ATE375157T1 - Kombinationspräparat aus epothilone derivate und imidazotetrazinone - Google Patents

Kombinationspräparat aus epothilone derivate und imidazotetrazinone

Info

Publication number: ATE375157T1
Authority: AT; Austria
Prior art keywords: imidazotetrazinone; combination preparation; epothilone derivatives; combination; hydrogen
Prior art date: 2002-03-08

Application number

AT03720323T

Other languages

English (en)

Inventor

Judith Anderson

John Rothermel

Sheehy Paul Mc

Alan Boddy

Original Assignee

Novartis Pharma Gmbh

Univ Newcastle

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-08

Filing date

2003-03-07

Publication date

2007-10-15

2003-03-07 Application filed by Novartis Pharma Gmbh, Univ Newcastle filed Critical Novartis Pharma Gmbh

2007-10-15 Application granted granted Critical

2007-10-15 Publication of ATE375157T1 publication Critical patent/ATE375157T1/de

Links

150000003883 epothilone derivatives Chemical class 0.000 title abstract 2
TWVFRCAHAAGDNR-UHFFFAOYSA-N imidazo[4,5-e]tetrazin-6-one Chemical compound N1=NN=NC2=NC(=O)N=C21 TWVFRCAHAAGDNR-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
229940100198 alkylating agent Drugs 0.000 abstract 1
239000002168 alkylating agent Substances 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Silicon Polymers (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT03720323T 2002-03-08 2003-03-07 Kombinationspräparat aus epothilone derivate und imidazotetrazinone ATE375157T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US36273802P	2002-03-08	2002-03-08

Publications (1)

Publication Number	Publication Date
ATE375157T1 true ATE375157T1 (de)	2007-10-15

Family

ID=27805222

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03720323T ATE375157T1 (de)	2002-03-08	2003-03-07	Kombinationspräparat aus epothilone derivate und imidazotetrazinone

Country Status (22)

Country	Link
EP (1)	EP1485090B1 (de)
JP (1)	JP2005522461A (de)
KR (1)	KR20040101274A (de)
CN (2)	CN100402029C (de)
AT (1)	ATE375157T1 (de)
AU (1)	AU2003223958B2 (de)
BR (1)	BR0308258A (de)
CA (1)	CA2478223C (de)
CY (1)	CY1107126T1 (de)
DE (1)	DE60316775T2 (de)
DK (1)	DK1485090T3 (de)
ES (1)	ES2295575T3 (de)
HU (1)	HUP0500092A2 (de)
IL (3)	IL163774A0 (de)
MX (1)	MXPA04008707A (de)
NO (1)	NO20044208L (de)
NZ (1)	NZ535081A (de)
PL (1)	PL371098A1 (de)
PT (1)	PT1485090E (de)
RU (1)	RU2341260C2 (de)
WO (1)	WO2003075899A2 (de)
ZA (1)	ZA200406790B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2273083C (en)	1996-12-03	2012-09-18	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US8536188B2 (en) *	2007-04-25	2013-09-17	Cyclacel Limited	Dosing regimens for treatment of proliferative disorders comprising administration of sapacitabine
US20110300150A1 (en)	2010-05-18	2011-12-08	Scott Eliasof	Compositions and methods for treatment of autoimmune and other disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6515016B2 (en) *	1996-12-02	2003-02-04	Angiotech Pharmaceuticals, Inc.	Composition and methods of paclitaxel for treating psoriasis
JP2001513098A (ja) *	1997-02-25	2001-08-28	ゲゼルシャフトフュアバイオテクノロギッシェフォーシュンクエムベーハー（ゲーベーエフ）	側鎖を修飾したエポチロン
US6320045B1 (en) *	1997-12-04	2001-11-20	Bristol-Myers Squibb Company	Process for the reduction of oxiranyl epothilones to olefinic epothilones
EP1051490A2 (de) *	1998-01-30	2000-11-15	Cold Spring Harbor Laboratory	Verfahren und reagentien zur steuerung der zellproliferation
CZ301498B6 (cs) *	1999-02-22	2010-03-24	Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf)	C-21 modifikované epothilony
UA75365C2 (en) *	2000-08-16	2006-04-17	Bristol Myers Squibb Co	Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon

2003
- 2003-03-07 CA CA2478223A patent/CA2478223C/en not_active Expired - Fee Related
- 2003-03-07 DK DK03720323T patent/DK1485090T3/da active
- 2003-03-07 KR KR10-2004-7014013A patent/KR20040101274A/ko not_active Ceased
- 2003-03-07 NZ NZ535081A patent/NZ535081A/en not_active IP Right Cessation
- 2003-03-07 DE DE60316775T patent/DE60316775T2/de not_active Expired - Lifetime
- 2003-03-07 IL IL16377403A patent/IL163774A0/xx unknown
- 2003-03-07 JP JP2003574174A patent/JP2005522461A/ja not_active Withdrawn
- 2003-03-07 PT PT03720323T patent/PT1485090E/pt unknown
- 2003-03-07 EP EP03720323A patent/EP1485090B1/de not_active Expired - Lifetime
- 2003-03-07 CN CNB038055309A patent/CN100402029C/zh not_active Expired - Fee Related
- 2003-03-07 WO PCT/EP2003/002364 patent/WO2003075899A2/en not_active Ceased
- 2003-03-07 MX MXPA04008707A patent/MXPA04008707A/es active IP Right Grant
- 2003-03-07 AU AU2003223958A patent/AU2003223958B2/en not_active Ceased
- 2003-03-07 ES ES03720323T patent/ES2295575T3/es not_active Expired - Lifetime
- 2003-03-07 AT AT03720323T patent/ATE375157T1/de active
- 2003-03-07 PL PL03371098A patent/PL371098A1/xx not_active Application Discontinuation
- 2003-03-07 CN CNA2006100879160A patent/CN1939299A/zh active Pending
- 2003-03-07 HU HU0500092A patent/HUP0500092A2/hu unknown
- 2003-03-07 BR BR0308258-0A patent/BR0308258A/pt not_active IP Right Cessation
- 2003-03-07 RU RU2004130283/15A patent/RU2341260C2/ru not_active IP Right Cessation
2004
- 2004-08-26 IL IL163774A patent/IL163774A/en not_active IP Right Cessation
- 2004-08-26 ZA ZA200406790A patent/ZA200406790B/en unknown
- 2004-10-04 NO NO20044208A patent/NO20044208L/no not_active Application Discontinuation
2008
- 2008-01-03 CY CY20081100012T patent/CY1107126T1/el unknown
- 2008-01-17 IL IL188859A patent/IL188859A0/en unknown

Also Published As

Publication number	Publication date
MXPA04008707A (es)	2006-03-08
IL163774A (en)	2010-12-30
WO2003075899A2 (en)	2003-09-18
ZA200406790B (en)	2006-05-31
IL163774A0 (en)	2005-12-18
WO2003075899A3 (en)	2004-03-11
RU2004130283A (ru)	2005-08-10
BR0308258A (pt)	2005-01-04
IL188859A0 (en)	2008-04-13
PT1485090E (pt)	2008-01-14
HUP0500092A2 (hu)	2005-04-28
NZ535081A (en)	2007-05-31
CA2478223C (en)	2012-05-15
CN1939299A (zh)	2007-04-04
DE60316775T2 (de)	2008-04-30
AU2003223958A1 (en)	2003-09-22
DE60316775D1 (de)	2007-11-22
CA2478223A1 (en)	2003-09-18
PL371098A1 (en)	2005-06-13
CY1107126T1 (el)	2012-10-24
AU2003223958B2 (en)	2007-04-19
RU2341260C2 (ru)	2008-12-20
EP1485090B1 (de)	2007-10-10
NO20044208L (no)	2004-10-14
ES2295575T3 (es)	2008-04-16
JP2005522461A (ja)	2005-07-28
CN100402029C (zh)	2008-07-16
DK1485090T3 (da)	2008-02-04
HK1072723A1 (en)	2005-09-09
NO20044208D0 (no)	2004-10-04
EP1485090A2 (de)	2004-12-15
KR20040101274A (ko)	2004-12-02
CN1638767A (zh)	2005-07-13

Legal Events

Date

Code

Title

Description

2008-04-15

UEP

Publication of translation of european patent specification

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