ATE369375T1 - Synthese von locked nucleic acid-derivaten - Google Patents

Synthese von locked nucleic acid-derivaten

Info

Publication number
ATE369375T1
ATE369375T1 AT03718663T AT03718663T ATE369375T1 AT E369375 T1 ATE369375 T1 AT E369375T1 AT 03718663 T AT03718663 T AT 03718663T AT 03718663 T AT03718663 T AT 03718663T AT E369375 T1 ATE369375 T1 AT E369375T1
Authority
AT
Austria
Prior art keywords
lna
synthesis
nucleic acid
acid derivatives
locked nucleic
Prior art date
Application number
AT03718663T
Other languages
English (en)
Inventor
Mads Sorensen
Jesper Wengel
Troels Koch
Signe Christensen
Christoph Rosenbohm
Daniel Sejer Pedersen
Original Assignee
Santaris Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santaris Pharma As filed Critical Santaris Pharma As
Application granted granted Critical
Publication of ATE369375T1 publication Critical patent/ATE369375T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT03718663T 2002-05-08 2003-05-08 Synthese von locked nucleic acid-derivaten ATE369375T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200200712 2002-05-08
DKPA200201214 2002-08-16

Publications (1)

Publication Number Publication Date
ATE369375T1 true ATE369375T1 (de) 2007-08-15

Family

ID=29421786

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03718663T ATE369375T1 (de) 2002-05-08 2003-05-08 Synthese von locked nucleic acid-derivaten

Country Status (9)

Country Link
EP (1) EP1501848B1 (de)
JP (1) JP4476802B2 (de)
AT (1) ATE369375T1 (de)
AU (1) AU2003222743B2 (de)
CA (1) CA2484526C (de)
DE (1) DE60315444T2 (de)
DK (1) DK1501848T3 (de)
ES (1) ES2290448T3 (de)
WO (1) WO2003095467A1 (de)

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US8492357B2 (en) 2008-08-01 2013-07-23 Santaris Pharma A/S Micro-RNA mediated modulation of colony stimulating factors
JP5773535B2 (ja) 2009-04-24 2015-09-02 ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブＲｏｃｈｅ Ｉｎｎｏｖａｔｉｏｎ Ｃｅｎｔｅｒ Ｃｏｐｅｎｈａｇｅｎ Ａ／Ｓ インターフェロンに非応答性のｈｃｖ患者の治療のための医薬組成物
US8563528B2 (en) 2009-07-21 2013-10-22 Santaris Pharma A/S Antisense oligomers targeting PCSK9
WO2011105901A2 (en) 2010-02-23 2011-09-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Antagonists of complement component 9 (c9) and uses thereof
WO2011105900A2 (en) 2010-02-23 2011-09-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Antagonists of complement component 8-alpha (c8-alpha) and uses thereof
WO2011105902A2 (en) 2010-02-23 2011-09-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Antagonists of complement component 8-beta (c8-beta) and uses thereof
EP3214174B1 (de) 2010-03-04 2019-10-16 InteRNA Technologies B.V. Mirna-molekül, das über seine quelle definiert ist, und seine diagnostischen und therapeutischen verwendungen bei mit emt assoziierten krankheiten
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GB201410693D0 (en) 2014-06-16 2014-07-30 Univ Southampton Splicing modulation
EP3201339A4 (de) 2014-10-03 2018-09-19 Cold Spring Harbor Laboratory Gezielten erhöhung der nukleären genleistung
US10731154B2 (en) 2015-02-15 2020-08-04 Arcturus Therapeutics, Inc. Acyl-amino-LNA and/or hydrocarbyl-amino-LNA oligonucleotides
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EP4332239A1 (de) 2022-08-30 2024-03-06 Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l. Mir-basierter test zur diagnose und prognose von gastro-entero-pankreatischen neuroendokrinen tumoren
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Also Published As

Publication number Publication date
DE60315444D1 (en) 2007-09-20
CA2484526A1 (en) 2003-11-20
ES2290448T3 (es) 2008-02-16
WO2003095467A1 (en) 2003-11-20
DE60315444T2 (de) 2008-04-30
JP4476802B2 (ja) 2010-06-09
CA2484526C (en) 2009-10-13
EP1501848B1 (de) 2007-08-08
AU2003222743B2 (en) 2008-12-11
DK1501848T3 (da) 2007-10-22
EP1501848A1 (de) 2005-02-02
JP2005532319A (ja) 2005-10-27
AU2003222743A1 (en) 2003-11-11

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