ATE370140T1 - Kondensierte bicyclische pyrimidinderivate - Google Patents

Kondensierte bicyclische pyrimidinderivate

Info

Publication number: ATE370140T1
Authority: AT; Austria
Prior art keywords: ring; bicyclic pyrimidine; pyrimidine derivatives; condensed bicyclic; receptor antagonist
Prior art date: 2002-03-26

Application number

AT03712828T

Other languages

English (en)

Inventor

Shigeki Seto

Asao Tanioka

Makoto Ikeda

Shigeru Izawa

Original Assignee

Kyorin Seiyaku Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-26

Filing date

2003-03-24

Publication date

2007-09-15

2003-03-24 Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk

2007-09-15 Application granted granted Critical

2007-09-15 Publication of ATE370140T1 publication Critical patent/ATE370140T1/de

Links

CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
102000002002 Neurokinin-1 Receptors Human genes 0.000 abstract 1
108010040718 Neurokinin-1 Receptors Proteins 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
-1 bicyclic pyrimidine derivative Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
239000002464 receptor antagonist Substances 0.000 abstract 1
229940044551 receptor antagonist Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
239000002462 tachykinin receptor antagonist Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Immunology (AREA)
Toxicology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT03712828T 2002-03-26 2003-03-24 Kondensierte bicyclische pyrimidinderivate ATE370140T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2002084759		2002-03-26

Publications (1)

Publication Number	Publication Date
ATE370140T1 true ATE370140T1 (de)	2007-09-15

Family

ID=28449223

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03712828T ATE370140T1 (de)	2002-03-26	2003-03-24	Kondensierte bicyclische pyrimidinderivate

Country Status (16)

Country	Link
US (1)	US7064119B2 (de)
EP (1)	EP1496059B1 (de)
JP (1)	JP4402959B2 (de)
KR (1)	KR20040093182A (de)
CN (1)	CN1330654C (de)
AT (1)	ATE370140T1 (de)
AU (1)	AU2003221205B2 (de)
BR (1)	BR0308844A (de)
CA (1)	CA2479277A1 (de)
DE (1)	DE60315626T2 (de)
DK (1)	DK1496059T3 (de)
MX (1)	MXPA04009300A (de)
NO (1)	NO20044331L (de)
NZ (1)	NZ535183A (de)
PT (1)	PT1496059E (de)
WO (1)	WO2003080619A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2004283038B9 (en) *	2003-10-27	2008-04-24	Novartis Ag	Use of neurokinin antagonists in the treatment of urinary incontinence
US20070183439A1 (en) *	2006-01-05	2007-08-09	Osann Robert Jr	Combined directional and mobile interleaved wireless mesh network
US20070297366A1 (en) *	2006-01-05	2007-12-27	Robert Osann	Synchronized wireless mesh network
US8102868B2 (en) *	2006-01-05	2012-01-24	Folusha Forte B.V., Llc	Interleaved and directional wireless mesh network
TW200914457A (en) *	2007-05-31	2009-04-01	Kyowa Hakko Kogyo Kk	Pyrimidodiazepinone derivative
CN115368363B (zh) *	2021-05-17	2024-02-20	中山大学	一种手性或消旋的嘧啶并二氮杂环庚酮类化合物及其制备方法和应用
WO2026154417A1 (en) *	2025-01-17	2026-07-23	Pfizer Inc.	Fused heterocyclic amide/sulfonamide compounds as agonists of the calcitonin/amylin receptors for the treatment of obesity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3993264B2 (ja)	1995-03-24	2007-10-17	武田薬品工業株式会社	環状化合物、その製造法および剤
US5770590A (en)	1995-03-24	1998-06-23	Takeda Chemical Industries, Ltd.	Cyclic compounds, their prudiction and use
JP2976097B2 (ja) *	1995-03-24	1999-11-10	武田薬品工業株式会社	環状化合物、その製造法および剤
JP2002348289A (ja)	2001-03-19	2002-12-04	Takeda Chem Ind Ltd	３環性複素環化合物、その製造法および用途

2003
- 2003-03-24 CN CNB038120410A patent/CN1330654C/zh not_active Expired - Fee Related
- 2003-03-24 US US10/509,224 patent/US7064119B2/en not_active Expired - Fee Related
- 2003-03-24 JP JP2003578373A patent/JP4402959B2/ja not_active Expired - Fee Related
- 2003-03-24 AT AT03712828T patent/ATE370140T1/de not_active IP Right Cessation
- 2003-03-24 AU AU2003221205A patent/AU2003221205B2/en not_active Ceased
- 2003-03-24 PT PT03712828T patent/PT1496059E/pt unknown
- 2003-03-24 MX MXPA04009300A patent/MXPA04009300A/es active IP Right Grant
- 2003-03-24 KR KR10-2004-7015036A patent/KR20040093182A/ko not_active Ceased
- 2003-03-24 WO PCT/JP2003/003488 patent/WO2003080619A1/ja not_active Ceased
- 2003-03-24 BR BR0308844-8A patent/BR0308844A/pt not_active IP Right Cessation
- 2003-03-24 CA CA002479277A patent/CA2479277A1/en not_active Abandoned
- 2003-03-24 DK DK03712828T patent/DK1496059T3/da active
- 2003-03-24 NZ NZ535183A patent/NZ535183A/xx unknown
- 2003-03-24 EP EP03712828A patent/EP1496059B1/de not_active Expired - Lifetime
- 2003-03-24 DE DE60315626T patent/DE60315626T2/de not_active Expired - Fee Related
2004
- 2004-10-12 NO NO20044331A patent/NO20044331L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP4402959B2 (ja)	2010-01-20
EP1496059B1 (de)	2007-08-15
US7064119B2 (en)	2006-06-20
AU2003221205B2 (en)	2008-09-18
US20050159409A1 (en)	2005-07-21
DK1496059T3 (da)	2007-12-03
PT1496059E (pt)	2007-10-29
KR20040093182A (ko)	2004-11-04
EP1496059A1 (de)	2005-01-12
DE60315626T2 (de)	2008-06-05
EP1496059A4 (de)	2006-02-08
NZ535183A (en)	2006-03-31
AU2003221205A1 (en)	2003-10-08
NO20044331L (no)	2004-10-25
CN1330654C (zh)	2007-08-08
JPWO2003080619A1 (ja)	2005-07-21
DE60315626D1 (de)	2007-09-27
MXPA04009300A (es)	2005-01-25
WO2003080619A1 (en)	2003-10-02
CN1656098A (zh)	2005-08-17
CA2479277A1 (en)	2003-10-02
BR0308844A (pt)	2005-01-04

Legal Events

Date	Code	Title	Description
2008-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
BRPI0414592A (pt)	2006-11-07	antagonistas de receptores de trombina
CY1113029T1 (el)	2016-04-13	Παραγωγα αζαδικυκλο [3.1.0] εξανιου χρησιμα ως ρυθμιστες υποδοχεων d3 ντοπαμινης
NO20071642L (no)	2007-06-01	N-Benzensulfonylsubstituerte anilino-pyrimidinanaloger
ATE429427T1 (de)	2009-05-15	Pyrimidinderivate als orexin-rezeptorantagonisten
EA200300595A1 (ru)	2003-10-30	Соединения пиперазинилпиразинов в качестве антагонистов серотонин 5-ht2 рецептора
BRPI0000596B8 (pt)	2021-05-25	composto piridona, processo de produção do composto, composição farmacêutica, e uso do dito composto
BR0315405A (pt)	2005-08-09	Compostos inibidores da integrase tricìclica pré-organizados
NO20050418L (no)	2005-04-28	Kondenserte pyridiner og pyrimidiner med TIE2(TEK) aktivitet
ATE377602T1 (de)	2007-11-15	Morphinanderivate und ihre medizinische anwendung
MXPA05013474A (es)	2006-03-09	Derivados de quinolilamida como antagonistas de ccr-5.
ATE427310T1 (de)	2009-04-15	Kondensierte bicyclische pyrimidinderivate
ATE374190T1 (de)	2007-10-15	Tetrahydrochinazolinderivate als cfr-antagonisten
EA200401455A1 (ru)	2005-06-30	Производные бензоксазина в качестве модуляторов 5-htи их применение
ATE503746T1 (de)	2011-04-15	Neue imidazolidinderivate
FR2801585B1 (fr)	2002-02-15	Nouveaux antagonistes des recepteurs de l'ii-8
EA200301317A1 (ru)	2004-06-24	Производные аминохинолина и его применение в качестве лигандов аденозина a3
DE60315626D1 (de)	2007-09-27	Kondensierte bicyclische pyrimidinderivate
TW200609218A (en)	2006-03-16	Bicyclic compounds
CY1108837T1 (el)	2014-07-02	ΝΕΑ ΠΑΡΑΓΩΓΑ ΑΜΙΝΟΠΥΡΙΔΙΝΗΣ ΩΣ ΑΝΤΑΓΩΝΙΣΤΕΣ mGluR5
EA200401077A1 (ru)	2005-06-30	2-оксазоламины и их применение в качестве антагонистов рецептора 5-ht2b
EA200400822A1 (ru)	2004-12-30	Производные 3,4-дигидро-1h-изохинолин-2-ила
MY139258A (en)	2009-09-30	Carbamoyl-type benzofuran derivatives
EA200700179A1 (ru)	2007-08-31	Производные пиррола, их получение и их применение в терапии
EA200300226A1 (ru)	2003-10-30	ГЕМ-ЗАМЕЩЕННЫЕ АНТАГОНИСТЫ ИНТЕГРИНА αvβ3
EP1489083A4 (de)	2006-02-08	Kondensierte, bicyclische pyridinderivate als antagonisten des tachykininrezeptors