ATE373491T1 - Bioaktive oberflächen-modifizierer für polymere und die daraus hergestellten gegenstände - Google Patents
Bioaktive oberflächen-modifizierer für polymere und die daraus hergestellten gegenständeInfo
- Publication number
- ATE373491T1 ATE373491T1 AT02732278T AT02732278T ATE373491T1 AT E373491 T1 ATE373491 T1 AT E373491T1 AT 02732278 T AT02732278 T AT 02732278T AT 02732278 T AT02732278 T AT 02732278T AT E373491 T1 ATE373491 T1 AT E373491T1
- Authority
- AT
- Austria
- Prior art keywords
- polymers
- oligo
- central portion
- segment
- oligomeric
- Prior art date
Links
- 239000003607 modifier Substances 0.000 title abstract 3
- 229920000642 polymer Polymers 0.000 title abstract 3
- 230000000975 bioactive effect Effects 0.000 title abstract 2
- 230000008878 coupling Effects 0.000 abstract 3
- 238000010168 coupling process Methods 0.000 abstract 3
- 238000005859 coupling reaction Methods 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 229920002521 macromolecule Polymers 0.000 abstract 2
- 239000002243 precursor Substances 0.000 abstract 2
- 229920005601 base polymer Polymers 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/64—Macromolecular compounds not provided for by groups C08G18/42 - C08G18/63
- C08G18/6415—Macromolecular compounds not provided for by groups C08G18/42 - C08G18/63 having nitrogen
- C08G18/6446—Proteins and derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0017—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using a surface active agent
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/2805—Compounds having only one group containing active hydrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/2805—Compounds having only one group containing active hydrogen
- C08G18/288—Compounds containing at least one heteroatom other than oxygen or nitrogen
- C08G18/2885—Compounds containing at least one heteroatom other than oxygen or nitrogen containing halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
- C08G18/44—Polycarbonates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/48—Polyethers
- C08G18/4854—Polyethers containing oxyalkylene groups having four carbon atoms in the alkylene group
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/64—Macromolecular compounds not provided for by groups C08G18/42 - C08G18/63
- C08G18/6484—Polysaccharides and derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
- C08G18/72—Polyisocyanates or polyisothiocyanates
- C08G18/77—Polyisocyanates or polyisothiocyanates having heteroatoms in addition to the isocyanate or isothiocyanate nitrogen and oxygen or sulfur
- C08G18/771—Polyisocyanates or polyisothiocyanates having heteroatoms in addition to the isocyanate or isothiocyanate nitrogen and oxygen or sulfur oxygen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
- C08G65/005—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds containing halogens
- C08G65/007—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds containing halogens containing fluorine
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Polyethers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002349989A CA2349989A1 (en) | 2001-06-07 | 2001-06-07 | Bioactive surface modifiers for polymers and articles made therefrom |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE373491T1 true ATE373491T1 (de) | 2007-10-15 |
Family
ID=4169231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02732278T ATE373491T1 (de) | 2001-06-07 | 2002-06-03 | Bioaktive oberflächen-modifizierer für polymere und die daraus hergestellten gegenstände |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6770725B2 (de) |
| EP (1) | EP1418946B1 (de) |
| AT (1) | ATE373491T1 (de) |
| AU (1) | AU2002304926B2 (de) |
| CA (2) | CA2349989A1 (de) |
| DE (1) | DE60222563T2 (de) |
| ES (1) | ES2294134T3 (de) |
| NZ (1) | NZ529795A (de) |
| WO (1) | WO2002098477A2 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004081055A1 (ja) * | 2003-02-21 | 2004-09-23 | Terumo Kabushiki Kaisha | 架橋性多糖誘導体、その製造方法、架橋性多糖組成物および医療用処置材 |
| US7220816B2 (en) * | 2003-12-16 | 2007-05-22 | Advanced Cardiovascular Systems, Inc. | Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same |
| GB0401202D0 (en) * | 2004-01-20 | 2004-02-25 | Ucl Biomedica Plc | Polymer for use in conduits and medical devices |
| US7736671B2 (en) * | 2004-03-02 | 2010-06-15 | Boston Scientific Scimed, Inc. | Embolization |
| CA2467321A1 (en) * | 2004-05-14 | 2005-11-14 | Paul J. Santerre | Polymeric coupling agents and pharmaceutically-active polymers made therefrom |
| US7556149B2 (en) | 2004-06-07 | 2009-07-07 | Ultimed, Inc. | Sharps container for safe transportation and dispensing of unused pen needle assemblies and for safe storage of used pen needle assemblies |
| WO2007004067A2 (en) * | 2005-04-15 | 2007-01-11 | Interface Biologics Inc. | Methods and compositions for the delivery of biologically active agents |
| CA2630099C (en) * | 2005-12-08 | 2014-06-03 | The Polymer Technology Group Incorporated | Self-assembling monomers and oligomers as surface-modifying endgroups for polymers |
| EP1976694A4 (de) * | 2006-01-17 | 2010-06-30 | Interface Biologics Inc | Alkohol- und wasserabweisende vliesstoffe |
| JP2009533519A (ja) * | 2006-04-14 | 2009-09-17 | インターフェース バイオロジクス，インコーポレーテッド | グラフトポリマーおよびその使用 |
| WO2008053362A2 (en) * | 2006-06-30 | 2008-05-08 | Interface Biologics, Inc. | Bioresponsive polymers |
| CA2678422A1 (en) * | 2007-02-14 | 2008-08-21 | Mount Sinai Hospital | Fibrous scaffold for use in soft tissue engineering |
| US8796248B2 (en) * | 2007-10-05 | 2014-08-05 | Nektar Therapeutics | Oligomer-corticosteroid conjugates |
| JP5599712B2 (ja) | 2007-10-05 | 2014-10-01 | インターフェース バイオロジクス，インコーポレーテッド | オリゴフッ素化架橋ポリマーおよびそれの使用 |
| CA2703017C (en) * | 2007-10-19 | 2017-04-25 | Roseita Esfand | Self-eliminating coatings |
| DE102007062273A1 (de) * | 2007-12-14 | 2009-06-18 | Aesculap Ag | Fluoriertes Implantat |
| US20090242479A1 (en) * | 2008-03-27 | 2009-10-01 | General Electric Company | Aromatic halosulfonyl isocyanate compositions |
| WO2009129630A1 (en) * | 2008-04-25 | 2009-10-29 | Interface Biologics Inc. | Covalently grafted pharmaceutically active polymers |
| WO2010141027A1 (en) * | 2009-06-05 | 2010-12-09 | Virginia Tech Intellectual Properties, Inc. | Electromagnetic controlled biofabrication for manufactcuring of mimetic biocompatible materials |
| PT2355853T (pt) * | 2008-10-10 | 2017-03-15 | Polyactiva Pty Ltd | Conjugados polímero biodegradável ¿ unidade bioativa |
| US8535655B2 (en) | 2008-10-10 | 2013-09-17 | Polyactiva Pty Ltd. | Biodegradable polymer—bioactive moiety conjugates |
| ES2602757T3 (es) | 2009-05-15 | 2017-02-22 | Interface Biologics Inc. | Membranas de fibra hueca, material de encapsulación y tubo para la sangre antitrombogénicos |
| US8160712B1 (en) | 2009-09-23 | 2012-04-17 | Marcy Freed | Apparatus and method for treating sleep apnea |
| CN102933658A (zh) * | 2009-12-18 | 2013-02-13 | 界面生物公司 | 从自组装涂层局部递送药物 |
| WO2011141341A1 (en) | 2010-05-14 | 2011-11-17 | Iberhospitex, S.A. | Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers |
| US8583240B2 (en) | 2011-07-18 | 2013-11-12 | Marcy L. Freed | Device and method for treating dysphagia with electrical stimulation |
| US9140684B2 (en) | 2011-10-27 | 2015-09-22 | University Of Washington Through Its Center For Commercialization | Device to expose cells to fluid shear forces and associated systems and methods |
| US9320465B2 (en) | 2012-06-25 | 2016-04-26 | International Business Machines Corporation | Bio-chips and nano-biochips |
| US9574107B2 (en) | 2015-02-16 | 2017-02-21 | International Business Machines Corporation | Fluoro-alcohol additives for orientation control of block copolymers |
| JP6940415B2 (ja) * | 2015-04-24 | 2021-09-29 | ルブリゾル アドバンスド マテリアルズ， インコーポレイテッド | 表面改質されたポリマー組成物 |
| ES2902972T3 (es) | 2015-10-12 | 2022-03-30 | Lubrizol Advanced Mat Inc | Composiciones de polímeros con actividad biocida |
| CN110167995B (zh) | 2016-10-18 | 2022-07-01 | 界面生物公司 | 具有表面改性大分子的塑化pvc混合物和由其制成的制品 |
| WO2018218348A1 (en) * | 2017-05-30 | 2018-12-06 | Interface Biologics, Inc. | Prosthetic valves having a modified surface |
| WO2018218347A1 (en) * | 2017-05-30 | 2018-12-06 | Interface Biologics, Inc. | Vascular grafts having a modified surface |
| CN111971292B (zh) | 2018-02-02 | 2024-12-13 | 波纹疗法公司 | 包含类固醇二聚体的玻璃制剂及其用途 |
| JP2021531061A (ja) | 2018-05-22 | 2021-11-18 | インターフェース バイオロジクス，インコーポレーテッド | 薬物を脈管壁に送達するための組成物及び方法 |
| WO2020154815A1 (en) | 2019-02-01 | 2020-08-06 | Ripple Therapeutics Corporation | Crystalline forms of dexamethasone dimers and uses thereof |
| US12509469B2 (en) | 2019-08-07 | 2025-12-30 | Ripple Therapeutics Corporation | Compositions and methods for the treatment of pain and dependence disorders |
| WO2021220061A2 (en) | 2020-05-01 | 2021-11-04 | Ripple Therapeutics Corporation | Heterodimer compositions and methods for the treatment of ocular disorders |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4861830A (en) * | 1980-02-29 | 1989-08-29 | Th. Goldschmidt Ag | Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming |
| US5235003A (en) * | 1985-01-04 | 1993-08-10 | Thoratec Laboratories Corporation | Polysiloxane-polylactone block copolymers |
| JP2502059B2 (ja) | 1986-02-05 | 1996-05-29 | 旭硝子株式会社 | 汚れ除去性の高い撥水撥油剤 |
| DE69127081T2 (de) * | 1990-06-14 | 1998-02-05 | Vitaphore Corp., Menlo Park, Calif. | Polyurethan-biopolymer verbindung |
| US5589563A (en) * | 1992-04-24 | 1996-12-31 | The Polymer Technology Group | Surface-modifying endgroups for biomedical polymers |
| US5405919A (en) * | 1992-08-24 | 1995-04-11 | The United States Of America As Represented By The Secretary Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders |
| WO1997006195A1 (en) * | 1995-08-03 | 1997-02-20 | Santerre Paul J | Fluoroligomer surface modifiers for polymers and articles made therefrom |
| EP0874643B1 (de) * | 1996-02-15 | 2001-11-21 | J. Paul Santerre | Bioresponsive pharmakologisch aktive polymere und daraus hergestellte gegenstände |
| US5954966A (en) * | 1997-01-31 | 1999-09-21 | University Of Ottawa | Membrane composition and method of preparation |
| US6503538B1 (en) * | 2000-08-30 | 2003-01-07 | Cornell Research Foundation, Inc. | Elastomeric functional biodegradable copolyester amides and copolyester urethanes |
-
2001
- 2001-06-07 CA CA002349989A patent/CA2349989A1/en not_active Abandoned
-
2002
- 2002-06-03 AT AT02732278T patent/ATE373491T1/de not_active IP Right Cessation
- 2002-06-03 WO PCT/CA2002/000817 patent/WO2002098477A2/en not_active Ceased
- 2002-06-03 ES ES02732278T patent/ES2294134T3/es not_active Expired - Lifetime
- 2002-06-03 NZ NZ529795A patent/NZ529795A/en not_active IP Right Cessation
- 2002-06-03 AU AU2002304926A patent/AU2002304926B2/en not_active Ceased
- 2002-06-03 DE DE60222563T patent/DE60222563T2/de not_active Expired - Lifetime
- 2002-06-03 CA CA002462529A patent/CA2462529C/en not_active Expired - Fee Related
- 2002-06-03 EP EP02732278A patent/EP1418946B1/de not_active Expired - Lifetime
- 2002-06-05 US US10/162,084 patent/US6770725B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60222563T2 (de) | 2008-07-10 |
| NZ529795A (en) | 2005-06-24 |
| US6770725B2 (en) | 2004-08-03 |
| EP1418946B1 (de) | 2007-09-19 |
| EP1418946A2 (de) | 2004-05-19 |
| CA2349989A1 (en) | 2002-12-07 |
| WO2002098477A3 (en) | 2004-02-05 |
| US20030097120A1 (en) | 2003-05-22 |
| WO2002098477A2 (en) | 2002-12-12 |
| AU2002304926B2 (en) | 2007-10-04 |
| ES2294134T3 (es) | 2008-04-01 |
| CA2462529A1 (en) | 2002-12-12 |
| CA2462529C (en) | 2010-02-02 |
| DE60222563D1 (de) | 2007-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |