ATE369144T1 - Verfahren zur steigerung des haarwuchses durch wnt polypeptid - Google Patents

Verfahren zur steigerung des haarwuchses durch wnt polypeptid

Info

Publication number
ATE369144T1
ATE369144T1 AT01926479T AT01926479T ATE369144T1 AT E369144 T1 ATE369144 T1 AT E369144T1 AT 01926479 T AT01926479 T AT 01926479T AT 01926479 T AT01926479 T AT 01926479T AT E369144 T1 ATE369144 T1 AT E369144T1
Authority
AT
Austria
Prior art keywords
hair growth
wnt polypeptide
wnt
increase hair
methods
Prior art date
Application number
AT01926479T
Other languages
English (en)
Inventor
Jiro Kishimoto
Robert Burgeson
Bruce Morgan
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Application granted granted Critical
Publication of ATE369144T1 publication Critical patent/ATE369144T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0627—Hair cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01926479T 2000-03-31 2001-03-30 Verfahren zur steigerung des haarwuchses durch wnt polypeptid ATE369144T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19377100P 2000-03-31 2000-03-31
US26169001P 2001-01-12 2001-01-12

Publications (1)

Publication Number Publication Date
ATE369144T1 true ATE369144T1 (de) 2007-08-15

Family

ID=26889330

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01926479T ATE369144T1 (de) 2000-03-31 2001-03-30 Verfahren zur steigerung des haarwuchses durch wnt polypeptid

Country Status (9)

Country Link
US (4) US6924141B2 (de)
EP (1) EP1267616B1 (de)
JP (3) JP4813734B2 (de)
AT (1) ATE369144T1 (de)
AU (2) AU2001253012B2 (de)
CA (1) CA2403817C (de)
DE (1) DE60129799T2 (de)
ES (1) ES2290125T3 (de)
WO (1) WO2001074164A1 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001253012B2 (en) * 2000-03-31 2006-02-23 The General Hospital Corporation Methods of modulating hair growth
EP1368493A2 (de) * 2001-03-07 2003-12-10 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Identifizierung und verwendung von inhibitoren der haarbildung
US20050130181A1 (en) * 2001-05-18 2005-06-16 Sirna Therapeutics, Inc. RNA interference mediated inhibition of wingless gene expression using short interfering nucleic acid (siNA)
CN1652743A (zh) * 2002-04-17 2005-08-10 大正制药株式会社 毛发生长补剂
WO2004013606A2 (en) * 2002-08-02 2004-02-12 Stratatech Corporation Species specific dna detection
CA2505409C (en) * 2002-11-14 2017-04-04 Intercytex Limited Cultivation of hair inductive cells
WO2004076642A2 (en) * 2003-02-27 2004-09-10 The Rockefeller University Method for modulating epithelial stem cell lineage
EP2093298A3 (de) 2003-10-10 2009-09-23 Deutsches Krebsforschungszentrum Zusammensetzungen zur Diagnose und Therapie für mit aberranter Expression von Futrins (R-Spondins) assoziierten Krankheiten
WO2005084223A2 (en) 2004-02-27 2005-09-15 The General Hospital Corporation Methods and compositions for hair growth
WO2006026730A2 (en) * 2004-08-30 2006-03-09 Iken Tissue Therapeutics, Inc. Cultured three dimensional tissues and uses thereof
WO2006026617A2 (en) * 2004-08-30 2006-03-09 Iken Tissue Therapeutics, Inc. Compositions and methods of promoting hair growth
WO2006036175A2 (en) * 2004-09-21 2006-04-06 Rhode Island Hospital, A Lifespan-Partner Wnt proteins and detection and treatment of cancer
WO2006036179A2 (en) * 2004-09-21 2006-04-06 Rhode Island Hospital, A Lifespan-Partner Frizzled proteins and detection and treatment of cancer
US7850960B2 (en) * 2004-12-30 2010-12-14 University Of Washington Methods for regulation of stem cells
JP2008179540A (ja) * 2005-01-07 2008-08-07 Noevir Co Ltd 細胞分化、発生、増殖を制御する物質および該物質を含む細胞分化・発生・増殖調節剤
US20090203134A1 (en) * 2005-01-18 2009-08-13 Kyoto University Remedy for nerve cell regeneration
ES2931949T3 (es) * 2005-03-29 2023-01-05 Univ Pennsylvania Minoxidilo para generar nuevos folículos pilosos y tratar la calvicie
AU2012204059B2 (en) * 2005-03-29 2015-01-15 The Trustees Of The University Of Pennsylvania Methods for generating new hair follicles, treating baldness and hair removal
EP3085389A1 (de) * 2005-04-07 2016-10-26 The Trustees Of The University Of Pennsylvania Methode um die funktion eines aav vektors zu erhöhen
WO2006124356A2 (en) * 2005-05-16 2006-11-23 The Rockefeller University Method for isolating dermal papilla cells and uses thereof
TW200800240A (en) 2005-11-22 2008-01-01 Aderans Res Inst Inc Hair follicle graft from tissue engineered skin
EP2007877B1 (de) 2006-02-28 2013-04-17 The Trustees of Columbia University in the City of New York Verfahren für kompakte aggregation von hautzellen
GB0605450D0 (en) 2006-03-17 2006-04-26 Intercytex Ltd Cell co-culture
ES2641528T3 (es) 2006-06-27 2017-11-10 Shiseido Company, Limited Masa celular capaz de servir como estructura de tipo órgano primitivo compuesta por una diversidad de tipos de células de origen somático
JP2010504974A (ja) 2006-09-28 2010-02-18 フォリカ，インコーポレーテッド 新しい毛嚢を生成させ毛髪を成長させる方法、キット、及び組成物
US7922688B2 (en) 2007-01-08 2011-04-12 Restoration Robotics, Inc. Automated delivery of a therapeutic or cosmetic substance to cutaneous, subcutaneous and intramuscular tissue regions
US8580236B2 (en) * 2007-03-19 2013-11-12 Richard P. De Maria Hair sustaining formulation
HRP20151261T1 (hr) 2007-07-02 2016-01-01 Oncomed Pharmaceuticals, Inc. Sastavi i postupci za lijeäśenje i dijagnosticiranje raka
JP5300273B2 (ja) 2008-01-21 2013-09-25 株式会社 資生堂 ヒトＷｎｔ３ａ遺伝子形質転換細胞
US8524494B2 (en) 2008-01-30 2013-09-03 Histogen, Inc. Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro
SG10201500237TA (en) * 2008-01-30 2015-04-29 Histogen Inc Extracellular matrix compositions
US8530415B2 (en) * 2008-01-30 2013-09-10 Histogen, Inc. Repair and/or regeneration of cells with a composition produced by culturing fibroblast cells under hypoxic conditions
US8535913B2 (en) 2008-01-30 2013-09-17 Histogen, Inc. Soluble composition for promoting hair growth produced by hypoxic culture of fibroblasts cells
US20100166824A1 (en) * 2008-01-30 2010-07-01 Histogen, Inc. Extracellular matrix compositions
FR2936255B1 (fr) * 2008-09-19 2010-10-15 Galderma Res & Dev Modulateurs de fzd2 dans le traitement de l'alopecie
KR20170024148A (ko) 2008-11-12 2017-03-06 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 손상된 모낭의 재생을 촉진하는 섬유모세포 성장 인자-9
US20120046242A1 (en) * 2008-12-24 2012-02-23 Massachusetts Institute Of Technology Molecular activators of the wnt/beta-catenin pathway
KR101198918B1 (ko) 2009-09-01 2012-11-07 (주)케어젠 Ｗｎｔ１０?유래 펩타이드 및 그의 용도
WO2011049958A2 (en) * 2009-10-21 2011-04-28 Otonomy, Inc. Modulation of gel temperature of poloxamer-containing formulations
KR101209117B1 (ko) 2010-03-25 2012-12-06 (주)케어젠 변형된 ｗｎｔ１０?유래 펩타이드 및 그의 용도
ES2667532T3 (es) * 2010-06-18 2018-05-11 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Neogénesis del folículo piloso
WO2012078649A1 (en) 2010-12-06 2012-06-14 Follica, Inc. Methods for treating baldness and promoting hair growth
WO2012174280A2 (en) 2011-06-15 2012-12-20 The Regents Of The University Of California Methods and compositions for modulating myofibroblast activities
JP6185463B2 (ja) 2011-07-15 2017-08-23 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｒｓｐｏ結合剤およびその使用法
KR101285259B1 (ko) 2011-08-04 2013-07-11 (주)케어젠 Ｗｎｔ 계열 유래 펩타이드 및 이의 용도
EA032038B1 (ru) 2012-07-13 2019-03-29 Онкомед Фармасьютикалс, Инк. Rspo3-связывающие агенты и их применение
CN104031055B (zh) * 2013-03-07 2016-08-24 中国科学院上海生命科学研究院 一种可用作Wnt信号途径激活剂的化合物及其制备与应用
JP6469655B2 (ja) 2013-05-03 2019-02-13 ザ ヘンリー エム． ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド 代用皮膚および毛包新生の方法
EP3191526B1 (de) 2014-09-12 2023-02-22 The Board of Trustees of the Leland Stanford Junior University Agonistenmoleküle des wnt-signalwegs
JP2017528523A (ja) 2014-09-16 2017-09-28 オンコメッド ファーマシューティカルズ インコーポレイテッド 線維性疾患の治療
US20180161389A1 (en) * 2015-01-09 2018-06-14 The Board Of Trustees Of The Leland Stanford Junior University R-spondin agonist-mediated hair growth
MX390321B (es) 2016-12-30 2025-03-20 Frequency Therapeutics Inc Compuestos de 1h-pirrol-2,5-diona y metodos de uso de los mismos para inducir la auto-renovacion de celulas madre/progenitoras de soporte.
CN106727682A (zh) * 2017-01-20 2017-05-31 李玉红 一种用于治疗脱发的制剂
US20200113913A1 (en) * 2017-04-11 2020-04-16 Frequency Therapeutics, Inc. Methods for hair follicle stem cell proliferation
WO2018232154A1 (en) 2017-06-15 2018-12-20 Belite Bio, Inc Methods of treating metabolic diseases with fused bicyclic pyrazoles
EP3638239A4 (de) 2017-06-15 2021-03-10 Belite Bio, Inc Verfahren zur behandlung von rbp4-bedingten krankheiten mit triazolopyridinen
EP3710060A4 (de) * 2017-11-16 2021-05-19 Aivita Biomedical, Inc. Verwendung von zellmembrangebundenen signalisierungsfaktoren
JP7317016B2 (ja) 2017-12-19 2023-07-28 スロゼン オペレーティング， インコーポレイテッド 抗ｌｒｐ５／６抗体及び使用方法
US11773171B2 (en) 2017-12-19 2023-10-03 Surrozen Operating, Inc. WNT surrogate molecules and uses thereof
JP7418332B2 (ja) 2017-12-19 2024-01-19 スロゼン オペレーティング， インコーポレイテッド 抗フリズルド抗体及び使用方法
TWI665217B (zh) * 2018-03-07 2019-07-11 臺鹽實業股份有限公司 膠原蛋白衍生胜肽及其用於製備促進生髮組成物之用途
GB201816902D0 (en) * 2018-10-17 2018-11-28 Hairclone Ltd Hair Rejuvenation
KR102242840B1 (ko) * 2019-04-04 2021-04-23 주식회사 비알팜 탈모 방지 또는 발모 촉진용 조성물
KR20220061093A (ko) 2019-07-08 2022-05-12 벨라이트 바이오 엘엘씨 Rbp4 억제제의 제제 및 사용 방법
JP7741559B2 (ja) * 2020-01-20 2025-09-18 イーブイ、セル、バイオテック、（コアンチョウ）、カンパニー、リミテッド 細胞外小胞及びその皮膚製品における使用
EP4100071A1 (de) * 2020-02-07 2022-12-14 King's College London Geweberegenerationspflaster
JP7829928B2 (ja) * 2020-04-30 2026-03-16 国立大学法人京都大学 膵前駆細胞の増殖方法
CA3198268A1 (en) 2020-11-16 2022-05-19 Surrozen Operating, Inc. Liver-specific wnt signal enhancing molecules and uses thereof
AU2022281340A1 (en) * 2021-05-26 2024-01-04 Figene, Llc Methods and compositions for alopecia treatment using fibroblasts and fibroblast-derived products

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091173A (en) * 1989-06-29 1992-02-25 The University Of Dundee Hair growth composition
US5208145A (en) * 1991-05-06 1993-05-04 The Salk Institute For Biological Studies Assay for the presence, in cultured cells, of functional ligand-gated channels, and substances which enhance intracellular lithium accumulation by cultured cells via such channels
US5549674A (en) * 1992-03-02 1996-08-27 The Regents Of The University Of Michigan Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
EP0736034A4 (de) 1993-12-22 1999-02-03 Merck & Co Inc Den wnt-x wachstumsfaktor kodierende dns
JP3573488B2 (ja) * 1994-04-11 2004-10-06 独立行政法人 科学技術振興機構 毛乳頭細胞の長期継代培養法
JP2991620B2 (ja) * 1994-08-30 1999-12-20 科学技術振興事業団 細胞活動の制御方法
AU7672996A (en) 1995-11-13 1997-06-05 Regents Of The University Of California, The Methods and compositions for hair growth promotion
DE19909251A1 (de) 1998-02-21 1999-08-26 Max Delbrueck Centrum Mittel zur Therapie von menschlichen Erkrankungen, ausgehend von beta-Catenin, seine Herstellung und seine Verwendung
US6485972B1 (en) * 1998-10-15 2002-11-26 President And Fellows Of Harvard College WNT signalling in reproductive organs
US6159950A (en) 1998-10-16 2000-12-12 Cornell Research Foundation, Inc. Method of modulating hair growth
WO2000031134A1 (en) * 1998-11-20 2000-06-02 Arch Development Corporation Regulation of hair follicle morphogenesis based on beta-catenin
AU2001253012B2 (en) * 2000-03-31 2006-02-23 The General Hospital Corporation Methods of modulating hair growth

