ATE374617T1 - Verfahren zur herstellung eines bluddrucksenkenden mittel enthaltenden ein dipeptid als wirksames bestandteil - Google Patents

Verfahren zur herstellung eines bluddrucksenkenden mittel enthaltenden ein dipeptid als wirksames bestandteil

Info

Publication number
ATE374617T1
ATE374617T1 AT02080463T AT02080463T ATE374617T1 AT E374617 T1 ATE374617 T1 AT E374617T1 AT 02080463 T AT02080463 T AT 02080463T AT 02080463 T AT02080463 T AT 02080463T AT E374617 T1 ATE374617 T1 AT E374617T1
Authority
AT
Austria
Prior art keywords
producing
dipeptide
agent containing
active ingredient
blood pressure
Prior art date
Application number
AT02080463T
Other languages
English (en)
Inventor
Naoyuki Yamamoto
Original Assignee
Calpis Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calpis Co Ltd filed Critical Calpis Co Ltd
Application granted granted Critical
Publication of ATE374617T1 publication Critical patent/ATE374617T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/80—Antihypertensive peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
AT02080463T 1996-08-02 1997-08-01 Verfahren zur herstellung eines bluddrucksenkenden mittel enthaltenden ein dipeptid als wirksames bestandteil ATE374617T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20466596 1996-08-02

Publications (1)

Publication Number Publication Date
ATE374617T1 true ATE374617T1 (de) 2007-10-15

Family

ID=16494265

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02080463T ATE374617T1 (de) 1996-08-02 1997-08-01 Verfahren zur herstellung eines bluddrucksenkenden mittel enthaltenden ein dipeptid als wirksames bestandteil
AT97305820T ATE238825T1 (de) 1996-08-02 1997-08-01 Antihypertensives mittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT97305820T ATE238825T1 (de) 1996-08-02 1997-08-01 Antihypertensives mittel

Country Status (8)

Country Link
US (1) US5854029A (de)
EP (2) EP0821968B1 (de)
JP (2) JP3364579B2 (de)
AT (2) ATE374617T1 (de)
DE (2) DE69738185T2 (de)
DK (2) DK0821968T3 (de)
ES (2) ES2196263T3 (de)
PT (1) PT1302207E (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6998259B1 (en) 1999-05-20 2006-02-14 Davisco Foods International Enzymatic treatment of whey proteins for the production of antihypertensive peptides and the resulting products
US6630320B1 (en) 2000-05-08 2003-10-07 Devisco Foods International, Inc. Treatment of hypertension in mammals with hydrolyzed whey proteins
FI113741B (fi) * 1999-11-01 2004-06-15 Valio Oy Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi
TWI225070B (en) 1999-12-01 2004-12-11 Food Industry Res & Dev Inst Novel peptides used as angiotensin converting enzyme inhibitor and preparation process thereof
WO2001068114A1 (en) * 2000-03-10 2001-09-20 Monsanto Company Novel peptides with anti-hypertensive activity
WO2001068113A1 (en) * 2000-03-10 2001-09-20 Monsanto Technology Llc Anti-hypertensive peptides
EP1287159A4 (de) * 2000-05-08 2005-02-09 Davisco Foods Int Inc Enzymatische behandlung von molkeproteinen zur produktion von blutdrucksenkenden peptiden, resultierende produkte daraus und behandlung von blutdruck in säugern
EP1529114A1 (de) 2002-08-09 2005-05-11 Chr. Hansen A/S Verfahren für die herstellung von peptiden mit blutdrucksenkenden eigenschaften
US7718171B2 (en) 2003-04-07 2010-05-18 Chr. Hansen A/S Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus
EP1466529A1 (de) * 2003-04-07 2004-10-13 Chr. Hansen A/S Präparat mit herzfrequenzsenkenden Eigenschaften
JP4680571B2 (ja) * 2003-12-25 2011-05-11 カルピス株式会社 経口摂取用保湿剤
ATE532416T1 (de) 2004-09-03 2011-11-15 Chr Hansen As Fermentierte milchproteine mit rezeptor-ligand und ihre verwendungen
JP4868619B2 (ja) * 2005-09-05 2012-02-01 独立行政法人農業・食品産業技術総合研究機構 ビタミンＵ、タウリン、カルノシン、Ｔｙｒ−Ｐｒｏおよび／またはＬ−カルニチンを高濃度に含有する食用植物体及びその製造方法
JP4635159B2 (ja) * 2005-09-05 2011-02-16 独立行政法人農業・食品産業技術総合研究機構 Ｇａｂａを高濃度に含有する食用植物体及びその製造方法
EP2161029A1 (de) * 2008-09-09 2010-03-10 Unilever N.V. Zusammensetzung, die Peptide umfasst
DE602008004345D1 (de) * 2008-09-09 2011-02-17 Unilever Nv Nahrungsmittel enthaltend Dipeptide mit blutdrucksenkenden Eigenschaften.
CA2756107A1 (en) * 2009-03-27 2010-09-30 Calpis Co., Ltd. Composition for regulating autonomic nervous activity and method for regulating autonomic nerve
MY160992A (en) * 2010-11-09 2017-03-31 Asahi Group Holdings Ltd Lactobacillus helveticus having high proteolysis activity
US8673862B1 (en) 2012-09-06 2014-03-18 Food Industry Research And Development Institute Peptides and use thereof in the inhibition of angiotensin converting enzyme
WO2017222029A1 (ja) * 2016-06-23 2017-12-28 国立大学法人鳥取大学 アンジオテンシン変換酵素阻害活性の高い発酵乳および生理活性ペプチドの製造方法
JP7453665B2 (ja) * 2019-01-29 2024-03-21 国立大学法人鳥取大学 ジペプチジルペプチダーゼｉｖ阻害活性が高い発酵乳およびその製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3047596A1 (de) * 1980-12-17 1982-07-22 Victor Dipl.- Chem. 8000 München Brantl Pharmakologisch aktive dipeptide
JP3782837B2 (ja) * 1995-04-10 2006-06-07 カルピス株式会社 血圧降下剤及びその製造法

Also Published As

Publication number Publication date
DE69738185T2 (de) 2008-07-10
EP1302207B1 (de) 2007-10-03
EP0821968B1 (de) 2003-05-02
EP1302207A3 (de) 2003-04-23
ES2291417T3 (es) 2008-03-01
JP4713053B2 (ja) 2011-06-29
ES2196263T3 (es) 2003-12-16
DK1302207T3 (da) 2007-11-05
PT1302207E (pt) 2007-11-08
EP0821968A2 (de) 1998-02-04
DE69721407D1 (de) 2003-06-05
DK0821968T3 (da) 2003-06-02
JP3364579B2 (ja) 2003-01-08
JPH1095736A (ja) 1998-04-14
EP1302207A2 (de) 2003-04-16
US5854029A (en) 1998-12-29
DE69721407T2 (de) 2004-05-06
DE69738185D1 (de) 2007-11-15
JP2003048849A (ja) 2003-02-21
EP0821968A3 (de) 1999-07-14
ATE238825T1 (de) 2003-05-15

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