ATE373105T1 - Verbindungen und methoden zum nachweis von biomolekülen - Google Patents

Verbindungen und methoden zum nachweis von biomolekülen

Info

Publication number
ATE373105T1
ATE373105T1 AT99949531T AT99949531T ATE373105T1 AT E373105 T1 ATE373105 T1 AT E373105T1 AT 99949531 T AT99949531 T AT 99949531T AT 99949531 T AT99949531 T AT 99949531T AT E373105 T1 ATE373105 T1 AT E373105T1
Authority
AT
Austria
Prior art keywords
methods
compounds
detecting biomolecules
photocleavable
nucleic acids
Prior art date
Application number
AT99949531T
Other languages
English (en)
Inventor
Kenneth Rothschild
Jerzy Olejnik
Original Assignee
Ambergen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambergen Inc filed Critical Ambergen Inc
Application granted granted Critical
Publication of ATE373105T1 publication Critical patent/ATE373105T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2429—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of arylalkanols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Cephalosporin Compounds (AREA)
AT99949531T 1998-06-02 1999-06-02 Verbindungen und methoden zum nachweis von biomolekülen ATE373105T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8764198P 1998-06-02 1998-06-02
US09/323,424 US6218530B1 (en) 1998-06-02 1999-06-01 Compounds and methods for detecting biomolecules

Publications (1)

Publication Number Publication Date
ATE373105T1 true ATE373105T1 (de) 2007-09-15

Family

ID=22206377

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99949531T ATE373105T1 (de) 1998-06-02 1999-06-02 Verbindungen und methoden zum nachweis von biomolekülen

Country Status (7)

Country Link
US (1) US6218530B1 (de)
EP (1) EP1086251B1 (de)
AT (1) ATE373105T1 (de)
AU (1) AU759399B2 (de)
CA (2) CA2333987C (de)
DE (1) DE69937108T2 (de)
WO (1) WO1999067619A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060057565A1 (en) * 2000-09-11 2006-03-16 Jingyue Ju Combinatorial fluorescence energy transfer tags and uses thereof
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
US6664079B2 (en) 2000-10-06 2003-12-16 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
WO2002095073A1 (en) * 2001-05-18 2002-11-28 Wisconsin Alumni Research Foundation Method for the synthesis of dna sequences
US7057031B2 (en) * 2001-07-13 2006-06-06 Ambergen, Inc. Nucleotide compositions comprising photocleavable markers and methods of preparation thereof
US7057026B2 (en) * 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
AU2003259350A1 (en) * 2002-08-23 2004-03-11 Solexa Limited Modified nucleotides for polynucleotide sequencing
AU2003297859A1 (en) * 2002-12-13 2004-07-09 The Trustees Of Columbia University In The City Of New York Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
US20040185473A1 (en) * 2002-12-17 2004-09-23 Affymetrix, Inc. Releasable polymer arrays
US20040248162A1 (en) * 2002-12-17 2004-12-09 Affymetrix, Inc. Releasable polymer arrays
WO2006073436A2 (en) * 2004-04-29 2006-07-13 The Trustees Of Columbia University In The City Of New York Mass tag pcr for multiplex diagnostics
US7547775B2 (en) * 2004-12-31 2009-06-16 Affymetrix, Inc. Parallel preparation of high fidelity probes in an array format
US9169510B2 (en) * 2005-06-21 2015-10-27 The Trustees Of Columbia University In The City Of New York Pyrosequencing methods and related compositions
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
WO2007062105A2 (en) * 2005-11-21 2007-05-31 The Trustees Of Columbia University In The City Of New York Multiplex digital immuno-sensing using a library of photocleavable mass tags
JP4984990B2 (ja) * 2006-03-28 2012-07-25 富士通株式会社 機能性分子の製造方法
US8399188B2 (en) 2006-09-28 2013-03-19 Illumina, Inc. Compositions and methods for nucleotide sequencing
US7883869B2 (en) 2006-12-01 2011-02-08 The Trustees Of Columbia University In The City Of New York Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
EP3431615A3 (de) 2007-10-19 2019-02-20 The Trustees of Columbia University in the City of New York Dna-sequenzierung mit nichtfluoreszierenden, reversiblen nukleotidterminatoren und spaltbaren, etikettmodifizierten nukleotidterminatoren
WO2009051807A1 (en) 2007-10-19 2009-04-23 The Trustees Of Columbia University In The City Of New York Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis
US20090286286A1 (en) * 2007-11-06 2009-11-19 Ambergen , Inc. Methods for controlling amplification
US9347092B2 (en) * 2009-02-25 2016-05-24 Roche Molecular System, Inc. Solid support for high-throughput nucleic acid analysis
US9523680B2 (en) 2010-06-30 2016-12-20 Ambergen, Inc. Global Proteomic screening of random bead arrays using mass spectrometry imaging
ES2676183T3 (es) 2010-07-02 2018-07-17 Ventana Medical Systems, Inc. Detección de dianas usando marcas de masa y espectrometría de masas
US9624539B2 (en) 2011-05-23 2017-04-18 The Trustees Of Columbia University In The City Of New York DNA sequencing by synthesis using Raman and infrared spectroscopy detection
US10648026B2 (en) 2013-03-15 2020-05-12 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
CN105377869B (zh) 2013-03-15 2018-07-10 伊鲁米纳剑桥有限公司 修饰的核苷或核苷酸
EP3372610A1 (de) * 2017-03-08 2018-09-12 ETH Zurich Neuartige phosphorylierungsreagenzien und verwendungen davon
WO2019104070A1 (en) * 2017-11-21 2019-05-31 Nanostring Technologies, Inc. O-nitrobenzyl photocleavable bifunctional linker
GB2626908B (en) 2020-10-29 2025-07-16 Ambergen Inc Methods of using photocleavable mass-tags comprising nucleic acid probes for multiplexed mass spectrometric imaging of tissues

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258506A (en) * 1984-10-16 1993-11-02 Chiron Corporation Photolabile reagents for incorporation into oligonucleotide chains
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5986076A (en) 1994-05-11 1999-11-16 Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
US5643722A (en) 1994-05-11 1997-07-01 Trustees Of Boston University Methods for the detection and isolation of proteins

Also Published As

Publication number Publication date
US6218530B1 (en) 2001-04-17
EP1086251B1 (de) 2007-09-12
CA2717107A1 (en) 1999-12-29
EP1086251A4 (de) 2002-04-03
EP1086251A2 (de) 2001-03-28
DE69937108T2 (de) 2008-06-12
DE69937108D1 (de) 2007-10-25
AU759399B2 (en) 2003-04-17
CA2333987C (en) 2011-01-18
WO1999067619A3 (en) 2000-04-20
CA2333987A1 (en) 1999-12-29
WO1999067619A2 (en) 1999-12-29
AU6238299A (en) 2000-01-10

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