ATE373730T1 - Verwendung von humanen oatp-c polymorphismen, die einen effekt auf die pharmakokinetik von statin haben, bei der statin-therapie - Google Patents
Verwendung von humanen oatp-c polymorphismen, die einen effekt auf die pharmakokinetik von statin haben, bei der statin-therapieInfo
- Publication number
- ATE373730T1 ATE373730T1 AT04743565T AT04743565T ATE373730T1 AT E373730 T1 ATE373730 T1 AT E373730T1 AT 04743565 T AT04743565 T AT 04743565T AT 04743565 T AT04743565 T AT 04743565T AT E373730 T1 ATE373730 T1 AT E373730T1
- Authority
- AT
- Austria
- Prior art keywords
- statin
- polymorphisms
- pharmacokinetics
- effect
- oatp
- Prior art date
Links
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title abstract 5
- 101000836291 Homo sapiens Solute carrier organic anion transporter family member 1B1 Proteins 0.000 title abstract 4
- 102100027233 Solute carrier organic anion transporter family member 1B1 Human genes 0.000 title abstract 3
- 102000054765 polymorphisms of proteins Human genes 0.000 title abstract 3
- 230000000694 effects Effects 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 abstract 2
- 229960000672 rosuvastatin Drugs 0.000 abstract 2
- 102000057538 human SLCO1B1 Human genes 0.000 abstract 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Semiconductor Lasers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0317592.4A GB0317592D0 (en) | 2003-07-26 | 2003-07-26 | Method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE373730T1 true ATE373730T1 (de) | 2007-10-15 |
Family
ID=27772801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04743565T ATE373730T1 (de) | 2003-07-26 | 2004-07-26 | Verwendung von humanen oatp-c polymorphismen, die einen effekt auf die pharmakokinetik von statin haben, bei der statin-therapie |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7700277B2 (de) |
| EP (1) | EP1651774B1 (de) |
| JP (1) | JP4166257B2 (de) |
| AT (1) | ATE373730T1 (de) |
| CY (1) | CY1107801T1 (de) |
| DE (1) | DE602004009083T2 (de) |
| DK (1) | DK1651774T3 (de) |
| ES (1) | ES2291899T3 (de) |
| GB (1) | GB0317592D0 (de) |
| PL (1) | PL1651774T3 (de) |
| PT (1) | PT1651774E (de) |
| WO (1) | WO2005012566A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1784504A2 (de) * | 2004-07-21 | 2007-05-16 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | C463a-polymorphismus des oatp-c-gens als grundlage für das variable ansprechen auf die statintherapie |
| WO2009106838A1 (en) * | 2008-02-29 | 2009-09-03 | Isis Innovation Limited | Diagnostic methods |
| US9817001B2 (en) | 2008-05-27 | 2017-11-14 | Boston Heart Diagnostics Corporation | Methods for determining LDL cholesterol treatment |
| US8470541B1 (en) | 2008-09-27 | 2013-06-25 | Boston Heart Diagnostics Corporation | Methods for separation and immuno-detection of biomolecules, and apparatus related thereto |
| AU2012322018B2 (en) * | 2011-10-13 | 2017-09-21 | Boston Heart Diagnostics | Compositions and methods for treating and preventing coronary heart disease |
| US9828624B2 (en) | 2013-07-24 | 2017-11-28 | Boston Heart Diagnostics Corporation | Driving patient compliance with therapy |
| EP3220810A4 (de) | 2014-11-17 | 2018-05-16 | Boston Heart Diagnostic Corporation | Beurteilung des risikos für herz-kreislauf-erkrankungen |
| US10572811B2 (en) * | 2015-01-29 | 2020-02-25 | Splunk Inc. | Methods and systems for determining probabilities of occurrence for events and determining anomalous events |
| CN120795059A (zh) | 2018-08-27 | 2025-10-17 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| CN110904215A (zh) * | 2019-12-16 | 2020-03-24 | 西安和合医学检验所有限公司 | 用于同步检测slco1b1基因的两个snp位点的基因多态性的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US32011A (en) * | 1861-04-09 | Coffee-pot | ||
| US4376110A (en) * | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4486530A (en) * | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
| US4411993A (en) * | 1981-04-29 | 1983-10-25 | Steven Gillis | Hybridoma antibody which inhibits interleukin 2 activity |
| USRE32011E (en) | 1981-12-14 | 1985-10-22 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
| US4543439A (en) * | 1982-12-13 | 1985-09-24 | Massachusetts Institute Of Technology | Production and use of monoclonal antibodies to phosphotyrosine-containing proteins |
| US4902614A (en) * | 1984-12-03 | 1990-02-20 | Teijin Limited | Monoclonal antibody to human protein C |
| IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| GB8902689D0 (en) | 1989-02-07 | 1989-03-30 | Ici Plc | Assay method |
| US5210015A (en) * | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| EP2423322A1 (de) | 1993-11-12 | 2012-02-29 | PHRI Properties, Inc. | Hybridisierungsprobe zur Nukleinsäuredetektion, universelle Stammstrukturen, Methoden und Reagentiensätze |
| EP1141282A2 (de) | 1998-08-07 | 2001-10-10 | Axys Pharmaceuticals, Inc. | Humäne anionstransporter-genen atnov |
| US20020090622A1 (en) | 2000-08-23 | 2002-07-11 | Monisola Adeokun | Chemical compounds |
-
2003
- 2003-07-26 GB GBGB0317592.4A patent/GB0317592D0/en not_active Ceased
-
2004
- 2004-07-26 WO PCT/GB2004/003236 patent/WO2005012566A2/en not_active Ceased
- 2004-07-26 PL PL04743565T patent/PL1651774T3/pl unknown
- 2004-07-26 US US10/566,054 patent/US7700277B2/en not_active Expired - Fee Related
- 2004-07-26 JP JP2006521655A patent/JP4166257B2/ja not_active Expired - Fee Related
- 2004-07-26 ES ES04743565T patent/ES2291899T3/es not_active Expired - Lifetime
- 2004-07-26 DE DE602004009083T patent/DE602004009083T2/de not_active Expired - Lifetime
- 2004-07-26 EP EP04743565A patent/EP1651774B1/de not_active Expired - Lifetime
- 2004-07-26 DK DK04743565T patent/DK1651774T3/da active
- 2004-07-26 PT PT04743565T patent/PT1651774E/pt unknown
- 2004-07-26 AT AT04743565T patent/ATE373730T1/de active
-
2007
- 2007-11-14 CY CY20071101470T patent/CY1107801T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB0317592D0 (en) | 2003-08-27 |
| CY1107801T1 (el) | 2013-06-19 |
| PL1651774T3 (pl) | 2007-12-31 |
| JP4166257B2 (ja) | 2008-10-15 |
| DE602004009083T2 (de) | 2008-06-19 |
| US20070031838A1 (en) | 2007-02-08 |
| ES2291899T3 (es) | 2008-03-01 |
| DK1651774T3 (da) | 2008-01-07 |
| EP1651774B1 (de) | 2007-09-19 |
| WO2005012566A2 (en) | 2005-02-10 |
| JP2007500005A (ja) | 2007-01-11 |
| EP1651774A2 (de) | 2006-05-03 |
| WO2005012566A3 (en) | 2005-06-16 |
| PT1651774E (pt) | 2007-11-16 |
| US7700277B2 (en) | 2010-04-20 |
| DE602004009083D1 (de) | 2007-10-31 |
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| UEP | Publication of translation of european patent specification |
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