ATE368861T1 - Neuartige verwendungen von durch ble-gene kodierten proteinen und antibiotika aus der bleomycin-familie - Google Patents
Neuartige verwendungen von durch ble-gene kodierten proteinen und antibiotika aus der bleomycin-familieInfo
- Publication number
- ATE368861T1 ATE368861T1 AT03811464T AT03811464T ATE368861T1 AT E368861 T1 ATE368861 T1 AT E368861T1 AT 03811464 T AT03811464 T AT 03811464T AT 03811464 T AT03811464 T AT 03811464T AT E368861 T1 ATE368861 T1 AT E368861T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- ble
- bleomycin family
- antibiotic
- bleomycin
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 9
- 102000004169 proteins and genes Human genes 0.000 title abstract 9
- 108010006654 Bleomycin Proteins 0.000 title abstract 6
- 229960001561 bleomycin Drugs 0.000 title abstract 6
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 title abstract 6
- 239000003242 anti bacterial agent Substances 0.000 title abstract 4
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 101150038738 ble gene Proteins 0.000 title 1
- 230000003115 biocidal effect Effects 0.000 abstract 4
- 239000012491 analyte Substances 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000027455 binding Effects 0.000 abstract 1
- 230000030570 cellular localization Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9446—Antibacterials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2415/00—Assays, e.g. immunoassays or enzyme assays, involving penicillins or cephalosporins
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0224872A GB0224872D0 (en) | 2002-10-25 | 2002-10-25 | Probe for mass spectrometry |
| GB0229640A GB2385327A (en) | 2001-12-21 | 2002-12-20 | Probe for mass spectrometry |
| GB0307379A GB2400102A (en) | 2003-03-31 | 2003-03-31 | Uses of Ble proteins and bleomycin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE368861T1 true ATE368861T1 (de) | 2007-08-15 |
Family
ID=32329543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03811464T ATE368861T1 (de) | 2002-10-25 | 2003-10-27 | Neuartige verwendungen von durch ble-gene kodierten proteinen und antibiotika aus der bleomycin-familie |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060194715A1 (de) |
| EP (1) | EP1565754B1 (de) |
| JP (2) | JP2006506447A (de) |
| AT (1) | ATE368861T1 (de) |
| AU (1) | AU2003302133A1 (de) |
| DE (1) | DE60315343T2 (de) |
| DK (1) | DK1565754T3 (de) |
| ES (1) | ES2290556T3 (de) |
| WO (1) | WO2004046730A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7094568B2 (en) * | 2000-08-17 | 2006-08-22 | Sense Proteomic Ltd. | Method for producing proteins tagged at the N- or C-terminus |
| EP1456668B1 (de) | 2001-12-05 | 2007-05-02 | Sense Proteomic Limited | Protein arrays für allelvarianten und deren verwendung |
| EP3276349B1 (de) * | 2006-11-01 | 2019-08-07 | Ventana Medical Systems, Inc. | Haptene, haptenkonjugate, zusammensetzungen daraus und verfahren für ihre herstellung und verwendung |
| CN101199866B (zh) * | 2007-12-27 | 2010-09-22 | 高景星 | 一种具有多种生物活性的可溶性棉纤维及其制备方法 |
| GB2460717A (en) | 2008-06-11 | 2009-12-16 | Sense Proteomic Ltd | Autoantibodies for the detection of a predisposition to Lupus |
| GB2478734A (en) | 2010-03-15 | 2011-09-21 | Sense Proteomic Ltd | Auto-antibody biomarkers of prostate cancer |
| GB201017520D0 (en) | 2010-10-15 | 2010-12-01 | Sense Proteomic Ltd | Biomarkers |
| CA2868555C (en) | 2012-03-30 | 2018-06-12 | Jetze Botma | Automated selection of microorganisms and identification using maldi |
| JP6231263B2 (ja) * | 2012-07-17 | 2017-11-15 | 株式会社島津製作所 | アフィニティ支持体及びそれを用いた物質の捕捉方法 |
| CN104569325B (zh) * | 2014-12-26 | 2016-11-23 | 华中农业大学 | 用于检测食品中氨基糖苷类抗生素残留的抗体芯片试剂盒及方法 |
| CN112116950B (zh) * | 2020-09-10 | 2022-08-12 | 南京理工大学 | 基于深度度量学习的蛋白质折叠识别方法 |
| CN118510902A (zh) * | 2021-12-21 | 2024-08-16 | Absci公司 | 用于鉴定具有增加的可溶性靶蛋白表达的菌株的FolA选择测定 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59225064A (ja) * | 1983-06-03 | 1984-12-18 | ユニチカ株式会社 | 生理活性物質固定化用担体 |
| US4705616A (en) * | 1986-09-15 | 1987-11-10 | Sepragen Corporation | Electrophoresis-mass spectrometry probe |
| US5420228A (en) * | 1991-04-05 | 1995-05-30 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Fluorescent-labelled bleomycin analogues |
| FR2706678B1 (fr) * | 1993-06-10 | 1995-07-13 | Commissariat Energie Atomique | Sonde de spectrométrie de masse, notamment en plasma magnétisé. |
| WO1997039106A1 (en) * | 1996-04-12 | 1997-10-23 | Martek Biosciences Corporation | Methods and tools for transformation of eukaryotic algae |
| EP1326970A2 (de) * | 2000-08-17 | 2003-07-16 | Sense Proteomic Limited | Schnelle profilierung zwischen einer chemischen verbindung und proteinen in einem gegebenen proteosom |
| US20030022151A1 (en) * | 2001-01-17 | 2003-01-30 | Gopal Thinakaran | Functional screening |
-
2003
- 2003-10-27 AT AT03811464T patent/ATE368861T1/de not_active IP Right Cessation
- 2003-10-27 AU AU2003302133A patent/AU2003302133A1/en not_active Abandoned
- 2003-10-27 US US10/532,834 patent/US20060194715A1/en not_active Abandoned
- 2003-10-27 DE DE60315343T patent/DE60315343T2/de not_active Expired - Lifetime
- 2003-10-27 WO PCT/IB2003/005430 patent/WO2004046730A2/en not_active Ceased
- 2003-10-27 EP EP03811464A patent/EP1565754B1/de not_active Expired - Lifetime
- 2003-10-27 ES ES03811464T patent/ES2290556T3/es not_active Expired - Lifetime
- 2003-10-27 JP JP2004570323A patent/JP2006506447A/ja not_active Ceased
- 2003-10-27 DK DK03811464T patent/DK1565754T3/da active
-
2010
- 2010-04-08 JP JP2010089809A patent/JP2010156715A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010156715A (ja) | 2010-07-15 |
| AU2003302133A1 (en) | 2004-06-15 |
| ES2290556T3 (es) | 2008-02-16 |
| WO2004046730A3 (en) | 2004-09-02 |
| EP1565754B1 (de) | 2007-08-01 |
| JP2006506447A (ja) | 2006-02-23 |
| DE60315343T2 (de) | 2008-04-17 |
| DE60315343D1 (de) | 2007-09-13 |
| AU2003302133A8 (en) | 2004-06-15 |
| US20060194715A1 (en) | 2006-08-31 |
| DK1565754T3 (da) | 2007-12-17 |
| WO2004046730A2 (en) | 2004-06-03 |
| EP1565754A2 (de) | 2005-08-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1565754 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |