ATE371680T1 - Polymerkonjugate - Google Patents
PolymerkonjugateInfo
- Publication number
- ATE371680T1 ATE371680T1 AT03700372T AT03700372T ATE371680T1 AT E371680 T1 ATE371680 T1 AT E371680T1 AT 03700372 T AT03700372 T AT 03700372T AT 03700372 T AT03700372 T AT 03700372T AT E371680 T1 ATE371680 T1 AT E371680T1
- Authority
- AT
- Austria
- Prior art keywords
- conjugates
- moiety
- polydispersity
- biologically active
- active compounds
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000178 monomer Substances 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- ZJXZSIYSNXKHEA-UHFFFAOYSA-N ethyl dihydrogen phosphate Chemical compound CCOP(O)(O)=O ZJXZSIYSNXKHEA-UHFFFAOYSA-N 0.000 abstract 1
- 230000000977 initiatory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F246/00—Copolymers in which the nature of only the monomers in minority is defined
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicinal Preparation (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02250289 | 2002-01-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE371680T1 true ATE371680T1 (de) | 2007-09-15 |
Family
ID=27589157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03700372T ATE371680T1 (de) | 2002-01-16 | 2003-01-16 | Polymerkonjugate |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8048408B2 (de) |
| EP (1) | EP1465933B1 (de) |
| AT (1) | ATE371680T1 (de) |
| DE (1) | DE60315949T2 (de) |
| ES (1) | ES2291613T3 (de) |
| WO (1) | WO2003062290A1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003062290A1 (en) | 2002-01-16 | 2003-07-31 | Biocompatibles Uk Limited | Polymer conjugates |
| EP1480619B1 (de) * | 2002-03-07 | 2013-08-07 | Biocompatibles UK Limited | Wirkstoffträger enthaltend amphiphile blockcopolymere |
| EP1480680B1 (de) | 2002-03-07 | 2010-11-03 | Biocompatibles UK Limited | Mit nucleinsäure complexierte block-copolymere |
| GB0301014D0 (en) * | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
| EP1590388A2 (de) * | 2003-02-05 | 2005-11-02 | Biocompatibles UK Limited | Blockcopolymere |
| GB0314472D0 (en) * | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
| WO2006003352A1 (en) * | 2004-07-06 | 2006-01-12 | Warwick Effect Polymers Limited | Living radical polymerization initiator comprising a functional group capable of reacting with polyeptides or the like, comb polymer obtained therewith, polypeptide conjugates and drugs obtained therefrom |
| WO2005039641A2 (en) * | 2003-10-15 | 2005-05-06 | The Regents Of The University Of California | Biomacromolecule polymer conjugates |
| PL1701940T3 (pl) * | 2003-12-23 | 2008-11-28 | H Lundbeck As | Pochodne 2-(1H-indolilosulfanylo)benzyloaminy jako SSRI |
| AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
| AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
| EP3222142A1 (de) | 2006-02-28 | 2017-09-27 | Kodiak Sciences Inc. | Acryloyloxyethylphosphorylcholin-haltige polymerkonjugate und deren herstellung |
| ES2444695T3 (es) * | 2006-06-23 | 2014-02-26 | Alethia Biotherapeutics Inc. | Polinucleótidos y polipéptidos implicados en el cáncer |
| JP2008060540A (ja) * | 2006-08-03 | 2008-03-13 | Seiko Epson Corp | 電子デバイスの製造方法、電子デバイスおよび電子機器 |
| WO2008025856A2 (en) | 2006-09-01 | 2008-03-06 | Novo Nordisk Health Care Ag | Modified glycoproteins |
| US8575397B2 (en) | 2007-02-14 | 2013-11-05 | Biocompatibles Uk Limited | Derivatisation of biological molecules |
| PL2257311T3 (pl) | 2008-02-27 | 2014-09-30 | Novo Nordisk As | Koniugaty cząsteczek czynnika VIII |
| CA2740900C (en) | 2008-11-03 | 2019-09-24 | Alethia Biotherapeutics Inc. | Antibodies that specifically block the biological activity of a tumor antigen |
| EP2260873B1 (de) | 2009-06-08 | 2019-07-24 | Biocompatibles UK Limited | Pcylierung von proteinen |
| WO2011075185A1 (en) | 2009-12-18 | 2011-06-23 | Oligasis | Targeted drug phosphorylcholine polymer conjugates |
| EP2536753B1 (de) | 2010-02-16 | 2017-12-20 | Novo Nordisk A/S | Faktor-VIII-Moleküle mit reduzierter VWF-Bindung |
| CN102905690B (zh) * | 2010-05-21 | 2016-03-30 | 西门子医疗保健诊断公司 | 两性离子试剂 |
| SI3173427T1 (sl) | 2011-03-31 | 2019-08-30 | ADC Therapeutics SA, | Protitelesa proti antigenu 1, povezanemu z ledvicami, in antigen vezavni fragmenti le-tega |
| AU2012311484B2 (en) | 2011-09-23 | 2017-04-13 | Novo Nordisk A/S | Novel glucagon analogues |
| KR102102239B1 (ko) | 2012-01-09 | 2020-04-21 | 에이디씨 테라퓨틱스 에스에이 | 유방암을 치료하기 위한 방법 |
| MX366404B (es) * | 2012-11-15 | 2019-07-08 | Apellis Pharmaceuticals Inc | Analogos de compstatina de celula reactiva, de acción prolongada u objetivos y composiciones y metodos relacionados. |
| EP2986313B1 (de) | 2013-04-18 | 2019-06-12 | Novo Nordisk A/S | Stabile, zeitverzögerte coagonisten des glucagon/glp-1-rezeptors |
| WO2015035342A2 (en) | 2013-09-08 | 2015-03-12 | Oligasis Llc | Factor viii zwitterionic polymer conjugates |
| US9309336B2 (en) | 2013-11-27 | 2016-04-12 | King Fahd University Of Petroleum And Minerals | Synthesis and antiscalant behavior of a novel polyzwitterionic acid |
| US10570184B2 (en) | 2014-06-04 | 2020-02-25 | Novo Nordisk A/S | GLP-1/glucagon receptor co-agonists for medical use |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| KR20210013299A (ko) | 2014-10-17 | 2021-02-03 | 코디악 사이언시스 인코포레이티드 | 부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트 |
| KR20250057128A (ko) | 2015-12-30 | 2025-04-28 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| EP3758737A4 (de) | 2018-03-02 | 2022-10-12 | Kodiak Sciences Inc. | Il-6-antikörper und fusionskonstrukte und konjugate davon |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| JP7849049B2 (ja) * | 2020-08-21 | 2026-04-21 | ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ テキサス システム | 機能性のイオン化可能なリン脂質 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260373A (en) * | 1987-03-13 | 1993-11-09 | Repligen Corporation | Immobilized immunoglobulin-binding proteins |
| WO1989005305A1 (en) * | 1987-12-09 | 1989-06-15 | 3I Research Exploitation Limited | Polymers and polymer-peptide conjugates |
| US5162430A (en) * | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
| US5122614A (en) * | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| SE466754B (sv) * | 1990-09-13 | 1992-03-30 | Berol Nobel Ab | Saett att kovalent binda biopolymerer till hydrofila ytor |
| US5286846A (en) * | 1991-06-14 | 1994-02-15 | The Government Of The United States Of America As Represented By The Dept. Of Health And Human Services | Amino acid derivative and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides |
| WO1993001221A1 (en) | 1991-07-05 | 1993-01-21 | Biocompatibles Limited | Polymeric surface coatings |
| JPH05220218A (ja) * | 1992-02-13 | 1993-08-31 | Norio Nakabayashi | 抗血栓性再生セルロース系膜及びその製造方法 |
| IL104734A0 (en) * | 1993-02-15 | 1993-06-10 | Univ Bar Ilan | Bioactive conjugates of cellulose with amino compounds |
| US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| EP0796112A4 (de) * | 1994-11-30 | 1999-12-01 | Amur Research Corp | Phosphocholin-arzneistoffderivate |
| US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5763548A (en) | 1995-03-31 | 1998-06-09 | Carnegie-Mellon University | (Co)polymers and a novel polymerization process based on atom (or group) transfer radical polymerization |
| TW517067B (en) * | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| DE69707452T3 (de) * | 1996-06-12 | 2015-07-23 | Warwick Effect Polymers Ltd. | Polymerisation-katalysator und -verfahren |
| EP0948341A4 (de) * | 1996-09-17 | 2003-05-21 | Supergen Inc | Derivate von phospholipide medikamenten |
| US5830432A (en) * | 1997-03-31 | 1998-11-03 | Amur Pharmacuticals, Inc. | Phospholipid drug derivatives |
| EP0922446A1 (de) * | 1997-12-03 | 1999-06-16 | Applied Research Systems Ars Holding N.V. | Lösungsphase Verfahrung zur ortspezifischer Herstellung von GRF-PEG Konjugaten |
| US6251382B1 (en) * | 1998-04-17 | 2001-06-26 | Enzon, Inc. | Biodegradable high molecular weight polymeric linkers and their conjugates |
| US6562330B1 (en) * | 1998-11-13 | 2003-05-13 | Biocompatibles Limited | Therapeutic use of polymers |
| DE60027309T2 (de) * | 1999-07-02 | 2006-08-31 | Symyx Technologies, Inc., Santa Clara | Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen |
| AU7025600A (en) * | 1999-09-08 | 2001-04-10 | School Of Pharmacy, University Of London, The | Uniform molecular weight polymers |
| GB9924502D0 (en) * | 1999-10-15 | 1999-12-15 | Biocompatibles Ltd | Polymer blend materials |
| EP1122258B1 (de) * | 2000-02-07 | 2004-05-12 | Biocompatibles UK Limited | Silizium enthaltende Verbindungen hergestellt durch Michael Addition als Monomere und Macromere |
| AU2001274146A1 (en) * | 2000-05-29 | 2001-12-11 | Bio Merieux | Biocompatible polymer for fixing biological ligands |
| AU2001292092A1 (en) * | 2000-10-06 | 2002-04-15 | Biocompatibles Uk Limited | Zwitterionic polymers |
| US6652886B2 (en) * | 2001-02-16 | 2003-11-25 | Expression Genetics | Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents |
| JP4577747B2 (ja) * | 2001-06-05 | 2010-11-10 | 和光純薬工業株式会社 | 免疫学的測定法用凝集促進剤 |
| US6939564B2 (en) | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
| US6908963B2 (en) * | 2001-10-09 | 2005-06-21 | Nektar Therapeutics Al, Corporation | Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith |
| WO2003062290A1 (en) | 2002-01-16 | 2003-07-31 | Biocompatibles Uk Limited | Polymer conjugates |
| EP1480680B1 (de) * | 2002-03-07 | 2010-11-03 | Biocompatibles UK Limited | Mit nucleinsäure complexierte block-copolymere |
| EP1480619B1 (de) * | 2002-03-07 | 2013-08-07 | Biocompatibles UK Limited | Wirkstoffträger enthaltend amphiphile blockcopolymere |
| GB0301014D0 (en) * | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
| EP1590388A2 (de) * | 2003-02-05 | 2005-11-02 | Biocompatibles UK Limited | Blockcopolymere |
| CA2515612A1 (en) * | 2003-02-19 | 2004-09-02 | Pharmacia Corporation | Activated polyethylene glycol esters |
| BRPI0407882B1 (pt) * | 2003-02-26 | 2021-07-27 | Nektar Therapeutics | Composição compreendendo conjugados de polímero-porção de fator viii e seu método de fabricação |
| BRPI0412671A (pt) * | 2003-08-08 | 2006-10-03 | Fresenius Kabi De Gmbh | conjugados de um polìmero e uma proteìna ligados por um grupo de ligação de oxima |
| WO2005039641A2 (en) * | 2003-10-15 | 2005-05-06 | The Regents Of The University Of California | Biomacromolecule polymer conjugates |
| US7179874B2 (en) * | 2003-11-21 | 2007-02-20 | Chia Nan University Of Pharmacy And Science | Biodegradable cationic polymer |
| US7365127B2 (en) * | 2005-02-04 | 2008-04-29 | Enzon Pharmaceuticals, Inc. | Process for the preparation of polymer conjugates |
| US20070123646A1 (en) * | 2005-09-13 | 2007-05-31 | Lele Bhalchandra S | Protein-polymer conjugates and synthesis thereof |
-
2003
- 2003-01-16 WO PCT/GB2003/000131 patent/WO2003062290A1/en not_active Ceased
- 2003-01-16 DE DE60315949T patent/DE60315949T2/de not_active Expired - Lifetime
- 2003-01-16 EP EP03700372A patent/EP1465933B1/de not_active Expired - Lifetime
- 2003-01-16 AT AT03700372T patent/ATE371680T1/de not_active IP Right Cessation
- 2003-01-16 US US10/501,393 patent/US8048408B2/en active Active
- 2003-01-16 ES ES03700372T patent/ES2291613T3/es not_active Expired - Lifetime
-
2011
- 2011-09-23 US US13/243,887 patent/US8431113B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1465933A1 (de) | 2004-10-13 |
| US20050123501A1 (en) | 2005-06-09 |
| US8431113B2 (en) | 2013-04-30 |
| WO2003062290A1 (en) | 2003-07-31 |
| ES2291613T3 (es) | 2008-03-01 |
| DE60315949T2 (de) | 2008-06-12 |
| EP1465933B1 (de) | 2007-08-29 |
| DE60315949D1 (de) | 2007-10-11 |
| US8048408B2 (en) | 2011-11-01 |
| US20120016085A1 (en) | 2012-01-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |