ATE379990T1 - Verfahren zur darstellung von abgestorbenen zellen in-vivo - Google Patents
Verfahren zur darstellung von abgestorbenen zellen in-vivoInfo
- Publication number
- ATE379990T1 ATE379990T1 AT98920065T AT98920065T ATE379990T1 AT E379990 T1 ATE379990 T1 AT E379990T1 AT 98920065 T AT98920065 T AT 98920065T AT 98920065 T AT98920065 T AT 98920065T AT E379990 T1 ATE379990 T1 AT E379990T1
- Authority
- AT
- Austria
- Prior art keywords
- vivo
- dead cells
- displaying
- displaying dead
- cells
- Prior art date
Links
- 238000001727 in vivo Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 102000000412 Annexin Human genes 0.000 abstract 1
- 108050008874 Annexin Proteins 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
- A61B6/037—Emission tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/40—Arrangements for generating radiation specially adapted for radiation diagnosis
- A61B6/4057—Arrangements for generating radiation specially adapted for radiation diagnosis by using radiation sources located in the interior of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/42—Arrangements for detecting radiation specially adapted for radiation diagnosis
- A61B6/4208—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
- A61B6/425—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector using detectors specially adapted to be used in the interior of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/42—Arrangements for detecting radiation specially adapted for radiation diagnosis
- A61B6/4208—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
- A61B6/4258—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector for detecting non x-ray radiation, e.g. gamma radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/087—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being an annexin, e.g. annexin V
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Radiology & Medical Imaging (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- High Energy & Nuclear Physics (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Hydroponics (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4539997P | 1997-04-30 | 1997-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE379990T1 true ATE379990T1 (de) | 2007-12-15 |
Family
ID=21937648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98920065T ATE379990T1 (de) | 1997-04-30 | 1998-04-28 | Verfahren zur darstellung von abgestorbenen zellen in-vivo |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US6197278B1 (de) |
| EP (1) | EP1017318B1 (de) |
| JP (1) | JP4963748B2 (de) |
| KR (1) | KR20010020443A (de) |
| CN (1) | CN1265572A (de) |
| AT (1) | ATE379990T1 (de) |
| AU (1) | AU754577B2 (de) |
| CA (1) | CA2288131A1 (de) |
| DE (1) | DE69838811T2 (de) |
| ES (1) | ES2398118T3 (de) |
| HU (1) | HUP0001261A3 (de) |
| NZ (1) | NZ500598A (de) |
| PL (1) | PL336571A1 (de) |
| RU (1) | RU2228765C2 (de) |
| TW (1) | TW541184B (de) |
| WO (1) | WO1998048699A1 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2398118T3 (es) * | 1997-04-30 | 2013-03-13 | The Board Of Trustees Of The Leland Stanford Junior University | Procedimiento de formación de imágenes de muerte celular in vivo |
| US7736651B1 (en) * | 2000-11-24 | 2010-06-15 | Sloan-Kettering Institute For Cancer Research | Alpha emitting constructs and uses thereof |
| IL140701A0 (en) * | 1998-07-13 | 2002-02-10 | Univ Texas | Cancer treatment methods using antibodies to aminophospholipids |
| US6818213B1 (en) | 1998-07-13 | 2004-11-16 | Board Of Regents, The University Of Texas System | Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids |
| US6406693B1 (en) | 1998-07-13 | 2002-06-18 | Board Of Regents, The University Of Texas System | Cancer treatment methods using antibodies to aminophospholipids |
| EP1098665B9 (de) | 1998-07-13 | 2003-08-13 | The Board Of Regents, The University Of Texas System | Krebsbehandlung mit aminophospholipide bindenden, therapeutischen konjugaten |
| US7067111B1 (en) * | 1999-10-25 | 2006-06-27 | Board Of Regents, University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
| US6692724B1 (en) | 1999-10-25 | 2004-02-17 | Board Of Regents, The University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
| JP5448284B2 (ja) | 2000-06-02 | 2014-03-19 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | エチレンジシステイン(ec)−薬物結合体 |
| WO2001097678A2 (en) * | 2000-06-22 | 2001-12-27 | Henry Ford Health System | Imaging and targeting tumors using sickle cells |
| US20050013778A1 (en) * | 2001-04-03 | 2005-01-20 | Theseus Imaging Corporation | Methods and compositions for predicting the response to a therapeutic regimen in a subject having a disease associated with cell death |
| EP1381839A4 (de) * | 2001-04-03 | 2005-10-12 | Univ Leland Stanford Junior | Verfahren zur bildlichen darstellung von zelltod in vivo |
| JP2004535375A (ja) * | 2001-04-03 | 2004-11-25 | テセウス イメージング コーポレーション | 生体内における細胞死の検出および随伴する症状の治療のためのアネキシンの使用方法 |
| EP1389090A2 (de) * | 2001-04-26 | 2004-02-18 | Board of Regents, The University of Texas System | Diagnostische bildgebende zusammensetzungen, ihre syntheseverfahren und ihre verwendung |
| US20030202937A1 (en) * | 2001-06-05 | 2003-10-30 | Sabbadini Roger A. | Minicell-based diagnostics |
| US20030152513A1 (en) * | 2001-09-06 | 2003-08-14 | Imetrix, Inc. | Intravascular delivery of therapeutic and imaging agents to stressed and apoptotic cells using annexin V as a targeting vector |
| US7261875B2 (en) | 2001-12-21 | 2007-08-28 | Board Of Regents, The University Of Texas System | Dendritic poly (amino acid) carriers and methods of use |
| US20040042959A1 (en) * | 2002-08-28 | 2004-03-04 | Michael Montalto | Imaging cell death in vivo using non-radionuclide contrast agents |
| WO2004044227A2 (en) * | 2002-11-07 | 2004-05-27 | Board Of Regents, The University Of Texas System | Ethylenedicysteine (ec)-drug conjugates, compositions and methods for tissue specific disease imaging |
| US20070031333A1 (en) * | 2003-01-02 | 2007-02-08 | Mease Ronnie C | Novel F-18 labeled annexin V, synthesis thereof, and use thereof |
| US9050378B2 (en) * | 2003-12-10 | 2015-06-09 | Board Of Regents, The University Of Texas System | N2S2 chelate-targeting ligand conjugates |
| RU2386449C2 (ru) * | 2004-01-15 | 2010-04-20 | Эйпосенс Лтд. | Соединения, связывающиеся с нарушенной мембраной, и их применение |
| US7511016B2 (en) * | 2004-07-07 | 2009-03-31 | Mosamedix B.V. | Annexins, derivatives thereof, and annexin-cys variants, as well as therapeutic and diagnostic uses thereof |
| JP5345383B2 (ja) * | 2005-04-22 | 2013-11-20 | コーニンクレッカ フィリップス エヌ ヴェ | 検出器画素、放射線検出器および方法、陽電子放出断層撮影システム、撮像検出器およびその較正方法、検出器セルの無効化方法 |
| US7874975B2 (en) * | 2005-07-20 | 2011-01-25 | Clear Vascular, Inc. | Methods and compositions for treating luminal inflammatory disease |
| US9623129B2 (en) * | 2005-09-26 | 2017-04-18 | Snip Holdings, Inc. | Methods and therapies for treating inflammatory conditions with exposed collagen |
| CA2626392A1 (en) * | 2005-10-21 | 2007-05-03 | Immunochemistry Technologies, Llc | In vivo detection of apoptosis |
| US7871623B2 (en) * | 2005-12-21 | 2011-01-18 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for imaging pain and stress in vivo |
| US8758723B2 (en) | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
| CN101490581A (zh) * | 2006-07-21 | 2009-07-22 | 皇家飞利浦电子股份有限公司 | 用于改进的tof pet重建的方法和系统 |
| US10925977B2 (en) * | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
| JP5468905B2 (ja) * | 2007-01-30 | 2014-04-09 | ジーイー・ヘルスケア・リミテッド | 神経変性疾患の診断を支援するためのツール |
| EP2162762B1 (de) * | 2007-05-16 | 2016-06-08 | Koninklijke Philips N.V. | Virtueller pet-detektor und quasi-gepixeltes ableseschema für pet |
| US8055039B2 (en) * | 2008-02-21 | 2011-11-08 | General Electric Company | System and method to obtain noise mitigated monochromatic representation for varying energy level |
| US8916570B2 (en) | 2008-03-31 | 2014-12-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A3 adenosine receptor agonists and antagonists |
| ES2531828T3 (es) * | 2008-03-31 | 2015-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Derivados de purina como agonistas selectivos de los receptores A3 de adenosina |
| CA2732320C (en) * | 2008-08-01 | 2017-08-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A3 adenosine receptor antagonists and partial agonists |
| US9181253B2 (en) | 2008-08-01 | 2015-11-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adenosine receptor agonists, partial agonists, and antagonists |
| JP5801196B2 (ja) | 2008-08-26 | 2015-10-28 | モサメディックス・ビー.ブイ.MosaMedix B.V. | 放射標識アネキシン |
| US8283167B2 (en) * | 2009-02-11 | 2012-10-09 | Clear Vascular Inc. | Preparation of annexin derivatives |
| JP6138759B2 (ja) | 2011-04-04 | 2017-05-31 | イデー インターナショナル アールアンドディー インコーポレイテッドIdee International R&D Inc. | 使い捨てシリンジ |
| US10286093B2 (en) * | 2013-05-23 | 2019-05-14 | Neurosn, Inc. | Method of diagnosing and treating Alzheimer's disease |
| CN105669855B (zh) * | 2016-02-04 | 2020-02-11 | 江苏省原子医学研究所 | 一种18F快速标记Cys-Annexin V的方法及其应用 |
| RU2622983C1 (ru) * | 2016-07-25 | 2017-06-21 | федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Способ интраоперационной визуализации ишемически-реперфузионного повреждения миокарда |
| WO2019169241A1 (en) * | 2018-03-02 | 2019-09-06 | Serene, Llc | Methods of treating and imaging ungulate laminitis |
| JP2024022034A (ja) * | 2022-08-05 | 2024-02-16 | 浜松ホトニクス株式会社 | プログラムされた細胞死を起こした細胞の領域を決定する方法、決定部を備える装置及び決定ステップを含む情報処理プログラム |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4665897A (en) * | 1984-05-25 | 1987-05-19 | Lemelson Jerome H | Composition and method for detecting and treating cancer |
| US5627036A (en) | 1989-12-27 | 1997-05-06 | Boehringer Ingelheim International Gmbh | Use of an anticoagulant as a diagnostic agent |
| US5552525A (en) | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5632986A (en) * | 1991-05-09 | 1997-05-27 | The University Of Washington | Phospholipid-targeted thrombolytic agents |
| JPH05508664A (ja) | 1991-05-09 | 1993-12-02 | ボード・オブ・リージェンツ・オブ・ザ・ユニヴァーシティ・オブ・ワシントン | リン脂質標的血栓溶解剤 |
| US5519221A (en) | 1992-01-22 | 1996-05-21 | Ansel M. Schwartz | Dedicated apparatus and method for emission mammography |
| EP0627940B1 (de) * | 1992-03-05 | 2003-05-07 | Board of Regents, The University of Texas System | Verwendung von Immunokonjugate zur Diagnose und/oder Therapie der vaskularisierten Tumoren |
| US5965132A (en) * | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US5660827A (en) * | 1992-03-05 | 1997-08-26 | Board Of Regents, The University Of Texas System | Antibodies that bind to endoglin |
| GB9223168D0 (en) | 1992-11-05 | 1992-12-16 | Johnson Matthey Plc | Improvements in molecule labelling |
| US5968477A (en) | 1994-01-24 | 1999-10-19 | Neorx Corporation | Radiolabeled annexin conjugates with hexose and a chelator |
| CA2185535C (en) | 1994-04-11 | 2000-10-24 | Christiaan Peter Maria Reutelingsperger | A method for detecting and/or optionally quantifying and/or separating apoptotic cells in or from a sample |
| JPH10504534A (ja) | 1994-06-16 | 1998-05-06 | ネオルクス コーポレイション | 放射性標識アネキシン−ガラクトース結合体 |
| EP0799050B1 (de) | 1994-12-07 | 2004-08-11 | Neorx Corporation | Radioaktivmarkierte annexin-galaktose-cluster konjugate |
| ES2398118T3 (es) * | 1997-04-30 | 2013-03-13 | The Board Of Trustees Of The Leland Stanford Junior University | Procedimiento de formación de imágenes de muerte celular in vivo |
| IL140701A0 (en) | 1998-07-13 | 2002-02-10 | Univ Texas | Cancer treatment methods using antibodies to aminophospholipids |
| EP1098665B9 (de) | 1998-07-13 | 2003-08-13 | The Board Of Regents, The University Of Texas System | Krebsbehandlung mit aminophospholipide bindenden, therapeutischen konjugaten |
| US6406693B1 (en) * | 1998-07-13 | 2002-06-18 | Board Of Regents, The University Of Texas System | Cancer treatment methods using antibodies to aminophospholipids |
-
1998
- 1998-04-28 ES ES07023446T patent/ES2398118T3/es not_active Expired - Lifetime
- 1998-04-28 PL PL98336571A patent/PL336571A1/xx unknown
- 1998-04-28 CN CN98804718A patent/CN1265572A/zh active Pending
- 1998-04-28 JP JP54740298A patent/JP4963748B2/ja not_active Expired - Lifetime
- 1998-04-28 EP EP98920065A patent/EP1017318B1/de not_active Expired - Lifetime
- 1998-04-28 DE DE69838811T patent/DE69838811T2/de not_active Expired - Lifetime
- 1998-04-28 KR KR1019997010074A patent/KR20010020443A/ko not_active Abandoned
- 1998-04-28 NZ NZ500598A patent/NZ500598A/en unknown
- 1998-04-28 HU HU0001261A patent/HUP0001261A3/hu unknown
- 1998-04-28 TW TW087106507A patent/TW541184B/zh not_active IP Right Cessation
- 1998-04-28 AT AT98920065T patent/ATE379990T1/de not_active IP Right Cessation
- 1998-04-28 RU RU99125653/14A patent/RU2228765C2/ru not_active IP Right Cessation
- 1998-04-28 WO PCT/US1998/008769 patent/WO1998048699A1/en not_active Ceased
- 1998-04-28 AU AU72714/98A patent/AU754577B2/en not_active Ceased
- 1998-04-28 CA CA002288131A patent/CA2288131A1/en not_active Abandoned
- 1998-04-29 US US09/069,878 patent/US6197278B1/en not_active Expired - Lifetime
-
2002
- 2002-08-02 US US10/210,986 patent/US7357915B2/en not_active Expired - Fee Related
-
2007
- 2007-11-15 US US11/985,567 patent/US7666389B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1017318A1 (de) | 2000-07-12 |
| CA2288131A1 (en) | 1998-11-05 |
| RU2228765C2 (ru) | 2004-05-20 |
| DE69838811T2 (de) | 2008-10-30 |
| US7666389B2 (en) | 2010-02-23 |
| TW541184B (en) | 2003-07-11 |
| ES2398118T3 (es) | 2013-03-13 |
| EP1017318A4 (de) | 2003-04-23 |
| JP2002500757A (ja) | 2002-01-08 |
| US20070243133A1 (en) | 2007-10-18 |
| JP4963748B2 (ja) | 2012-06-27 |
| PL336571A1 (en) | 2000-07-03 |
| AU7271498A (en) | 1998-11-24 |
| US6197278B1 (en) | 2001-03-06 |
| NZ500598A (en) | 2001-09-28 |
| HUP0001261A2 (hu) | 2000-08-28 |
| US7357915B2 (en) | 2008-04-15 |
| KR20010020443A (ko) | 2001-03-15 |
| CN1265572A (zh) | 2000-09-06 |
| US20080138279A1 (en) | 2008-06-12 |
| DE69838811D1 (de) | 2008-01-17 |
| HUP0001261A3 (en) | 2001-11-28 |
| AU754577B2 (en) | 2002-11-21 |
| WO1998048699A1 (en) | 1998-11-05 |
| EP1017318B1 (de) | 2007-12-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |