ATE378328T1 - Pyrrolo-indol- und pyrrolo-chinolin-derivate als prodrugs zur tumorbehandlung - Google Patents

Pyrrolo-indol- und pyrrolo-chinolin-derivate als prodrugs zur tumorbehandlung

Info

Publication number: ATE378328T1
Authority: AT; Austria
Prior art keywords: pyrrolo; prodrugs; indole; tumor treatment; quinoline derivatives
Prior art date: 2001-02-22

Application number

AT02712114T

Other languages

English (en)

Inventor

Mark Searcey

L Patterson

Original Assignee

Univ London Pharmacy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-22

Filing date

2002-02-22

Publication date

2007-11-15

2002-02-22 Application filed by Univ London Pharmacy filed Critical Univ London Pharmacy

2007-11-15 Application granted granted Critical

2007-11-15 Publication of ATE378328T1 publication Critical patent/ATE378328T1/de

Links

229940002612 prodrug Drugs 0.000 title abstract 3
239000000651 prodrug Substances 0.000 title abstract 3
206010028980 Neoplasm Diseases 0.000 title abstract 2
SLHCMPVPVQSTBV-UHFFFAOYSA-N C1=CNC2=C3C=CN=C3C=CC2=C1 Chemical class C1=CNC2=C3C=CN=C3C=CC2=C1 SLHCMPVPVQSTBV-UHFFFAOYSA-N 0.000 title 1
ZCOSUVZGFDGWFV-UHFFFAOYSA-N pyrrolo[2,3-e]indole Chemical compound C1=CC2=NC=CC2=C2N=CC=C21 ZCOSUVZGFDGWFV-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 abstract 1
102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 abstract 1
102100027417 Cytochrome P450 1B1 Human genes 0.000 abstract 1
229940126161 DNA alkylating agent Drugs 0.000 abstract 1
239000012624 DNA alkylating agent Substances 0.000 abstract 1
230000004568 DNA-binding Effects 0.000 abstract 1
101000725164 Homo sapiens Cytochrome P450 1B1 Proteins 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000032823 cell division Effects 0.000 abstract 1
VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical class COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 abstract 1
210000004881 tumor cell Anatomy 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Catalysts (AREA)

AT02712114T 2001-02-22 2002-02-22 Pyrrolo-indol- und pyrrolo-chinolin-derivate als prodrugs zur tumorbehandlung ATE378328T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP01301636		2001-02-22

Publications (1)

Publication Number	Publication Date
ATE378328T1 true ATE378328T1 (de)	2007-11-15

Family

ID=8181737

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02712114T ATE378328T1 (de)	2001-02-22	2002-02-22	Pyrrolo-indol- und pyrrolo-chinolin-derivate als prodrugs zur tumorbehandlung

Country Status (7)

Country	Link
US (1)	US7626026B2 (de)
EP (1)	EP1409480B1 (de)
JP (1)	JP2004529887A (de)
AT (1)	ATE378328T1 (de)
DE (1)	DE60223544T2 (de)
ES (1)	ES2299560T3 (de)
WO (1)	WO2002068412A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1408960B1 (de) *	2001-02-22	2006-05-31	School Of Pharmacy, University Of London	Benz-indol- und benzo-chinolin-derivate als prodrugs zur tumorbehandlung
GB0302094D0 (en)	2003-01-29	2003-02-26	Pharmagene Lab Ltd	EP4 receptor antagonists
GB0324269D0 (en)	2003-10-16	2003-11-19	Pharmagene Lab Ltd	EP4 receptor antagonists
GB0505644D0 (en)	2005-03-18	2005-04-27	Univ London Pharmacy	Analogues of the azinomycins as anti-tumour agents and as prodrugs
CN101611025A (zh)	2006-12-22	2009-12-23	先灵公司	5,6-环化的吲哚衍生物及其使用方法
US8557848B2 (en) *	2006-12-22	2013-10-15	Merck Sharp & Dohme Corp.	4,5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections
WO2008082488A1 (en) *	2006-12-22	2008-07-10	Schering Corporation	4, 5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections
US9901567B2 (en)	2007-08-01	2018-02-27	Syntarga B.V.	Substituted CC-1065 analogs and their conjugates
EP2408761B1 (de)	2007-08-29	2014-01-01	Merck Sharp & Dohme Corp.	Substituierte indolderivate und verwendungsverfahren dafür
WO2009032116A1 (en)	2007-08-29	2009-03-12	Schering Corporation	2, 3-substituted indole derivatives for treating viral infections
ATE541845T1 (de)	2007-08-29	2012-02-15	Schering Corp	2,3-substituierte azaindolderivate zur behandlung von virusinfektionen
US8377928B2 (en)	2007-11-16	2013-02-19	Merck Sharp & Dohme Corp.	3-aminosulfonyl substituted indole derivatives and methods of use thereof
MX2010005356A (es)	2007-11-16	2010-05-27	Schering Corp	Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos.
MX2010013630A (es)	2008-06-13	2010-12-21	Schering Corp	Derivados triciclicos de indol y metodos de uso de los mismos.
ES2647317T3 (es)	2008-11-03	2017-12-20	Syntarga B.V.	Análogos de CC-1065 y sus conjugados
PT3056203T (pt)	2010-04-21	2018-02-15	Syntarga Bv	Conjugados de análogos de cc-1065 e ligantes bifuncionais
US8496218B2 (en) *	2011-06-08	2013-07-30	Alcon Research, Ltd.	Display monitor guide
RU2680404C2 (ru)	2014-01-10	2019-02-21	Синтон Байофармасьютикалс Б. В.	Способ очистки cys-связанных конъюгатов антитело-лекарственное средство
GB202300668D0 (en) *	2023-01-17	2023-03-01	Univ Bradford	Cancer treating compounds

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4413132A (en)	1980-11-18	1983-11-01	The Upjohn Company	Antibiotic CC-1065 indoline intermediates
EP0244120A3 (de)	1986-04-16	1989-07-12	Courtaulds Plc	Element aus Verbundwerkstoff
FI85403C (fi)	1989-12-22	1992-04-10	Neste Oy	Foerfarande foer framstaellning av en plastkompositbalk eller -pelare med staolfoerstaerkningen.
EP0563475B1 (de)	1992-03-25	2000-05-31	Immunogen Inc	Konjugaten von Zell-bindender Mittel und Derivaten von CC-1065
FR2700805B1 (fr)	1993-01-27	1995-04-07	Ind Entreprise	Procédé de renforcement d'une poutre détériorée, et poutre ainsi obtenue.
US5448869A (en)	1994-02-17	1995-09-12	Marvin Lumber And Cedar Co.	Composite framing member and window or door assembly incorporating a composite framing member
US5501054A (en)	1994-03-01	1996-03-26	The United States Of America As Represented By The Secretary Of Agriculture	Bolted wood connections
US5720143A (en)	1994-03-01	1998-02-24	The United States Of America As Represented By The Secretary Of Agriculture	Localized notch reinforcement for wooden beams
US5679432A (en)	1994-05-09	1997-10-21	Benchmark Foam, Inc.	Multi-layer laminate structure
US5688426A (en)	1995-06-07	1997-11-18	The Boeing Company	Hybrid metal webbed composite beam
US5657595A (en)	1995-06-29	1997-08-19	Hexcel-Fyfe Co., L.L.C.	Fabric reinforced beam and column connections
GB9519490D0 (en)	1995-09-25	1995-11-29	Melvin William T	Use of a cytochrome P450 enzyme in tumour cells as a marker and target
EP0888301B1 (de)	1996-03-08	2005-08-10	The Scripps Research Institute	Mcbi analoge von cc-1065 und die duocarmycine
US5843937A (en)	1996-05-23	1998-12-01	Panorama Research, Inc.	DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents
EP0934269A4 (de)	1996-05-31	2000-01-12	Scripps Research Inst	Analoge von cc-1065 und duocarmycine
US5794402A (en)	1996-09-30	1998-08-18	Martin Marietta Materials, Inc.	Modular polymer matrix composite support structure and methods of constructing same
NZ500789A (en)	1997-05-22	2002-05-31	Scripps Research Inst	Analogs of duocarmycin and CC-1065
JP4642226B2 (ja)	1998-02-06	2011-03-02	デモントフォートユニヴァーシティ	ヒドロキシル化により活性化されたプロドラッグ

2002
- 2002-02-22 ES ES02712114T patent/ES2299560T3/es not_active Expired - Lifetime
- 2002-02-22 US US10/468,741 patent/US7626026B2/en not_active Expired - Fee Related
- 2002-02-22 WO PCT/GB2002/000796 patent/WO2002068412A1/en not_active Ceased
- 2002-02-22 JP JP2002567925A patent/JP2004529887A/ja active Pending
- 2002-02-22 DE DE60223544T patent/DE60223544T2/de not_active Expired - Lifetime
- 2002-02-22 AT AT02712114T patent/ATE378328T1/de not_active IP Right Cessation
- 2002-02-22 EP EP02712114A patent/EP1409480B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO2002068412A1 (en)	2002-09-06
EP1409480A1 (de)	2004-04-21
DE60223544D1 (de)	2007-12-27
DE60223544T2 (de)	2008-09-25
EP1409480B1 (de)	2007-11-14
JP2004529887A (ja)	2004-09-30
ES2299560T3 (es)	2008-06-01
US20040157873A1 (en)	2004-08-12
US7626026B2 (en)	2009-12-01

Legal Events

Date	Code	Title	Description
2008-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE378328T1 (de)	2007-11-15	Pyrrolo-indol- und pyrrolo-chinolin-derivate als prodrugs zur tumorbehandlung
ATE327750T1 (de)	2006-06-15	Benz-indol- und benzo-chinolin-derivate als prodrugs zur tumorbehandlung
DE60220057D1 (de)	2007-06-21	Indoline und tetrahydro-chinoline als prodrugs zur tumorbehandlung
PT2420234E (pt)	2013-10-08	1h-benzimidazole-4-carboxamidas substituídas com um carbono quaternário na posição 2 como inibidores de parp para uso no tratamento do cancro
WO2006084017A3 (en)	2006-12-14	Phenyl-substituted pyrimidine compounds useful as kinase inhibitors
MX2009013341A (es)	2010-01-18	Derivados de 6-(pirrolopiridinil)-pirimidinil-2-amina.
SG164368A1 (en)	2010-09-29	Treatment of cancer
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NZ580226A (en)	2012-11-30	Dimer compounds as inhibitors of iap
TW200726753A (en)	2007-07-16	2,4-diamino-pyrimidines as aurora inhibitors
MX2009006864A (es)	2009-08-28	Inhibidores novedosos de c jun-n-terminal cinasas.
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WO2010003475A8 (de)	2011-01-20	Neue pyrrolidinderivate als metap-2 inhibitoren
SI1766010T1 (sl)	2011-06-30	Protismiselni oligonukleotidi za induciranje preskakovanja eksonov in postopki za njihovo uporabo
WO2010000364A8 (de)	2011-01-06	Pyrrolopyridinyl-pyrimidin-2-yl-amin-derivate
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WO2003063787A3 (en)	2004-01-22	Non-steroidal analogs of 2-methoxyestradiol
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WO2006071966A3 (en)	2006-08-17	Rapamycin compounds in the treatment of neurofibromatosis type 1
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MX2007006090A (es)	2007-07-11	2-metilen-19-nor-(20r)-1a-hidroxi-bishomopregnacalciferol.
WO2006124996A3 (en)	2007-01-04	Inhibitors of polo-like kinase-1
PT2121682E (pt)	2013-10-17	Derivados de 4-(pirrololpiridinil)-pirimidin-2-il-amina