ATE373483T1 - Zusammensetzung zur behandlung von prostatakrebs - Google Patents
Zusammensetzung zur behandlung von prostatakrebsInfo
- Publication number
- ATE373483T1 ATE373483T1 AT00989699T AT00989699T ATE373483T1 AT E373483 T1 ATE373483 T1 AT E373483T1 AT 00989699 T AT00989699 T AT 00989699T AT 00989699 T AT00989699 T AT 00989699T AT E373483 T1 ATE373483 T1 AT E373483T1
- Authority
- AT
- Austria
- Prior art keywords
- prostate cancer
- composition
- treating prostate
- living mammal
- glycosidase
- Prior art date
Links
- 206010060862 Prostate cancer Diseases 0.000 title abstract 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 abstract 4
- 241000124008 Mammalia Species 0.000 abstract 3
- -1 for example Proteins 0.000 abstract 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 2
- 102000029816 Collagenase Human genes 0.000 abstract 2
- 108060005980 Collagenase Proteins 0.000 abstract 2
- 108010031186 Glycoside Hydrolases Proteins 0.000 abstract 2
- 102000005744 Glycoside Hydrolases Human genes 0.000 abstract 2
- 229910001424 calcium ion Inorganic materials 0.000 abstract 2
- 229960002424 collagenase Drugs 0.000 abstract 2
- AXMJGXMRGDCRND-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)cyclohexyl]oxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CC(C)(C)CC(C)(C)C1CCC(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)CC1 AXMJGXMRGDCRND-UHFFFAOYSA-N 0.000 abstract 1
- 108090000371 Esterases Proteins 0.000 abstract 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 abstract 1
- 229930182566 Gentamicin Natural products 0.000 abstract 1
- 108010003272 Hyaluronate lyase Proteins 0.000 abstract 1
- 102000009066 Hyaluronoglucosaminidase Human genes 0.000 abstract 1
- 102000004882 Lipase Human genes 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 239000004367 Lipase Substances 0.000 abstract 1
- 101710163270 Nuclease Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 108010001014 Plasminogen Activators Proteins 0.000 abstract 1
- 102000001938 Plasminogen Activators Human genes 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 108010023197 Streptokinase Proteins 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 229960002518 gentamicin Drugs 0.000 abstract 1
- 229960002773 hyaluronidase Drugs 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 235000019421 lipase Nutrition 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
- 229940127126 plasminogen activator Drugs 0.000 abstract 1
- 229960005202 streptokinase Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/428,375 US6428785B1 (en) | 1999-10-28 | 1999-10-28 | Method and composition for treating prostate cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE373483T1 true ATE373483T1 (de) | 2007-10-15 |
Family
ID=23698630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00989699T ATE373483T1 (de) | 1999-10-28 | 2000-10-25 | Zusammensetzung zur behandlung von prostatakrebs |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6428785B1 (de) |
| EP (1) | EP1242110B1 (de) |
| JP (1) | JP2003513931A (de) |
| CN (1) | CN1176714C (de) |
| AT (1) | ATE373483T1 (de) |
| AU (1) | AU2617901A (de) |
| CA (1) | CA2389176A1 (de) |
| DE (1) | DE60036490T2 (de) |
| WO (1) | WO2001034176A1 (de) |
Families Citing this family (63)
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| US7595199B1 (en) * | 1998-07-31 | 2009-09-29 | Max-Planck-Gesellschaft zur Förderung der Wissenchaften e.V. | Method of detecting amyloid-like fibrils or protein aggregates |
| ES2424348T3 (es) * | 2002-06-24 | 2013-10-01 | Incept, Llc | Cargas y métodos para desplazar tejidos para mejorar los resultados radiológicos |
| AU2003298972A1 (en) * | 2003-07-14 | 2005-02-04 | Dmitry Dmitrievich Genkin | Method for treating oncological, virulent and somatic diseases, method for controlling treatment efficiency, pharmaceutical agents and composition for carrying out said treatment |
| WO2006130034A1 (fr) * | 2005-04-25 | 2006-12-07 | Dmitry Dmitrievich Genkin | Procede pour prolonger la duree de vie d'animaux ou de l'humain |
| US8388951B2 (en) | 2003-07-14 | 2013-03-05 | Cls Therapeutics Limited | Method for treating systemic DNA mutation disease |
| US9248166B2 (en) | 2003-07-14 | 2016-02-02 | Cls Therapeutics Limited | Method for treating oncological diseases |
| US8431123B2 (en) * | 2003-07-14 | 2013-04-30 | Cls Therapeutics Limited | Method for treating systemic bacterial, fungal and protozoan infection |
| US8710012B2 (en) * | 2003-07-14 | 2014-04-29 | Cls Therapeutics Limited | Method for treating oncological diseases |
| GB2408207A (en) * | 2003-11-24 | 2005-05-25 | Johnson & Johnson Medical Ltd | Wound dressing for the controlled release of therapeutic agents comprising also an inhibitor of a protease enzyme & a linker group cleavable by such an enzyme |
| MXPA03011987A (es) * | 2003-12-19 | 2005-06-23 | Osio Sancho Alberto | Metodo para el tratamiento de la presbicia induciendo cambios en el poder y fisiologia corneal. |
| WO2005080589A1 (en) * | 2004-02-19 | 2005-09-01 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with kallikrein 3 (klk3) |
| WO2005097149A2 (en) * | 2004-04-09 | 2005-10-20 | Nicholas Piramal India Limited | Herbal extract for renal disorders |
| JP2008505853A (ja) | 2004-04-13 | 2008-02-28 | クインテセンス バイオサイエンシーズ インコーポレーティッド | 細胞傷害性薬剤としての非天然のリボヌクレアーゼ複合体 |
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| JP3989936B2 (ja) * | 2005-04-07 | 2007-10-10 | 進 須永 | 抗腫瘍剤及び新規dnアーゼ |
| CA2633980A1 (en) * | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Improved composition for collecting and preserving placental stem cells and methods of using the composition |
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| US20080027554A1 (en) * | 2006-07-31 | 2008-01-31 | Talmadge Karen D | Kit and methods of treatment of an intervertebral disc |
| US8871200B2 (en) * | 2006-11-28 | 2014-10-28 | Cls Therapeutics Limited | Method for treating human diseases associated with an increased deoxyribonucleic acid content in extracellular spaces of tissues and a medicinal preparation for carrying out said method |
| CA2678038C (en) | 2007-02-15 | 2016-10-11 | Allergan, Inc. | Use of botulinum toxin and enzymes for treating bladder or prostate disorders, or hyperhydrosis |
| CN101313926B (zh) * | 2007-05-30 | 2012-12-26 | 中央研究院 | 转录调控物组合物 |
| PL2187965T3 (pl) | 2007-08-17 | 2020-05-18 | Purdue Research Foundation | Koniugaty wiążący psma ligand-łącznik i sposoby ich zastosowania |
| WO2009048909A1 (en) * | 2007-10-08 | 2009-04-16 | Quintessence Biosciences, Inc. | Compositions and methods for ribonuclease-based therapies |
| CA2734446C (en) | 2008-08-22 | 2017-06-20 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| BRPI0920743A2 (pt) | 2008-10-01 | 2016-09-20 | Quintessence Biosciences Inc | ribonucleases terapeuticas |
| WO2010138918A1 (en) * | 2009-05-29 | 2010-12-02 | Pacira Pharmaceuticals, Inc. | Hyaluronidase as an adjuvant for increasing the injection volume and dispersion of large diameter synthetic membrane vesicles containing a therapeutic agent |
| CA3149284A1 (en) | 2009-12-15 | 2011-07-14 | Incept, Llc | Implants and biodegradable fiducial markers |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| MX2012011543A (es) | 2010-04-08 | 2013-05-06 | Anthrogenesis Corp | Tratamiento de sarcoidosis empleando celulas madre placentarias. |
| US8557777B2 (en) | 2010-07-09 | 2013-10-15 | The Board Of Trustees Of The University Of Illinois | Methods for treating cancer using prostate specific antigen and tumor endothelial marker peptides |
| WO2012006634A2 (en) * | 2010-07-09 | 2012-01-12 | The Board Of Trustees Of The University Of Illiniois | Prostate specific antigen (psa) peptide therapy |
| US8969315B2 (en) | 2010-12-31 | 2015-03-03 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory RNA molecules |
| WO2012109387A1 (en) | 2011-02-08 | 2012-08-16 | Halozyme, Inc. | Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia |
| JP6104896B2 (ja) | 2011-06-01 | 2017-03-29 | アントフロゲネシス コーポレーション | 胎盤幹細胞を使用する疼痛の治療 |
| WO2013091657A1 (en) * | 2011-12-22 | 2013-06-27 | Herlev Hospital | Therapeutic applications of calcium electroporation to effectively induce tumor necrosis |
| DK2883104T3 (da) | 2012-08-10 | 2024-07-29 | Osio Corp D/B/A Yolia Health | Anvendelse af kontaktlinse ved behandling af en ofthalmologisk lidelse |
| EA201590783A1 (ru) | 2012-11-15 | 2015-11-30 | Эндосайт, Инк. | Конъюгаты для доставки лекарственных средств и способы лечения заболеваний, вызванных клетками, экспрессирующими psma |
| EP3456700A1 (de) | 2013-10-18 | 2019-03-20 | Deutsches Krebsforschungszentrum | Markierte inhibitoren des prostataspezifischen membranantigens (psma), deren verwendung als kontrastmittel und pharmazeutika zur behandlung von prostatakrebs |
| EP3533473A3 (de) | 2013-11-14 | 2019-12-18 | Endocyte, Inc. | Verbindungen für positronenemissionstomografie |
| CZ307195B6 (cs) * | 2013-11-18 | 2018-03-14 | František Trnka | Farmaceutická kompozice obsahující směs proenzymů a enzymů |
| WO2015140802A2 (en) * | 2014-03-20 | 2015-09-24 | Technion Research & Development Foundation Limited | Delivery system comprising a proteolytic enzyme or effector thereof for use in a method for oral treatment and uses thereof |
| US12144519B2 (en) | 2014-04-03 | 2024-11-19 | Corbin Clinical Resources, Llc | Transperineal prostate biopsy and treatment methods |
| US10743909B2 (en) | 2014-04-03 | 2020-08-18 | Corbin Clinical Resources, Llc | Transperineal prostate biopsy device, systems, and methods of use |
| US10064681B2 (en) | 2014-04-03 | 2018-09-04 | Corbin Clinical Resources, Llc | Method, system, and device for planning and performing, guided and free-handed transperineal prostate biopsies |
| US10617743B2 (en) | 2014-06-19 | 2020-04-14 | Cls Therapeutics Limited | Method to improve safety and efficacy of anti-cancer therapy |
| GB2528304B (en) * | 2014-07-17 | 2020-05-13 | Cambridge Univ Hospitals Nhs Foundation Trust | Perineal prostate biopsy apparatus |
| WO2016025922A1 (en) * | 2014-08-14 | 2016-02-18 | Dana-Farber Cancer Institute, Inc. | Coated particles for drug delivery |
| CN105477627B (zh) * | 2014-09-19 | 2021-04-30 | 山东蓝金生物工程有限公司 | 治疗前列腺癌的组合物及其用途 |
| KR101683635B1 (ko) | 2014-12-29 | 2016-12-09 | 가천대학교 산학협력단 | 락테이트 금속염을 포함하는 암 치료용 약학 조성물 |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| ES2799515T3 (es) | 2015-05-22 | 2020-12-18 | Dmitry Dmitrievich Genkin | ADN extracelular como una diana terapéutica en la neurodegeneración |
| WO2017074257A1 (en) * | 2015-10-26 | 2017-05-04 | Nanyang Technological University | Non-viable derivatives of clostridium sporogenes as anti-cancer therapeutic agents |
| CN105255825B (zh) * | 2015-11-16 | 2019-07-19 | 广州赛莱拉干细胞科技股份有限公司 | 一种跟腱来源肌腱干细胞原代分离消化液及分离方法 |
| AU2019209770B2 (en) | 2018-01-16 | 2025-07-31 | Cls Therapeutics Limited | Treatment of diseases by liver expression of an enzyme which has a deoxyribonuclease (DNase) activity |
| WO2019145950A1 (en) | 2018-01-23 | 2019-08-01 | Technion Research & Development Foundation Limited | Collagenase loaded liposomes for enhancing drug delivery |
| CN112368024A (zh) | 2018-04-17 | 2021-02-12 | 恩多塞特公司 | 治疗癌症的方法 |
| EP3698806A1 (de) * | 2019-02-19 | 2020-08-26 | Fundacion Instituto De Investigacion Sanitaria Fundacion Jimenez Diaz | Chemisches skalpell |
| CN114096264B (zh) | 2019-05-20 | 2025-03-14 | 因多塞特股份有限公司 | 制备psma缀合物的方法 |
| CN111705051A (zh) * | 2020-07-28 | 2020-09-25 | 金紫晶(南京)生物医药技术有限公司 | 一种复合消化酶及复合消化酶冻干粉 |
| CN112941009B (zh) * | 2021-02-22 | 2024-03-01 | 新格元(南京)生物科技有限公司 | 一种ffpe样本预处理液及从ffpe样本中分离单细胞的方法 |
| CN115671267A (zh) * | 2021-07-23 | 2023-02-03 | 上海宝济药业有限公司 | 一种皮下抗生素药物组合物 |
| CN117258047B (zh) * | 2023-10-12 | 2024-06-18 | 成都世联康健生物科技有限公司 | 一种猪牙髓组织脱细胞外基质水凝胶及其制备方法和应用 |
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| US4524065A (en) | 1983-08-04 | 1985-06-18 | Bio-Specifics N.V. | Method for the prevention and treatment of scars with enzymes |
| US4645668A (en) | 1983-08-04 | 1987-02-24 | Biospecifics, Nv | Method for the prevention and treatment of scars with enzymes |
| US4678668A (en) | 1985-10-28 | 1987-07-07 | Md Associates | Method of reducing soft tissue swelling and pain |
| US4978332A (en) | 1987-09-28 | 1990-12-18 | Matrix Pharmaceutical, Inc. | Treatments employing vasoconstrictive substances in combination with cytotoxic agents for introduction into cellular lesion areas |
| US5116615A (en) | 1989-01-27 | 1992-05-26 | Immunolytics, Inc. | Method for treating benign prostatic hypertrophy |
| HK1003981A1 (en) * | 1989-01-27 | 1998-11-13 | Immunolytics, Inc. | Composition and method for treating benign prostatic hypertrophy |
| US5162115A (en) | 1989-05-09 | 1992-11-10 | Pietronigro Dennis D | Antineoplastic solution and method for treating neoplasms |
| US5051257A (en) | 1989-05-09 | 1991-09-24 | Pietronigro Dennis D | Antineoplastic solution and method for treating neoplasms |
| US5958406A (en) * | 1994-11-22 | 1999-09-28 | Phairson Medical Inc. | Acne treatment with multifunctional enzyme |
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| JPH09508892A (ja) | 1993-11-17 | 1997-09-09 | マサチューセッツ インスティテュート オブ テクノロジー | ヘパリナーゼを用いる血管形成の阻害方法 |
| CA2189646C (en) | 1994-06-24 | 1999-05-25 | Francis E. Dwulet | A purified mixture of collagenases and two other proteases obtained from clostridium histolyticum |
| US5658730A (en) | 1994-12-23 | 1997-08-19 | Ctrc Research Foundation | Methods of human prostate cancer diagnosis |
| US5854206A (en) | 1995-08-25 | 1998-12-29 | Corixa Corporation | Compounds and methods for treatment and diagnosis of prostate cancer |
| AU7130696A (en) | 1995-09-19 | 1997-04-09 | Schering Aktiengesellschaft | Combination of beta-interferon for the treatment of prostate cancer |
| US5783182A (en) | 1996-01-30 | 1998-07-21 | Baylor College Of Medicine | Method for identifying metastatic sequences |
| US5780435A (en) | 1995-12-15 | 1998-07-14 | Praecis Pharmaceuticals Incorporated | Methods for treating prostate cancer with LHRH-R antagonists |
| US5989888A (en) | 1996-01-24 | 1999-11-23 | Roche Diagnostics Corporation | Purified mixture of collagenase I, collagenase II and two other proteases |
| US5716541A (en) | 1996-09-23 | 1998-02-10 | Bayer Corporation | Azeotrope-like compositions of 1,1,1,3,3 pentafluoropropane and tetramethylsilane |
| US5830741A (en) | 1996-12-06 | 1998-11-03 | Boehringer Mannheim Corporation | Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease |
-
1999
- 1999-10-28 US US09/428,375 patent/US6428785B1/en not_active Expired - Fee Related
-
2000
- 2000-10-25 JP JP2001536173A patent/JP2003513931A/ja active Pending
- 2000-10-25 WO PCT/US2000/041562 patent/WO2001034176A1/en not_active Ceased
- 2000-10-25 EP EP00989699A patent/EP1242110B1/de not_active Expired - Lifetime
- 2000-10-25 AU AU26179/01A patent/AU2617901A/en not_active Abandoned
- 2000-10-25 CN CNB008149208A patent/CN1176714C/zh not_active Expired - Fee Related
- 2000-10-25 AT AT00989699T patent/ATE373483T1/de not_active IP Right Cessation
- 2000-10-25 DE DE60036490T patent/DE60036490T2/de not_active Expired - Fee Related
- 2000-10-25 CA CA002389176A patent/CA2389176A1/en not_active Abandoned
-
2002
- 2002-01-22 US US10/055,063 patent/US6913744B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60036490D1 (de) | 2007-10-31 |
| CA2389176A1 (en) | 2001-05-17 |
| US6428785B1 (en) | 2002-08-06 |
| EP1242110A1 (de) | 2002-09-25 |
| US20020106359A1 (en) | 2002-08-08 |
| WO2001034176A1 (en) | 2001-05-17 |
| CN1384754A (zh) | 2002-12-11 |
| JP2003513931A (ja) | 2003-04-15 |
| US6913744B2 (en) | 2005-07-05 |
| US20020061300A1 (en) | 2002-05-23 |
| AU2617901A (en) | 2001-06-06 |
| DE60036490T2 (de) | 2008-06-19 |
| EP1242110B1 (de) | 2007-09-19 |
| CN1176714C (zh) | 2004-11-24 |
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