ATE374178T1 - 2-alkylidene-19-nor-vitamin d verbindungen und ihre therapeutische verwendungen - Google Patents

2-alkylidene-19-nor-vitamin d verbindungen und ihre therapeutische verwendungen

Info

Publication number: ATE374178T1
Authority: AT; Austria
Prior art keywords: compounds; vitamin; group; diseases; alkylidene
Prior art date: 2000-03-31

Application number

AT01920897T

Other languages

English (en)

Inventor

Hector Deluca

Rafal Sicinski

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-31

Filing date

2001-03-29

Publication date

2007-10-15

2001-03-29 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

2007-10-15 Application granted granted Critical

2007-10-15 Publication of ATE374178T1 publication Critical patent/ATE374178T1/de

Links

230000001225 therapeutic effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
230000000694 effects Effects 0.000 abstract 3
229930003316 Vitamin D Natural products 0.000 abstract 2
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
235000019166 vitamin D Nutrition 0.000 abstract 2
239000011710 vitamin D Substances 0.000 abstract 2
150000003710 vitamin D derivatives Chemical class 0.000 abstract 2
229940046008 vitamin d Drugs 0.000 abstract 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
201000004681 Psoriasis Diseases 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
210000000988 bone and bone Anatomy 0.000 abstract 1
230000008416 bone turnover Effects 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
230000004069 differentiation Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
238000007429 general method Methods 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
230000000968 intestinal effect Effects 0.000 abstract 1
210000001616 monocyte Anatomy 0.000 abstract 1
230000011164 ossification Effects 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
230000027425 release of sequestered calcium ion into cytosol Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Nutrition Science (AREA)
Biomedical Technology (AREA)
Transplantation (AREA)
Neurosurgery (AREA)
Reproductive Health (AREA)
Oncology (AREA)
Neurology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT01920897T 2000-03-31 2001-03-29 2-alkylidene-19-nor-vitamin d verbindungen und ihre therapeutische verwendungen ATE374178T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/540,686 US6392071B1 (en)	1997-03-17	2000-03-31	26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds

Publications (1)

Publication Number	Publication Date
ATE374178T1 true ATE374178T1 (de)	2007-10-15

Family

ID=24156520

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01920897T ATE374178T1 (de)	2000-03-31	2001-03-29	2-alkylidene-19-nor-vitamin d verbindungen und ihre therapeutische verwendungen

Country Status (14)

Country	Link
US (5)	US6392071B1 (de)
EP (1)	EP1268416B1 (de)
JP (1)	JP4022071B2 (de)
KR (1)	KR20020091167A (de)
AT (1)	ATE374178T1 (de)
AU (2)	AU2001247905B2 (de)
CA (1)	CA2404548C (de)
DE (1)	DE60130640T2 (de)
DK (1)	DK1268416T3 (de)
ES (1)	ES2291305T3 (de)
IL (1)	IL152020A (de)
MX (1)	MXPA02009590A (de)
NZ (1)	NZ522160A (de)
WO (1)	WO2001074766A1 (de)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
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US6316642B1 (en) *	1997-03-17	2001-11-13	Wisconsin Alumni Research Foundation	26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds
US6392071B1 (en) *	1997-03-17	2002-05-21	Wisconsin Alumni: Research Foundation	26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
CN1308303C (zh) *	2001-12-13	2007-04-04	威斯康星校友研究基金会	(20S)－1α－羟基－2－亚甲基－19－去甲－双高孕钙化醇及其应用
US6627622B2 (en)	2002-02-18	2003-09-30	Wisconsin Alumni Research Foundation	(20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses
US20030195175A1 (en) *	2002-03-25	2003-10-16	Deluca Hector F.	Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone
WO2004033420A1 (ja) *	2002-10-10	2004-04-22	Chugai Pharmaceutical Co Ltd	２,２−ジ置換−１α，２５−ジヒドロキシ−１９−ノルビタミンＤ誘導体
RU2317992C2 (ru)	2003-02-25	2008-02-27	Кей Эн Си Лэборэтериз Ко., Лтд.	Новые промежуточные соединения для синтеза производных витамина d
ZA200506204B (en) *	2003-04-10	2006-10-25	Wisconsin Alumni Res Found	2-propylidene-19-nor-vitamin D compounds
US20070032461A1 (en) *	2003-04-30	2007-02-08	Bioxell S.P.A.	1,3 Aclyated 24-keto-vitamin d3 compounds and methods of use thereof
US6894037B2 (en) *	2003-07-03	2005-05-17	Wisconsin Alumni Research Foundation	2-methylene-19-nor-20(S)-25-methyl-1α-hydroxycalciferol and its uses
EP1641466B1 (de) *	2003-07-03	2007-01-03	Wisconsin Alumni Research Foundation	2-methylen-19-nor-20(s)-25-methyl-1alpha-hydroxycalciferol und seine verwendungen
US20050009792A1 (en) *	2003-07-08	2005-01-13	Deluca Hector F.	(20S)-1alpha-hydroxy-2-methylene-19-nor-vitamin D3 and its uses
EP1656157B1 (de) *	2003-08-20	2011-12-21	Wisconsin Alumni Research Foundation	2-methylen-19-nor-vitamin d2-verbindungen
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WO2005027928A1 (en) *	2003-09-19	2005-03-31	Pfizer Products Inc.	2-alkylidene-19-nor-vit amin d derivatives for the treatment of hypocalcemic tetany or hyproparathyroidism
US7214670B2 (en) *	2003-09-24	2007-05-08	Wisconsin Alumni Research Foundation	Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 to increase the life expectancy of human beings
US7704980B2 (en) *	2003-10-08	2010-04-27	Wisconsin Alumni Research Foundation	Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds
EP1694333A2 (de) *	2003-11-25	2006-08-30	Deltanoid Pharmaceuticals, Inc.	Verfahren zur reduzierung des körperfetts mit vitamin-d-verbindungen
WO2005051323A2 (en) *	2003-11-25	2005-06-09	Wisconsin Alumni Research Foundation	Vitamin d analogs for obesity prevention and treatment
US8404667B2 (en)	2006-12-29	2013-03-26	Wisconsin Alumni Research Foundation	Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
WO2005079464A2 (en) *	2004-02-17	2005-09-01	Wisconsin Alumni Research Foundation	Vitamin d receptor antagonists and their use in treating asthma
US7214671B2 (en) *	2004-02-19	2007-05-08	Wisconsin Alumni Research Foundation	Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases
US7713951B2 (en) *	2004-04-09	2010-05-11	Wisconsin Alumni Research Foundation	2-alkylidene-18,19-dinor-vitamin D compounds
US20080293647A1 (en)	2004-11-12	2008-11-27	Luciano Adorini	Combined Use Of Vitamin D Derivatives And Anti-Proliferative Agents For Treating Bladder Cancer
EP1831161B1 (de) *	2004-11-22	2017-07-26	Wisconsin Alumni Research Foundation	Medizinische und kosmetische verwendung von 2-methylen-19-nor-(20r)-1-alpha-hydroxy-bishomopregnacalciferol
NZ555282A (en) *	2004-11-22	2010-12-24	Wisconsin Alumni Res Found	17,20(z)-dehydro vitamin D analogs and their uses
NZ555281A (en) *	2004-11-22	2011-01-28	Wisconsin Alumni Res Found	2-methylene-19,26,27-trinor-(20s)-1alpha-alpha-hydroxyvitamin D3 and its uses
AU2005309819A1 (en) *	2004-11-22	2006-06-01	Wisconsin Alumni Research Foundation	2-methylene-19-nor-(20S)-1alpha-hydroxy-trishomopregnacalciferol
NZ555561A (en) *	2004-11-22	2009-02-28	Wisconsin Alumni Res Found	2-methylene-19,21-dinor-1alpha-hydroxy-bishomopregnacalciferol (a Vitamin D derivative)
EP1853274B1 (de) *	2005-02-11	2013-01-23	Wisconsin Alumni Research Foundation	2-methylen-19-nor- (20s-24s) - 1alpha, 25-dihydroxyvitamin-d2
JP5036565B2 (ja) *	2005-02-11	2012-09-26	ウイスコンシンアラムニリサーチファンデーション	２−メチレン−１９−ノル−（２０Ｓ−２４エピ）−１α，２５−ジヒドロキシビタミン−Ｄ２
JP2008538214A (ja) *	2005-03-29	2008-10-16	ウイスコンシンアラムニリサーチファンデーション	２−メチレン−１９−ノル−（２３Ｓ）−２５−デヒドロ−１α−ヒドロキシビタミンＤ３−２６，２３−ラクトンおよび２−メチレン−１９−ノル−（２３Ｒ）−２５−デヒドロ−１α−ヒドロキシビタミンＤ３−２６，２３−ラクトン
EP1877063A4 (de) *	2005-05-03	2009-11-04	Wisconsin Alumni Res Found	19,26,27-trinor-1alpha ,25-dihydroxyvitamin-d3-verbindungen
AU2006284622B2 (en)	2005-08-30	2011-10-06	Wisconsin Alumni Research Foundation	Des-C,D analogs of 1alpha,25-dihydroxy-19-norvitamin D3
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WO2007117563A2 (en) *	2006-04-05	2007-10-18	Wisconsin Alumni Research Foundation	1.alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and use thereof
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CA2648324A1 (en) *	2006-04-06	2007-10-18	Wisconsin Alumni Research Foundation	2-methylene-1.alpha.,25-dihydroxy-19,21-dinorvitamin d3 analogs and uses thereof
US7648972B2 (en) *	2006-04-06	2010-01-19	Wisconsin Alumni Research Foundation	2-methylene-1α-hydroxy-19,21-dinorvitamin D3 analogs and uses thereof
EP2001841B1 (de) *	2006-04-06	2012-06-13	Wisconsin Alumni Research Foundation	2-methylen-1-alpha-hydroxy-18,19,21-trinorvitamin-d3-analoge und deren verwendungen
JP2009532460A (ja)	2006-04-06	2009-09-10	ウイスコンシンアラムニリサーチファンデーション	２−置換−１α，２５−ジヒドロキシ−１９，２６，２７−トリノルビタミンＤ類縁体およびその使用
EP2021321B1 (de) *	2006-04-06	2012-06-20	Wisconsin Alumni Research Foundation	2-methylen-1alpha,25-dihydroxy-18,19,21-trinorvitamin d3 und anwendungen davon
WO2008026078A2 (en) *	2006-04-06	2008-03-06	Wisconsin Alumni Research Foundation	19-nor-vitamin d analogs with 1,2,or 3,2 heterocyclic ring
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2000
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2001
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NZ522160A (en)	2004-11-26
IL152020A (en)	2008-03-20
DK1268416T3 (da)	2008-02-04
AU4790501A (en)	2001-10-15
US20030181427A1 (en)	2003-09-25
JP4022071B2 (ja)	2007-12-12
EP1268416B1 (de)	2007-09-26
US6392071B1 (en)	2002-05-21
ES2291305T3 (es)	2008-03-01
IL152020A0 (en)	2003-04-10
US6696431B2 (en)	2004-02-24
US20090143342A1 (en)	2009-06-04
US20020087015A1 (en)	2002-07-04
DE60130640D1 (de)	2007-11-08
CA2404548C (en)	2009-07-21
CA2404548A1 (en)	2001-10-11
EP1268416A1 (de)	2003-01-02
MXPA02009590A (es)	2004-03-26
US7094774B2 (en)	2006-08-22
US20040167104A1 (en)	2004-08-26
WO2001074766A1 (en)	2001-10-11
AU2001247905B2 (en)	2005-05-19
DE60130640T2 (de)	2008-07-17
US6537981B2 (en)	2003-03-25
KR20020091167A (ko)	2002-12-05
JP2003529581A (ja)	2003-10-07

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