ATE371729T1 - Kristallstruktur der 2c-methyl-d-erythritol-2,4- cyclodiphosphat-synthase - Google Patents

Kristallstruktur der 2c-methyl-d-erythritol-2,4- cyclodiphosphat-synthase

Info

Publication number: ATE371729T1
Authority: AT; Austria
Prior art keywords: erythritol; methyl; crystal structure; synthase; cytidine
Prior art date: 2001-05-15

Application number

AT02748701T

Other languages

English (en)

Inventor

Adelbert Bacher

Stefan Hecht

Robert Huber

Johannes Kaiser

Felix Rohdich

Stefan Steinbacher

Original Assignee

Adelbert Bacher

Max Planck Gesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-15

Filing date

2002-05-13

Publication date

2007-09-15

2001-05-15 Priority claimed from DE2001123597 external-priority patent/DE10123597A1/de

2002-05-13 Application filed by Adelbert Bacher, Max Planck Gesellschaft filed Critical Adelbert Bacher

2007-09-15 Application granted granted Critical

2007-09-15 Publication of ATE371729T1 publication Critical patent/ATE371729T1/de

Links

239000013078 crystal Substances 0.000 title abstract 3
108030005203 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthases Proteins 0.000 title abstract 2
YFAUKWZNPVBCFF-XHIBXCGHSA-N 4-CDP-2-C-methyl-D-erythritol Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H](O)[C@@](O)(CO)C)O[C@H]1N1C(=O)N=C(N)C=C1 YFAUKWZNPVBCFF-XHIBXCGHSA-N 0.000 abstract 2
IERHLVCPSMICTF-XVFCMESISA-N cytidine 5'-monophosphate Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O1 IERHLVCPSMICTF-XVFCMESISA-N 0.000 abstract 2
IERHLVCPSMICTF-UHFFFAOYSA-N cytidine monophosphate Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(COP(O)(O)=O)O1 IERHLVCPSMICTF-UHFFFAOYSA-N 0.000 abstract 2
239000003112 inhibitor Substances 0.000 abstract 2
UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 abstract 1
SFRQRNJMIIUYDI-RFZPGFLSSA-N 2c-methyl-d-erythritol 2,4-cyclodiphosphate Chemical compound OC[C@@]1(C)O[P@@](O)(=O)O[P@](O)(=O)OC[C@H]1O SFRQRNJMIIUYDI-RFZPGFLSSA-N 0.000 abstract 1
HTJXTKBIUVFUAR-XHIBXCGHSA-N 4-CDP-2-C-methyl-D-erythritol 2-phosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H](O)[C@](CO)(OP(O)(O)=O)C)O[C@H]1N1C(=O)N=C(N)C=C1 HTJXTKBIUVFUAR-XHIBXCGHSA-N 0.000 abstract 1
ZWIADYZPOWUWEW-XVFCMESISA-N CDP Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O1 ZWIADYZPOWUWEW-XVFCMESISA-N 0.000 abstract 1
UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 abstract 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 abstract 1
239000011701 zinc Substances 0.000 abstract 1
229910052725 zinc Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y406/00—Phosphorus-oxygen lyases (4.6)
- C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
- C12Y406/01012—2-C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (4.6.1.12)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Enzymes And Modification Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT02748701T 2001-05-15 2002-05-13 Kristallstruktur der 2c-methyl-d-erythritol-2,4- cyclodiphosphat-synthase ATE371729T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE2001123597 DE10123597A1 (de)	2001-05-15	2001-05-15	Kristallstruktur der 2C-Methyl-D-erythritol 2,4-cyclodiphosphat Synthase
US29387501P	2001-05-25	2001-05-25

Publications (1)

Publication Number	Publication Date
ATE371729T1 true ATE371729T1 (de)	2007-09-15

Family

ID=26009297

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02748701T ATE371729T1 (de)	2001-05-15	2002-05-13	Kristallstruktur der 2c-methyl-d-erythritol-2,4- cyclodiphosphat-synthase

Country Status (6)

Country	Link
US (1)	US20040226502A1 (de)
EP (1)	EP1390488B1 (de)
AT (1)	ATE371729T1 (de)
AU (1)	AU2002319171A1 (de)
DE (1)	DE60222115T2 (de)
WO (1)	WO2002092800A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1198575B1 (de)	1999-08-04	2007-09-19	Adelbert Bacher	Isoprenoid biosynthese
DE10027821A1 (de)	2000-06-05	2001-12-06	Adelbert Bacher	Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
DE10201458A1 (de) *	2001-04-11	2002-10-17	Adelbert Bacher	Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
WO2004072276A1 (en) *	2003-02-14	2004-08-26	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Crystal structure of 2-c-methyl-d-erythritol 4-phosphate synthase in complex with inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9315751D0 (en) *	1993-07-30	1993-09-15	Zeneca Ltd	Dna,dna constructs,cells and plants derived therefrom
US5885782A (en) *	1994-09-13	1999-03-23	Nce Pharmaceuticals, Inc.	Synthetic antibiotics
US6183121B1 (en) *	1997-08-14	2001-02-06	Vertex Pharmaceuticals Inc.	Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets
DE10027821A1 (de) *	2000-06-05	2001-12-06	Adelbert Bacher	Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
DE10201458A1 (de) *	2001-04-11	2002-10-17	Adelbert Bacher	Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
WO2002102991A2 (en) *	2001-06-18	2002-12-27	Structural Genomix	Crystals and structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase mecps

2002
- 2002-05-13 WO PCT/EP2002/005238 patent/WO2002092800A2/en not_active Ceased
- 2002-05-13 AT AT02748701T patent/ATE371729T1/de not_active IP Right Cessation
- 2002-05-13 EP EP02748701A patent/EP1390488B1/de not_active Expired - Lifetime
- 2002-05-13 US US10/478,284 patent/US20040226502A1/en not_active Abandoned
- 2002-05-13 AU AU2002319171A patent/AU2002319171A1/en not_active Abandoned
- 2002-05-13 DE DE60222115T patent/DE60222115T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60222115D1 (en)	2007-10-11
WO2002092800A2 (en)	2002-11-21
EP1390488A2 (de)	2004-02-25
WO2002092800A3 (en)	2003-08-21
US20040226502A1 (en)	2004-11-18
AU2002319171A1 (en)	2002-11-25
DE60222115T2 (de)	2008-05-21
EP1390488B1 (de)	2007-08-29

Legal Events

Date	Code	Title	Description
2008-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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