ATE367819T1 - Isolierte stromazellen und methoden zu deren verwendung - Google Patents

Isolierte stromazellen und methoden zu deren verwendung

Info

Publication number: ATE367819T1
Authority: AT; Austria
Prior art keywords: methods; isolated power; power cells; bone; cartilage
Prior art date: 1995-03-28

Application number

AT03075116T

Other languages

English (en)

Inventor

Darwin Prockop

Ruth Pereira

Dennis Leeper

Michael O'hara

Joseph Kulkosky

Donald Phinney

Alexander Laptev

Jose Caro

Original Assignee

Univ Jefferson

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-28

Filing date

1996-03-28

Publication date

2007-08-15

1995-03-28 Priority claimed from US08/412,066 external-priority patent/US5716616A/en

1996-03-28 Application filed by Univ Jefferson filed Critical Univ Jefferson

2007-08-15 Application granted granted Critical

2007-08-15 Publication of ATE367819T1 publication Critical patent/ATE367819T1/de

Links

208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
210000000988 bone and bone Anatomy 0.000 abstract 1
210000001185 bone marrow Anatomy 0.000 abstract 1
210000000845 cartilage Anatomy 0.000 abstract 1
230000007547 defect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
238000001990 intravenous administration Methods 0.000 abstract 1
210000004072 lung Anatomy 0.000 abstract 1
210000002536 stromal cell Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
- A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/135—Platelet-derived growth factor [PDGF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1311—Osteocytes, osteoblasts, odontoblasts
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
- C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Developmental Biology & Embryology (AREA)
Biotechnology (AREA)
Immunology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Cell Biology (AREA)
Wood Science & Technology (AREA)
Child & Adolescent Psychology (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Virology (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Microbiology (AREA)
Pulmonology (AREA)

AT03075116T 1995-03-28 1996-03-28 Isolierte stromazellen und methoden zu deren verwendung ATE367819T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/412,066 US5716616A (en)	1995-03-28	1995-03-28	Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects
US662795P	1995-11-13	1995-11-13

Publications (1)

Publication Number	Publication Date
ATE367819T1 true ATE367819T1 (de)	2007-08-15

Family

ID=26675866

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT96912514T ATE241369T1 (de)	1995-03-28	1996-03-28	Isolierte stromazellen und methoden zu deren verwendung
AT03075115T ATE329603T1 (de)	1995-03-28	1996-03-28	Implantat mit immunisolierten stromazellen und deren verwendung
AT03075116T ATE367819T1 (de)	1995-03-28	1996-03-28	Isolierte stromazellen und methoden zu deren verwendung

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
AT96912514T ATE241369T1 (de)	1995-03-28	1996-03-28	Isolierte stromazellen und methoden zu deren verwendung
AT03075115T ATE329603T1 (de)	1995-03-28	1996-03-28	Implantat mit immunisolierten stromazellen und deren verwendung

Country Status (8)

Country	Link
EP (3)	EP0871457B1 (de)
JP (1)	JPH11509171A (de)
AT (3)	ATE241369T1 (de)
CA (1)	CA2215143A1 (de)
DE (3)	DE69628452T2 (de)
DK (1)	DK0871457T3 (de)
ES (3)	ES2266715T3 (de)
WO (1)	WO1996030031A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5902741A (en) *	1986-04-18	1999-05-11	Advanced Tissue Sciences, Inc.	Three-dimensional cartilage cultures
US6653134B2 (en) *	1995-03-28	2003-11-25	Cp Hahnemann University	Isolated stromal cells for use in the treatment of diseases of the central nervous system
JP2001509163A (ja) *	1997-01-24	2001-07-10	オシリスセラピューティクス，インコーポレイテッド	ヒト骨髄間葉細胞を用いる骨粗鬆症での骨再生
US7514074B2 (en)	1997-07-14	2009-04-07	Osiris Therapeutics, Inc.	Cardiac muscle regeneration using mesenchymal stem cells
AU766064B2 (en) *	1998-10-26	2003-10-09	Philadelphia Health & Education Corporation	Stromal cell use
RU2226104C2 (ru) *	1998-12-16	2004-03-27	Центр эмбриональных тканей "ЭМСЕЛЛ"	Способ лечения людей эмбриональными клеточными суспензиями
AU2969899A (en) *	1998-12-16	2000-07-03	Tsentr Embrionalnykh Tkanei "Emcell"	Method for treating patients using cellular suspensions of embryonic tissues
US6713293B1 (en) *	1999-02-08	2004-03-30	Friedrich Grummt	Encapsulated cells containing an amplified expression vector as a drug delivery device
ES2292564T3 (es)	2000-02-11	2008-03-16	Philadelphia Health And Education Corporation	Diferenciacion de celulas de la medula osea en celulas neuronales y usos asociados.
US20030003090A1 (en)	2001-05-31	2003-01-02	Prockop Darwin J.	Directed in vitro differentiation of marrow stromal cells into neural cell progenitors
US7485460B2 (en)	2003-05-21	2009-02-03	Tulane University Health Sciences Center	Enhanced growth of adult stem cells with Dkk-1
EP2298864B1 (de)	2004-03-22	2017-10-11	Mesoblast International Sàrl	Mesenchymale stammzellen und deren verwendungen
NZ612888A (en)	2007-02-12	2015-02-27	Anthrogenesis Corp	Treatment of inflammatory diseases using placental stem cells
WO2011047040A2 (en) *	2009-10-13	2011-04-21	University Of Louisville Research Foundation, Inc.	Methods and compositions to support transplanted tissue integration and innosculation with adipose stromal cells
US20120087933A1 (en)	2010-10-08	2012-04-12	Samson Tom	Enhanced msc preparations
WO2012156968A2 (en)	2011-05-19	2012-11-22	Ariel - University Research And Development Company, Ltd.	Use of mesenchymal stem cells for the improvement of affective and cognitive function
CN119033819A (zh)	2017-11-22	2024-11-29	迈索布拉斯特国际有限公司	细胞组合物及治疗方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4904259A (en) *	1988-04-29	1990-02-27	Samuel Itay	Compositions and methods for repair of cartilage and bone
DE69012601T2 (de) *	1989-02-02	1995-01-19	Joel S Greenberger	Gentherapie durch stützgewebebezügliche Zellen.
US5334640A (en) *	1992-04-08	1994-08-02	Clover Consolidated, Ltd.	Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
US5631236A (en) *	1993-08-26	1997-05-20	Baylor College Of Medicine	Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk

1996
- 1996-03-28 DK DK96912514T patent/DK0871457T3/da active
- 1996-03-28 WO PCT/US1996/004407 patent/WO1996030031A1/en not_active Ceased
- 1996-03-28 DE DE69628452T patent/DE69628452T2/de not_active Expired - Lifetime
- 1996-03-28 EP EP96912514A patent/EP0871457B1/de not_active Expired - Lifetime
- 1996-03-28 ES ES03075115T patent/ES2266715T3/es not_active Expired - Lifetime
- 1996-03-28 EP EP03075115A patent/EP1304112B1/de not_active Expired - Lifetime
- 1996-03-28 DE DE69636260T patent/DE69636260T2/de not_active Expired - Lifetime
- 1996-03-28 EP EP03075116A patent/EP1304113B1/de not_active Expired - Lifetime
- 1996-03-28 AT AT96912514T patent/ATE241369T1/de not_active IP Right Cessation
- 1996-03-28 DE DE69637185T patent/DE69637185T2/de not_active Expired - Lifetime
- 1996-03-28 AT AT03075115T patent/ATE329603T1/de not_active IP Right Cessation
- 1996-03-28 CA CA002215143A patent/CA2215143A1/en not_active Abandoned
- 1996-03-28 ES ES96912514T patent/ES2200061T3/es not_active Expired - Lifetime
- 1996-03-28 AT AT03075116T patent/ATE367819T1/de not_active IP Right Cessation
- 1996-03-28 ES ES03075116T patent/ES2291588T3/es not_active Expired - Lifetime
- 1996-03-28 JP JP8529717A patent/JPH11509171A/ja active Pending

Also Published As

Publication number	Publication date
DE69628452T2 (de)	2004-03-11
JPH11509171A (ja)	1999-08-17
EP0871457B1 (de)	2003-05-28
CA2215143A1 (en)	1996-10-03
DE69628452D1 (de)	2003-07-03
ATE241369T1 (de)	2003-06-15
DE69636260T2 (de)	2007-07-05
WO1996030031A1 (en)	1996-10-03
ES2200061T3 (es)	2004-03-01
ES2266715T3 (es)	2007-03-01
HK1055390A1 (en)	2004-01-09
HK1055255A1 (en)	2004-01-02
EP0871457A4 (de)	2000-08-23
ATE329603T1 (de)	2006-07-15
EP1304112A1 (de)	2003-04-23
EP0871457A1 (de)	1998-10-21
DK0871457T3 (da)	2003-07-28
EP1304113A1 (de)	2003-04-23
DE69637185D1 (de)	2007-09-06
EP1304113B1 (de)	2007-07-25
ES2291588T3 (es)	2008-03-01
DE69637185T2 (de)	2008-04-10
DE69636260D1 (de)	2006-07-27
EP1304112B1 (de)	2006-06-14

Legal Events

Date	Code	Title	Description
2008-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE367819T1 (de)	2007-08-15	Isolierte stromazellen und methoden zu deren verwendung
DE69321218D1 (de)	1998-10-29	Klonierung und expression von humanisierten monoklonalen antikörpern gegen menschliches interleukin-4
DE69926639D1 (de)	2005-09-15	Knochenmarkszellen als quelle von neuronen zur wiederherstellung von gehirn und knochenmark
ATE238800T1 (de)	2003-05-15	Verwendung von squalamin zur herstellung eines arzneimittels zur inhibierung von nhe
DE69933037D1 (de)	2006-10-12	Systeme zur platzierung von materialien in knochen
DE69510810D1 (de)	1999-08-19	Lamanin-ketten: diagnostische und therapeutische verwendung
ATE149999T1 (de)	1997-03-15	Monofluorierte derivate von n-propargyl-1- aminoindan und deren verwendung als monoamino- oxidaseinhibitoren
ATE512233T1 (de)	2011-06-15	Screeningverfahren für die aktivität von agenzien unter verwendung von teleosten
DE69607476D1 (de)	2000-05-04	System zur blutanalyse, mit mitteln zur aufbewahrung und zum transport des blutes, sowie zur selbsttätigen herstellung von blutauftragsproben
MY108526A (en)	1996-10-31	Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
NO20011283D0 (no)	2001-03-14	Anvendelse av integrin-antagonister ved behandling av multippelt myelom og myelom-indusert benresorpsjon
DE68914412D1 (de)	1994-05-11	Methode, System und Apparat zur Züchtung von Zellen.
SE8205244L (sv)	1984-03-15	Medel for avlegsnande av mikroorganismer fran vevnader
DE69940248D1 (de)	2009-02-26	Gassensor, Methode zu dessen Herstellung und System unter Verwendung dieses Gassensors
ATE414417T1 (de)	2008-12-15	Translations-kontrollelemente für proteinexpression mit hoher ausbeute in den plastiden von höheren pflanzen und verfahren zu deren verwendung
EP1135531A4 (de)	2005-03-09	Methoden zur introduktion heterologer zellen in fische
DK0914043T3 (da)	2004-02-09	Implanterbare agarose-kollagen-korn, som indeholder celler, der dannet et diffunderbart produkt, og anvendelser heraf
DE69504959D1 (de)	1998-10-29	Humanisierte monoklonale antikörper gegen humanes interleukin - 4
FI921721A7 (fi)	1992-10-17	Menetelmä biologisten aineiden erityisesti nopeutettua, aerobista mikrobiologista hajottamista varten
DE3785175D1 (de)	1993-05-06	A-assoziierte h-antigene, spezifische monoklonale antikoerper und methoden zu deren verwendung zur blutgruppenbestimmung.
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