ATE367390T1 - Phenylalanin enamidderivate - Google Patents

Phenylalanin enamidderivate

Info

Publication number: ATE367390T1
Authority: AT; Austria
Prior art keywords: compounds; diseases; enamide derivatives; phenylalanine enamide; phenylalanine
Prior art date: 2002-07-17

Application number

AT03740814T

Other languages

English (en)

Inventor

Julien Alistair Brown

Stuart Bailey

Stephen Brand

Original Assignee

Celltech R&D Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-17

Filing date

2003-07-16

Publication date

2007-08-15

2003-07-16 Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd

2007-08-15 Application granted granted Critical

2007-08-15 Publication of ATE367390T1 publication Critical patent/ATE367390T1/de

Links

COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 title abstract 2
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
201000010099 disease Diseases 0.000 abstract 2
208000035475 disorder Diseases 0.000 abstract 2
125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 abstract 1
206010015866 Extravasation Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
229940124639 Selective inhibitor Drugs 0.000 abstract 1
230000021164 cell adhesion Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000036251 extravasation Effects 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
102000006495 integrins Human genes 0.000 abstract 1
108010044426 integrins Proteins 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
210000000265 leukocyte Anatomy 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Diabetes (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT03740814T 2002-07-17 2003-07-16 Phenylalanin enamidderivate ATE367390T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0216571.0A GB0216571D0 (en)	2002-07-17	2002-07-17	Chemical compounds

Publications (1)

Publication Number	Publication Date
ATE367390T1 true ATE367390T1 (de)	2007-08-15

Family

ID=9940613

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03740814T ATE367390T1 (de)	2002-07-17	2003-07-16	Phenylalanin enamidderivate

Country Status (10)

Country	Link
US (1)	US6835738B1 (de)
EP (1)	EP1525204B1 (de)
JP (1)	JP4451777B2 (de)
AT (1)	ATE367390T1 (de)
AU (1)	AU2003280965B2 (de)
CA (1)	CA2492430A1 (de)
DE (1)	DE60315032T2 (de)
ES (1)	ES2290477T3 (de)
GB (1)	GB0216571D0 (de)
WO (1)	WO2004007494A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6962818B2 (en)	2000-10-19	2005-11-08	Target Discovery	Mass defect labeling for the determination of oligomer sequences
CA2434666A1 (en) *	2001-02-22	2002-09-06	Celltech R&D Limited	Phenylalanine enamide derivatives possessing a cyclobutene group, for use as integrin inhibitors
WO2007082131A1 (en) *	2006-01-09	2007-07-19	Bristol-Myers Squibb Company	Process for the preparation of hydroxy substituted heterocycles
GB0605766D0 (en) *	2006-03-22	2006-05-03	Ucb Sa	Process
WO2008103378A2 (en)	2007-02-20	2008-08-28	Merrimack Pharmaceuticals, Inc.	Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
MX2010011145A (es)	2008-04-11	2011-04-11	Merrimack Pharmaceuticals Inc	Enlazadores de la albumina de suero humana y conjugados de la misma.
WO2010059315A1 (en)	2008-11-18	2010-05-27	Merrimack Pharmaceuticals, Inc.	Human serum albumin linkers and conjugates thereof
MX2014004025A (es)	2011-10-17	2014-08-01	Univ Muenster Wilhelms	Metodos de valoracion de riesgo de lmp y aparatos relacionados.
WO2014036520A1 (en)	2012-08-30	2014-03-06	Merrimack Pharmaceuticals, Inc.	Combination therapies comprising anti-erbb3 agents
FI3873884T3 (fi)	2018-10-30	2025-02-24	Gilead Sciences Inc	3-(kinolin-8-yyli)-1,4-dihydropyrido[3,4-d]pyrimidiini-2,4-dionijohdannaisia alfa-4-beta-7-integriinin estäjinä tulehdussairauksien hoidossa
JP7189368B2 (ja)	2018-10-30	2022-12-13	ギリアードサイエンシーズ，インコーポレイテッド	アルファ４ベータ７インテグリンの阻害のための化合物
ES3013256T3 (en)	2018-10-30	2025-04-11	Gilead Sciences Inc	Imidazo[1,2-a]pyridine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases
EP3873605B1 (de)	2018-10-30	2024-10-23	Gilead Sciences, Inc.	Verbindungen zur inhibierung von alpha4-beta7-integrin
WO2021030438A1 (en)	2019-08-14	2021-02-18	Gilead Sciences, Inc.	Compounds for inhibition of alpha 4 beta 7 integrin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60130910T2 (de) *	2000-04-17	2008-07-10	Ucb Pharma, S.A.	Enamin-derivate als zell-adhäsionsmoleküle
CA2434666A1 (en)	2001-02-22	2002-09-06	Celltech R&D Limited	Phenylalanine enamide derivatives possessing a cyclobutene group, for use as integrin inhibitors

2002
- 2002-07-17 GB GBGB0216571.0A patent/GB0216571D0/en not_active Ceased
2003
- 2003-07-16 JP JP2004520903A patent/JP4451777B2/ja not_active Expired - Fee Related
- 2003-07-16 DE DE60315032T patent/DE60315032T2/de not_active Expired - Fee Related
- 2003-07-16 WO PCT/GB2003/003104 patent/WO2004007494A1/en not_active Ceased
- 2003-07-16 EP EP03740814A patent/EP1525204B1/de not_active Expired - Lifetime
- 2003-07-16 US US10/620,531 patent/US6835738B1/en not_active Expired - Fee Related
- 2003-07-16 AU AU2003280965A patent/AU2003280965B2/en not_active Ceased
- 2003-07-16 AT AT03740814T patent/ATE367390T1/de not_active IP Right Cessation
- 2003-07-16 CA CA002492430A patent/CA2492430A1/en not_active Abandoned
- 2003-07-16 ES ES03740814T patent/ES2290477T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2492430A1 (en)	2004-01-22
DE60315032D1 (de)	2007-08-30
JP2005536505A (ja)	2005-12-02
ES2290477T3 (es)	2008-02-16
AU2003280965A1 (en)	2004-02-02
GB0216571D0 (en)	2002-08-28
AU2003280965B2 (en)	2008-10-09
DE60315032T2 (de)	2008-04-10
US6835738B1 (en)	2004-12-28
WO2004007494A1 (en)	2004-01-22
JP4451777B2 (ja)	2010-04-14
EP1525204B1 (de)	2007-07-18
EP1525204A1 (de)	2005-04-27

Legal Events

Date	Code	Title	Description
2008-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
NO20055421L (no)	2005-12-20	Kinolinderivater som fosfodiestrase-inhibitorer
ATE367390T1 (de)	2007-08-15	Phenylalanin enamidderivate
ATE365742T1 (de)	2007-07-15	4-aminothieno(2,3-d) pyrimidin -6-carbonitril- derivative zur verwendung als pde7 inhibitoren
NO20051962L (no)	2005-05-19	Fenetanolaminderivater for behandling av respiratoriske sykdommer
PT1373263E (pt)	2005-03-31	Compostos heterociclicos para complicacoes relacionadas com a idade e complicacoes vasculares diabeticas
IL165264A (en)	2011-07-31	Protein kinase inhibitors, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for treating protein kinase-associated diseases
DE60315492D1 (de)	2007-09-20	Medizinisch verwendbare arylethanolamin verbindungen
JO2371B1 (en)	2006-12-12	4-phenyl-pyridine derivatives
SE0202462D0 (sv)	2002-08-14	Novel use
BR9709959A (pt)	2000-05-09	Derivados tricìclicos de fenilamino substituìdo para o tratamento de doenças hiperproliferativas
NO20050851L (no)	2005-03-29	Kaspase-inhibitorer og anvendelser derav
GB0112348D0 (en)	2001-07-11	Compounds
DE60305514D1 (de)	2006-06-29	Neue verwendung von benzothiazolderivaten
BR0309343A (pt)	2005-02-15	Composto, composição farmacêutica, uso de um composto, e, método de tratamento ou profilaxia de doenças ou condições humanas
TR200101120T2 (tr)	2001-08-21	Serin proteaz inhibitörü
BR0309342A (pt)	2005-02-15	Composto, composição farmacêutica, uso de um composto, e, método de tratamento ou profilaxia de doenças ou condições humanas
IL156827A (en)	2013-12-31	Derivatives of 2-mercapto- [3,1] thiazolo [4,5 [b- pyridine and pharmaceutical preparations containing them for the treatment of cardiovascular disease
IS8175A (is)	2005-12-12	Píperasín afleiður og aðferðir við notkun þeirra
ATE372995T1 (de)	2007-09-15	Benzo(b)(1,4)dioxepinderivate
BR0316458A (pt)	2005-10-11	Composto, composição farmacêutica, método de tratamento ou prevenção de doenças, método para intensificar a cognição em um paciente saudável, e, uso de um composto
DK1458393T3 (da)	2008-10-13	Substituerede diketopiperaziner som oxytocinantagonister
HUP0402577A2 (hu)	2005-03-29	Citoszol foszfolipáz A2 inhibitor hatású indolszármazékok, eljárás előállításukra
NO20052182L (no)	2005-05-03	Nye forbindelser
NO975028L (no)	1997-12-30	Piperazinoderivater som neurokininantagonister
AR040579A1 (es)	2005-04-13	Derivados de fenilalanina enamida