ATE368030T1 - Substituierte chinoline zur behandlung von durch protozoen und retroviren verursachten co- infektionen - Google Patents
Substituierte chinoline zur behandlung von durch protozoen und retroviren verursachten co- infektionenInfo
- Publication number
- ATE368030T1 ATE368030T1 AT02700323T AT02700323T ATE368030T1 AT E368030 T1 ATE368030 T1 AT E368030T1 AT 02700323 T AT02700323 T AT 02700323T AT 02700323 T AT02700323 T AT 02700323T AT E368030 T1 ATE368030 T1 AT E368030T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- alkenyl
- alkynyl
- protozoa
- retroviruses
- Prior art date
Links
- 208000003322 Coinfection Diseases 0.000 title abstract 2
- 229940111121 antirheumatic drug quinolines Drugs 0.000 title abstract 2
- 150000003248 quinolines Chemical class 0.000 title abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 5
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
- 125000004665 trialkylsilyl group Chemical group 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0100580A FR2819507B1 (fr) | 2001-01-17 | 2001-01-17 | Quinoleines substituees pour le traitement de co-infections a protozoaires et a retrovirus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE368030T1 true ATE368030T1 (de) | 2007-08-15 |
Family
ID=8858905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02700323T ATE368030T1 (de) | 2001-01-17 | 2002-01-15 | Substituierte chinoline zur behandlung von durch protozoen und retroviren verursachten co- infektionen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7342026B2 (de) |
| EP (1) | EP1351940B1 (de) |
| AT (1) | ATE368030T1 (de) |
| BR (1) | BR0206552A (de) |
| CA (1) | CA2434063C (de) |
| DE (1) | DE60221348T2 (de) |
| ES (1) | ES2291438T3 (de) |
| FR (1) | FR2819507B1 (de) |
| WO (1) | WO2002057238A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0603871B8 (pt) * | 2006-08-24 | 2021-05-25 | Univ Brasilia Fundacao | composições farmacêuticas para o tratamento de tripanossomíases e de doença de chagas |
| ATE541841T1 (de) * | 2007-11-15 | 2012-02-15 | Boehringer Ingelheim Int | Inhibitoren der replikation des human immunodeficiency virus |
| ES2402322T3 (es) * | 2007-11-15 | 2013-04-30 | Gilead Sciences, Inc. | Inhibidores de la replicación del virus de la inmunodeficiencia humana |
| EA019259B1 (ru) * | 2007-11-16 | 2014-02-28 | Джилид Сайенсиз, Инк. | Ингибиторы репликации вируса иммунодефицита человека |
| ES2463720T3 (es) * | 2007-11-16 | 2014-05-29 | Gilead Sciences, Inc. | Inhibidores de la replicación del virus de inmunodeficiencia humana |
| FR2929943B1 (fr) * | 2008-04-15 | 2010-09-24 | Inst Rech Developpement Ird | Sels de quinoleines 2-substituees |
| FR2931479B1 (fr) * | 2008-05-20 | 2012-12-07 | I R D | Nouveaux derives de quinoleines 2-substituees et un procede pour leur preparation |
| FR2933977B1 (fr) * | 2008-07-18 | 2013-04-26 | Centre Nat Rech Scient | Derives heterocycliques utiles dans le traitement des maladies neurodegeneratives |
| WO2010144101A1 (en) * | 2009-06-09 | 2010-12-16 | The United States Of America, As Represented By The Secretary Of The Army, On Behalf Of U.S. | Next generation quinoloine methanols |
| EP2588455B1 (de) * | 2010-07-02 | 2018-04-04 | Gilead Sciences, Inc. | 2-quinolinyl-essigsäure derivate als hiv antivirale verbindungen |
| MX2012015097A (es) | 2010-07-02 | 2013-05-28 | Gilead Sciences Inc | Derivados de acido naft-2-ilacetico para tratar sida. |
| UA111841C2 (uk) | 2011-04-21 | 2016-06-24 | Гіліад Сайєнсіз, Інк. | Сполуки бензотіазолу та їх фармацевтичне застосування |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
| UY34750A (es) | 2012-04-20 | 2013-11-29 | Gilead Sciences Inc | ?compuestos para el tratamiento del hiv, composiciones,métodos de preparación, intermediarios y métodos terapéuticos?. |
| CN102690042A (zh) * | 2012-05-28 | 2012-09-26 | 常熟市建华模具有限责任公司 | 一种用于制作玻璃容器用的模具 |
| US9302992B2 (en) | 2013-04-02 | 2016-04-05 | Annji Pharmaceutical Co., Ltd. | Multifunctional quinoline derivatives as anti-neurodegenerative agents |
| RU2642466C2 (ru) * | 2013-04-02 | 2018-01-25 | Аннцзи Фармасьютикал Ко., Лтд. | Многофункциональные производные хинолина в качестве антинейродегенеративных агентов |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH471810A (de) * | 1964-10-22 | 1969-04-30 | Ciba Geigy | Verfahren zur Herstellung von neuen heterocyclischen Verbindungen |
| IE861607L (en) * | 1985-06-18 | 1986-12-18 | Bunce Roger A | 2-substituted quinolines |
| IL83715A0 (en) * | 1987-08-31 | 1988-01-31 | Yeda Res & Dev | Pharmaceutical anti-protozoal compositions |
| US5278173A (en) * | 1988-06-30 | 1994-01-11 | Davis Michael H | Method of inhibiting the activity of human immunodeficiency virus (HIV) in vivo |
| US5153202A (en) * | 1988-06-30 | 1992-10-06 | Davis Michael H | Method of inhibiting the activity of human immuno deficiency virus (HIV) in vivo |
| US5360811A (en) * | 1990-03-13 | 1994-11-01 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents |
| FR2682107B1 (fr) * | 1991-10-03 | 1995-04-21 | Orstom Inst Fs Rech Scient | Quinoleines 2-substituees pour le traitement des leishmanioses. |
| GB9614347D0 (en) | 1996-07-09 | 1996-09-04 | Smithkline Beecham Spa | Novel compounds |
| FR2761687B1 (fr) * | 1997-04-08 | 2000-09-15 | Centre Nat Rech Scient | Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques |
| EP1155698A4 (de) * | 1999-01-29 | 2003-01-15 | Nitto Kasei Co Ltd | Organoborverbindungen mit antikokzidischer aktivität |
| US6309663B1 (en) * | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
| AU7511800A (en) * | 1999-08-30 | 2001-03-26 | K.U. Leuven Research And Development | Novel target for antiparasitic agents and inhibitors thereof |
-
2001
- 2001-01-17 FR FR0100580A patent/FR2819507B1/fr not_active Expired - Fee Related
-
2002
- 2002-01-15 CA CA2434063A patent/CA2434063C/fr not_active Expired - Fee Related
- 2002-01-15 DE DE60221348T patent/DE60221348T2/de not_active Expired - Lifetime
- 2002-01-15 US US10/466,566 patent/US7342026B2/en not_active Expired - Fee Related
- 2002-01-15 BR BR0206552-5A patent/BR0206552A/pt not_active IP Right Cessation
- 2002-01-15 AT AT02700323T patent/ATE368030T1/de active
- 2002-01-15 EP EP02700323A patent/EP1351940B1/de not_active Expired - Lifetime
- 2002-01-15 ES ES02700323T patent/ES2291438T3/es not_active Expired - Lifetime
- 2002-01-15 WO PCT/FR2002/000140 patent/WO2002057238A1/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| FR2819507B1 (fr) | 2007-09-28 |
| CA2434063C (fr) | 2011-08-02 |
| ES2291438T3 (es) | 2008-03-01 |
| BR0206552A (pt) | 2004-03-23 |
| DE60221348D1 (de) | 2007-09-06 |
| US20050165052A1 (en) | 2005-07-28 |
| FR2819507A1 (fr) | 2002-07-19 |
| WO2002057238A1 (fr) | 2002-07-25 |
| US7342026B2 (en) | 2008-03-11 |
| EP1351940A1 (de) | 2003-10-15 |
| DE60221348T2 (de) | 2008-04-10 |
| EP1351940B1 (de) | 2007-07-25 |
| CA2434063A1 (fr) | 2002-07-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE368030T1 (de) | Substituierte chinoline zur behandlung von durch protozoen und retroviren verursachten co- infektionen | |
| ATE366724T1 (de) | Kondensierte heterocyclische derivate | |
| RU2342367C2 (ru) | Ненуклеозидные ингибиторы i обратной транскриптазы, предназначенные для лечения заболеваний, опосредованных вич | |
| BR9810829A (pt) | Composto, processo para preparar o mesmo, composição, uso de um composto ou um sal farmaceuticamente aceitável do mesmo ou uma composição, e, processo de tratamento de uma condição | |
| DE69823344D1 (de) | Substituierte benzimidazol-derivaten und ihre verwendung zur behandlung retroviraler infektionen | |
| CA2445190A1 (en) | Indole, azaindole and related heterocyclic amidopiperazine derivatives | |
| PE20011348A1 (es) | Agentes antivirales de imidazopiridina e imidazopimiridina | |
| ATE381542T1 (de) | Nr1h4-kern-rezeptor-bindende verbindungen | |
| DE60220422D1 (de) | Substituierte pyrazoloverbindungen zur behandlung von entzündungen | |
| DK0769010T3 (da) | 2-[1',2',4'-triazol-3'-yloxymethylen]-anilider og deres anvendelse som pesticider | |
| DK0794949T3 (da) | Hidtil ukendte 3,5-dioxo-(2H,4H)-1,2,4-triazinderivater, fremstilling heraf og deres anvendelse som lægemidler | |
| DK1295890T3 (da) | Hidtil ukendte pyrazinderivater eller salte deraf, farmaceutiske præparater, der indeholder derivaterne eller saltene, og mellemprodukter til fremstilling af begge | |
| DE60137948D1 (de) | Triazinone sowie deren medizinale anwendung | |
| NO20004485L (no) | Sykloalkenderivater, deres fremstilling og anvendelse | |
| DK405786D0 (da) | Nitromethylenderivater, deres fremstilling og anvendelse | |
| NO20050088L (no) | Kationisk substituerte difenylazefidinoner, fremgangsmate for deres fremstilling, medikamenter inneholdende nevnte forbindelser og anvendelse derav | |
| UA85502C2 (en) | Diazaindole-dicarbonyl-piperazinyl antiviral agents | |
| NO20001046L (no) | 6,7-asymmetriske disubstituerte kinoksalinkarboksylsyrederivater, addisjonssalter derav og fremgangsmõter ved fremstilling av begge | |
| DK1511472T3 (da) | Anvendelige forbindelser til behandling af Anthrax og hæmning af letalfaktor | |
| ID24231A (id) | Derivat-derivat 5-disubstitusi-1,2,4-tiadiazolil yang menghambat angiogenesis | |
| ATE346040T1 (de) | Aryl-sulfonamide als serotonin-antagonisten für de behandlung von fettleibigkeit | |
| CA2531766A1 (en) | Entry inhibitors of the hiv virus | |
| DE69428206D1 (de) | Chinolincarbonsäurederivate und ihre salze | |
| NO20030500D0 (no) | Dihydroporfyrinderivater og deres anvendelse | |
| BR0317259A (pt) | Complexos de e-2-metóxi-n-(3-{4-[3-metil-4-(6-metilpiridin-3-ilóxi)-fenil amino]- quinazolin-6-il}-alil)-acetamida, seus métodos de produção e utilização |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1351940 Country of ref document: EP |