ATE368227T1 - Screening nach verbindungen, die tgf-beta abhängige zellsignale modifizieren können - Google Patents

Screening nach verbindungen, die tgf-beta abhängige zellsignale modifizieren können

Info

Publication number: ATE368227T1
Authority: AT; Austria
Prior art keywords: tgf; agents; screening; compounds; dependent cell
Prior art date: 1999-08-30

Application number

AT00959571T

Other languages

English (en)

Inventor

Merl Hoekstra

Weilin Xie

Brion Murray

Frank Mercurio

Original Assignee

Signal Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-30

Filing date

2000-08-29

Publication date

2007-08-15

2000-08-29 Application filed by Signal Pharm Inc filed Critical Signal Pharm Inc

2007-08-15 Application granted granted Critical

2007-08-15 Publication of ATE368227T1 publication Critical patent/ATE368227T1/de

Links

ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title abstract 5
150000001875 compounds Chemical class 0.000 title 1
230000001419 dependent effect Effects 0.000 title 1
238000012216 screening Methods 0.000 title 1
102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 4
108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 4
239000003795 chemical substances by application Substances 0.000 abstract 4
230000001404 mediated effect Effects 0.000 abstract 2
230000011664 signaling Effects 0.000 abstract 2
102000007374 Smad Proteins Human genes 0.000 abstract 1
108010007945 Smad Proteins Proteins 0.000 abstract 1
210000000988 bone and bone Anatomy 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000000921 morphogenic effect Effects 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
230000017854 proteolysis Effects 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/495—Transforming growth factor [TGF]
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Hematology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Urology & Nephrology (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pathology (AREA)
Endocrinology (AREA)
General Physics & Mathematics (AREA)
Cell Biology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Food Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT00959571T 1999-08-30 2000-08-29 Screening nach verbindungen, die tgf-beta abhängige zellsignale modifizieren können ATE368227T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/385,918 US7358056B1 (en)	1999-08-30	1999-08-30	Methods for modulating signal transduction mediated by TGF-β and related proteins

Publications (1)

Publication Number	Publication Date
ATE368227T1 true ATE368227T1 (de)	2007-08-15

Family

ID=23523429

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00959571T ATE368227T1 (de)	1999-08-30	2000-08-29	Screening nach verbindungen, die tgf-beta abhängige zellsignale modifizieren können

Country Status (8)

Country	Link
US (2)	US7358056B1 (de)
EP (2)	EP1212621B1 (de)
JP (1)	JP2003508755A (de)
AT (1)	ATE368227T1 (de)
AU (1)	AU781152B2 (de)
CA (1)	CA2383514A1 (de)
DE (1)	DE60035697T2 (de)
WO (1)	WO2001016604A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7846746B2 (en) *	2001-04-10	2010-12-07	Children's Medical Center Corporation	Methods of analysis and labeling of protein-protein interactions
WO2002085422A1 (en) *	2001-04-25	2002-10-31	Eidgenössische Technische Hochschule Zürich	Drug delivery matrices to enhance wound healing
NZ532310A (en) *	2001-10-05	2007-02-23	Combinatorx Inc	Combinations comprising a tetra-substituted pyrimidopyrimidine and a corticosteroid for the treatment of immunoinflammatory disorders
GB0302315D0 (en) *	2003-02-01	2003-03-05	Univ East Anglia	Novel therapeutic target
JP2008507288A (ja) *	2004-07-23	2008-03-13	アクセルロンファーマインコーポレーテッド	ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物
US20100183514A1 (en)	2007-05-29	2010-07-22	President And Fellows Of Harvard College	Molecules involved in regulation of osteoblast activity and osteoclast activity, and methods of use thereof
WO2011088163A1 (en)	2010-01-14	2011-07-21	President And Fellows Of Harvard College	Methods for modulating skeletal remodeling and patterning by modulating shn2 activity, shn3 activity, or shn2 and shn3 activity in combination
GB201013284D0 (en) *	2010-08-06	2010-09-22	Isogenica Ltd	Scaffold peptides
RS61778B1 (sr)	2013-05-06	2021-06-30	Scholar Rock Inc	Kompozicije i postupci za modulaciju faktora rasta
CN103558395B (zh) *	2013-10-28	2015-08-26	深圳市第二人民医院	Smad3基因在检测上尿路上皮癌中的应用
KR101683544B1 (ko) *	2014-12-19	2016-12-08	한양대학교 산학협력단	탈인산화 또는 인산화 효소 활성 검출용 조성물 및 검출 방법
US10961305B2 (en)	2016-12-21	2021-03-30	Mereo Biopharma 3 Limited	Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta
EP3969592A4 (de) *	2019-05-15	2023-01-04	Synthex, Inc.	Selektiver abbau von proteinen
WO2022082006A1 (en) *	2020-10-15	2022-04-21	Sri International	Binding assays involving a plurality of synthetic compounds, targets, and counter targets

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6001619A (en)	1995-10-04	1999-12-14	Cold Spring Harbor Laboratory	Ubiquitin ligases, and uses related thereto
US6011137A (en) *	1996-04-03	2000-01-04	University Of North Carolina At Chapel Hill	Identification and isolation of novel polypeptides having WW domains and methods of using same
WO1998053066A1 (en)	1997-05-20	1998-11-26	Ludwig Institute For Cancer Research	Smad2 phosphorylation and interaction with smad4
WO1999001765A1 (en)	1997-07-01	1999-01-14	Sloan Kettering Institute For Cancer Research	METHODS OF INHIBITING OR ENHANCING THE TGFβ-SMAD SIGNALING PATHWAY
US6060262A (en)	1997-07-16	2000-05-09	Mitotix, Inc.	Regulation of I Kappa B (IκB) degradation and methods and reagents related thereto
US5976849A (en) *	1998-02-05	1999-11-02	Zeneca Limited	Human E3 ubiquitin protein ligase
EP1192174A4 (de)	1999-06-11	2002-08-28	Univ New York State Res Found	Antagonisten von bmp- und tgf-beta signalwegen

1999
- 1999-08-30 US US09/385,918 patent/US7358056B1/en not_active Expired - Fee Related
2000
- 2000-08-29 CA CA002383514A patent/CA2383514A1/en not_active Abandoned
- 2000-08-29 JP JP2001520108A patent/JP2003508755A/ja active Pending
- 2000-08-29 EP EP00959571A patent/EP1212621B1/de not_active Expired - Lifetime
- 2000-08-29 WO PCT/US2000/023729 patent/WO2001016604A1/en not_active Ceased
- 2000-08-29 AT AT00959571T patent/ATE368227T1/de not_active IP Right Cessation
- 2000-08-29 DE DE60035697T patent/DE60035697T2/de not_active Expired - Fee Related
- 2000-08-29 EP EP07010063A patent/EP1918716A2/de not_active Withdrawn
- 2000-08-29 AU AU70866/00A patent/AU781152B2/en not_active Ceased
2002
- 2002-12-02 US US10/307,956 patent/US20030119072A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU7086600A (en)	2001-03-26
DE60035697T2 (de)	2008-04-30
US7358056B1 (en)	2008-04-15
US20030119072A1 (en)	2003-06-26
AU781152B2 (en)	2005-05-12
EP1212621A1 (de)	2002-06-12
EP1212621B1 (de)	2007-07-25
EP1918716A2 (de)	2008-05-07
JP2003508755A (ja)	2003-03-04
CA2383514A1 (en)	2001-03-08
WO2001016604A1 (en)	2001-03-08
DE60035697D1 (de)	2007-09-06

Legal Events

Date	Code	Title	Description
2008-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE368227T1 (de)	2007-08-15	Screening nach verbindungen, die tgf-beta abhängige zellsignale modifizieren können
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MX9207074A (es)	1993-07-01	Piperazinil- y piperidinil -ciclohexanoles y composicion farmaceutica que los comprende
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ATE337021T1 (de)	2006-09-15	Anordnungen, systeme und verfahren zur behandlung von biologischen flüssigkeiten mit licht
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DE59709515D1 (de)	2003-04-17	Verfahren zur herstellung von wirkstoffhaltigen knochenzementen
AR010062A1 (es)	2000-05-17	Nuevos benzamidaldehidos y su utilizacion
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MX9101958A (es)	1992-07-08	Inhibidores de acat de urea de aminosulfonilo
NO983802L (no)	1998-08-19	Benzothiofener, formuleringer inneholdende samme og fremgangsmåter
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