ATE376672T1 - METHOD FOR DIAGNOSING MULTIPLE SCLERosis - Google Patents

METHOD FOR DIAGNOSING MULTIPLE SCLERosis

Info

Publication number
ATE376672T1
ATE376672T1 AT03784432T AT03784432T ATE376672T1 AT E376672 T1 ATE376672 T1 AT E376672T1 AT 03784432 T AT03784432 T AT 03784432T AT 03784432 T AT03784432 T AT 03784432T AT E376672 T1 ATE376672 T1 AT E376672T1
Authority
AT
Austria
Prior art keywords
multiple sclerosis
diagnosing multiple
diagnosing
glycans
antibodies
Prior art date
Application number
AT03784432T
Other languages
German (de)
Inventor
Nir Dotan
Avinoam Dukler
Mikael Schwarz
Ari Gargir
Original Assignee
Glycominds Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycominds Ltd filed Critical Glycominds Ltd
Application granted granted Critical
Publication of ATE376672T1 publication Critical patent/ATE376672T1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/285—Demyelinating diseases; Multipel sclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Testing Of Engines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Control Of Electric Motors In General (AREA)
  • Steering Control In Accordance With Driving Conditions (AREA)

Abstract

Disclosed is a method for diagnosing multiple sclerosis and more particularly to a method for diagnosing multiple sclerosis by measuring levels of antibodies to glycans in a biological sample.
AT03784432T 2002-08-02 2003-08-04 METHOD FOR DIAGNOSING MULTIPLE SCLERosis ATE376672T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40091402P 2002-08-02 2002-08-02
US44707603P 2003-02-13 2003-02-13
US46298403P 2003-04-15 2003-04-15
US47323103P 2003-05-23 2003-05-23

Publications (1)

Publication Number Publication Date
ATE376672T1 true ATE376672T1 (en) 2007-11-15

Family

ID=31721743

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03784432T ATE376672T1 (en) 2002-08-02 2003-08-04 METHOD FOR DIAGNOSING MULTIPLE SCLERosis

Country Status (18)

Country Link
US (2) US7537900B2 (en)
EP (1) EP1529216B1 (en)
JP (2) JP4721703B2 (en)
AT (1) ATE376672T1 (en)
AU (1) AU2003263409B2 (en)
BR (1) BR0313194A (en)
CA (1) CA2494422A1 (en)
CY (1) CY1107859T1 (en)
DE (1) DE60317070T2 (en)
DK (1) DK1529216T3 (en)
ES (1) ES2297248T3 (en)
IL (1) IL166539A (en)
MX (1) MXPA05001270A (en)
NO (1) NO20051024L (en)
NZ (1) NZ585114A (en)
PL (1) PL210512B1 (en)
PT (1) PT1529216E (en)
WO (1) WO2004015420A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ585114A (en) * 2002-08-02 2011-09-30 Glycominds Ltd Elevated serum levels of auto antibodies to IgG, IgA and IgM that bind to glycan structures used in a diagnostic test for MS
EP1692519B1 (en) 2003-12-03 2010-06-02 Glycominds Ltd. Method for diagnosing diseases based on levels of anti-glycan antibodies
US7592150B2 (en) 2003-12-03 2009-09-22 Glycominds, Ltd Method for diagnosing diseases based on levels of anti-glycan antibodies
AU2005258281A1 (en) * 2004-06-24 2006-01-05 The Scripps Research Institute Arrays with cleavable linkers
US8216791B2 (en) * 2005-01-31 2012-07-10 Glycominds Ltd. Method for diagnosing multiple sclerosis
US7572592B2 (en) * 2005-01-31 2009-08-11 Glycominds Ltd Method for diagnosing multiple sclerosis
US20100062471A1 (en) * 2005-09-29 2010-03-11 Ppd Biomarker Discovery Sciences Llc Biomarkers for Multiple Sclerosis and Methods of Use Thereof
US20100203569A1 (en) * 2009-02-12 2010-08-12 Glycominks LTD Method for Evaluating Risk in Multiple Sclerosis
WO2011031472A2 (en) * 2009-08-25 2011-03-17 The Johns Hopkins University Detection of auto-antibodies to specific glycans as diagnostic tests for autoimmune diseases
SI3116887T1 (en) 2014-03-13 2021-06-30 Universitaet Basel Carbohydrate ligands that bind to igm antibodies against myelin-associated glycoprotein
WO2016026143A1 (en) * 2014-08-22 2016-02-25 Huiru Wang Saccharide-based biomarkers and therapeutics
EP3250923A4 (en) 2015-01-30 2018-06-20 The Regents of The University of California N-acetyl glucosamine as a biomarker of ms disease course
US11091591B2 (en) 2015-09-16 2021-08-17 Universität Basel Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids
EP4521117A3 (en) * 2016-07-01 2025-06-04 Dignity Health Diagnostic or predictor of relapsing remitting multiple sclerosis
JP2021520493A (en) * 2018-04-03 2021-08-19 クリエイティクス エルエルシー Cancer detection method for evaluating glycan binding pattern of immunoglobulin in gastrointestinal lavage fluid sample

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281061A (en) * 1979-07-27 1981-07-28 Syva Company Double antibody for enhanced sensitivity in immunoassay
US5030560A (en) * 1988-11-04 1991-07-09 Immucor, Inc. Method for drying mammalian cells for use in solid phase immunoassays and articles incorporating same
JPH02161357A (en) * 1988-12-15 1990-06-21 Tosoh Corp Method for stabilizing material for immunosassay
AU776632B2 (en) 1999-02-17 2004-09-16 Glycominds Ltd. Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof
US20010051349A1 (en) * 2000-02-17 2001-12-13 Glycominds Ltd. Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof
US6762032B1 (en) * 1999-08-23 2004-07-13 Biocrystal, Ltd. Compositions, assay kits, and methods for use related to a disease condition comprising multiple sclerosis and/or a pro-MS immune response
KR20020089323A (en) * 2000-01-10 2002-11-29 제노스펙트라 인코포레이티드 Linear probe carrier
AU2001288431A1 (en) * 2000-08-28 2002-03-13 The Trustees Of Columbia University In The City Of New York Detection of anti-glycolipid antibodies by latex agglutination assay
ITFI20010114A1 (en) * 2001-06-22 2002-12-22 Univ Firenze GLYCOPEPTIDES, THEIR PREPARATION AND THEIR USE IN THE DIAGNOSIS OR THERAPEUTIC TREATMENT OF MULTIPLE SCLEROSIS
US20040241763A1 (en) * 2002-08-02 2004-12-02 Nir Dotan Method for diagnosing multiple sclerosis
NZ585114A (en) * 2002-08-02 2011-09-30 Glycominds Ltd Elevated serum levels of auto antibodies to IgG, IgA and IgM that bind to glycan structures used in a diagnostic test for MS
US7572592B2 (en) * 2005-01-31 2009-08-11 Glycominds Ltd Method for diagnosing multiple sclerosis

Also Published As

Publication number Publication date
AU2003263409B2 (en) 2010-05-27
EP1529216B1 (en) 2007-10-24
JP2009258138A (en) 2009-11-05
NZ585114A (en) 2011-09-30
DE60317070D1 (en) 2007-12-06
US20040077023A1 (en) 2004-04-22
DK1529216T3 (en) 2008-02-25
AU2003263409A1 (en) 2004-02-25
DE60317070T2 (en) 2008-07-24
NO20051024L (en) 2005-05-02
WO2004015420B1 (en) 2004-04-29
PL374869A1 (en) 2005-11-14
US7537900B2 (en) 2009-05-26
US20100081160A1 (en) 2010-04-01
PT1529216E (en) 2008-01-30
MXPA05001270A (en) 2005-08-03
CA2494422A1 (en) 2004-02-19
JP4721703B2 (en) 2011-07-13
ES2297248T3 (en) 2008-05-01
WO2004015420A8 (en) 2004-09-10
EP1529216A1 (en) 2005-05-11
IL166539A0 (en) 2006-01-15
PL210512B1 (en) 2012-01-31
BR0313194A (en) 2005-07-12
IL166539A (en) 2010-11-30
CY1107859T1 (en) 2013-06-19
JP2006501441A (en) 2006-01-12
WO2004015420A1 (en) 2004-02-19

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