ATE366814T1 - Gl50 moleküle, sowie verwendungen derselben - Google Patents

Gl50 moleküle, sowie verwendungen derselben

Info

Publication number
ATE366814T1
ATE366814T1 AT00965251T AT00965251T ATE366814T1 AT E366814 T1 ATE366814 T1 AT E366814T1 AT 00965251 T AT00965251 T AT 00965251T AT 00965251 T AT00965251 T AT 00965251T AT E366814 T1 ATE366814 T1 AT E366814T1
Authority
AT
Austria
Prior art keywords
nucleic acid
acid molecules
polypeptides
expression vectors
molecules
Prior art date
Application number
AT00965251T
Other languages
English (en)
Inventor
Vincent Ling
Kyriaki Dunussi-Joannopolulos
Original Assignee
Genetics Inst Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst Llc filed Critical Genetics Inst Llc
Application granted granted Critical
Publication of ATE366814T1 publication Critical patent/ATE366814T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
AT00965251T 1999-09-21 2000-09-21 Gl50 moleküle, sowie verwendungen derselben ATE366814T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15504399P 1999-09-21 1999-09-21

Publications (1)

Publication Number Publication Date
ATE366814T1 true ATE366814T1 (de) 2007-08-15

Family

ID=22553907

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00965251T ATE366814T1 (de) 1999-09-21 2000-09-21 Gl50 moleküle, sowie verwendungen derselben

Country Status (10)

Country Link
US (4) US6521749B1 (de)
EP (1) EP1218504B1 (de)
JP (1) JP4737905B2 (de)
AT (1) ATE366814T1 (de)
AU (1) AU7599500A (de)
DE (1) DE60035517T2 (de)
DK (1) DK1218504T3 (de)
ES (1) ES2290052T3 (de)
PT (1) PT1218504E (de)
WO (1) WO2001021796A2 (de)

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US7112655B1 (en) 1997-02-27 2006-09-26 Japan Tobacco, Inc. JTT-1 protein and methods of inhibiting lymphocyte activation
JP3521382B2 (ja) 1997-02-27 2004-04-19 日本たばこ産業株式会社 細胞間接着及びシグナル伝達を媒介する細胞表面分子
EP2332976B1 (de) * 1999-02-03 2014-04-02 Amgen, Inc An der Immunreaktion beteiligte neuartige Polypeptiden
US7435796B1 (en) 1999-02-03 2008-10-14 Amgen Inc. Antibodies which bind B7RP1
US7708993B2 (en) * 1999-02-03 2010-05-04 Amgen Inc. Polypeptides involved in immune response
US8624010B1 (en) 1999-02-03 2014-01-07 Steven K. Yoshinaga Nucleic acids encoding B7RP1
JP3871503B2 (ja) 1999-08-30 2007-01-24 日本たばこ産業株式会社 免疫性疾患治療剤
JP4210454B2 (ja) 2001-03-27 2009-01-21 日本たばこ産業株式会社 炎症性腸疾患治療剤
JP3597140B2 (ja) 2000-05-18 2004-12-02 日本たばこ産業株式会社 副刺激伝達分子ａｉｌｉｍに対するヒトモノクローナル抗体及びその医薬用途
US20030031675A1 (en) 2000-06-06 2003-02-13 Mikesell Glen E. B7-related nucleic acids and polypeptides useful for immunomodulation
US20030166531A1 (en) * 2001-02-16 2003-09-04 Genetics Institute, Inc. Methods for modulating an immune response by modulating the interaction between CTLA4 and PP2A
JP4212278B2 (ja) 2001-03-01 2009-01-21 日本たばこ産業株式会社 移植片拒絶反応抑制剤
US7235631B2 (en) * 2002-02-07 2007-06-26 Mayo Foundation For Medical Education And Research ICOS mutants
US20040102398A1 (en) * 2002-11-23 2004-05-27 Isis Pharmaceuticals Inc. Modulation of B7H expression
AT500650B1 (de) 2003-04-17 2009-11-15 Altropus Gmbh Immunogener rekombinanter antikörper
DK1915398T3 (en) * 2005-07-18 2016-07-04 Amgen Inc Humane anti-B7RP1 neutraliserende antistoffer
US9127086B2 (en) * 2008-06-30 2015-09-08 Inserm (Institut National De La Sante Et De La Recherche Medicale) CD31 peptides in the treatment of thrombotic and autoimmune disorders
EP2464661B1 (de) * 2009-08-13 2018-01-17 The Johns Hopkins University Verfahren zur modulierung der immunfunktion mittles anti-b7-h7cr antikörper
WO2011041613A2 (en) * 2009-09-30 2011-04-07 Memorial Sloan-Kettering Cancer Center Combination immunotherapy for the treatment of cancer
CA2791975C (en) * 2010-02-04 2021-02-09 The Trustees Of The University Of Pennsylvania Icos critically regulates the expansion and function of inflammatory human th17 cells
CN102675470B (zh) * 2012-04-01 2015-06-17 江苏省弗泰生物科技有限公司 SCF-Fc融合蛋白
PH12022550138A1 (en) 2013-03-13 2023-03-06 Amgen Inc Proteins specific for baff and b7rp1 and uses thereof
US9458246B2 (en) 2013-03-13 2016-10-04 Amgen Inc. Proteins specific for BAFF and B7RP1
CN104232667A (zh) * 2014-09-16 2014-12-24 宁夏医科大学 FcRn介导的抗细粒棘球蚴靶向黏膜疫苗载体的构建方法
MA53297A (fr) 2015-03-23 2022-05-04 Jounce Therapeutics Inc Anticorps anti-icos
SMT202100467T1 (it) 2015-04-17 2021-09-14 Alpine Immune Sciences Inc Proteine immunomodulatorie con affinità regolabili
US10968277B2 (en) 2015-10-22 2021-04-06 Jounce Therapeutics, Inc. Gene signatures for determining ICOS expression
JP6580791B2 (ja) * 2016-02-26 2019-09-25 エスシーエム ライフサイエンス カンパニー リミテッド 調節ｔ細胞媒介性疾患の予防または治療用薬学的組成物
SG11201808457PA (en) 2016-04-15 2018-10-30 Alpine Immune Sciences Inc Icos ligand variant immunomodulatory proteins and uses thereof
AU2017248830B2 (en) 2016-04-15 2023-03-09 Alpine Immune Sciences, Inc. CD80 variant immunomodulatory proteins and uses thereof
EP3491013A1 (de) 2016-07-28 2019-06-05 Alpine Immune Sciences, Inc. Cd155-variante immunmodulatorische proteine und verwendungen davon
EP3694870A1 (de) 2017-10-10 2020-08-19 Alpine Immune Sciences, Inc. Ctla-4-variante immunmodulatorische proteine und verwendungen davon
JP7282760B2 (ja) 2017-10-18 2023-05-29 アルパイン イミューン サイエンシズ インコーポレイテッド バリアントｉｃｏｓリガンド免疫調節タンパク質ならびに関連する組成物および方法
SG11202006148UA (en) 2018-01-03 2020-07-29 Alpine Immune Sciences Inc Multi-domain immunomodulatory proteins and methods of use thereof
CN112424219A (zh) * 2018-03-12 2021-02-26 得克萨斯州大学系统董事会 免疫外排体及其使用方法
CA3095134A1 (en) 2018-03-28 2019-10-03 Board Of Regents, The University Of Texas System Identification of epigenetic alterations in dna isolated from exosomes
EP3860653A1 (de) 2018-10-05 2021-08-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren und systeme zur steuerung der agonistischen eigenschaften von variablen antikörperdomänen durch licht
UA129038C2 (uk) 2019-10-28 2024-12-25 Медіммуне Лімітед Сухий порошкоподібний склад антитіла, що зв'язує тимічний стромальний лімфопоетин (tslp)
US12202882B2 (en) 2020-05-08 2025-01-21 Alpine Immune Sciences, Inc. APRIL and BAFF inhibitory immunomodulatory proteins and methods of use thereof
EP4507779A1 (de) 2022-04-14 2025-02-19 Institut National de la Santé et de la Recherche Médicale Verfahren zur kontrolle der tumorzellabtötung durch licht

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837306A (en) * 1985-02-25 1989-06-06 The Ontario Cancer Institute Method for selecting hybridomas producing antibodies specific to the P-glycoprotein cell suface antigen and a cDNA clone encoding the C-terminal portion of the antigen
US6641809B1 (en) * 1990-03-26 2003-11-04 Bristol-Myers Squibb Company Method of regulating cellular processes mediated by B7 and CD28
US6130316A (en) * 1993-07-26 2000-10-10 Dana Farber Cancer Institute Fusion proteins of novel CTLA4/CD28 ligands and uses therefore
JP3521382B2 (ja) 1997-02-27 2004-04-19 日本たばこ産業株式会社 細胞間接着及びシグナル伝達を媒介する細胞表面分子
JP4463418B2 (ja) * 1997-09-23 2010-05-19 ドイツ連邦共和国 Ｔ細胞共同刺激性ポリペプチド、モノクローナル抗体、ならびにその製法および使用
EP2332976B1 (de) * 1999-02-03 2014-04-02 Amgen, Inc An der Immunreaktion beteiligte neuartige Polypeptiden

Also Published As

Publication number Publication date
DE60035517D1 (de) 2007-08-23
DK1218504T3 (da) 2007-11-12
ES2290052T3 (es) 2008-02-16
WO2001021796A3 (en) 2001-08-09
US20100055091A1 (en) 2010-03-04
EP1218504A2 (de) 2002-07-03
US20060099635A1 (en) 2006-05-11
WO2001021796A9 (en) 2002-12-05
JP4737905B2 (ja) 2011-08-03
WO2001021796A2 (en) 2001-03-29
US20040054158A1 (en) 2004-03-18
US6521749B1 (en) 2003-02-18
AU7599500A (en) 2001-04-24
DE60035517T2 (de) 2008-03-20
US7521532B2 (en) 2009-04-21
EP1218504B1 (de) 2007-07-11
US7601813B2 (en) 2009-10-13
PT1218504E (pt) 2007-10-22
US7976840B2 (en) 2011-07-12
JP2003510047A (ja) 2003-03-18

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