNTech SE | Rna encoding an immune inhibitory il-1 family member |
| WO2025155753A2 (en) | 2024-01-17 | 2025-07-24 | Renagade Therapeutics Management Inc. | Improved gene editing system, guides, and methods |
| WO2025184508A1 (en) | 2024-03-01 | 2025-09-04 | Acuitas Therapeutics, Inc. | Materials and methods for encapsulating therapeutics in lipid nanoparticles |
| WO2025202937A1 (en) | 2024-03-26 | 2025-10-02 | BioNTech SE | Cancer vaccines |
| WO2025213131A1 (en) | 2024-04-05 | 2025-10-09 | BioNTech SE | Rna compositions for delivery of orthopox antigens and related methods |
| WO2025262460A1 (en) | 2024-06-21 | 2025-12-26 | BioNTech SE | Lipid compositions for nucleic acid delivery |
| WO2026015882A1 (en) | 2024-07-12 | 2026-01-15 | BioNTech SE | Hsv antigen fragments and related methods |
| WO2026018213A1 (en) | 2024-07-18 | 2026-01-22 | Vaxthera Sas | A broadly protective mosaic vaccine against highly pathogenic avian influenza viruses |
| WO2026020171A2 (en) | 2024-07-19 | 2026-01-22 | Aera Therapeutics, Inc. | Chimeric antigen receptor constructs |
| WO2026047603A1 (en) | 2024-08-28 | 2026-03-05 | BioNTech SE | Sars-cov-2 immunogenic compositions |
| WO2026057626A1 (en) | 2024-09-11 | 2026-03-19 | BioNTech SE | Peptidoglycan hydrolases having multiple enzymatically active domains |
| WO2026057625A1 (en) | 2024-09-11 | 2026-03-19 | BioNTech SE | Peptidoglycan hydrolases having a chap domain with engineered active site |
| WO2026068864A1 (en) | 2024-09-30 | 2026-04-02 | BioNTech SE | Engineered ch1 and cl domains for the prevention of chain mispairing |
| WO2026096919A1 (en) | 2024-11-01 | 2026-05-07 | Sail Biomedicines, Inc. | Novel dipepetide core lipids, lipid carriers, and methods of using thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| EP0452457B1 (de) * | 1989-11-03 | 1997-08-20 | Vanderbilt University | Verfahren zur in vivo-verabreichung von funktionsfähigen fremden genen |
| US5676954A (en) | 1989-11-03 | 1997-10-14 | Vanderbilt University | Method of in vivo delivery of functioning foreign genes |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| WO1993012240A1 (en) | 1991-12-17 | 1993-06-24 | The Regents Of The University Of California | Gene therapy for cystic fibrosis transmembrane conductance regulator activity (cftr) |
| WO1993024640A2 (en) | 1992-06-04 | 1993-12-09 | The Regents Of The University Of California | Methods and compositions for in vivo gene therapy |
| JPH09501936A (ja) * | 1993-08-26 | 1997-02-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 生物活性ペプチドをコードする裸のポリヌクレオチドを投与するための方法、組成物および装置 |
| US5631236A (en) * | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
| ATE355379T1 (de) | 1994-04-26 | 2006-03-15 | Childrens Medical Center | Angiostatin und verfahren zu seiner nutzung zur vermeidung der angiogenese |
| GB9415167D0 (en) | 1994-07-27 | 1994-09-14 | Springer Caroline J | Improvements relating to cancer therapy |
| GB9501052D0 (en) | 1995-01-19 | 1995-03-08 | Cancer Res Campaign Tech | Improvements relating to prodrugs |
| US5705385A (en) | 1995-06-07 | 1998-01-06 | Inex Pharmaceuticals Corporation | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| CA2222328C (en) * | 1995-06-07 | 2012-01-10 | Inex Pharmaceuticals Corporation | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| US7517858B1 (en) * | 1995-06-07 | 2009-04-14 | The Regents Of The University Of California | Prodrugs of pharmaceuticals with improved bioavailability |
| GB9517001D0 (en) | 1995-08-18 | 1995-10-18 | Denny William | Enediyne compounds |
| JP3840262B2 (ja) | 1995-10-23 | 2006-11-01 | ザ チルドレンズ メディカル センター コーポレイション | 治療用の抗血管新生組成物および方法 |
| GB9523703D0 (en) | 1995-11-20 | 1996-01-24 | Wellcome Found | Enzyme prodrug thearapy |
| US6347397B1 (en) | 1999-03-29 | 2002-02-12 | International Business Machines Corporation | System, method, and program for providing an object-oriented install architecture |
| US8266598B2 (en) | 2008-05-05 | 2012-09-11 | Microsoft Corporation | Bounding resource consumption using abstract interpretation |
-
1999
- 1999-02-03 WO PCT/CA1999/000090 patent/WO1999039741A2/en not_active Ceased
- 1999-02-03 JP JP2000530238A patent/JP2002502831A/ja active Pending
- 1999-02-03 WO PCT/CA1999/000089 patent/WO1999039740A2/en not_active Ceased
- 1999-02-03 DE DE69936444T patent/DE69936444T3/de not_active Expired - Lifetime
- 1999-02-03 AT AT99903557T patent/ATE366121T1/de not_active IP Right Cessation
- 1999-02-03 EP EP99903557A patent/EP1053023B2/de not_active Expired - Lifetime
- 1999-02-03 CA CA002319468A patent/CA2319468A1/en not_active Abandoned
- 1999-02-03 AU AU24057/99A patent/AU749881B2/en not_active Expired
- 1999-02-03 CA CA2321837A patent/CA2321837C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999039741A3 (en) | 1999-09-30 |
| EP1053023B1 (de) | 2007-07-04 |
| DE69936444T3 (de) | 2012-05-10 |
| WO1999039740A9 (en) | 1999-11-25 |
| CA2319468A1 (en) | 1999-08-12 |
| CA2321837C (en) | 2011-08-16 |
| AU2405799A (en) | 1999-08-23 |
| WO1999039740A8 (en) | 1999-09-23 |
| CA2321837A1 (en) | 1999-08-12 |
| AU749881B2 (en) | 2002-07-04 |
| DE69936444D1 (de) | 2007-08-16 |
| JP2002502831A (ja) | 2002-01-29 |
| EP1053023B2 (de) | 2011-03-30 |
| DE69936444T2 (de) | 2008-03-20 |
| WO1999039740A3 (en) | 1999-10-28 |
| WO1999039741A2 (en) | 1999-08-12 |
| WO1999039740A2 (en) | 1999-08-12 |
| EP1053023A2 (de) | 2000-11-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69936444D1 (de) | Systemische verabreichung von serum-stabilen plasmid-lipid partikeln zur krebstherapie | |
| ATE196844T1 (de) | Zusammensetzungen die konjugate von cis- docosahexaenoic-säure und taxotere enthalten | |
| DE69708100D1 (de) | Konjugate von cis-docosahexaensäure und paclitaxel | |
| AU2592600A (en) | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia | |
| MX9709915A (es) | Heterociclos de peptidilo y composiciones que los contienen, utiles en el tratamiento de trastornos relacionados con trombina, y uso de los mismos. | |
| TR199902956T2 (xx) | Pozisyonlar 5 ve 6 i�inde de�i�tirilmi� olan GnRH antagonistleri. | |
| NO985574L (no) | FremgangsmÕter og preparater anvendelige for inhibering av angiogenese | |
| BG104599A (en) | Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas | |
| IL134445A0 (en) | A method of preventing or treating estrogen-dependent diseases and disorders | |
| ID21529A (id) | Metode dan komposisi untuk pengobatan dan pencegahan tumor, gangguan yang berhubungan dengan tumor dan kakeksia | |
| CY2431B1 (en) | Novel phenanthridines substituted in the 6 position. | |
| TW362971B (en) | Pharmaceutical composition and kit for treating cancer by conjunctive therapy with 2'-halomethylidene derivatives and a S-phase or M-phase specific anti | |
| IL141686A0 (en) | Methods of treating hypertension and compositions for use therein | |
| ATE239509T1 (de) | Konjugate zur behandlung von prostatakrebs | |
| MXPA04003674A (es) | Uso mejorado de compuesto antitumoral en terapia de cancer. | |
| ATE241993T1 (de) | Zubereitungen zur tumorbehandlung enthaltend hai- knorpelextrakte und antineoplastische mittel | |
| IL146125A0 (en) | Novel quinones as disease therapies | |
| HUP0004326A3 (en) | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms | |
| BG103832A (en) | Leptin as tumour cells proliferation inhibitor | |
| EP0944389A4 (de) | Gereinigte zubereitungen von 10-propargyl-10-deazaaminopterin und verfahren zu ihrer verwendung in der tumorbehandlung | |
| IL141550A0 (en) | Methods and compositions for the prevention or treatment of cancer | |
| DE69633178D1 (de) | Eisenverbindungen, zusammensetzungen, herstellungsverfahren und verwendungen davon | |
| DE69720783D1 (de) | Reaktive sauerstoffverbindungen enthaltende verbindungen zur induzierung von zelldifferentiation maligner zellen so wie leukämie | |
| ATE258797T1 (de) | Verwendung von amifostin | |
| IL136167A0 (en) | Conjugates useful in the treatment of prostate cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |