ATE371680T1 - Polymerkonjugate - Google Patents

Polymerkonjugate

Info

Publication number
ATE371680T1
ATE371680T1 AT03700372T AT03700372T ATE371680T1 AT E371680 T1 ATE371680 T1 AT E371680T1 AT 03700372 T AT03700372 T AT 03700372T AT 03700372 T AT03700372 T AT 03700372T AT E371680 T1 ATE371680 T1 AT E371680T1
Authority
AT
Austria
Prior art keywords
conjugates
moiety
polydispersity
biologically active
active compounds
Prior art date
Application number
AT03700372T
Other languages
English (en)
Inventor
Andrew Lewis
Original Assignee
Biocompatibles Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatibles Uk Ltd filed Critical Biocompatibles Uk Ltd
Application granted granted Critical
Publication of ATE371680T1 publication Critical patent/ATE371680T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F246/00—Copolymers in which the nature of only the monomers in minority is defined

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
AT03700372T 2002-01-16 2003-01-16 Polymerkonjugate ATE371680T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02250289 2002-01-16

Publications (1)

Publication Number Publication Date
ATE371680T1 true ATE371680T1 (de) 2007-09-15

Family

ID=27589157

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03700372T ATE371680T1 (de) 2002-01-16 2003-01-16 Polymerkonjugate

Country Status (6)

Country Link
US (2) US8048408B2 (de)
EP (1) EP1465933B1 (de)
AT (1) ATE371680T1 (de)
DE (1) DE60315949T2 (de)
ES (1) ES2291613T3 (de)
WO (1) WO2003062290A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8048408B2 (en) 2002-01-16 2011-11-01 Biocompatibles Uk Limited Polymer conjugates
US20050220880A1 (en) 2002-03-07 2005-10-06 Lewis Andrew L Drug carriers comprising amphiphilic block copolymers
AU2003217009A1 (en) 2002-03-07 2003-09-16 Biocompatibles Uk Limited Compositions of polymers
GB0301014D0 (en) * 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
EP2267049A1 (de) * 2003-02-05 2010-12-29 Biocompatibles UK Limited Blockcopolymere
GB0314472D0 (en) 2003-06-20 2003-07-23 Warwick Effect Polymers Ltd Polymer
US7786213B2 (en) * 2003-10-15 2010-08-31 The Regents Of The University Of California Biomacromolecule polymer conjugates
ATE396970T1 (de) * 2003-12-23 2008-06-15 Lundbeck & Co As H 2-(1h-indolylsulfanyl)-benzylaminderivate als ssri
CA2558767A1 (en) * 2004-07-06 2006-01-12 Warwick Effect Polymers Limited Living radical polymerization initiator comprising a functional group capable of reacting with polyeptides or the like, comb polymer obtained therewith, polypeptide conjugates anddrugs obtained therefrom
AR052308A1 (es) * 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
US7629473B2 (en) * 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
AR054393A1 (es) * 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
EP1988910B1 (de) * 2006-02-28 2017-12-06 Kodiak Sciences Inc. Acryloyloxyethylphosphorylcholin-haltige polymerkonjugate und ihre zubereitung
JP5564249B2 (ja) * 2006-06-23 2014-07-30 アレシア・バイオセラピューティクス・インコーポレーテッド 癌に関与するポリヌクレオチド配列およびポリペプチド配列
JP2008060540A (ja) * 2006-08-03 2008-03-13 Seiko Epson Corp 電子デバイスの製造方法、電子デバイスおよび電子機器
ES2531934T3 (es) 2006-09-01 2015-03-20 Novo Nordisk Health Care Ag Glicoproteínas modificadas
WO2008098930A1 (en) * 2007-02-14 2008-08-21 Biocompatibes Uk Limited Derivatisation of biological molecules
DK2257311T3 (da) 2008-02-27 2014-06-30 Novo Nordisk As Konjugerede Faktor VIII-Molekyler
AU2009321508B2 (en) 2008-11-03 2015-03-12 Adc Therapeutics Sa Antibodies that specifically block the biological activity of a tumor antigen
DK2260873T3 (da) 2009-06-08 2019-09-16 Biocompatibles Uk Ltd Pcylering af proteiner
WO2011075185A1 (en) 2009-12-18 2011-06-23 Oligasis Targeted drug phosphorylcholine polymer conjugates
JP5914363B2 (ja) 2010-02-16 2016-05-11 ノヴォ ノルディスク アー/エス 低減されたvwf結合を有する因子viii分子
CN102905690B (zh) 2010-05-21 2016-03-30 西门子医疗保健诊断公司 两性离子试剂
CN106146664B (zh) 2011-03-31 2021-09-07 Adc治疗股份有限公司 针对肾相关抗原1的抗体及其抗原结合片段
MY167234A (en) 2011-09-23 2018-08-14 Novo Nordisk As Novel glucagon analogues
CA3115623A1 (en) 2012-01-09 2013-07-18 Adc Therapeutics Sa Method for treating breast cancer
EP3929206A1 (de) * 2012-11-15 2021-12-29 Apellis Pharmaceuticals, Inc. Langwirkende compstatin-analoga sowie verwandte zusammensetzungen und verfahren
MY174727A (en) 2013-04-18 2020-05-11 Novo Nordisk As Stable, protracted glp-1/glucagon receptor co-agonists for medical use
WO2015035342A2 (en) 2013-09-08 2015-03-12 Oligasis Llc Factor viii zwitterionic polymer conjugates
US9309336B2 (en) 2013-11-27 2016-04-12 King Fahd University Of Petroleum And Minerals Synthesis and antiscalant behavior of a novel polyzwitterionic acid
US10570184B2 (en) 2014-06-04 2020-02-25 Novo Nordisk A/S GLP-1/glucagon receptor co-agonists for medical use
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
KR20210013299A (ko) 2014-10-17 2021-02-03 코디악 사이언시스 인코포레이티드 부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트
KR20250057128A (ko) 2015-12-30 2025-04-28 코디악 사이언시스 인코포레이티드 항체 및 이의 접합체
US12071476B2 (en) 2018-03-02 2024-08-27 Kodiak Sciences Inc. IL-6 antibodies and fusion constructs and conjugates thereof
AU2020364071A1 (en) 2019-10-10 2022-05-26 Kodiak Sciences Inc. Methods of treating an eye disorder
AU2021327782A1 (en) * 2020-08-21 2023-03-23 The Board Of Regents Of The University Of Texas System Functional ionizable phospholipids

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260373A (en) * 1987-03-13 1993-11-09 Repligen Corporation Immobilized immunoglobulin-binding proteins
WO1989005305A1 (en) * 1987-12-09 1989-06-15 3I Research Exploitation Limited Polymers and polymer-peptide conjugates
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5122614A (en) * 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
SE466754B (sv) * 1990-09-13 1992-03-30 Berol Nobel Ab Saett att kovalent binda biopolymerer till hydrofila ytor
US5286846A (en) * 1991-06-14 1994-02-15 The Government Of The United States Of America As Represented By The Dept. Of Health And Human Services Amino acid derivative and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
WO1993001221A1 (en) 1991-07-05 1993-01-21 Biocompatibles Limited Polymeric surface coatings
JPH05220218A (ja) * 1992-02-13 1993-08-31 Norio Nakabayashi 抗血栓性再生セルロース系膜及びその製造方法
IL104734A0 (en) * 1993-02-15 1993-06-10 Univ Bar Ilan Bioactive conjugates of cellulose with amino compounds
US5919455A (en) * 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
WO1996016680A1 (en) * 1994-11-30 1996-06-06 Amur Research Corp. Phosphocholine drug derivatives
US5932462A (en) * 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5763548A (en) * 1995-03-31 1998-06-09 Carnegie-Mellon University (Co)polymers and a novel polymerization process based on atom (or group) transfer radical polymerization
TW517067B (en) * 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
ATE207082T1 (de) * 1996-06-12 2001-11-15 Univ Warwick Polymerisation-katalysator und -verfahren
JP2002514183A (ja) * 1996-09-17 2002-05-14 スーパージェン・インコーポレーテッド リン脂質薬剤誘導体
US5830432A (en) * 1997-03-31 1998-11-03 Amur Pharmacuticals, Inc. Phospholipid drug derivatives
EP0922446A1 (de) * 1997-12-03 1999-06-16 Applied Research Systems Ars Holding N.V. Lösungsphase Verfahrung zur ortspezifischer Herstellung von GRF-PEG Konjugaten
US6251382B1 (en) * 1998-04-17 2001-06-26 Enzon, Inc. Biodegradable high molecular weight polymeric linkers and their conjugates
ES2203203T3 (es) * 1998-11-13 2004-04-01 Biocompatibles Uk Limited Utilizacion terapeutica de polimeros.
DE60027309T2 (de) * 1999-07-02 2006-08-31 Symyx Technologies, Inc., Santa Clara Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen
US6803438B1 (en) * 1999-09-08 2004-10-12 Polytherics Limited Uniform molecular weight polymers
GB9924502D0 (en) * 1999-10-15 1999-12-15 Biocompatibles Ltd Polymer blend materials
DE60010644T2 (de) * 2000-02-07 2005-05-19 Biocompatibles Uk Ltd., Farnham Silizium enthaltende Verbindungen hergestellt durch Michael Addition als Monomere und Macromere
US20040091451A1 (en) * 2000-05-29 2004-05-13 Marie-Therese Charreyre Biocompatible polymer for fixing biological ligands
JP5049452B2 (ja) 2000-10-06 2012-10-17 バイオコンパティブルズ ユーケー リミテッド 両性イオン重合体
US6652886B2 (en) * 2001-02-16 2003-11-25 Expression Genetics Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
JP4577747B2 (ja) * 2001-06-05 2010-11-10 和光純薬工業株式会社 免疫学的測定法用凝集促進剤
US6939564B2 (en) 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US6908963B2 (en) * 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
US8048408B2 (en) 2002-01-16 2011-11-01 Biocompatibles Uk Limited Polymer conjugates
US20050220880A1 (en) * 2002-03-07 2005-10-06 Lewis Andrew L Drug carriers comprising amphiphilic block copolymers
AU2003217009A1 (en) 2002-03-07 2003-09-16 Biocompatibles Uk Limited Compositions of polymers
GB0301014D0 (en) * 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
EP2267049A1 (de) * 2003-02-05 2010-12-29 Biocompatibles UK Limited Blockcopolymere
CA2515612A1 (en) * 2003-02-19 2004-09-02 Pharmacia Corporation Activated polyethylene glycol esters
WO2004075923A2 (en) * 2003-02-26 2004-09-10 Nektar Therapeutics Al, Corporation Polymer-factor viii moiety conjugates
WO2005014024A2 (en) * 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of a polymer and a protein linked by an oxime linking group
US7786213B2 (en) * 2003-10-15 2010-08-31 The Regents Of The University Of California Biomacromolecule polymer conjugates
US7179874B2 (en) * 2003-11-21 2007-02-20 Chia Nan University Of Pharmacy And Science Biodegradable cationic polymer
US7365127B2 (en) * 2005-02-04 2008-04-29 Enzon Pharmaceuticals, Inc. Process for the preparation of polymer conjugates
US20070123646A1 (en) * 2005-09-13 2007-05-31 Lele Bhalchandra S Protein-polymer conjugates and synthesis thereof

Also Published As

Publication number Publication date
US8431113B2 (en) 2013-04-30
WO2003062290A1 (en) 2003-07-31
US20120016085A1 (en) 2012-01-19
US20050123501A1 (en) 2005-06-09
US8048408B2 (en) 2011-11-01
EP1465933B1 (de) 2007-08-29
DE60315949T2 (de) 2008-06-12
EP1465933A1 (de) 2004-10-13
ES2291613T3 (es) 2008-03-01
DE60315949D1 (de) 2007-10-11

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