ATE371727T1 - Kdr, ein menschlicher tyrosin kinase rezeptor - Google Patents

Kdr, ein menschlicher tyrosin kinase rezeptor

Info

Publication number
ATE371727T1
ATE371727T1 AT98931318T AT98931318T ATE371727T1 AT E371727 T1 ATE371727 T1 AT E371727T1 AT 98931318 T AT98931318 T AT 98931318T AT 98931318 T AT98931318 T AT 98931318T AT E371727 T1 ATE371727 T1 AT E371727T1
Authority
AT
Austria
Prior art keywords
kdr
tyrosine kinase
kinase receptor
human
human tyrosine
Prior art date
Application number
AT98931318T
Other languages
English (en)
Inventor
Richard Kendall
Kenneth Thomas
Xianzhi Mao
Andrew Tebben
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21968566&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE371727(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE371727T1 publication Critical patent/ATE371727T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT98931318T 1997-06-18 1998-06-17 Kdr, ein menschlicher tyrosin kinase rezeptor ATE371727T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5096297P 1997-06-18 1997-06-18

Publications (1)

Publication Number Publication Date
ATE371727T1 true ATE371727T1 (de) 2007-09-15

Family

ID=21968566

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98931318T ATE371727T1 (de) 1997-06-18 1998-06-17 Kdr, ein menschlicher tyrosin kinase rezeptor

Country Status (8)

Country Link
US (4) US6204011B1 (de)
EP (1) EP1009814B1 (de)
JP (1) JP4405597B2 (de)
AT (1) ATE371727T1 (de)
CA (1) CA2293723A1 (de)
DE (1) DE69838334T2 (de)
ES (1) ES2292204T3 (de)
WO (1) WO1998058053A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448077B1 (en) * 1994-02-10 2002-09-10 Imclone Systems, Inc. Chimeric and humanized monoclonal antibodies specific to VEGF receptors
US20030108545A1 (en) * 1994-02-10 2003-06-12 Patricia Rockwell Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist
US6891082B2 (en) * 1997-08-01 2005-05-10 The Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a truncated activintype II receptor
EP1037981A1 (de) * 1997-12-09 2000-09-27 Children's Medical Center Corporation Lösliche inhibitoren des vaskularen endothelialen wachstumsfaktors, und verwendung davon
US6852533B1 (en) * 1998-01-23 2005-02-08 Cornell Research Foundation, Inc. Purified populations of stem cells
JP2002529421A (ja) * 1998-11-06 2002-09-10 ビーエーエスエフ アクチェンゲゼルシャフト 血管過浸透性の阻害方法
US7625859B1 (en) * 2000-02-16 2009-12-01 Oregon Health & Science University HER-2 binding antagonists
US7396810B1 (en) * 2000-08-14 2008-07-08 Oregon Health Sciences University Compositions and methods for treating cancer by modulating HER-2 and EGF receptors
US7393823B1 (en) 1999-01-20 2008-07-01 Oregon Health And Science University HER-2 binding antagonists
GB9918057D0 (en) * 1999-07-30 1999-10-06 Univ Bristol Therapeutic agents
BR0111530A (pt) 2000-06-07 2003-07-22 Ortho Mcneil Pharm Inc Processo para detectar modulação de domìnio cinase de vegf
US20040247597A1 (en) * 2001-06-20 2004-12-09 Peter Carmeliet Method of treating atherosclerosis and other inflammatory diseases
US6734017B2 (en) * 2001-09-28 2004-05-11 Isis Pharmaceuticals, Inc. Antisense modulation of vascular endothelial growth factor receptor-2 expression
GB0124317D0 (en) 2001-10-10 2001-11-28 Celltech R&D Ltd Biological products
US20050250700A1 (en) * 2002-03-01 2005-11-10 Sato Aaron K KDR and VEGF/KDR binding peptides
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US7985402B2 (en) * 2002-03-01 2011-07-26 Bracco Suisse Sa Targeting vector-phospholipid conjugates
AU2003278807A1 (en) 2002-03-01 2004-08-13 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US8623822B2 (en) * 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7666979B2 (en) * 2002-03-01 2010-02-23 Bracco International B.V. Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same
US7794693B2 (en) * 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7094410B2 (en) * 2002-03-02 2006-08-22 The Scripps Research Institute DNA vaccine against proliferating endothelial cells and methods of use thereof
EP2298346A3 (de) * 2002-03-04 2011-11-16 Imclone LLC KDR-spezifische menschliche Antikörper und ihre Verwendung
GB0206072D0 (en) * 2002-03-15 2002-04-24 Astrazeneca Ab Epitope
DE60327786D1 (de) * 2002-09-12 2009-07-09 Oncotherapy Science Inc Kdr-peptide und diese enthaltende impfstoffe
US20060057694A1 (en) * 2003-01-29 2006-03-16 Thomas Kenneth A Jr Rat receptor tyrosine knase, kdr
ES2396368T3 (es) * 2003-03-03 2013-02-21 Dyax Corporation Péptidos que se unen específicamente al receptor del HGF (CMET) y usos de los mismos
AU2004265226A1 (en) * 2003-05-16 2005-02-24 Receptor Biologix, Inc. Intron fusion proteins, and methods of identifying and using same
US7582726B2 (en) * 2003-11-10 2009-09-01 Ghc Research Development Corporation VEGF receptor antagonists
CA2565974A1 (en) * 2004-05-14 2005-12-01 Receptor Biologix, Inc. Cell surface receptor isoforms and methods of identifying and using the same
PT2229956E (pt) 2004-09-13 2013-07-31 Genzyme Corp Contruções multiméricas
CA2583230A1 (en) * 2004-10-05 2006-04-20 Oregon Health And Science University Compositions and methods for treating disease
CN101171721B (zh) * 2005-05-11 2013-01-23 株式会社村田制作所 天线结构及包含该天线结构的无线通信装置
US20090170769A1 (en) * 2005-05-13 2009-07-02 Pei Jin Cell surface receptor isoforms and methods of identifying and using the same
UA96139C2 (uk) 2005-11-08 2011-10-10 Дженентек, Інк. Антитіло до нейропіліну-1 (nrp1)
US20080254481A1 (en) * 2006-11-13 2008-10-16 Invitrogen Corporation Methods and kits for detecting prostate cancer biomarkers
TW201109029A (en) 2009-06-11 2011-03-16 Oncotherapy Science Inc Vaccine therapy for choroidal neovascularization
WO2012006503A1 (en) 2010-07-09 2012-01-12 Genentech, Inc. Anti-neuropilin antibodies and methods of use
EP3327032A1 (de) 2010-08-06 2018-05-30 Genzyme Corporation Vegf-antagonisten-zusammensetzungen und verwendungen davon
WO2013074814A2 (en) * 2011-11-15 2013-05-23 University Of Utah Research Fourdation Morpholinos, morpholino upregulating, and associated methods
WO2013159051A1 (en) 2012-04-19 2013-10-24 University Of Utah Research Foundation Morpholino-mediated increase in soluble flt-1 expression results in decreased ocular and tumor neovascularization

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240848A (en) 1988-11-21 1993-08-31 Monsanto Company Dna sequences encoding human vascular permeability factor having 189 amino acids
US5332671A (en) 1989-05-12 1994-07-26 Genetech, Inc. Production of vascular endothelial cell growth factor and DNA encoding same
DE69232718T2 (de) * 1991-02-22 2003-04-03 American Cyanamid Co., Madison Identifizierung eines menschlichen rezeptor-tyrosinkinasegens
EP0506477B1 (de) 1991-03-28 1999-06-23 Merck & Co. Inc. Untereinheit-C des vaskulären endothelialen Zellwachstumsfaktors
US5861301A (en) 1992-02-20 1999-01-19 American Cayanamid Company Recombinant kinase insert domain containing receptor and gene encoding same
CN1701814A (zh) * 1992-11-13 2005-11-30 马克斯普朗克科学促进协会 作为血管内皮生长因子受体的f1k－1
US6177401B1 (en) * 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis

Also Published As

Publication number Publication date
US6359115B1 (en) 2002-03-19
US20030055239A1 (en) 2003-03-20
JP4405597B2 (ja) 2010-01-27
CA2293723A1 (en) 1998-12-23
ES2292204T3 (es) 2008-03-01
US20030032160A1 (en) 2003-02-13
DE69838334D1 (de) 2007-10-11
EP1009814A1 (de) 2000-06-21
WO1998058053A1 (en) 1998-12-23
JP2002507119A (ja) 2002-03-05
EP1009814A4 (de) 2001-12-12
DE69838334T2 (de) 2008-06-12
EP1009814B1 (de) 2007-08-29
US6841382B2 (en) 2005-01-11
US6841367B2 (en) 2005-01-11
US6204011B1 (en) 2001-03-20
WO1998058053A9 (en) 1999-04-08

Similar Documents

Publication Publication Date Title
DE69838334D1 (de) Kdr, ein menschlicher tyrosin kinase rezeptor
WO1999055868A3 (en) Fizz proteins
ATE321855T1 (de) Tumor-nekrose-faktor rezeptor 5
DK1129190T3 (da) Human TSLP DNA og polypeptider
DK1005540T3 (da) IKK-beta-proteiner, nukleinsyrer og fremgangsmåder
ATE519847T1 (de) Il-17-homologe polypeptide und ihre therapeutische verwendung
MY120693A (en) Human bikunin
ATE412740T1 (de) Menschliches alpha-endokin
DK1025237T3 (da) Human kontrolpunktskinase, hCDS1, præparater og fremgangsmåder
WO1995006735A3 (en) Nucleotide sequences for novel protein tyrosine phosphatases
DE69837475D1 (de) Polypeptide mit aminopeptidaseaktivität und dafür kodierende nukleinsäuren
DK1082423T3 (da) Cyclin E2-gener og -proteiner
CY1108619T1 (el) Πρωτεϊνη σπονδυλωτων patched-2
AU2001238064A1 (en) 18477, a human protein kinase and uses therefor
WO1998027932A3 (en) Cerebellum and embryo specific protein
WO2002012475A3 (en) C1q-related factor, homologous polypeptides and therapeutic uses thereof
WO2002002771A3 (en) Human sparc-homologous (hsparc-h1) gene and methods and uses thereof
WO2002074960A3 (en) 38650, 28472, 5495, 65507, 81588 and 14354 methods and compositions of human proteins and uses thereof
DE60124380D1 (de) Angiogenese-assoziierte proteine und dafür kodierende nukleinsäure
WO1998025957A3 (en) Human prt1-like subunit protein (hprt1) and human eif4g-like protein (p97) genes
WO2004070004A3 (en) Rat receptor tyrosine kinase, kdr
NZ510812A (en) Novel peptides
AU4956901A (en) Novel human 7tm proteins and polynucleotides encoding the same
WO2001057086A3 (en) Novel human g protein coupled receptor proteins and polynucleotides encoding the same
WO2002072765A3 (en) Isolated human ras-like proteins, nucleic acid molecules encoding these human ras-like proteins, and uses thereof

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties