ATE367374T1 - Sulphonsäurederivate von hydroxamsäuren und deren verwendung in medizinischen produkten - Google Patents

Sulphonsäurederivate von hydroxamsäuren und deren verwendung in medizinischen produkten

Info

Publication number
ATE367374T1
ATE367374T1 AT01951935T AT01951935T ATE367374T1 AT E367374 T1 ATE367374 T1 AT E367374T1 AT 01951935 T AT01951935 T AT 01951935T AT 01951935 T AT01951935 T AT 01951935T AT E367374 T1 ATE367374 T1 AT E367374T1
Authority
AT
Austria
Prior art keywords
acid derivatives
sulphonic acid
medical products
hydroxamic acids
relates
Prior art date
Application number
AT01951935T
Other languages
English (en)
Inventor
Kazuhiro Maeda
Shuji Sonda
Tadahiro Takemoto
Tomokazu Goto
Fujio Kobayashi
Masahiko Kajii
Naruyasu Komorita
Fumihiro Hirayama
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Application granted granted Critical
Publication of ATE367374T1 publication Critical patent/ATE367374T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
    • C07C309/09—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton
    • C07C309/11—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton with the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
    • C07C309/15—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton the nitrogen atom of at least one of the amino groups being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/51—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01951935T 2000-07-19 2001-07-19 Sulphonsäurederivate von hydroxamsäuren und deren verwendung in medizinischen produkten ATE367374T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000219245 2000-07-19
JP2000219034 2000-07-19

Publications (1)

Publication Number Publication Date
ATE367374T1 true ATE367374T1 (de) 2007-08-15

Family

ID=26596313

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01951935T ATE367374T1 (de) 2000-07-19 2001-07-19 Sulphonsäurederivate von hydroxamsäuren und deren verwendung in medizinischen produkten

Country Status (9)

Country Link
US (1) US6989401B2 (de)
EP (1) EP1306367B1 (de)
KR (1) KR100799192B1 (de)
CN (1) CN1215052C (de)
AT (1) ATE367374T1 (de)
AU (1) AU2001272761A1 (de)
CA (1) CA2415954A1 (de)
DE (1) DE60129442T2 (de)
WO (1) WO2002006214A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005016455A2 (en) 2003-08-14 2005-02-24 D. Collen Research Foundation Vzw Antibodies against factor viii with modified glycosylation in the variable region
US7829085B2 (en) 1999-07-14 2010-11-09 Life Sciences Research Partners Vzw Methods of treating hemostasis disorders using antibodies binding the C1 domain of factor VIII
WO2004085396A1 (ja) * 2003-03-26 2004-10-07 Mitsubishi Pharma Corporation 虚血再灌流障害の予防または治療剤、臓器保存剤およびスクリーニング方法
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
JPWO2005037265A1 (ja) * 2003-10-17 2006-12-28 三菱ウェルファーマ株式会社 併用薬剤
US7253291B2 (en) * 2003-11-17 2007-08-07 Wyeth Processes for the preparation of N-substituted phthalimides
CN1917899B (zh) 2004-02-04 2013-04-17 塞浦西斯阿瓦药物集团 碱性磷酸酶对存在于粘膜屏障的脂多糖解毒的用途
US8044100B2 (en) 2004-12-22 2011-10-25 Bellus Health Inc. Methods and compositions for treating amyloid-related diseases
CA2830727C (en) * 2006-10-12 2016-11-29 Bhi Limited Partnership Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
CN104854082A (zh) 2012-07-20 2015-08-19 中央研究院 3,5,n-三羟基烷酰胺及其衍生物、及其制造方法与用途
PE20161442A1 (es) 2014-01-24 2017-01-12 Am-Pharma B V Proteinas quimericas tipo fosfatasa alcalina
PT3461891T (pt) 2014-01-24 2020-07-30 Am Pharma Bv Processamento a jusante de uma fosfatase alcalina
RU2022101392A (ru) * 2017-02-28 2022-03-02 Иммуноджен, Инк. Производные майтанзиноида с саморасщепляющимися пептидными линкерами и их конъюгаты
JP7714224B2 (ja) * 2022-01-21 2025-07-29 ステラファーマ株式会社 ボロノフェニルアラニンアミド誘導体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
CA2058797A1 (en) * 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
GB9102635D0 (en) 1991-02-07 1991-03-27 British Bio Technology Compounds
US5318964A (en) 1992-06-11 1994-06-07 Hoffmann-La Roche Inc. Hydroxamic derivatives and pharmaceutical compositions
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
JPH08508027A (ja) 1993-03-16 1996-08-27 ブリテッシュ バイオテック ファーマシューティカルズ リミテッド 金属タンパク加水分解酵素阻害剤である天然アミノ酸誘導体
JPH07157470A (ja) 1993-03-18 1995-06-20 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
EP0832875B1 (de) * 1995-04-25 2004-06-30 Daiichi Fine Chemical Co., Ltd. In wasser hochlöslicher metalloproteinase-inhibitor
ATE261428T1 (de) * 1998-05-22 2004-03-15 Mitsubishi Pharma Corp Hydroxamsäurederivate und ihre medizinische anwendung
US6797505B2 (en) * 1998-05-27 2004-09-28 Cell Genesys, Inc. Recombinant AAV vectors for gene therapy of hemophilia A

Also Published As

Publication number Publication date
DE60129442T2 (de) 2008-04-17
WO2002006214A1 (en) 2002-01-24
KR20030029628A (ko) 2003-04-14
EP1306367B1 (de) 2007-07-18
US20030176486A1 (en) 2003-09-18
CN1215052C (zh) 2005-08-17
CN1443158A (zh) 2003-09-17
EP1306367A4 (de) 2004-06-09
CA2415954A1 (en) 2003-01-17
KR100799192B1 (ko) 2008-01-31
DE60129442D1 (de) 2007-08-30
US6989401B2 (en) 2006-01-24
EP1306367A1 (de) 2003-05-02
AU2001272761A1 (en) 2002-01-30

Similar Documents

Publication Publication Date Title
NO2022019I1 (no) Eribulin eller et farmasøytisk akseptabelt salt derav - forlenget SPC
ATE367374T1 (de) Sulphonsäurederivate von hydroxamsäuren und deren verwendung in medizinischen produkten
ATE260255T1 (de) 5-oxo-pyrrolidine-2-carbonsäure- hydroxamidderivate
CY1108522T1 (el) Μεθοδος συνθεσης της περινδοπριλης και των φαρμακευτικως αποδεκτων αλατων της
EA200300065A1 (ru) Окисленные сложные эфиры 4-йодфениламинобензгидроксамовых кислот
EA200200940A1 (ru) Производные азетидина, способ их получения и содержащие их фармацевтические композиции
IS6859A (is) Kristölluð form atorvastatíns
ATE297203T1 (de) Antithrombotische mitteln
PT896533E (pt) Pentafluorobenzenosulfonamidas e analogos
EA200200938A1 (ru) Фармацевтические композиции, содержащие производные азетидина, новые производные азетидина и их получение
TR200002542T2 (tr) Meta-azasiklik amino benzoik asit bileşikleri ve bunların integrin antagonistleri olan türevleri
NO963370D0 (no) Nye mercaptoacetylamido-1,3,4,5-tetrahydro-benzo[cÅazepin-3-on-disulfidderivater som er anvendbare som inhibitorer av enkefalinase og ACE
EA200000826A1 (ru) Галоидированные производные амидиноаминокислот, применимые в качестве ингибиторов no-синтазы
NO20052907L (no) Sykloalkylendikarboksylsyreforbindelser som antiinflammatoriske, immunmodulatoriske og antiproliferative midler
EE04564B1 (et) Bifenlamidiini derivaadid, eelravim, vere koagulatsiooniinhibiitor ning proflaktiline ja terapeutiline toimeaine tromboosi v?i emboolia vastu
EA200000094A1 (ru) Способ получения замещенного пергидроизоиндола
EA200000204A1 (ru) Производные пирролопирролона в качестве ингибиторов эластазы нейтрофилов
NO954609D0 (no) Niopecotiske syrederivater som antitrombiske forbindelser
EA200400806A1 (ru) Способ получения эхинокандиновых соединений
EP1434762A4 (de) 4'-methansulfonylbiphenylderivate als hochselektive cyclooxygenase-2-inhibitoren
DK1180094T3 (da) Kondenserede polycykliske aminosyrer som farmaceutiske midler
DE69904519D1 (de) Sulfonamid-Derivate
DE60111634D1 (de) Verfahren zur herstellung von thiazolidinedion-derivaten und zwischenprodukte
CY1106472T1 (el) Η χρηση των παραγωγων υδροξυπυριδονης στην επουλωση πληγων
DE60202575D1 (de) 3,4-Dihydro-1H-Naphthalin-Derivate als hoch selektive Cyclooxygenase-2-Inhibitoren

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties