ATE368051T1 - Angiostatinfragmente und verfahren für deren verwendung - Google Patents

Angiostatinfragmente und verfahren für deren verwendung

Info

Publication number: ATE368051T1
Authority: AT; Austria
Prior art keywords: angiostatin; fragments; methods; proliferation inhibitor; aggregate
Prior art date: 1995-04-26

Application number

AT96913208T

Other languages

English (en)

Inventor

M Folkman

Michael O'reilly

Yihai Cao

Jie Lin

Original Assignee

Childrens Medical Center

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-26

Filing date

1996-04-26

Publication date

2007-08-15

1995-04-26 Priority claimed from US08/429,743 external-priority patent/US5885795A/en

1996-02-22 Priority claimed from US08/605,598 external-priority patent/US5861372A/en

1996-03-08 Priority claimed from US08/612,788 external-priority patent/US5837682A/en

1996-04-26 Application filed by Childrens Medical Center filed Critical Childrens Medical Center

2007-08-15 Application granted granted Critical

2007-08-15 Publication of ATE368051T1 publication Critical patent/ATE368051T1/de

Links

102000012936 Angiostatins Human genes 0.000 title abstract 6
108010079709 Angiostatins Proteins 0.000 title abstract 6
FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 title abstract 6
239000012634 fragment Substances 0.000 title abstract 5
239000003112 inhibitor Substances 0.000 abstract 3
230000004663 cell proliferation Effects 0.000 abstract 2
210000002889 endothelial cell Anatomy 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
102000013566 Plasminogen Human genes 0.000 abstract 1
108010051456 Plasminogen Proteins 0.000 abstract 1
230000033115 angiogenesis Effects 0.000 abstract 1
230000002491 angiogenic effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000003511 endothelial effect Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Diabetes (AREA)
Oncology (AREA)
Obesity (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Communicable Diseases (AREA)
Microbiology (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Endocrinology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT96913208T 1995-04-26 1996-04-26 Angiostatinfragmente und verfahren für deren verwendung ATE368051T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/429,743 US5885795A (en)	1994-04-26	1995-04-26	Methods of expressing angiostatic protein
US08/605,598 US5861372A (en)	1996-02-22	1996-02-22	Aggregate angiostatin and method of use
US08/612,788 US5837682A (en)	1996-03-08	1996-03-08	Angiostatin fragments and method of use

Publications (1)

Publication Number	Publication Date
ATE368051T1 true ATE368051T1 (de)	2007-08-15

Family

ID=27411639

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96913208T ATE368051T1 (de)	1995-04-26	1996-04-26	Angiostatinfragmente und verfahren für deren verwendung

Country Status (16)

Country	Link
EP (1)	EP0824546B1 (de)
JP (2)	JP3787157B2 (de)
CN (1)	CN1195375A (de)
AT (1)	ATE368051T1 (de)
AU (1)	AU709633B2 (de)
BR (1)	BR9608326A (de)
CA (1)	CA2219081C (de)
CZ (1)	CZ334097A3 (de)
DE (1)	DE69637179T2 (de)
ES (1)	ES2292174T3 (de)
HU (1)	HUP9800784A3 (de)
MX (1)	MX9708217A (de)
NO (1)	NO974943L (de)
NZ (1)	NZ307044A (de)
PL (1)	PL323256A1 (de)
WO (1)	WO1996035774A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5945403A (en) *	1997-05-30	1999-08-31	The Children's Medical Center Corporation	Angiostatin fragments and method of use
US6440729B1 (en)	1995-06-30	2002-08-27	University Of Kansas Medical Center	Treating angiogenesis-mediated diseases with the α2 monomer of type IV collagen
US6358735B1 (en)	1995-06-30	2002-03-19	University Of Kansas Medical Center	Method for inhibiting angiogenesis and tumors with the isolated NC1 α3 chain monomer of type IV collagen
DK0869970T3 (da) *	1995-12-13	2004-07-05	Abbott Lab	Endothelcelleprolifereringsinhibitor og dens anvendelse
US5801012A (en)	1996-09-17	1998-09-01	Northwestern University	Methods and compositions for generating angiostatin
WO1999016889A1 (en) *	1997-10-01	1999-04-08	G.D. Searle & Co.	Fusion proteins comprising an angiostatin moiety and their use in anti-tumor treatment
AU1598599A (en) *	1997-11-20	1999-06-15	Genetix Pharmaceuticals, Inc.	Anti-angiogenic gene therapy vectors and their use in treating angiogenesis-related diseases
IL136665A0 (en) *	1997-12-08	2001-06-14	Beth Israel Hospital	Mutants of endostatin, "em 1" having anti-angiogenic activity and methods of use thereof
US6797488B1 (en)	1997-12-08	2004-09-28	Beth Israel Deaconess Medical Center	Methods of producing anti-angiogenic proteins
CA2263784A1 (en)	1998-03-23	1999-09-23	Megabios Corporation	Dual-tagged proteins and their uses
ATE408415T1 (de) *	1998-04-28	2008-10-15	Toshikazu Nakamura	Inhibitoren für die gefässneubildung
WO1999061464A1 (en) *	1998-05-28	1999-12-02	Korea Green Cross Corporation	Process of purifying angiogenesis inhibitors
JP2002518341A (ja)	1998-06-15	2002-06-25	アーチ・デヴェロップメント・コーポレイション	放射線療法と抗血管形成因子の組み合わせ
US6201104B1 (en) *	1998-12-04	2001-03-13	Entremed, Inc.	Angiogenesis—inhibiting protein binding peptides and proteins and methods of use
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
CA2360690A1 (en) *	1999-01-28	2000-08-03	Michael S. O'reilly	Plasminogen kringle 4 region fragments and methods of use
US7157556B1 (en)	1999-02-10	2007-01-02	The Children's Medical Center Corporation	Deglycosylated kringle 1-3 region fragments of plasminogen and methods of use
WO2000047729A1 (en) *	1999-02-10	2000-08-17	Entremed, Inc.	Deglycosylated kringle 1-5 region fragments of plasminogen and methods of use
AR030631A1 (es) *	2000-09-29	2003-08-27	Abbott Lab	Polipeptidos antiangiogenicos y metodos para inhibir la angiogenesis
JP2006506321A (ja) *	2002-04-11	2006-02-23	チルドレンズメディカルセンターコーポレーション	血管透過性亢進を阻害する方法
KR100681762B1 (ko) *	2004-01-09	2007-02-15	재단법인 목암생명공학연구소	인간 아포리포단백질(ａ) 크링글 ＬＫ68 또는 ＬＫ8유전자를 유효성분으로 함유하는 항암 치료제 및 그를이용한 암 치료방법
AU2004316095A1 (en) *	2004-02-24	2005-09-01	Ttc Co., Ltd.	Anticancer agent containing BL angiostatin
ITMI20041962A1 (it) *	2004-10-15	2005-01-15	Istituto Naz Per La Ricerca S	"peptide di angiostatina e suoi impieghio terapeutici"
CN101219219B (zh) *	2007-01-10	2013-02-13	北京普罗吉生物科技发展有限公司	包含血管抑素或其片段的复合物、其制备方法及应用
WO2010070746A1 (ja) *	2008-12-17	2010-06-24	株式会社ティムス	イヌアンジオスタチン様ポリペプチド
JP5749229B2 (ja) *	2012-07-31	2015-07-15	京セラドキュメントソリューションズ株式会社	ジェスチャー管理プログラム及び情報処理装置
JP6682008B2 (ja)	2015-12-18	2020-04-15	タレンゲンインターナショナルリミテッドＴａｌｅｎｇｅｎＩｎｔｅｒｎａｔｉｏｎａｌＬｉｍｉｔｅｄ	糖尿病性腎症を予防及び治療するための方法
CN106890324A (zh) *	2015-12-18	2017-06-27	深圳瑞健生命科学研究院有限公司	一种预防和治疗糖尿病肾病的方法
JP7554557B2 (ja)	2016-12-15	2024-09-20	タレンゲンインターナショナルリミテッド	インスリン受容体基質－２の発現を促進する方法
US11266710B2 (en)	2017-08-31	2022-03-08	Singapore Health Services Pte Ltd.	Angio-3 for treatment of retinal angiogenic diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUT76095A (en) *	1994-04-26	1997-06-30	Childrens Medical Center	Angiostatin and method of use for inhibition of angiogenesis

1996
- 1996-04-26 WO PCT/US1996/005856 patent/WO1996035774A2/en not_active Ceased
- 1996-04-26 CA CA002219081A patent/CA2219081C/en not_active Expired - Lifetime
- 1996-04-26 ES ES96913208T patent/ES2292174T3/es not_active Expired - Lifetime
- 1996-04-26 MX MX9708217A patent/MX9708217A/es unknown
- 1996-04-26 EP EP96913208A patent/EP0824546B1/de not_active Expired - Lifetime
- 1996-04-26 AU AU55795/96A patent/AU709633B2/en not_active Expired
- 1996-04-26 NZ NZ307044A patent/NZ307044A/en not_active IP Right Cessation
- 1996-04-26 AT AT96913208T patent/ATE368051T1/de active
- 1996-04-26 CZ CZ973340A patent/CZ334097A3/cs unknown
- 1996-04-26 DE DE69637179T patent/DE69637179T2/de not_active Expired - Lifetime
- 1996-04-26 JP JP53410496A patent/JP3787157B2/ja not_active Expired - Lifetime
- 1996-04-26 CN CN96194077A patent/CN1195375A/zh active Pending
- 1996-04-26 HU HU9800784A patent/HUP9800784A3/hu unknown
- 1996-04-26 PL PL96323256A patent/PL323256A1/xx unknown
- 1996-04-26 BR BR9608326-3A patent/BR9608326A/pt unknown
1997
- 1997-10-24 NO NO974943A patent/NO974943L/no not_active Application Discontinuation
2000
- 2000-10-06 JP JP2000308481A patent/JP2001151691A/ja active Pending

Also Published As

Publication number	Publication date
AU709633B2 (en)	1999-09-02
BR9608326A (pt)	2000-03-08
EP0824546B1 (de)	2007-07-25
HUP9800784A2 (hu)	1998-07-28
CN1195375A (zh)	1998-10-07
NO974943L (no)	1997-12-18
JP2001151691A (ja)	2001-06-05
MX9708217A (es)	1997-12-31
AU5579596A (en)	1996-11-29
PL323256A1 (en)	1998-03-16
DE69637179T2 (de)	2008-04-10
ES2292174T3 (es)	2008-03-01
HUP9800784A3 (en)	2000-07-28
NZ307044A (en)	2002-03-01
WO1996035774A2 (en)	1996-11-14
JPH11508228A (ja)	1999-07-21
NO974943D0 (no)	1997-10-24
DE69637179D1 (de)	2007-09-06
CZ334097A3 (cs)	1998-04-15
CA2219081C (en)	2004-02-24
CA2219081A1 (en)	1996-11-14
EP0824546A2 (de)	1998-02-25
JP3787157B2 (ja)	2006-06-21
WO1996035774A3 (en)	1997-02-13
HK1002457A1 (en)	1998-08-28

Legal Events

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2007-11-15

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