Also Published As

Publication number Publication date
ES2290125T3 (es) 2008-02-16
AU5301201A (en) 2001-10-15
DE60129799D1 (de) 2007-09-20
JP5960749B2 (ja) 2016-08-02
EP1267616A4 (de) 2003-07-16
US7985587B2 (en) 2011-07-26
DE60129799T2 (de) 2008-04-30
CA2403817C (en) 2012-05-29
JP2011207908A (ja) 2011-10-20
EP1267616A1 (de) 2003-01-02
JP5580252B2 (ja) 2014-08-27
CA2403817A1 (en) 2001-10-11
JP4813734B2 (ja) 2011-11-09
US7175842B2 (en) 2007-02-13
WO2001074164A1 (en) 2001-10-11
JP2004500407A (ja) 2004-01-08
JP2014159471A (ja) 2014-09-04
US20020114772A1 (en) 2002-08-22
US20080286261A1 (en) 2008-11-20
EP1267616B1 (de) 2007-08-08
US20050271632A1 (en) 2005-12-08
US20040170611A1 (en) 2004-09-02
AU2001253012B2 (en) 2006-02-23
US6924141B2 (en) 2005-08-02
WO2001074164A9 (en) 2002-01-10

Similar Documents

Publication Publication Date Title
DE60129799D1 (de) Verfahren zur steigerung des haarwuchses durch wnt polypeptid
DE60223058D1 (de) Zusammensetzungen und verfahren zur behandlung von diabetes
WO2003089457A3 (en) Peptide inhibitors of protein kinase c ϝ for pain management
ATE453653T1 (de) Platinkomplexe zur behandlung von tumoren
ATE308045T1 (de) Verfahren zur bestimmung der immunabwehraktivität des blutes sowie testkit hierfür
ATE416619T1 (de) Verfahren zur dearomatisierung von molkeprotein
ATE336597T1 (de) Verfahren zur gewinnung von gold
DE60037886D1 (de) Verfahren zur reinigung von rekombinanten proteinen, welche wachstumshormon antagonisten sind, mittels wässriger zweiphasen-extraktion
IL172729A0 (en) Reagents and methods for the formation of disulfide bonds and the glycosylation of proteins
ATE406438T1 (de) Menschliches homolog aus der familie der metalloproteasen
DK0786004T3 (da) Kloning, ekspression og karakterisering af en hidtil ukendt form af phosphatidylinositol-3-kinase
DE602004014799D1 (de) System und assoziiertes verfahren zur bestimmung der authentifikationspriorität zwischen einrichtungen
DE60325194D1 (de) Methoden zur verwendung von lamellaren körpern für therapeutische zwecke
DE59809283D1 (de) Inhibitoren für den urokinaserezeptor
ATE517629T1 (de) Verwendung eines proteins der crmp familie zur behandlung von krankheiten des immunsystems
TR200102655T2 (tr) Dört L. infantum proteininin antijen belirleyicilerini kodlayan kimerik gen.
DE602004023811D1 (de) Verfahren zur modularen Potenzierung zur Entschlüsselung bzw. zur Erzeugung von digitalen Signaturen
NO20055309D0 (no) Slurp-1 samrnensetninger og fremgangsmater for anvendelse derav
DE602004003966D1 (de) Verbessertes verfahren zur herstellung von alpha-polymorphem eletriptan hydrobromid
EP1734827A4 (de) Verfahren und zusammensetzungen zur behandlung von mit anomaler mikrosatellitenexpansion in verbindung stehenden krankheiten
ATE402948T1 (de) Verfahren zur aufreinigung eines nichtimmunoglobulinproteins, das eine immunoglobulinähnliche (ig-like) domäne enthält
DE60325737D1 (de) Verfahren und zusammensetzungen zum targeting sekretorischer lysosomen
DE60119458D1 (de) Vorrichtung zur Feststellung der genetischen Sequenz von Biopolymeren
DE60011785D1 (de) Verfahren zur herstellung von proteinen in wirtszellen unter verwendung von chaperoninen
MXPA06013176A (es) Dominios semejantes al factor de crecimiento epidermico de mucina 3.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties