ATE371680T1 - Polymerkonjugate - Google Patents
PolymerkonjugateInfo
- Publication number
- ATE371680T1 ATE371680T1 AT03700372T AT03700372T ATE371680T1 AT E371680 T1 ATE371680 T1 AT E371680T1 AT 03700372 T AT03700372 T AT 03700372T AT 03700372 T AT03700372 T AT 03700372T AT E371680 T1 ATE371680 T1 AT E371680T1
- Authority
- AT
- Austria
- Prior art keywords
- conjugates
- moiety
- polydispersity
- biologically active
- active compounds
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000178 monomer Substances 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- ZJXZSIYSNXKHEA-UHFFFAOYSA-N ethyl dihydrogen phosphate Chemical compound CCOP(O)(O)=O ZJXZSIYSNXKHEA-UHFFFAOYSA-N 0.000 abstract 1
- 230000000977 initiatory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F246/00—Copolymers in which the nature of only the monomers in minority is defined
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicinal Preparation (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02250289 | 2002-01-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE371680T1 true ATE371680T1 (de) | 2007-09-15 |
Family
ID=27589157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03700372T ATE371680T1 (de) | 2002-01-16 | 2003-01-16 | Polymerkonjugate |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8048408B2 (de) |
| EP (1) | EP1465933B1 (de) |
| AT (1) | ATE371680T1 (de) |
| DE (1) | DE60315949T2 (de) |
| ES (1) | ES2291613T3 (de) |
| WO (1) | WO2003062290A1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003062290A1 (en) | 2002-01-16 | 2003-07-31 | Biocompatibles Uk Limited | Polymer conjugates |
| EP1480680B1 (de) | 2002-03-07 | 2010-11-03 | Biocompatibles UK Limited | Mit nucleinsäure complexierte block-copolymere |
| US20050220880A1 (en) * | 2002-03-07 | 2005-10-06 | Lewis Andrew L | Drug carriers comprising amphiphilic block copolymers |
| GB0301014D0 (en) * | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
| WO2004069888A2 (en) * | 2003-02-05 | 2004-08-19 | Biocompatibles Uk Limited | Block copolymers |
| WO2006003352A1 (en) * | 2004-07-06 | 2006-01-12 | Warwick Effect Polymers Limited | Living radical polymerization initiator comprising a functional group capable of reacting with polyeptides or the like, comb polymer obtained therewith, polypeptide conjugates and drugs obtained therefrom |
| GB0314472D0 (en) * | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
| WO2005039641A2 (en) * | 2003-10-15 | 2005-05-06 | The Regents Of The University Of California | Biomacromolecule polymer conjugates |
| RS50589B (sr) * | 2003-12-23 | 2010-05-07 | H. Lundbeck A/S. | 2-(1h-indolilsulfanil)-benzil amin derivati kao ssri |
| AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
| AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
| ES2657628T3 (es) * | 2006-02-28 | 2018-03-06 | Kodiak Sciences Inc. | Conjugados poliméricos que contienen acriloiloxietilfosforilcolina y su preparación |
| JP5564249B2 (ja) | 2006-06-23 | 2014-07-30 | アレシア・バイオセラピューティクス・インコーポレーテッド | 癌に関与するポリヌクレオチド配列およびポリペプチド配列 |
| JP2008060540A (ja) * | 2006-08-03 | 2008-03-13 | Seiko Epson Corp | 電子デバイスの製造方法、電子デバイスおよび電子機器 |
| EP2059527B1 (de) | 2006-09-01 | 2014-12-03 | Novo Nordisk Health Care AG | Modifizierte glykoproteine |
| WO2008098930A1 (en) | 2007-02-14 | 2008-08-21 | Biocompatibes Uk Limited | Derivatisation of biological molecules |
| CN103497247A (zh) | 2008-02-27 | 2014-01-08 | 诺沃—诺迪斯克有限公司 | 缀合的因子viii分子 |
| WO2010060186A1 (en) | 2008-11-03 | 2010-06-03 | Alethia Biotherapeutics Inc. | Antibodies that specifically block the biological activity of a tumor antigen |
| DK2260873T3 (da) | 2009-06-08 | 2019-09-16 | Biocompatibles Uk Ltd | Pcylering af proteiner |
| WO2011075185A1 (en) | 2009-12-18 | 2011-06-23 | Oligasis | Targeted drug phosphorylcholine polymer conjugates |
| WO2011101242A1 (en) | 2010-02-16 | 2011-08-25 | Novo Nordisk A/S | Factor viii molecules with reduced vwf binding |
| WO2011146595A2 (en) * | 2010-05-21 | 2011-11-24 | Siemens Healthcare Diagnostics Inc. | Zwitterionic reagents |
| JP6294221B2 (ja) | 2011-03-31 | 2018-03-14 | アー・デー・ツェー・セラピューティクス・エス・アー | 腎臓関連抗原１に対する抗体およびその抗原結合性フラグメント |
| JP6352806B2 (ja) | 2011-09-23 | 2018-07-04 | ノヴォ ノルディスク アー／エス | 新規のグルカゴン類似体 |
| TR201908872T4 (tr) | 2012-01-09 | 2019-07-22 | Adc Therapeutics Sa | Üçlü negatif meme kanserini tedavi etmek için ajanlar. |
| ES2780674T3 (es) * | 2012-11-15 | 2020-08-26 | Apellis Pharmaceuticals Inc | Análogos de compstatina de acción prolongada y composiciones y métodos relacionados |
| PL2986313T3 (pl) | 2013-04-18 | 2019-12-31 | Novo Nordisk A/S | Stabilni, dłużej działający współagoniści receptora glp-1/glukagonu do zastosowań medycznych |
| WO2015035342A2 (en) | 2013-09-08 | 2015-03-12 | Oligasis Llc | Factor viii zwitterionic polymer conjugates |
| US9309336B2 (en) | 2013-11-27 | 2016-04-12 | King Fahd University Of Petroleum And Minerals | Synthesis and antiscalant behavior of a novel polyzwitterionic acid |
| EP3151852A1 (de) | 2014-06-04 | 2017-04-12 | Novo Nordisk A/S | Glp-1/glucagon-rezeptor-coagonisten zur medizinischen verwendung |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| JP6849590B2 (ja) | 2014-10-17 | 2021-03-24 | コディアック サイエンシーズ インコーポレイテッドＫｏｄｉａｋ Ｓｃｉｅｎｃｅｓ Ｉｎｃ． | ブチリルコリンエステラーゼ両性イオン性ポリマーコンジュゲート |
| BR112018013407A2 (en) | 2015-12-30 | 2018-12-18 | Kodiak Sciences Inc. | antibodies and conjugates thereof |
| SG11202008242XA (en) | 2018-03-02 | 2020-09-29 | Kodiak Sciences Inc | Il-6 antibodies and fusion constructs and conjugates thereof |
| US11912784B2 (en) | 2019-10-10 | 2024-02-27 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CA3189905A1 (en) * | 2020-08-21 | 2022-02-24 | Daniel J. Siegwart | Functional ionizable phospholipids |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260373A (en) | 1987-03-13 | 1993-11-09 | Repligen Corporation | Immobilized immunoglobulin-binding proteins |
| EP0394318A1 (de) | 1987-12-09 | 1990-10-31 | Medical Research Council | Polymere und polymer-peptid-konjugate |
| US5162430A (en) | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
| US5122614A (en) | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| SE466754B (sv) | 1990-09-13 | 1992-03-30 | Berol Nobel Ab | Saett att kovalent binda biopolymerer till hydrofila ytor |
| US5286846A (en) | 1991-06-14 | 1994-02-15 | The Government Of The United States Of America As Represented By The Dept. Of Health And Human Services | Amino acid derivative and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides |
| DK0593561T3 (da) | 1991-07-05 | 2000-08-21 | Biocompatibles Ltd | Polymere overfladecoatinger |
| JPH05220218A (ja) | 1992-02-13 | 1993-08-31 | Norio Nakabayashi | 抗血栓性再生セルロース系膜及びその製造方法 |
| IL104734A0 (en) | 1993-02-15 | 1993-06-10 | Univ Bar Ilan | Bioactive conjugates of cellulose with amino compounds |
| US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| JPH10509976A (ja) * | 1994-11-30 | 1998-09-29 | アムール リサーチ コーポレーション | ホスホコリン薬物誘導体 |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5763548A (en) | 1995-03-31 | 1998-06-09 | Carnegie-Mellon University | (Co)polymers and a novel polymerization process based on atom (or group) transfer radical polymerization |
| TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| DE69707452T3 (de) * | 1996-06-12 | 2015-07-23 | Warwick Effect Polymers Ltd. | Polymerisation-katalysator und -verfahren |
| JP2002514183A (ja) * | 1996-09-17 | 2002-05-14 | スーパージェン・インコーポレーテッド | リン脂質薬剤誘導体 |
| US5830432A (en) * | 1997-03-31 | 1998-11-03 | Amur Pharmacuticals, Inc. | Phospholipid drug derivatives |
| EP0922446A1 (de) | 1997-12-03 | 1999-06-16 | Applied Research Systems Ars Holding N.V. | Lösungsphase Verfahrung zur ortspezifischer Herstellung von GRF-PEG Konjugaten |
| US6251382B1 (en) | 1998-04-17 | 2001-06-26 | Enzon, Inc. | Biodegradable high molecular weight polymeric linkers and their conjugates |
| DK1128784T3 (da) * | 1998-11-13 | 2003-11-17 | Biocompatibles Uk Ltd | Terapeutisk anvendelse af polymerer |
| US6692914B1 (en) | 1999-07-02 | 2004-02-17 | Symyx Technologies, Inc. | Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto |
| EP1222217B1 (de) | 1999-09-08 | 2005-06-15 | Polytherics Limited | Polymere mit uniformem molekulargewicht |
| GB9924502D0 (en) * | 1999-10-15 | 1999-12-15 | Biocompatibles Ltd | Polymer blend materials |
| DE60010644T2 (de) | 2000-02-07 | 2005-05-19 | Biocompatibles Uk Ltd., Farnham | Silizium enthaltende Verbindungen hergestellt durch Michael Addition als Monomere und Macromere |
| WO2001092361A1 (fr) | 2000-05-29 | 2001-12-06 | Bio Merieux | Polymere biocompatible pour la fixation de ligands biologiques |
| US6852816B2 (en) * | 2000-10-06 | 2005-02-08 | Biocompatibles Uk Limited | Zwitterionic polymers |
| US6652886B2 (en) | 2001-02-16 | 2003-11-25 | Expression Genetics | Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents |
| JP4577747B2 (ja) | 2001-06-05 | 2010-11-10 | 和光純薬工業株式会社 | 免疫学的測定法用凝集促進剤 |
| US6939564B2 (en) | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
| US6908963B2 (en) | 2001-10-09 | 2005-06-21 | Nektar Therapeutics Al, Corporation | Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith |
| WO2003062290A1 (en) | 2002-01-16 | 2003-07-31 | Biocompatibles Uk Limited | Polymer conjugates |
| US20050220880A1 (en) | 2002-03-07 | 2005-10-06 | Lewis Andrew L | Drug carriers comprising amphiphilic block copolymers |
| EP1480680B1 (de) | 2002-03-07 | 2010-11-03 | Biocompatibles UK Limited | Mit nucleinsäure complexierte block-copolymere |
| GB0301014D0 (en) | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
| WO2004069888A2 (en) | 2003-02-05 | 2004-08-19 | Biocompatibles Uk Limited | Block copolymers |
| MXPA05008785A (es) | 2003-02-19 | 2005-10-18 | Pharmacia Corp | Esteres de polietilen glicol activados. |
| CA2788505C (en) | 2003-02-26 | 2018-09-04 | Nektar Therapeutics | Polymer-factor viii moiety conjugates |
| EP1653991A2 (de) | 2003-08-08 | 2006-05-10 | Fresenius Kabi Deutschland GmbH | Durch oxime als bindungsgruppe verbundene konjugate eines polymers mit einem protein |
| WO2005039641A2 (en) | 2003-10-15 | 2005-05-06 | The Regents Of The University Of California | Biomacromolecule polymer conjugates |
| US7179874B2 (en) | 2003-11-21 | 2007-02-20 | Chia Nan University Of Pharmacy And Science | Biodegradable cationic polymer |
| US7365127B2 (en) | 2005-02-04 | 2008-04-29 | Enzon Pharmaceuticals, Inc. | Process for the preparation of polymer conjugates |
| US20070123646A1 (en) | 2005-09-13 | 2007-05-31 | Lele Bhalchandra S | Protein-polymer conjugates and synthesis thereof |
-
2003
- 2003-01-16 WO PCT/GB2003/000131 patent/WO2003062290A1/en not_active Ceased
- 2003-01-16 DE DE60315949T patent/DE60315949T2/de not_active Expired - Lifetime
- 2003-01-16 EP EP03700372A patent/EP1465933B1/de not_active Expired - Lifetime
- 2003-01-16 AT AT03700372T patent/ATE371680T1/de not_active IP Right Cessation
- 2003-01-16 ES ES03700372T patent/ES2291613T3/es not_active Expired - Lifetime
- 2003-01-16 US US10/501,393 patent/US8048408B2/en active Active
-
2011
- 2011-09-23 US US13/243,887 patent/US8431113B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60315949T2 (de) | 2008-06-12 |
| US20050123501A1 (en) | 2005-06-09 |
| ES2291613T3 (es) | 2008-03-01 |
| EP1465933B1 (de) | 2007-08-29 |
| US20120016085A1 (en) | 2012-01-19 |
| US8048408B2 (en) | 2011-11-01 |
| US8431113B2 (en) | 2013-04-30 |
| WO2003062290A1 (en) | 2003-07-31 |
| EP1465933A1 (de) | 2004-10-13 |
| DE60315949D1 (de) | 2007-10-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |