ATE374599T1 - In der mundhöhle schnell zerfallende orale arzneizubereitung enthaltend einen cyclooxygenase-2 hemmer - Google Patents

In der mundhöhle schnell zerfallende orale arzneizubereitung enthaltend einen cyclooxygenase-2 hemmer

Info

Publication number: ATE374599T1
Authority: AT; Austria
Prior art keywords: oral; cyclooxygenase; inhibitor; medicinal preparation; cavity containing
Prior art date: 2000-08-18

Application number

AT01965984T

Other languages

English (en)

Inventor

Trang Le

Tugrul Kararli

Mark Kontny

Srikonda Sastry

Janaki Nyshadham

Arthur Pagliero

Original Assignee

Pharmacia Corp

Yamanouchi Pharma Tech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-18

Filing date

2001-08-17

Publication date

2007-10-15

2001-08-17 Application filed by Pharmacia Corp, Yamanouchi Pharma Tech Inc filed Critical Pharmacia Corp

2007-10-15 Application granted granted Critical

2007-10-15 Publication of ATE374599T1 publication Critical patent/ATE374599T1/de

Links

229940093444 Cyclooxygenase 2 inhibitor Drugs 0.000 title 1
239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title 1
210000000214 mouth Anatomy 0.000 title 1
239000000203 mixture Substances 0.000 abstract 4
229940079593 drug Drugs 0.000 abstract 3
239000003814 drug Substances 0.000 abstract 3
238000000034 method Methods 0.000 abstract 3
102000010907 Cyclooxygenase 2 Human genes 0.000 abstract 2
108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 2
239000008187 granular material Substances 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
238000002156 mixing Methods 0.000 abstract 2
229920000881 Modified starch Polymers 0.000 abstract 1
239000002202 Polyethylene glycol Substances 0.000 abstract 1
239000000783 alginic acid Substances 0.000 abstract 1
235000010443 alginic acid Nutrition 0.000 abstract 1
229920000615 alginic acid Polymers 0.000 abstract 1
229960001126 alginic acid Drugs 0.000 abstract 1
150000004781 alginic acids Chemical class 0.000 abstract 1
235000012216 bentonite Nutrition 0.000 abstract 1
239000011230 binding agent Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001720 carbohydrates Chemical class 0.000 abstract 1
239000000796 flavoring agent Substances 0.000 abstract 1
235000013355 food flavoring agent Nutrition 0.000 abstract 1
235000003599 food sweetener Nutrition 0.000 abstract 1
239000000314 lubricant Substances 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
235000019426 modified starch Nutrition 0.000 abstract 1
229920001223 polyethylene glycol Polymers 0.000 abstract 1
229920000193 polymethacrylate Polymers 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
150000004760 silicates Chemical class 0.000 abstract 1
239000003765 sweetening agent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
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- A61P27/02—Ophthalmic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Physiology (AREA)
Nutrition Science (AREA)
Zoology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Reproductive Health (AREA)
Gastroenterology & Hepatology (AREA)
Cardiology (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT01965984T 2000-08-18 2001-08-17 In der mundhöhle schnell zerfallende orale arzneizubereitung enthaltend einen cyclooxygenase-2 hemmer ATE374599T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US22634700P	2000-08-18	2000-08-18

Publications (1)

Publication Number	Publication Date
ATE374599T1 true ATE374599T1 (de)	2007-10-15

Family

ID=22848576

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01965984T ATE374599T1 (de)	2000-08-18	2001-08-17	In der mundhöhle schnell zerfallende orale arzneizubereitung enthaltend einen cyclooxygenase-2 hemmer

Country Status (20)

Country	Link
US (1)	US20020049233A1 (de)
EP (2)	EP1355631B1 (de)
JP (2)	JP2004512274A (de)
KR (1)	KR20030045035A (de)
CN (1)	CN1638739A (de)
AT (1)	ATE374599T1 (de)
AU (3)	AU8653001A (de)
BR (1)	BR0113293A (de)
CA (2)	CA2420190A1 (de)
CZ (1)	CZ2003422A3 (de)
DE (1)	DE60130801T2 (de)
DK (1)	DK1355631T3 (de)
ES (1)	ES2292614T3 (de)
IL (1)	IL154386A0 (de)
MX (2)	MXPA03001346A (de)
NO (1)	NO20030727L (de)
NZ (2)	NZ524115A (de)
PL (1)	PL360704A1 (de)
PT (1)	PT1355631E (de)
WO (2)	WO2002015885A2 (de)

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US20040132780A1 (en) *	2001-05-04	2004-07-08	Allen Christopher P.	Method and compositions for treating migraines
EP1429736A2 (de) *	2001-09-26	2004-06-23	Pharmacia Corporation	Organoleptisch annehmbare, im mund sich zersetzende zusammensetzungen
HUP0401776A2 (hu) *	2001-10-10	2004-12-28	Pharmacia Corporation	Intraorálisan széteső valdekoxib készítmények porlasztásos szárítási eljárással előállítva
WO2003039472A2 (en) *	2001-11-07	2003-05-15	Pharmacia Corporation	Intraorally disintegrating valdecoxib compositions prepared by fluid bed granulation process
US7838029B1 (en) *	2003-07-31	2010-11-23	Watson Laboratories, Inc.	Mirtazapine solid dosage forms
US20080095850A1 (en) *	2004-11-04	2008-04-24	Ho Jennifer S	Process for Granulating Particles
JP4945917B2 (ja) *	2005-01-19	2012-06-06	大正製薬株式会社	薬物含有コーティング用核粒子
EP3782655A1 (de)	2005-05-17	2021-02-24	Amicus Therapeutics, Inc.	Verfahren zur behandlung der pompe-krankheit unter verwendung von 1-deoxynojirimycin und derivaten
EP1843770B1 (de) *	2005-08-29	2008-06-18	Teva Pharmaceutical Industries Ltd	Festes, teilchenförmiges tadalafil mit bimodaler teilchengrössenverteilung
US7811604B1 (en)	2005-11-14	2010-10-12	Barr Laboratories, Inc.	Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same
AU2006328880A1 (en) *	2005-12-23	2007-06-28	Lek Pharmaceuticals D.D.	Bursting pellets
EP2222282A1 (de) *	2007-11-15	2010-09-01	Pfizer Products Inc.	Dosierformen mit celecoxib für schnelle und anhaltende schmerzlinderung
KR20230066482A (ko)	2012-03-07	2023-05-15	아미쿠스 세라퓨틱스, 인코포레이티드	폼페병의 치료를 위한 고농도 알파-글루코시다제 조성물
CN104027319A (zh) *	2014-06-25	2014-09-10	万特制药(海南)有限公司	一种塞来昔布分散片及其制备方法
CN114540327B (zh)	2014-09-30	2026-03-24	阿米库斯治疗学公司	具有增强的碳水化合物的高强度酸性α-葡糖苷酶
KR20250007693A (ko)	2015-12-30	2025-01-14	아미쿠스 세라퓨틱스, 인코포레이티드	폼페병 치료용의 강화된 산 알파-글루코시다제
CA3019354A1 (en)	2016-03-30	2017-10-05	Amicus Therapeutics, Inc.	Method for selection of high m6p recombinant proteins
AU2017239641A1 (en)	2016-03-30	2018-10-18	Amicus Therapeutics, Inc.	Formulations comprising recombinant acid alpha-glucosidase
SMT202300187T1 (it)	2017-05-15	2023-07-20	Amicus Therapeutics Inc	Alfa-glucosidasi acida umana ricombinante
US10350171B2 (en)	2017-07-06	2019-07-16	Dexcel Ltd.	Celecoxib and amlodipine formulation and method of making the same
CN108576205B (zh) *	2018-03-22	2022-01-04	湖北省农业科学院农产品加工与核农技术研究所	一种草莓联合干燥的处理方法
JP7291220B2 (ja)	2018-11-21	2023-06-14	トレモ― ファーマシューティカルズ，インコーポレーテッド	ロフェコキシブの精製形態、製造方法および使用
JP2020183359A (ja) *	2019-05-09	2020-11-12	日医工株式会社	セレコキシブ含有医薬組成物
US10945992B1 (en)	2019-11-13	2021-03-16	Tremeau Pharmaceuticals, Inc.	Dosage forms of rofecoxib and related methods
US20240000705A1 (en) *	2020-09-17	2024-01-04	Catalent U.K. Swindon Zydis Limited	Use of surfactant with high molecular weight fish gelatin based dosage formulations to improve flow characteristics
US11161833B1 (en)	2021-04-09	2021-11-02	Tremeau Pharmaceuticals, Inc.	Deuterated etoricoxib, methods of manufacture, and use thereof

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ATE253899T1 (de) *	1994-01-31	2003-11-15	Yamanouchi Pharma Co Ltd	Intraoral löslicher formpressling und verfahren zu seiner herstellung
US5633272A (en) *	1995-02-13	1997-05-27	Talley; John J.	Substituted isoxazoles for the treatment of inflammation
CA2178686A1 (en) *	1995-06-13	1996-12-14	Leslie G. Humber	Oral formulations of s(+)-etodolac
BR9709097A (pt) *	1996-05-17	1999-08-03	Merck & Co Inc	Composição farmacêutica para o tratamento de doenças mediadas por ciclooxigenase processo para tratar uma doença inflamatória suscetível de tratamento com um agente antinflamatório n o esteróide uso e forma oral de dose unitária
EP0839526A3 (de) *	1996-10-31	1999-01-07	Takeda Chemical Industries, Ltd.	Festes pharmazeutisches Präparat mit schneller Auflösungs- oder Disintegrationeigenschaften
IT1293764B1 (it) *	1997-07-23	1999-03-10	Chiesi Farma Spa	Composizioni farmaceutiche sotto forma di compresse effervescenti contenenti un principio attivo instabile in presenza di acqua
US6465009B1 (en) *	1998-03-18	2002-10-15	Yamanouchi Pharmaceutical Co., Ltd.	Water soluble polymer-based rapidly dissolving tablets and production processes thereof
SA99191255B1 (ar) *	1998-11-30	2006-11-25	جي دي سيرل اند كو	مركبات سيليكوكسيب celecoxib
PL351069A1 (en) *	1999-12-08	2003-03-10	Pharmacia Corp	Valdecoxib compositions
US6316029B1 (en) *	2000-05-18	2001-11-13	Flak Pharma International, Ltd.	Rapidly disintegrating solid oral dosage form
WO2002067894A2 (en) *	2001-02-27	2002-09-06	Ranbaxy Laboratories Limited	Fast dissolving tablets of cyclooxygenase-2 enzyme inhibitors

2001
- 2001-08-13 CN CN01814092.0A patent/CN1638739A/zh active Pending
- 2001-08-17 DE DE60130801T patent/DE60130801T2/de not_active Expired - Fee Related
- 2001-08-17 MX MXPA03001346A patent/MXPA03001346A/es not_active Application Discontinuation
- 2001-08-17 WO PCT/US2001/025803 patent/WO2002015885A2/en not_active Ceased
- 2001-08-17 NZ NZ524115A patent/NZ524115A/en unknown
- 2001-08-17 KR KR10-2003-7002392A patent/KR20030045035A/ko not_active Ceased
- 2001-08-17 CA CA002420190A patent/CA2420190A1/en not_active Abandoned
- 2001-08-17 PT PT01965984T patent/PT1355631E/pt unknown
- 2001-08-17 AU AU8653001A patent/AU8653001A/xx active Pending
- 2001-08-17 US US09/932,500 patent/US20020049233A1/en not_active Abandoned
- 2001-08-17 CZ CZ2003422A patent/CZ2003422A3/cs unknown
- 2001-08-17 CA CA002418730A patent/CA2418730A1/en not_active Abandoned
- 2001-08-17 BR BR0113293-8A patent/BR0113293A/pt not_active Application Discontinuation
- 2001-08-17 WO PCT/US2001/025834 patent/WO2002015886A2/en not_active Ceased
- 2001-08-17 JP JP2002520807A patent/JP2004512274A/ja not_active Withdrawn
- 2001-08-17 AU AU2001286533A patent/AU2001286533A1/en not_active Abandoned
- 2001-08-17 MX MXPA03001408A patent/MXPA03001408A/es not_active Application Discontinuation
- 2001-08-17 JP JP2002520808A patent/JP2004506681A/ja not_active Withdrawn
- 2001-08-17 EP EP01965984A patent/EP1355631B1/de not_active Expired - Lifetime
- 2001-08-17 IL IL15438601A patent/IL154386A0/xx unknown
- 2001-08-17 PL PL36070401A patent/PL360704A1/xx not_active Application Discontinuation
- 2001-08-17 AT AT01965984T patent/ATE374599T1/de not_active IP Right Cessation
- 2001-08-17 DK DK01965984T patent/DK1355631T3/da active
- 2001-08-17 NZ NZ524123A patent/NZ524123A/en unknown
- 2001-08-17 ES ES01965984T patent/ES2292614T3/es not_active Expired - Lifetime
- 2001-08-17 EP EP01965987A patent/EP1309316A2/de not_active Withdrawn
- 2001-08-17 AU AU2001286530A patent/AU2001286530B2/en not_active Ceased
2003
- 2003-02-14 NO NO20030727A patent/NO20030727L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
MXPA03001408A (es)	2005-06-30
JP2004512274A (ja)	2004-04-22
KR20030045035A (ko)	2003-06-09
ES2292614T3 (es)	2008-03-16
US20020049233A1 (en)	2002-04-25
EP1309316A2 (de)	2003-05-14
NO20030727D0 (no)	2003-02-14
WO2002015886A2 (en)	2002-02-28
NO20030727L (no)	2003-03-24
AU2001286533A1 (en)	2002-03-04
PL360704A1 (en)	2004-09-20
BR0113293A (pt)	2003-06-10
IL154386A0 (en)	2003-09-17
CA2418730A1 (en)	2002-02-28
EP1355631A2 (de)	2003-10-29
MXPA03001346A (es)	2003-06-06
PT1355631E (pt)	2007-11-29
EP1355631B1 (de)	2007-10-03
JP2004506681A (ja)	2004-03-04
WO2002015885A3 (en)	2003-08-28
CA2420190A1 (en)	2002-02-28
AU8653001A (en)	2002-03-04
WO2002015885A2 (en)	2002-02-28
AU2001286530B2 (en)	2007-01-25
DE60130801T2 (de)	2008-06-26
CZ2003422A3 (cs)	2003-06-18
DK1355631T3 (da)	2008-02-04
DE60130801D1 (de)	2007-11-15
NZ524115A (en)	2004-10-29
NZ524123A (en)	2005-02-25
CN1638739A (zh)	2005-07-13
WO2002015886A3 (en)	2002-07-25

Legal Events

Date	Code	Title	Description
2009-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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