ATE370135T1 - Substituierte piperidine als histamin-h3- rezeptorliganden - Google Patents
Substituierte piperidine als histamin-h3- rezeptorligandenInfo
- Publication number
- ATE370135T1 ATE370135T1 AT04763339T AT04763339T ATE370135T1 AT E370135 T1 ATE370135 T1 AT E370135T1 AT 04763339 T AT04763339 T AT 04763339T AT 04763339 T AT04763339 T AT 04763339T AT E370135 T1 ATE370135 T1 AT E370135T1
- Authority
- AT
- Austria
- Prior art keywords
- histamine
- receptor ligands
- substituted piperidines
- piperidines
- substituted
- Prior art date
Links
- 102000004384 Histamine H3 receptors Human genes 0.000 title 1
- 108090000981 Histamine H3 receptors Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000003053 piperidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Addiction (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0316893A GB0316893D0 (en) | 2003-07-18 | 2003-07-18 | Novel compounds |
| GB0411167A GB0411167D0 (en) | 2004-05-19 | 2004-05-19 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE370135T1 true ATE370135T1 (de) | 2007-09-15 |
Family
ID=34137741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04763339T ATE370135T1 (de) | 2003-07-18 | 2004-07-16 | Substituierte piperidine als histamin-h3- rezeptorliganden |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060247227A1 (de) |
| EP (1) | EP1646620B1 (de) |
| JP (1) | JP2006528147A (de) |
| AR (1) | AR045999A1 (de) |
| AT (1) | ATE370135T1 (de) |
| DE (1) | DE602004008291T2 (de) |
| ES (1) | ES2291913T3 (de) |
| TW (1) | TW200514781A (de) |
| WO (1) | WO2005014571A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007010350A1 (en) * | 2005-07-19 | 2007-01-25 | Pfizer Products Inc. | Synthesis of therapeutic diphenyl ethers |
| US7851474B2 (en) | 2005-08-02 | 2010-12-14 | Neurogen Corporation | Dipiperazinyl ketones and related analogues |
| JP5603770B2 (ja) | 2007-05-31 | 2014-10-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ２受容体拮抗薬およびその使用 |
| CA2700963A1 (en) * | 2007-09-28 | 2009-04-09 | Schering Corporation | Oxypiperidine derivatives and methods of use thereof |
| CN102256963B (zh) | 2008-12-19 | 2014-06-11 | 贝林格尔.英格海姆国际有限公司 | 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺 |
| ES2674275T3 (es) | 2009-12-17 | 2018-06-28 | Centrexion Therapeutics Corporation | Antagonistas del receptor CCR2 y usos de los mismos |
| JP5646736B2 (ja) | 2010-05-12 | 2014-12-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ｃｃｒ２受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用 |
| WO2011141474A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| WO2011144501A1 (en) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Ccr2 antagonists and uses thereof |
| CN102260277B (zh) | 2010-05-24 | 2013-07-24 | 中国科学院上海药物研究所 | 新型苯并噁嗪噁唑烷酮类化合物及其制备方法和用途 |
| WO2011147772A1 (en) | 2010-05-25 | 2011-12-01 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists |
| US8962656B2 (en) | 2010-06-01 | 2015-02-24 | Boehringer Ingelheim International Gmbh | CCR2 antagonists |
| PE20130774A1 (es) | 2010-07-29 | 2013-06-26 | Rigel Pharmaceuticals Inc | Compuestos heterociclicos activadores de ampk y metodos para emplearlos |
| EP2731941B1 (de) | 2011-07-15 | 2019-05-08 | Boehringer Ingelheim International GmbH | Neuartige und selektive ccr2-antagonisten |
| CN104114538B (zh) * | 2012-01-16 | 2016-04-13 | 葛兰素史克知识产权发展有限公司 | 治疗用途 |
| AU2013211417A1 (en) * | 2012-01-16 | 2014-07-31 | Glaxosmithkline Intellectual Property Development Limited | Therapeutic uses |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| EP2647377A1 (de) | 2012-04-06 | 2013-10-09 | Sanofi | Verwendung eines H3-Rezeptorantagonisten zur Behandlung von Morbus Alzheimer |
| PT3317270T (pt) | 2015-07-02 | 2020-08-24 | Centrexion Therapeutics Corp | (4-((3r,4r)-3-metoxitetrahidro-pirano-4-ilamino)piperidina-1-il)(5-metil-6-(((2r,6s)-6-(p-tolil)tetrahidro-2h-pirano-2-il)metilamino)pirimidina-4-il)citrato de metanona |
| WO2017095758A1 (en) * | 2015-12-01 | 2017-06-08 | Merck Sharp & Dohme Corp. | Homobispiperidinyl derivatives as liver x receptor beta agonists, compositions, and their use |
| EP4506344A4 (de) * | 2022-03-31 | 2026-04-22 | Bebetter Med Inc | 1,4-diheterocyclisch substituierter aromatischer ring oder aromatische heterocyclische verbindung und verwendung davon |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
| AU2002253929A1 (en) * | 2001-02-08 | 2002-09-24 | Schering Corporation | Use of dual h3/m2 antagonists with a bipiperidinic structure in the treatment of cognition deficit disorders |
| WO2003031432A1 (en) * | 2001-10-12 | 2003-04-17 | Novo Nordisk A/S | Substituted piperidines and their use for the treatment of diseases related to the histamine h3 receptor |
| JPWO2003104230A1 (ja) * | 2002-06-07 | 2005-10-06 | 協和醗酵工業株式会社 | 二環性ピリミジン誘導体 |
-
2004
- 2004-07-16 JP JP2006520762A patent/JP2006528147A/ja active Pending
- 2004-07-16 WO PCT/EP2004/008061 patent/WO2005014571A1/en not_active Ceased
- 2004-07-16 AT AT04763339T patent/ATE370135T1/de not_active IP Right Cessation
- 2004-07-16 US US10/564,931 patent/US20060247227A1/en not_active Abandoned
- 2004-07-16 DE DE602004008291T patent/DE602004008291T2/de not_active Expired - Fee Related
- 2004-07-16 EP EP04763339A patent/EP1646620B1/de not_active Expired - Lifetime
- 2004-07-16 AR ARP040102526A patent/AR045999A1/es unknown
- 2004-07-16 TW TW093121228A patent/TW200514781A/zh unknown
- 2004-07-16 ES ES04763339T patent/ES2291913T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1646620A1 (de) | 2006-04-19 |
| JP2006528147A (ja) | 2006-12-14 |
| DE602004008291T2 (de) | 2008-05-08 |
| US20060247227A1 (en) | 2006-11-02 |
| DE602004008291D1 (de) | 2007-09-27 |
| EP1646620B1 (de) | 2007-08-15 |
| WO2005014571A1 (en) | 2005-02-17 |
| AR045999A1 (es) | 2005-11-23 |
| TW200514781A (en) | 2005-05-01 |
| ES2291913T3 (es) | 2008-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE370135T1 (de) | Substituierte piperidine als histamin-h3- rezeptorliganden | |
| ZA200700683B (en) | Piperidine derivatives as histamine H3 receptor ligands | |
| ATE529112T1 (de) | 1-(4-piperidinyl)benzimidazolone als histamin h3 antagonisten | |
| ATE494285T1 (de) | Muscarinische acetylcholin-rezeptor-antagonisten | |
| ATE448217T1 (de) | Substituierte piperidine als renin-inhibitoren | |
| DE602006010870D1 (de) | Als antagonisten von histamin h3 geeignete piperidinderivate | |
| ATE389406T1 (de) | 1-(4-piperidinyl)benzimidazole als histamin h3 antagonisten | |
| DE60137461D1 (de) | Substituierte Piperidinverbindungen zur Verwendung als H3 Histaminerezeptorantagonisten | |
| DK1682142T3 (da) | M3-muscarin-acetylcholin-receptor-antagonister | |
| DE60331751D1 (de) | N-substituierte 2-oxodihydropyridinderivate als npy antagonisten | |
| DK1515969T3 (da) | Spiroindolinpiperidinderivater | |
| ATE344798T1 (de) | Als histamin-h3-antagonisten geeignete indolderivate | |
| NO20053650D0 (no) | Nedihullsverktoy | |
| ATE414698T1 (de) | Durch 5gliedrige heterocyclen substituierte mtp- inhibierende arylpiperidine oder -piperazine | |
| DE602005005080D1 (de) | Pyrrolidinderivate als histaminrezeptor-liganden | |
| DE60320529D1 (de) | Chinolinderivate als npy antagonisten | |
| DK1472256T3 (da) | Piperidinderivater | |
| DE60314170D1 (de) | Substituierte 4-amino-1-(pyridylmethyl)piperidine zur verwendung als muscarinrezeptor-antagonisten | |
| ATE479681T1 (de) | Substituierte piperidine | |
| DE60316411D1 (de) | Thiazolderivate als npy-rezeptorantagonisten | |
| ATE364602T1 (de) | 4-(aminomethyl)-piperidinbenzamide als 5ht4 - antagonisten | |
| DE602004015610D1 (de) | 3-fluoro-piperidine als nmda/nr2b antagonisten | |
| ATE377008T1 (de) | Imidazolderivate als glutamatrezeptorantagonisten | |
| ATE471321T1 (de) | Substituierte piperidine als renin-inhibitoren | |
| ATE390413T1 (de) | 4-(2-phenylsulfanyl-phenyl)-1,2,3,6- tetrahydropyridinderivaten zur verwendung als serotonin-wiederaufnahmehemmer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |