ATE377763T1 - Kontaktloses verfahren zur verteilung geringer flüssigkeitsvolumen - Google Patents

Kontaktloses verfahren zur verteilung geringer flüssigkeitsvolumen

Info

Publication number
ATE377763T1
ATE377763T1 AT03704032T AT03704032T ATE377763T1 AT E377763 T1 ATE377763 T1 AT E377763T1 AT 03704032 T AT03704032 T AT 03704032T AT 03704032 T AT03704032 T AT 03704032T AT E377763 T1 ATE377763 T1 AT E377763T1
Authority
AT
Austria
Prior art keywords
dispensing
liquid
system fluid
communication passageway
dispensing orifice
Prior art date
Application number
AT03704032T
Other languages
English (en)
Inventor
James Johnson
Neil Picha
Craig Storms
David Martin
Original Assignee
Innovadyne Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovadyne Technologies Inc filed Critical Innovadyne Technologies Inc
Application granted granted Critical
Publication of ATE377763T1 publication Critical patent/ATE377763T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/148—Specific details about calibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/14—Means for pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/02—Drop detachment mechanisms of single droplets from nozzles or pins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0666—Solenoid valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1041—Ink-jet like dispensers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1044—Using pneumatic means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G01N35/00712—Automatic status testing, e.g. at start-up or periodic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/2931—Diverse fluid containing pressure systems
    • Y10T137/3003—Fluid separating traps or vents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/15—Inorganic acid or base [e.g., hcl, sulfuric acid, etc. ]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Quality & Reliability (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Sampling And Sample Adjustment (AREA)
AT03704032T 2002-01-25 2003-01-27 Kontaktloses verfahren zur verteilung geringer flüssigkeitsvolumen ATE377763T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35185802P 2002-01-25 2002-01-25

Publications (1)

Publication Number Publication Date
ATE377763T1 true ATE377763T1 (de) 2007-11-15

Family

ID=27663031

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03704032T ATE377763T1 (de) 2002-01-25 2003-01-27 Kontaktloses verfahren zur verteilung geringer flüssigkeitsvolumen

Country Status (7)

Country Link
US (3) US7169616B2 (de)
EP (1) EP1470427B1 (de)
JP (3) JP2005516220A (de)
AT (1) ATE377763T1 (de)
CA (1) CA2473860A1 (de)
DE (1) DE60317305T2 (de)
WO (1) WO2003065049A2 (de)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1354211A1 (de) * 2001-01-25 2003-10-22 Tecan Trading AG Pipettiervorrichtung
US6579724B2 (en) * 2001-09-13 2003-06-17 First Ten Angstroms Dispensing method and apparatus for dispensing very small quantities of fluid
US6865425B2 (en) * 2002-01-07 2005-03-08 Siemens Energy & Automation, Inc. State machine for a pulse output function
US7410615B2 (en) * 2002-01-24 2008-08-12 Perkinelmer Las, Inc. Precision liquid dispensing system
US7288228B2 (en) * 2002-02-12 2007-10-30 Gilson, Inc. Sample injection system
CN100392587C (zh) 2002-06-03 2008-06-04 西门子能量及自动化公司 用于编程智能模块的向导
DE10255595A1 (de) * 2002-11-26 2004-06-03 Cybio Ag Mehrkanaldosiervorrichtung mit automatischer Kalibrierung
US6746966B1 (en) * 2003-01-28 2004-06-08 Taiwan Semiconductor Manufacturing Company Method to solve alignment mark blinded issues and a technology for application of semiconductor etching at a tiny area
JP3972012B2 (ja) 2003-03-19 2007-09-05 株式会社日立ハイテクノロジーズ 試料分注機構及びそれを備えた自動分析装置
US7543720B2 (en) * 2003-05-05 2009-06-09 The Lee Company Method and apparatus for dispensing small volumes of fluid
DE602004027146D1 (de) 2003-08-25 2010-06-24 Dip Tech Ltd Tinte für keramische oberflächen
US8211214B2 (en) * 2003-10-02 2012-07-03 Molecular Imprints, Inc. Single phase fluid imprint lithography method
US7396512B2 (en) * 2003-11-04 2008-07-08 Drummond Scientific Company Automatic precision non-contact open-loop fluid dispensing
US20050203482A1 (en) * 2004-03-15 2005-09-15 Chinea Vanessa I. Pharmaceutical dispensing apparatus and method
US8187535B2 (en) * 2004-06-14 2012-05-29 Parker-Hannifin Corporation Robotic handling system and method with independently operable detachable tools
US8161020B2 (en) * 2004-11-15 2012-04-17 Zi Corporation Of Canada, Inc. Searching for and providing objects using byte-by-byte comparison
US8057756B2 (en) * 2005-01-28 2011-11-15 Parker-Hannifin Corporation Sampling probe, gripper and interface for laboratory sample management systems
US20060258011A1 (en) * 2005-04-22 2006-11-16 Igor Shvets Cleaning of system for dispensing of liquid droplets
US20070116608A1 (en) * 2005-11-23 2007-05-24 Birdsell Michael P Vented ceramic tip arrangement for use with a microarray
EP1963837A1 (de) * 2005-12-05 2008-09-03 Parker-Hannifin Selbstreinigende injektionsports für analytische anwendungen
EP1963868A2 (de) * 2005-12-08 2008-09-03 Parker Hannifin Corporation Spritzenwaschstation für analyse-anwendungen
DE112007000247T5 (de) * 2006-02-06 2008-12-11 Kanji Takada Vorrichtung zur Herstellung eines laminierten Mikrokapselblatts
JP4906416B2 (ja) * 2006-07-11 2012-03-28 日本碍子株式会社 物体の通過検出装置
WO2008038812A1 (en) * 2006-09-28 2008-04-03 Shimadzu Corporation Method of preparing sample for matrix-assisted laser desorption ionization mass spectrometry and matrix-assisted laser desorption ionization mass spectrometry
EP2071313A4 (de) * 2006-09-28 2012-10-31 Shimadzu Corp Verfahren zur entparaffinisierung von in paraffin eingebetteten präparaten und verfahren zur analyse von in paraffin eingebetteten präparaten
US7832252B2 (en) * 2006-10-05 2010-11-16 Watson Gary W Precise droplet injection for calibrating a gas chromatography instrument
US7628085B2 (en) * 2006-11-17 2009-12-08 Sru Biosystems, Inc. Simultaneous aspirator and dispenser for multiwell plates and similar devices
WO2008070548A2 (en) * 2006-12-01 2008-06-12 Nanogen, Inc. Fluidic volume dispense verification tool
US20080134806A1 (en) * 2006-12-06 2008-06-12 Agamatrix, Inc. Container system for dispensing a liquid
WO2008089449A2 (en) 2007-01-19 2008-07-24 Biodot, Inc. Systems and methods for high speed array printing and hybridization
US8016260B2 (en) 2007-07-19 2011-09-13 Formulatrix, Inc. Metering assembly and method of dispensing fluid
JP4952470B2 (ja) * 2007-09-19 2012-06-13 和光純薬工業株式会社 分注装置および分注装置における吐出状態判定方法
CH712572B1 (de) * 2007-11-28 2017-12-15 Integra Biosciences Ag Handpipettiergerät.
JP2009146241A (ja) * 2007-12-17 2009-07-02 Fuji Koki Corp 弁制御装置及び弁制御方法
US8808625B2 (en) * 2008-01-11 2014-08-19 National Institute Of Advanced Industrial Science And Technology Dispensing apparatus and a dispensing method
US8100293B2 (en) * 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
JP2010223638A (ja) * 2009-03-19 2010-10-07 Beckman Coulter Inc 分注装置、自動分析装置及び分注装置の分注監視方法
US8444935B2 (en) * 2009-06-12 2013-05-21 Bose Corporation Multiple-specimen device testing with particle measurement
KR20110046935A (ko) * 2009-10-29 2011-05-06 포항공과대학교 산학협력단 액적 토출 장치
CN102656464A (zh) * 2009-12-22 2012-09-05 通用电气健康护理生物科学股份公司 具有改进混合的分析方法
JP4919119B2 (ja) * 2010-01-19 2012-04-18 株式会社日立プラントテクノロジー 試薬分注ノズルによる分取・分注方法および試薬分取・分注機構
CH702769B1 (de) * 2010-02-22 2019-07-31 Reseachem Gmbh Dosiervorrichtung und Verfahren zur Dosierung eines Fluids in ein Reaktionsgefäss.
US8969098B2 (en) * 2010-04-08 2015-03-03 Siemens Healthcare Diagnostics Inc. Methods and systems providing reagent mixing
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
CN103429348B (zh) 2011-01-21 2016-03-09 拜奥-多特公司 具有纵向变换器和可替换毛细管的压电分配器
FR2978064B1 (fr) * 2011-07-18 2016-02-19 Interlab Procede et dispositif de distribution gravimetrique et en serie de solution.
CN103998144A (zh) * 2011-10-28 2014-08-20 惠普发展公司,有限责任合伙企业 并行寻址方法
US8671733B2 (en) * 2011-12-13 2014-03-18 Intermolecular, Inc. Calibration procedure considering gas solubility
EP2836815B1 (de) * 2012-04-12 2020-08-05 Bio-Rad Laboratories, Inc. Partikelausgabevorrichtung und verfahren
WO2013156408A1 (en) * 2012-04-18 2013-10-24 Sias Ag Pipetting arrangement and method of controlling pipetting
JP6433982B2 (ja) 2013-04-19 2018-12-05 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドSiemens Healthcare Diagnostics Inc. 無接触微小滴ディスペンサおよび方法
FI3030645T3 (fi) 2013-08-08 2023-02-10 Fluidijärjestelmä reagenssien toimittamiseen virtauskennoon
GB2546424A (en) * 2014-07-14 2017-07-19 Harvard College Systems and methods for improved performance of fluidic and microfluidic systems
PL3279618T3 (pl) * 2016-08-01 2021-09-13 Harro Höfliger Verpackungsmaschinen GmbH Urządzenie kalibrujące i sposób dozowania jednostek dawkowania
ES2922878T3 (es) * 2016-10-28 2022-09-21 Becton Dickinson Co Sensor de verificación de dispensación positiva
KR20250035025A (ko) * 2018-04-10 2025-03-11 엘리멘탈 사이언티픽, 인코포레이티드 액체 샘플 세그먼트를 유지하면서 액체 샘플을 수집하고 원거리를 운반하는 시스템
WO2019236053A1 (en) 2018-06-04 2019-12-12 Hewlett-Packard Development Company, L.P. Ejection subassembly pitches to match nanowell spacing
CN108636469A (zh) * 2018-06-14 2018-10-12 成都瀚辰光翼科技有限责任公司 一种非接触式移液装置及移液方法
CN112714674B (zh) * 2018-07-20 2022-12-09 布赖顿技术有限责任公司 用于从液体微滴分配系统收集的样本数据确定微滴的质量的方法和装置
JP7433821B2 (ja) 2019-09-24 2024-02-20 東芝テック株式会社 薬液滴下装置
US12042991B2 (en) 2021-02-25 2024-07-23 Xerox Corporation Energy dissipative nozzles for drop-on-demand printing and methods thereof
US11919241B1 (en) * 2021-02-25 2024-03-05 Xerox Corporation Optimized nozzle design for drop-on-demand printers and methods thereof
US12226776B2 (en) 2021-11-04 2025-02-18 Instrumentation Laboratory Company Preparing substances in a medical diagnostic system
CN114965310B (zh) * 2022-04-26 2023-05-26 上海亚新城市建设有限公司 水质在线监测系统量程自切换控制方法及系统
WO2024144798A1 (en) * 2022-12-30 2024-07-04 Artel, Inc. Hybrid fluorescence-absorbance measurement system and method for sub-microliter and sub-nanoliter volume measurement
WO2024256951A1 (en) * 2023-06-12 2024-12-19 3M Innovative Properties Company A dispensing system, a method of purging a dispenser and a purge initiation system

Family Cites Families (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1428878A (fr) 1965-03-24 1966-02-18 Ct D Etudes Des Matieres Plast Dispositif émetteur et compteur de gouttes
US3405734A (en) 1966-12-01 1968-10-15 London Concrete Machinery Comp Self-draining valve
BE758245A (fr) * 1969-11-03 1971-04-30 Hoffmann La Roche Pipette de precision
GB1354486A (en) 1970-05-20 1974-06-05 Unilever Ltd Plate valve
US3796239A (en) 1971-07-22 1974-03-12 Instrumentation Labor Inc Dispenser system
US3832579A (en) * 1973-02-07 1974-08-27 Gould Inc Pulsed droplet ejecting system
US3868970A (en) 1973-06-04 1975-03-04 Phillips Petroleum Co Multipositional selector valve
US3994423A (en) * 1973-06-28 1976-11-30 American Hospital Supply Corporation Drop dispensing apparatus for laboratory reagents
US3963148A (en) * 1974-01-10 1976-06-15 Coulter Electronics, Inc. Apparatus for drawing, measuring and discharging proportional amounts of fluid
US4013413A (en) * 1975-07-10 1977-03-22 The United States Of America As Represented By The Secretary Of Agriculture Apparatus and method for rapid analyses of plurality of samples
JPS53111782A (en) 1977-03-03 1978-09-29 Jeol Ltd Sampling and metering system
FR2463920A1 (fr) 1979-08-17 1981-02-27 Commissariat Energie Atomique Dispositif microdoseur de liquides
EP0028478B1 (de) * 1979-10-31 1985-02-20 The University Of Birmingham Pipettenmittel
DE3367661D1 (en) 1982-02-04 1987-01-02 Toray Industries Rotary valve
US4461328A (en) * 1982-06-04 1984-07-24 Drummond Scientific Company Pipette device
US4818706A (en) 1983-04-19 1989-04-04 American Monitor Corporation Reagent-dispensing system and method
US4623008A (en) 1983-08-12 1986-11-18 Sakata Shokai, Ltd. Automatic dispensing system
FR2550990B1 (fr) 1983-08-22 1987-01-30 Colgate Palmolive Co Procede de fabrication d'un corps creux par extrusion et soufflage de matiere plastique et installation pour la mise en oeuvre de ce procede
CH674580A5 (de) 1983-10-06 1990-06-15 Contraves Ag
US4625569A (en) 1984-01-17 1986-12-02 Toyo Soda Manufacturing Co., Ltd. Liquid injection device
DE3586244T2 (de) * 1984-12-26 2000-04-20 Kabushiki Kaisha Toshiba Vorrichtung zur Erzeugung von Weich-Röntgenstrahlen durch ein Hochenergiebündel.
US4702889A (en) 1986-01-16 1987-10-27 Coulter Electronics Inc. Liquid sampling valve
US5104621A (en) * 1986-03-26 1992-04-14 Beckman Instruments, Inc. Automated multi-purpose analytical chemistry processing center and laboratory work station
US4694861A (en) 1986-12-22 1987-09-22 Beckman Instruments, Inc. Rotary pinch valve
JP2659954B2 (ja) * 1987-05-27 1997-09-30 キヤノン株式会社 インクジェット記録装置
US4917351A (en) * 1989-03-15 1990-04-17 Micro-Flo Technologies, Inc. Metering valve
US4948565A (en) 1989-04-25 1990-08-14 Fisher Scientific Company Analytical system
ATE230024T1 (de) * 1990-10-25 2003-01-15 Univ Columbia Entwicklung von dns-sonden und immunologischen reagenzien von menschlichen tumor-assoziierten antigenen
EP0484278B1 (de) 1990-11-01 1995-04-12 Ciba-Geigy Ag Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse
US5207109A (en) 1991-02-07 1993-05-04 Rheodyne, Inc. Internal-external sample injector
US5312757A (en) 1991-05-02 1994-05-17 Olympus Optical Co., Ltd. Sample distributing method
US6096276A (en) * 1991-08-14 2000-08-01 Trustees Of Boston University Apparatus for effecting sequential chemical syntheses
JP2913984B2 (ja) * 1992-03-11 1999-06-28 株式会社ニコン 傾斜角測定装置
GB9208386D0 (en) 1992-04-16 1992-06-03 Amersham Int Plc Storage and dispensing device for liquids
JPH08500052A (ja) 1992-07-06 1996-01-09 ベックマン インスツルメンツ インコーポレーテッド 多重ポート弁を使用する流体配送装置
US5324480A (en) * 1992-12-04 1994-06-28 Hamilton Company Liquid handling system
US5525515A (en) 1993-02-03 1996-06-11 Blattner; Frederick R. Process of handling liquids in an automated liquid handling apparatus
JP3365806B2 (ja) * 1993-02-25 2003-01-14 オリンパス光学工業株式会社 自動分注装置
GB9309637D0 (en) * 1993-05-11 1993-06-23 Boc Group Plc Cryogenic liquid dispensers
US6521187B1 (en) * 1996-05-31 2003-02-18 Packard Instrument Company Dispensing liquid drops onto porous brittle substrates
US6203759B1 (en) * 1996-05-31 2001-03-20 Packard Instrument Company Microvolume liquid handling system
CA2143451A1 (en) * 1993-07-09 1995-01-19 Donald Jones Fluid dispensing apparatus and method
WO1996001994A1 (en) 1994-07-11 1996-01-25 Tekmar Company Modular vial autosampler
CA2202649C (en) 1994-10-31 2000-12-19 Richard A. Domanik Method and apparatus for dispense verification
US5578275A (en) 1995-02-16 1996-11-26 The United States Of America As Represented By The Secretary Of The Army In-line sampling with continuous flushing for friction sensitive liquid nitrate ester compositions
JP3537208B2 (ja) * 1995-03-07 2004-06-14 オリンパス株式会社 吸光度測定方法
US5601115A (en) 1995-05-31 1997-02-11 Vantege Technologies, Inc. Multiport sampling valve
US5649687A (en) * 1995-06-06 1997-07-22 Borg-Warner Automotive, Inc. Pulse width modulated solenoid purge valve
US6158269A (en) 1995-07-13 2000-12-12 Bayer Corporation Method and apparatus for aspirating and dispensing sample fluids
US5763278A (en) 1995-11-01 1998-06-09 Tecan Ag Automated pipetting of small volumes
TW384398B (en) 1995-12-19 2000-03-11 Toa Medical Electronics Sample agitating and sucking apparatus
US6660233B1 (en) 1996-01-16 2003-12-09 Beckman Coulter, Inc. Analytical biochemistry system with robotically carried bioarray
US5849598A (en) 1996-03-15 1998-12-15 Washington University Method for transferring micro quantities of liquid samples to discrete locations
JP3572792B2 (ja) 1996-04-04 2004-10-06 東ソー株式会社 前処理装置
EP0801309A3 (de) 1996-04-08 1998-08-12 SANYO ELECTRIC Co., Ltd. Pipettiervorrichtung
US6083762A (en) * 1996-05-31 2000-07-04 Packard Instruments Company Microvolume liquid handling system
ATE259068T1 (de) 1996-05-31 2004-02-15 Packard Instrument Co Inc Vorrichtung zur handhabung von mikroflüssigkeitsmengen
US5915284A (en) 1996-07-22 1999-06-22 Cyberlab, Inc. Multiple channel pipetting device
US5743960A (en) * 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
US5741554A (en) * 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
US5916524A (en) * 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
US5738728A (en) * 1996-07-26 1998-04-14 Bio Dot, Inc. Precision metered aerosol dispensing apparatus
JPH10115621A (ja) * 1996-10-14 1998-05-06 Aloka Co Ltd 分注装置
US5833925A (en) * 1996-11-13 1998-11-10 Beckman Instruments, Inc. Automatic chemistry analyzer with improved ion selective electrode assembly
JP4663824B2 (ja) * 1996-12-31 2011-04-06 ハイ スループット ジェノミクス インコーポレイテッド 多重化分子分析装置および方法
US6045755A (en) * 1997-03-10 2000-04-04 Trega Biosciences,, Inc. Apparatus and method for combinatorial chemistry synthesis
US5985214A (en) * 1997-05-16 1999-11-16 Aurora Biosciences Corporation Systems and methods for rapidly identifying useful chemicals in liquid samples
US5869004A (en) 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
US6323035B1 (en) * 1997-09-24 2001-11-27 Glaxo Wellcome, Inc. Systems and methods for handling and manipulating multi-well plates
DK114497A (da) 1997-10-07 1999-04-08 Alka Electronic Aps Optisk flowmåler
US5955373A (en) * 1997-11-05 1999-09-21 Zymark Corporation Environmentally controlled system for processing chemical products
US6068393A (en) * 1997-11-05 2000-05-30 Zymark Corporation Robotic system for processing chemical products
DE19754000A1 (de) 1997-12-05 1999-06-17 Max Planck Gesellschaft Vorrichtung und Verfahren zur elektrisch ausgelösten Mikrotropfenabgabe mit einem Dispensierkopf
NL1008703C1 (nl) 1998-01-08 1999-07-12 Jan Hendrik Fondse Meerwegklep.
US6063339A (en) * 1998-01-09 2000-05-16 Cartesian Technologies, Inc. Method and apparatus for high-speed dot array dispensing
US6042729A (en) 1998-02-18 2000-03-28 Chau; Yiu Chau Regeneration of water treatment media
US6537505B1 (en) * 1998-02-20 2003-03-25 Bio Dot, Inc. Reagent dispensing valve
US20030215957A1 (en) * 1998-02-20 2003-11-20 Tony Lemmo Multi-channel dispensing system
US6033911A (en) * 1998-02-27 2000-03-07 Hamilton Company Automated assaying device
JP3543604B2 (ja) * 1998-03-04 2004-07-14 株式会社日立製作所 送液装置および自動分析装置
JP3582351B2 (ja) * 1998-04-02 2004-10-27 松下電器産業株式会社 スクリーニング装置
JP3584732B2 (ja) * 1998-05-08 2004-11-04 松下電器産業株式会社 分注装置および分注方法ならびに分注チップの装着方法
US6627446B1 (en) * 1998-07-02 2003-09-30 Amersham Biosciences (Sv) Corp Robotic microchannel bioanalytical instrument
US6551557B1 (en) * 1998-07-07 2003-04-22 Cartesian Technologies, Inc. Tip design and random access array for microfluidic transfer
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US20040047765A1 (en) * 1998-10-16 2004-03-11 Gordon Steven J. Automated robotic workstation and methods of operation thereof
US20020006359A1 (en) * 1998-11-25 2002-01-17 Affymetrix, Inc. Microplate sample and reagent loading system
US6296811B1 (en) * 1998-12-10 2001-10-02 Aurora Biosciences Corporation Fluid dispenser and dispensing methods
EP1434055B1 (de) * 1999-02-16 2006-09-27 Applera Corporation Vorrichtung zur Handhabung von Kügelchen
US6627157B1 (en) * 1999-03-04 2003-09-30 Ut-Battelle, Llc Dual manifold system and method for fluid transfer
US20020176801A1 (en) * 1999-03-23 2002-11-28 Giebeler Robert H. Fluid delivery and analysis systems
US20020009394A1 (en) * 1999-04-02 2002-01-24 Hubert Koster Automated process line
US6395232B1 (en) 1999-07-09 2002-05-28 Orchid Biosciences, Inc. Fluid delivery system for a microfluidic device using a pressure pulse
DE60028665T2 (de) * 1999-08-09 2007-06-06 Thk Co., Ltd. Vorrichtung zur Herstellung von Mikroarrays
US6322752B1 (en) 1999-09-08 2001-11-27 Coulter International Corp. Method and apparatus for aspirating and dispensing liquids
US6558623B1 (en) * 2000-07-06 2003-05-06 Robodesign International, Inc. Microarray dispensing with real-time verification and inspection
JP3833024B2 (ja) * 1999-10-06 2006-10-11 ローム株式会社 レーザビームの受光部ユニットおよびインクジェットプリンタ
DE60011671T2 (de) 1999-10-15 2004-10-21 Packard Instrument Co Inc Piezoelektrische drop-on-demand technik und spüllung von kapillaren
JP2001113725A (ja) * 1999-10-15 2001-04-24 Canon Inc インクジェットプリンタ装置
JP2001113681A (ja) * 1999-10-15 2001-04-24 Canon Inc 記録装置
AU1437601A (en) * 1999-10-26 2001-05-08 Genometrix Genomics Incorporated A storage card for hosting a biological specimen
DE10002475C1 (de) 2000-01-21 2001-05-31 Roche Diagnostics Gmbh Analysegerät zur Analyse von Proben
US6325114B1 (en) 2000-02-01 2001-12-04 Incyte Genomics, Inc. Pipetting station apparatus
JP4717312B2 (ja) 2000-02-29 2011-07-06 ジェン−プローブ・インコーポレイテッド 流体搬送プローブ
US6432365B1 (en) * 2000-04-14 2002-08-13 Discovery Partners International, Inc. System and method for dispensing solution to a multi-well container
JP2001324510A (ja) * 2000-05-15 2001-11-22 Toyobo Engineering Kk 吐出容量可変液体分注装置
JP2002001092A (ja) 2000-06-22 2002-01-08 Shimadzu Corp 排液装置
US6852291B1 (en) * 2000-10-11 2005-02-08 Innovadyne Technologies, Inc. Hybrid valve apparatus and method for fluid handling
US7135146B2 (en) * 2000-10-11 2006-11-14 Innovadyne Technologies, Inc. Universal non-contact dispense peripheral apparatus and method for a primary liquid handling device
DE10052819B4 (de) * 2000-10-24 2004-02-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Pipettensystem und Pipettenarray sowie Verfahren zum Befüllen eines Pipettensystems
DE20018628U1 (de) * 2000-11-01 2002-03-14 EVOTEC BioSystems AG, 22525 Hamburg Probenabgabevorrichtung
CH695544A5 (de) * 2000-11-17 2006-06-30 Tecan Trading Ag Vorrichtung zur Abgabe bzw. Aufnahme/Abgabe von Flüssigkeitsproben.
US6503454B1 (en) * 2000-11-22 2003-01-07 Xerox Corporation Multi-ejector system for ejecting biofluids
DE60221984T2 (de) * 2001-06-13 2008-05-15 Kenneth F. Los Gatos Uffenheimer Automatisches flüssigkeitsbehandlungssystem und -verfahren
US7250303B2 (en) * 2001-07-20 2007-07-31 Ortho-Clinical Diagnostics, Inc. Chemistry system for a clinical analyzer
US6846680B2 (en) * 2001-07-31 2005-01-25 Caliper Life Sciences, Inc. Liquid handling system with automatically interchangeable cannula array
US6579724B2 (en) * 2001-09-13 2003-06-17 First Ten Angstroms Dispensing method and apparatus for dispensing very small quantities of fluid
US7410615B2 (en) 2002-01-24 2008-08-12 Perkinelmer Las, Inc. Precision liquid dispensing system
US7479391B2 (en) * 2004-12-10 2009-01-20 Tecan Trading Ag Pipetting apparatus with integrated liquid level and/or gas bubble detection

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EP1470427A2 (de) 2004-10-27
US6983636B2 (en) 2006-01-10
JP2009162761A (ja) 2009-07-23
JP4621777B2 (ja) 2011-01-26
DE60317305D1 (de) 2007-12-20
WO2003065049A3 (en) 2003-10-16
US20030167822A1 (en) 2003-09-11
JP2005516220A (ja) 2005-06-02
DE60317305T2 (de) 2008-08-28
WO2003065049A2 (en) 2003-08-07
CA2473860A1 (en) 2003-08-07
EP1470427B1 (de) 2007-11-07
JP2009168816A (ja) 2009-07-30
US7169616B2 (en) 2007-01-30
US20070155019A1 (en) 2007-07-05
US20030170903A1 (en) 2003-09-11

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