ATE369343T1 - Verfahren zur hestellung carbostyrilderivate wie aripiprazole und deren zwischenverbindungen - Google Patents
Verfahren zur hestellung carbostyrilderivate wie aripiprazole und deren zwischenverbindungenInfo
- Publication number
- ATE369343T1 ATE369343T1 AT04729020T AT04729020T ATE369343T1 AT E369343 T1 ATE369343 T1 AT E369343T1 AT 04729020 T AT04729020 T AT 04729020T AT 04729020 T AT04729020 T AT 04729020T AT E369343 T1 ATE369343 T1 AT E369343T1
- Authority
- AT
- Austria
- Prior art keywords
- aripiprazole
- intermediate compounds
- carbostyril derivatives
- producing
- producing carbostyril
- Prior art date
Links
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 title 1
- 229960004372 aripiprazole Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2428237A CA2428237C (en) | 2003-05-08 | 2003-05-08 | Process for the preparation of carbostyril derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE369343T1 true ATE369343T1 (de) | 2007-08-15 |
Family
ID=33426203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04729020T ATE369343T1 (de) | 2003-05-08 | 2004-04-23 | Verfahren zur hestellung carbostyrilderivate wie aripiprazole und deren zwischenverbindungen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20070032651A1 (de) |
| EP (1) | EP1625116B1 (de) |
| CN (1) | CN1784385A (de) |
| AR (1) | AR041937A1 (de) |
| AT (1) | ATE369343T1 (de) |
| CA (1) | CA2428237C (de) |
| DE (1) | DE602004008058D1 (de) |
| ES (1) | ES2290698T3 (de) |
| PT (1) | PT1625116E (de) |
| WO (1) | WO2004099152A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7714129B2 (en) | 2003-12-16 | 2010-05-11 | Teva Pharmaceutical Industries Ltd. | Methods of preparing anhydrous aripiprazole form II |
| WO2005058835A2 (en) | 2003-12-16 | 2005-06-30 | Teva Pharmaceutical Industries Ltd. | Methods of preparing aripiprazole crystalline forms |
| WO2006079549A1 (en) * | 2005-01-27 | 2006-08-03 | Sandoz Ag | Salts of aripiprazole |
| EP1686117A1 (de) * | 2005-01-27 | 2006-08-02 | Sandoz AG | Polymorph und Solvate von Aripiprazol |
| DE06790055T1 (de) | 2005-08-30 | 2008-09-25 | Honeywell International Inc. | Verfahren zur synthese von quaternären ammoniumspirosystemen |
| WO2008026220A1 (en) * | 2006-08-28 | 2008-03-06 | Lupin Limited | A process for purification of 7-(4-bromobutoxy)-3,4 dihydrocarbostyril, an intermediate for manufacture of aripirazole |
| JP5466147B2 (ja) | 2007-05-21 | 2014-04-09 | レビバ ファーマシューティカルズ，インコーポレーテッド | キノリノン系非定型抗精神病薬剤の組成物、合成、及び使用方法 |
| US8207163B2 (en) | 2008-05-27 | 2012-06-26 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using piperazine based antipsychotic agents |
| DK2400968T3 (da) | 2009-02-26 | 2017-01-02 | Reviva Pharmaceuticals Inc | Sammensætninger, syntese og fremgangsmåder til anvendelse af arylpiperazinderivater |
| BR112013010190B1 (pt) * | 2010-10-28 | 2019-12-31 | Aequus Pharmaceuticals Inc | composição farmacêutica |
| US9757374B2 (en) | 2010-10-28 | 2017-09-12 | Aequus Pharmaceuticals Inc. | Aripiprazole compositions and methods for its transdermal delivery |
| WO2016181406A1 (en) * | 2015-05-08 | 2016-11-17 | Davuluri Ramamohan Rao | Improved process for the preparation of aripiprazole with reduced particle size |
| CN110128336A (zh) * | 2019-06-10 | 2019-08-16 | 岳阳新华达制药有限公司 | 一种阿立哌唑的制备方法 |
| CN118121699A (zh) * | 2022-12-02 | 2024-06-04 | 上海日馨医药科技股份有限公司 | Tpk激动剂及使用其治疗神经退行性疾病的方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5006528A (en) * | 1988-10-31 | 1991-04-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
| FR2673628B1 (fr) * | 1991-03-07 | 1993-07-09 | Esteve Labor Dr | Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles. |
-
2003
- 2003-05-08 CA CA2428237A patent/CA2428237C/en not_active Expired - Fee Related
- 2003-11-11 AR ARP030104140A patent/AR041937A1/es unknown
-
2004
- 2004-04-23 ES ES04729020T patent/ES2290698T3/es not_active Expired - Lifetime
- 2004-04-23 CN CNA2004800124742A patent/CN1784385A/zh active Pending
- 2004-04-23 AT AT04729020T patent/ATE369343T1/de not_active IP Right Cessation
- 2004-04-23 WO PCT/CA2004/000605 patent/WO2004099152A1/en not_active Ceased
- 2004-04-23 DE DE602004008058T patent/DE602004008058D1/de not_active Expired - Lifetime
- 2004-04-23 PT PT04729020T patent/PT1625116E/pt unknown
- 2004-04-23 EP EP04729020A patent/EP1625116B1/de not_active Expired - Lifetime
- 2004-04-23 US US10/555,485 patent/US20070032651A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004008058D1 (de) | 2007-09-20 |
| EP1625116B1 (de) | 2007-08-08 |
| US20070032651A1 (en) | 2007-02-08 |
| PT1625116E (pt) | 2007-08-27 |
| CA2428237C (en) | 2010-07-20 |
| AR041937A1 (es) | 2005-06-01 |
| CN1784385A (zh) | 2006-06-07 |
| ES2290698T3 (es) | 2008-02-16 |
| WO2004099152A1 (en) | 2004-11-18 |
| EP1625116A1 (de) | 2006-02-15 |
| CA2428237A1 (en) | 2004-11-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |