ATE367816T1 - Verwendung von niedrigen dosen estrogen in kombination mit immunotherapeutischen verbindungen zur behandlung von immunkrankheiten - Google Patents
Verwendung von niedrigen dosen estrogen in kombination mit immunotherapeutischen verbindungen zur behandlung von immunkrankheitenInfo
- Publication number
- ATE367816T1 ATE367816T1 AT01933418T AT01933418T ATE367816T1 AT E367816 T1 ATE367816 T1 AT E367816T1 AT 01933418 T AT01933418 T AT 01933418T AT 01933418 T AT01933418 T AT 01933418T AT E367816 T1 ATE367816 T1 AT E367816T1
- Authority
- AT
- Austria
- Prior art keywords
- estrogen
- combination
- low doses
- immune diseases
- treat immune
- Prior art date
Links
- 229940011871 estrogen Drugs 0.000 title abstract 3
- 239000000262 estrogen Substances 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title 1
- 208000026278 immune system disease Diseases 0.000 title 1
- 230000001024 immunotherapeutic effect Effects 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 3
- 239000002955 immunomodulating agent Substances 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20398000P | 2000-05-12 | 2000-05-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE367816T1 true ATE367816T1 (de) | 2007-08-15 |
Family
ID=22756094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01933418T ATE367816T1 (de) | 2000-05-12 | 2001-05-11 | Verwendung von niedrigen dosen estrogen in kombination mit immunotherapeutischen verbindungen zur behandlung von immunkrankheiten |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US7371385B2 (de) |
| EP (1) | EP1286664B1 (de) |
| AT (1) | ATE367816T1 (de) |
| AU (2) | AU2001259847B9 (de) |
| CA (1) | CA2408935A1 (de) |
| DE (1) | DE60129550T2 (de) |
| WO (1) | WO2001085154A2 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130203722A1 (en) | 2006-09-26 | 2013-08-08 | Rhonda R. Voskuhl | Estriol therapy for autoimmune and neurodegenerative disease and disorders |
| WO2008150547A1 (en) | 2007-06-04 | 2008-12-11 | The Regents Of The University Of California | Pregnancy hormone combination for treatment of autoimmune diseases |
| US20050209208A1 (en) * | 2001-04-25 | 2005-09-22 | The Regents Of The University Of California | Use of estriol and other estranes, estrogens and estrogen receptor active compositions in the treatment of psoriasis and other autoimmune disorders |
| US6936599B2 (en) * | 2001-04-25 | 2005-08-30 | The Regents Of The University Of California | Estriol therapy for multiple sclerosis and other autoimmune diseases |
| DE60217324T2 (de) | 2001-05-18 | 2007-04-26 | Pantarhei Bioscience B.V. | Pharmazeutische zusammensetzung für die hormonersatztherapie |
| US7732430B2 (en) | 2001-05-23 | 2010-06-08 | Pantarhei Bioscience B.V. | Drug delivery system comprising a tetrahydroxilated estrogen for use in hormonal contraception |
| EP1390041B1 (de) | 2001-05-23 | 2009-11-25 | Pantarhei Bioscience B.V. | Tetrahydroxylierte estrogen enthaltendes arzneistoffverabreichungssystem zur verwendung in hormonalen kontrazeption |
| ATE347365T1 (de) | 2001-11-15 | 2006-12-15 | Pantarhei Bioscience Bv | Verwendung von öestrogen in kombination mit progestogen für die hormonsubstitutions-therapie |
| EP1358881A1 (de) | 2002-04-30 | 2003-11-05 | Schering Aktiengesellschaft | Verwendung von biogenen Estrioldiester-Prodrugs zur Behandlung von Autoimmunkrankheiten |
| EP1358882A1 (de) * | 2002-04-30 | 2003-11-05 | Schering Aktiengesellschaft | Verwendung von Prodrogue von Estriol sulfamate zur Behandlung von autoimmunischen Erkrankungen |
| AU2003274946A1 (en) | 2002-06-11 | 2003-12-22 | Pantarhei Bioscience B.V. | Method of treating or preventing immune mediated disorders and pharmaceutical formulation for use therein |
| CA2489270C (en) | 2002-06-11 | 2012-08-07 | Pantarhei Bioscience B.V. | A method of treating human skin and a skin care composition for use in such a method |
| US9034854B2 (en) | 2002-07-12 | 2015-05-19 | Pantarhei Bioscience B.V. | Pharmaceutical composition comprising estetrol derivatives for use in cancer therapy |
| US8987240B2 (en) | 2002-10-23 | 2015-03-24 | Pantarhei Bioscience B.V. | Pharmaceutical compositions comprising estetrol derivatives for use in cancer therapy |
| US20040167112A1 (en) * | 2003-01-06 | 2004-08-26 | Wyeth | Use of estrogen receptor alpha modulators for the treatment of multiple sclerosis |
| JP2008500368A (ja) * | 2004-05-27 | 2008-01-10 | ミジェニックス コーポレイション | 細胞保護のための2置換17−イミノエストロゲン化合物 |
| WO2010048415A1 (en) * | 2008-10-22 | 2010-04-29 | Cedars-Sinai Medical Center | Methods of using jak3 genetic variants to diagnose and predict crohn's disease |
| AU2005314089B2 (en) * | 2004-12-08 | 2011-03-03 | Cedars-Sinai Medical Center | Methods for diagnosis and treatment of Crohn's disease |
| WO2007127981A2 (en) * | 2006-04-28 | 2007-11-08 | University Of Rochester | Analyte-releasing beads and use thereof in quantitative elispot or fluorispot assay |
| CN101583363B (zh) | 2007-01-08 | 2013-08-21 | 潘塔希生物科学股份有限公司 | 治疗或预防雌性哺乳动物不育症的方法和此类方法中使用的药物试剂盒 |
| US20100021917A1 (en) * | 2007-02-14 | 2010-01-28 | Cedars-Sinai Medical Center | Methods of using genes and genetic variants to predict or diagnose inflammatory bowel disease |
| US20100190162A1 (en) * | 2007-02-26 | 2010-07-29 | Cedars-Sinai Medical Center | Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease |
| WO2008137762A2 (en) * | 2007-05-04 | 2008-11-13 | Cedars-Sinai Medical Center | Methods of diagnosis and treatment of crohn's disease |
| WO2010039931A2 (en) * | 2008-10-01 | 2010-04-08 | Cedars-Sinai Medical Center | Methods of using il17rd and il23-il17 pathway genes to diagnose crohn's disease |
| US20100015156A1 (en) * | 2007-03-06 | 2010-01-21 | Cedars-Sinai Medical Center | Diagnosis of inflammatory bowel disease in children |
| US8486640B2 (en) | 2007-03-21 | 2013-07-16 | Cedars-Sinai Medical Center | Ileal pouch-anal anastomosis (IPAA) factors in the treatment of inflammatory bowel disease |
| WO2008134569A2 (en) * | 2007-04-26 | 2008-11-06 | Cedars-Sinai Medical Center | Diagnosis and treatment of inflammatory bowel disease in the puerto rican population |
| US20110262365A1 (en) * | 2008-11-13 | 2011-10-27 | Alek Itsekson | Methods of diagnosing hypersensitivity to a female reproductive hormone and treating medical conditions associated with same |
| WO2010062960A2 (en) | 2008-11-26 | 2010-06-03 | Cedars-Sinai Medical Center | METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE |
| WO2010075579A2 (en) | 2008-12-24 | 2010-07-01 | Cedars-Sinai Medical Center | Methods of predicting medically refractive ulcerative colitis (mr-uc) requiring colectomy |
| EP2408812B1 (de) * | 2009-03-17 | 2015-12-16 | CardioVax, LLC | Immunmodulatorische Verfahren und Systeme zur Behandlung und/oder Prävention von Atherosklerose sowie zugehörige Proteine, Peptide und Zusammensetzungen |
| WO2014085679A1 (en) * | 2012-11-27 | 2014-06-05 | Deepath Medical Inc. | Methods and combinations of signaling markers for assessment of disease states |
| US10845363B2 (en) * | 2012-11-27 | 2020-11-24 | DeePath Medical Diagnostics, Inc. | Cell-specific signaling biomarker analysis by high parameter cytometry; sample processing, assay set-up, method, analysis |
| KR20230109779A (ko) | 2013-03-27 | 2023-07-20 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전 |
| EP4105236A1 (de) | 2013-07-19 | 2022-12-21 | Cedars-Sinai Medical Center | Anti-tl1a (tnfsf15) antikörper zur behandlung von entzündlichen darmerkrankungen |
| KR20180127416A (ko) | 2016-03-17 | 2018-11-28 | 세다르스-신나이 메디칼 센터 | Rnaset2를 통한 염증성 장 질환의 진단 방법 |
| CN116615456A (zh) * | 2020-09-11 | 2023-08-18 | 詹森生物科技公司 | 用于调节β链介导的免疫的方法和组合物 |
| EP4472742A1 (de) * | 2022-02-03 | 2024-12-11 | University College Cardiff Consultants Limited | Neuer t-zell-rezeptor |
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| US183299A (en) * | 1876-10-17 | Improvement in devices for securing fence-wire to posts | ||
| US614192A (en) * | 1898-11-15 | Automatic locking device for chairs | ||
| US4701450A (en) * | 1984-03-21 | 1987-10-20 | Akzo N.V. | Steroids for use as immunomodulators |
| US5849298A (en) | 1987-06-24 | 1998-12-15 | Autoimmune Inc. | Treatment of multiple sclerosis by oral administration of bovine myelin |
| US6039947A (en) | 1987-06-24 | 2000-03-21 | Autoimmune, Inc. | Peptides derived from immunodominant epitopes of myelin basic protein |
| US5194425A (en) | 1988-06-23 | 1993-03-16 | Anergen, Inc. | Mhc-mediated toxic conjugates useful in ameliorating autoimmunity |
| US5223426A (en) | 1988-12-15 | 1993-06-29 | T Cell Sciences, Inc. | Monoclonal antibodies reactive with defined regions of the t-cell antigen receptor |
| US6464978B1 (en) | 1989-03-21 | 2002-10-15 | The Immune Response Corporation | Vaccination and methods against multiple sclerosis resulting from pathogenic responses by specific T cell populations |
| US6113903A (en) | 1989-03-21 | 2000-09-05 | The Immune Response Corporation | Peptides and methods against diabetes |
| US5612035A (en) | 1989-03-21 | 1997-03-18 | The Immune Response Corporation | Vaccination against diseases resulting from pathogenic responses by specific T cell populations |
| US5837246A (en) | 1989-03-21 | 1998-11-17 | The Immune Response Corporation | Vaccination and methods against diseases resulting from pathogenic responses by specific T cell populations |
| US6207645B1 (en) | 1989-03-21 | 2001-03-27 | The Immune Response Corporation | Vaccination and methods against diseases resulting from pathogenic responses by specific T cell populations |
| US6221352B1 (en) | 1989-03-21 | 2001-04-24 | The Immune Response Corporation | Method of preventing the proliferation of Vβ14 or Vβ17-Expressing T cells |
| US5776459A (en) | 1989-07-19 | 1998-07-07 | Connetics Corporation | TCR V beta 5 peptides |
| US5614192A (en) | 1989-07-19 | 1997-03-25 | Connective Therapeutics, Inc. | T cell receptor peptides as therapeutics for immune-related disease |
| IL99699A (en) | 1990-10-10 | 2002-04-21 | Autoimmune Inc | Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes |
| EP0553291B1 (de) | 1990-10-15 | 2006-03-08 | Autoimmune, Inc. | Behandlung von autoimmunkrankheiten durch orale verabreichung von autoantigenen |
| US6045796A (en) | 1992-12-17 | 2000-04-04 | Anergen, Inc. | Vaccination with peptide of MHC class II molecules for treatment of autoimmune disease |
| EP0688223A4 (de) | 1993-03-12 | 1998-05-13 | Cellcor Inc | -i(IN VITRO) 'ASSAY' ZUM MESSEN DES GRADES DER AKTIVIERUNG VON IMMUNZELLEN |
| US5856446A (en) | 1995-07-07 | 1999-01-05 | Autoimmune Inc. | Method of treating rheumatoid arthritis with low dose type II collagen |
| US5939400A (en) | 1996-02-26 | 1999-08-17 | The Board Of Trustees Of The Leland Stanford Junior University | DNA vaccination for induction of suppressive T cell response |
| US5750356A (en) | 1996-05-31 | 1998-05-12 | Anergen, Inc. | Method for monitoring T cell reactivity |
| US5939281A (en) | 1996-09-16 | 1999-08-17 | Case Western Reserve University | Detecting alloreactivity |
| JPH10175854A (ja) * | 1996-10-18 | 1998-06-30 | Dokutaazu Kosumeteikusu:Kk | 津液改善用皮膚外用剤 |
| IL137904A0 (en) | 1998-02-23 | 2001-10-31 | Neurocrine Biosciences Inc | Peptide analogues of insulin and pharmaceutical compositions containing the same |
| JP4601166B2 (ja) | 1998-05-11 | 2010-12-22 | ミルテニィ バイオテック ゲーエムベーハー | 抗原特異的t細胞の直接的選択方法 |
| DE19821289A1 (de) | 1998-05-13 | 1999-11-18 | Volkmar Schoellhorn | Verfahren zur Bestimmung der Aktivität von menschlichen und tierischen Zellen, insbesondere Blutzellen, und Mikrotiterplatten |
| US6958327B1 (en) | 1999-11-02 | 2005-10-25 | Schering, Ag | 18 Norsteroids as selectively active estrogens |
| EP1226155B1 (de) * | 1999-11-02 | 2007-05-02 | Bayer Schering Pharma AG | 18-nor-steroide als selektiv wirksame estrogene |
| US6936599B2 (en) | 2001-04-25 | 2005-08-30 | The Regents Of The University Of California | Estriol therapy for multiple sclerosis and other autoimmune diseases |
-
2001
- 2001-05-11 US US10/275,833 patent/US7371385B2/en not_active Expired - Fee Related
- 2001-05-11 AU AU2001259847A patent/AU2001259847B9/en not_active Ceased
- 2001-05-11 EP EP01933418A patent/EP1286664B1/de not_active Expired - Lifetime
- 2001-05-11 DE DE60129550T patent/DE60129550T2/de not_active Expired - Lifetime
- 2001-05-11 WO PCT/US2001/040710 patent/WO2001085154A2/en not_active Ceased
- 2001-05-11 AU AU5984701A patent/AU5984701A/xx active Pending
- 2001-05-11 CA CA002408935A patent/CA2408935A1/en not_active Abandoned
- 2001-05-11 AT AT01933418T patent/ATE367816T1/de not_active IP Right Cessation
-
2008
- 2008-04-03 US US12/062,476 patent/US7579006B2/en not_active Expired - Fee Related
- 2008-04-15 US US12/103,633 patent/US7731973B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001085154A3 (en) | 2002-08-29 |
| AU2001259847B2 (en) | 2006-02-02 |
| WO2001085154A8 (en) | 2003-10-30 |
| US20030176409A1 (en) | 2003-09-18 |
| US7371385B2 (en) | 2008-05-13 |
| US7579006B2 (en) | 2009-08-25 |
| AU2001259847B8 (en) | 2006-02-23 |
| WO2001085154A2 (en) | 2001-11-15 |
| US20080207580A1 (en) | 2008-08-28 |
| DE60129550D1 (de) | 2007-09-06 |
| AU5984701A (en) | 2001-11-20 |
| US7731973B2 (en) | 2010-06-08 |
| CA2408935A1 (en) | 2001-11-15 |
| AU2001259847B9 (en) | 2006-08-10 |
| EP1286664A2 (de) | 2003-03-05 |
| EP1286664B1 (de) | 2007-07-25 |
| DE60129550T2 (de) | 2008-04-10 |
| US20080227761A1 (en) | 2008-09-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |